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Matrix metalloproteinase 2 contributes to adult eclosion and immune response in the small hive beetle,Aethina tumida

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Insect Science 2024年第3期31卷 733-747页

作者： Lixian Wu Yajing Xu liangbin Li Dainan Cao Fang Liu Hongxia Zhao Guangdong Key Laboratssory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouChina

During the pupal-adult eclosion process of holometabolous insects,the old cuticle is shed and replaced by a completely different new cuticle that requires tanning and expansion,along with extensive extracellular matrix(ECM)*** vertebrates,matrix metalloproteinases(MMPs),a class of zinc-dependent endopeptidases,play key roles in regulating the ECM that surrounds ***,little is known about these extracellular proteinases available in *** small hive beetle(SHB),Aethina tumida,is a widespread invasive parasite of honey *** this study,6 MMP homologs were identified in the SHB *** interference experiments showed that all 6 AtMmps are not required for the larval-pupal transition,only AtMmp2 was essential for pupal-adult eclosion in *** of AtMmp2 resulted in eclosion defects and wing expansion failure,as well as mortality within 3 d of adult *** analysis revealed that knockdown of AtMmp2 significantly increased expression of the Toll and Imd pathways,chitin metabolism,and cross-linking(such as the pro-phenoloxidase activating cascade pathway and the tyrosine-mediated cuticle sclerotization and pigmentation pathway).These data revealed evolutionarily conserved functions of Mmp2 in controlling adult eclosion and wing expansion,also provided a preliminary exploration of the novel function of regulating Toll and Imd pathways,as well as new insights into how MMPs regulate insect development and defense barriers.

关键词： Aethina tumida adult eclosion immune response matrix metalloproteinase RNAinterference

Nickel-catalyzed arylcyanation of alkenes via cyano group translocation:access to 1.n-dinitriles or 4-amino nitriles

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Science China Chemistry 2024年第9期67卷 2975-2981页

作者： Xiaohong Li Shenfan Wang Xiangxiang Fu Donghui Xing Zeyuan Fu Yuanfu Deng Huanfeng Jiang liangbin Huang State Key Laboratory of Pulp and Paper Engineering School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China

Herein,a nickel-catalyzed arylcyanation of unactivated alkenes via cyano group translocation with aryl boronic acids has been *** transformations provided a robust approach to constructing structurally diverse 1.n-dinitriles or 4-amino nitriles from easily prepared and commercially available starting *** cyano group translocation was achieved,involving the addition into the intramolecular C–N triple bond followed by the retro-Thorpe *** studies revealed that high temperature and CsHCO_(3) as the base were crucial for the cyano group translocation.

关键词： arylcyanation nickel catalysis cyano group translocation 1 n-dinitriles 4-amino nitriles

Controlled Synthesis of Proton-Conductive Porous Organic Polymer Gels via Electrostatically Stabilized Colloidal Formation

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CCS Chemistry 2024年第7期6卷 1767-1775页

作者： Bin Chen Yifeng Kuang Lu Liu Linkun Cai Zaoming Wang Panchao Yin liangbin Huang Cheng Gu State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSouth China University of TechnologyGuangzhou 510640 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065 Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641 South China Advanced Institute for Soft Matter Science and Technology South China University of TechnologyGuangzhou 510640 Institute for Integrated Cell-Material Sciences Institute for Advanced StudyKyoto UniversityKyoto 606-8501

Porous organic polymers(POPs)have attracted extensive interest due to their structural diversity and predesigned ***,the majority of POPs are synthesized as insoluble and unprocessable powders,which greatly impede their advanced applications because of limited mass transport and inadaptation for device ***,we report a controlled synthetic strategy of macroscopic POP gels by a cation-stabilized colloidal formation mechanism,which is widely adaptable to a large variety of tetra-/tri-amino build blocks for the synthesis of Tröger’s base-linked POP gels,aerogels,and ionic *** POP gels combined the integrated advantages of hierarchically porous structures and tailorable mechanical stiffness,whereas they could load substantial amounts of phosphoric acids and construct unimpeded transport pathways for proton conduction,exhibiting unprecedented proton conductivity at subzero *** strategy offers a new solution to the intractable processing issues of POPs toward device applications with cutting-edge performances.

关键词： porous organic polymers Tröger’s base linkage gels superprotonic conduction subzero temperatures

Market Operation of Energy Storage System in Smart Grid:A Review

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Energy Engineering 2024年第6期121卷 1403-1437页

作者： Li Deng Jiafei Huan Wei Wang Weitao Zhang liangbin Xie Lun Dong Jingrong Guo Zhongping Li Yuan Huang Yue Xiang North China Dispatching Center North China Branch of State Grid Corporation of ChinaBeijing100053China College of Electrical Engineering Sichuan UniversityChengdu610065China

As a flexible resource,energy storage plays an increasingly significant role in stabilizing and supporting the power system,while providing auxiliary ***,the current high demand for energy storage contrasts with the fuzzy lack of market-oriented mechanisms for energy storage,the principle of market-oriented operation has not been embodied,and there is no unified and systematic analytical framework for the business ***,the dispatch management model of energy storage in actual power system operation is not ***,the specific scheduling process and energy storage strategy on the source-load-network side could be more specific,and there needs to be a greater understanding of the collaborative scheduling process of the multilevel scheduling *** this basis,this paper reviews the energy storage operation model and market-based incentive mechanism,For different functional types and installation locations of energy storage within the power system,the operational models and existing policies for energy storage participation in the market that are adapted to multiple operating states are *** the point of view of the actual scheduling and operation management of energy storage in China,an energy storage regulation and operation management model based on“national,provincial,and local”multilevel coordination is proposed,as well as key technologies in the interactive scenarios of source-load,network and storage.

关键词： Energy storage operation marketization scheduling management national-branch-provincial local dispatch

Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 481-495页

作者： Xiaokang Wang Xianjing Hu Chunxiao Ye Jingqian Zhao Shing Cheng Tan liangbin Zhou Chenyu Zhao Kit Hang Wu Xixiao Yang Jinbin Wei Maoxun Yang The Marine Biomedical Research Institute of Guangdong Zhanjiang ZhanjiangGuangdongChina Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs Guangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy Shenzhen Longhua District Central HospitalShenzhenGuangdongChina Dongguan Key Laboratory of Chronic Inflammatory Diseases The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Pharmacy Shenzhen Hospital of Southern Medical UniversityShenzhenGuangdongChina UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongHong Kong SARChina Department of Pharmacy Nossa Senhora do Carmo-Lago Health CentreHealth BureauMacaoChina Pharmaceutical College Guangxi Medical UniversityNanningGuangxiChina

Background and Aims:Voriconazole(VRC),a widely used antifungal drug,often causes hepatotoxicity,which presents a significant clinical *** studies demonstrated that Astragalus polysaccharide(APS)can regulate VRC metabolism,thereby potentially mitigating its hepatotoxic *** this study,we aimed to explore the mechanism by which APS regulates VRC ***:First,we assessed the association of abnormal VRC metabolism with hepatotoxicity using the Roussel Uclaf Causality Assessment Method ***,we conducted a series of basic experiments to verify the promotive effect of APS on VRC *** in vitro and in vivo assays,including cytokine profiling,immunohistochemistry,quantitative polymerase chain reaction,metabolite analysis,and drug concentration measurements,were performed using a lipopolysaccharideinduced rat inflammation ***,experiments such as intestinal biodiversity analysis,intestinal clearance assessments,and Bifidobacterium bifidum replenishment were performed to examine the ability of *** to regulate the expression of the VRC-metabolizing enzyme CYP2C1. through the gut–liver ***:The results indicated that APS does not have a direct effect on ***,the assessment of gut microbiota function revealed that APS significantly increases the abundance of ***,which could lead to an anti-inflammatory response in the liver and indirectly enhance VRC *** dual-luciferase reporter gene assay revealed that APS can hinder the secretion of pro-inflammatory mediators and reduce the inhibitory effect on CYP2C1. transcription through the nuclear factor-􀇉B signaling ***:The study offers valuable insights into the mechanism by which APS alleviates VRC-induced liver damage,highlighting its immunomodulatory influence on hepatic tissues and its indirect regulatory control of VRC-metabolizing enzymes within hepatocytes.

关键词： Astragalus polysaccharide Voriconazole Metabolism RUCAM Bifidobacterium bifidum Anti-inflammatory responses Gut Microbiota Hepatotoxicity

承认形式的缘起及其演进——霍耐特对黑格尔《耶拿实在哲学》的解读

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湖南师范大学社会科学学报 2024年第1期53卷 40-47页

作者：陈良斌东南大学马克思主义学院东南大学江苏南京211189

黑格尔早期的《耶拿实在哲学》日益受到学界的关注,霍耐特认为《耶拿实在哲学》比《伦理体系》更为清晰地将层次化的承认形式(即爱、法律和团结)作为精神发展的逻辑主线。首先,主观精神由于不满足于自身的状态,期望在现实中(即他者身上... 详细信息

黑格尔早期的《耶拿实在哲学》日益受到学界的关注,霍耐特认为《耶拿实在哲学》比《伦理体系》更为清晰地将层次化的承认形式(即爱、法律和团结)作为精神发展的逻辑主线。首先,主观精神由于不满足于自身的状态,期望在现实中(即他者身上)寻找自我,去拥有自己的本质,最初表现为性别互动所产生的爱的承认形式。但家庭领域中的爱注定是未完成的经验领域,一旦主观精神走出家庭,精神经历了“自然状态”到社会契约的过渡,黑格尔就以法律承认形式作为中介,构建起新的个体意志(即法人)的经验阶段。但犯罪行为的挑衅,就会使作为普遍意志的法律陷入再次分裂的境地。因此,黑格尔力图在更高的国家和共同体领域中对法律体系进行重构,霍耐特指出这就是团结的承认形式。在霍耐特看来,《耶拿实在哲学》中的承认线索在后来的《精神现象学》《法哲学原理》中得到进一步丰富,从而论证了承认形式的演进,本质上反映出精神的外化和现实化历程。

关键词：《耶拿实在哲学》承认形式爱法律团结

5种杀菌剂对水稻稻瘟病的田间防效及产量的影响

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农药 2024年第3期63卷 212-216页

作者：于良斌黑龙江省农业科学院植物保护研究所哈尔滨150086

[目的]为筛选出防治稻瘟病及增产效果明显的杀菌剂,为水稻病害的防控提供科学依据。[方法]采用田间药效试验的方法对防治稻瘟病常用的5种杀菌剂进行方差分析,继而通过聚类分析对5种杀菌剂的不同处理剂量进行田间防效评价。[结果]施药后... 详细信息

[目的]为筛选出防治稻瘟病及增产效果明显的杀菌剂,为水稻病害的防控提供科学依据。[方法]采用田间药效试验的方法对防治稻瘟病常用的5种杀菌剂进行方差分析,继而通过聚类分析对5种杀菌剂的不同处理剂量进行田间防效评价。[结果]施药后均未对水稻产生药害,5种杀菌剂均能抑制稻瘟病的发生,并起到增产的效果。其中制剂用量为1.50 g/hm^(2)的35%肟菌酯·三环唑悬浮剂防效最佳(91.40%),制剂用量为1.00 mL/hm^(2)的200亿芽孢/mL枯草芽孢杆菌可分散油悬浮剂增产最显著(1..74%);聚类分析针对综合效果将5种杀菌剂的20个处理剂量分为3类,筛选出综合效果最佳的药剂处理6个。[结论]处理剂量为1.50 g/hm^(2)的35%肟菌酯·三环唑悬浮剂和浓度为1.00 mL/hm^(2)的200亿芽孢/mL枯草芽孢杆菌可分散油悬浮剂对稻瘟病的防效最佳。

关键词：水稻稻瘟病杀菌剂防治效果聚类分析

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基于预训练模型的漏洞信息检索系统研究

情报杂志 2024年第8期43卷 84-91页

作者：刘烨杨良斌国际关系学院网络空间安全学院北京100091

[研究目的]威胁情报中漏洞信息是指有关网络、系统、应用程序或供应链中存在的漏洞的信息。目前搜索引擎在漏洞信息检索上存在短板,利用预训练模型来构建漏洞检索系统可以提高检索效率。[研究方法]以公开的漏洞信息作为数据来源,构建了... 详细信息

[研究目的]威胁情报中漏洞信息是指有关网络、系统、应用程序或供应链中存在的漏洞的信息。目前搜索引擎在漏洞信息检索上存在短板,利用预训练模型来构建漏洞检索系统可以提高检索效率。[研究方法]以公开的漏洞信息作为数据来源,构建了一个问答数据集,对Tiny Bert进行增量预训练。使用模型对于每个查询向量化,并把漏洞信息构建成faiss向量数据库,利用HNSW索引进行多通道和单通道召回检索。然后对模型进行对比学习微调生成双塔和单塔模型,利用双塔召回和单塔精排构建了一个简易的知识检索系统。[研究结论]实验结果表明,预训练模型可以显著地提升检索性能,对比学习微调的双塔模型在构建的漏洞信息测试集中TOP1.回率为92.1.%。通过漏洞信息领域的检索实践,对构建威胁情报的检索系统提供了参考。

关键词：威胁情报预训练模型漏洞信息多通道搜索技术信息检索系统

重审马克思“新世界观”创立的哲学史进路:从类本质到唯一者再到现实的个人

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世界哲学 2024年第3期 123-131页

作者：陈良斌王静东南大学马克思主义学院

在马克思“新世界观”萌芽的前夜,费尔巴哈的类本质与施蒂纳的唯一者构成了现实个人出场前的辩证环节。如果说费尔巴哈的类哲学走出了德国观念论的统治并尝试突破一般哲学形而上学,那么施蒂纳的唯一者哲学就是在扬弃类哲学的基础上对一... 详细信息

在马克思“新世界观”萌芽的前夜,费尔巴哈的类本质与施蒂纳的唯一者构成了现实个人出场前的辩证环节。如果说费尔巴哈的类哲学走出了德国观念论的统治并尝试突破一般哲学形而上学,那么施蒂纳的唯一者哲学就是在扬弃类哲学的基础上对一般哲学形而上学的第二次突破。但无论是类本质还是唯一者,因其自身的抽象片面性都没能完成这一任务。马克思在创立“新世界观”之际注意到了施蒂纳的独特性,并借助对施蒂纳的批判完成了对费尔巴哈的批判,从而快速地告别了费尔巴哈,开拓了新的哲学地平。在这段思想发展过程中,施蒂纳和费尔巴哈分别为马克思提供了一条通向现实个人的进路。正是在此基础上,马克思将感性对象性原则变成了感性对象性活动,从而使得现实的个人完成了对一般哲学形而上学的批判性超越。

关键词：类本质唯一者形而上学 “新世界观” 现实的个人