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Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota

Journal of Clinical and Translational Hepatology 2024年第5期12卷 481-495页

作者： Xiaokang Wang Xianjing Hu Chunxiao Ye Jingqian Zhao Shing Cheng Tan liangbin zhou Chenyu Zhao Kit Hang Wu Xixiao Yang Jinbin Wei Maoxun Yang The Marine Biomedical Research Institute of Guangdong Zhanjiang ZhanjiangGuangdongChina Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs Guangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy Shenzhen Longhua District Central HospitalShenzhenGuangdongChina Dongguan Key Laboratory of Chronic Inflammatory Diseases The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Pharmacy Shenzhen Hospital of Southern Medical UniversityShenzhenGuangdongChina UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongHong Kong SARChina Department of Pharmacy Nossa Senhora do Carmo-Lago Health CentreHealth BureauMacaoChina Pharmaceutical College Guangxi Medical UniversityNanningGuangxiChina

Background and Aims:Voriconazole(VRC),a widely used antifungal drug,often causes hepatotoxicity,which presents a significant clinical *** studies demonstrated that Astragalus polysaccharide(APS)can regulate VRC metabolism,thereby potentially mitigating its hepatotoxic *** this study,we aimed to explore the mechanism by which APS regulates VRC ***:First,we assessed the association of abnormal VRC metabolism with hepatotoxicity using the Roussel Uclaf Causality Assessment Method ***,we conducted a series of basic experiments to verify the promotive effect of APS on VRC *** in vitro and in vivo assays,including cytokine profiling,immunohistochemistry,quantitative polymerase chain reaction,metabolite analysis,and drug concentration measurements,were performed using a lipopolysaccharideinduced rat inflammation ***,experiments such as intestinal biodiversity analysis,intestinal clearance assessments,and Bifidobacterium bifidum replenishment were performed to examine the ability of *** to regulate the expression of the VRC-metabolizing enzyme CYP2C19 through the gut–liver ***:The results indicated that APS does not have a direct effect on ***,the assessment of gut microbiota function revealed that APS significantly increases the abundance of ***,which could lead to an anti-inflammatory response in the liver and indirectly enhance VRC *** dual-luciferase reporter gene assay revealed that APS can hinder the secretion of pro-inflammatory mediators and reduce the inhibitory effect on CYP2C19 transcription through the nuclear factor-􀇉B signaling ***:The study offers valuable insights into the mechanism by which APS alleviates VRC-induced liver damage,highlighting its immunomodulatory influence on hepatic tissues and its indirect regulatory control of VRC-metabolizing enzymes within hepatocytes.

关键词： Astragalus polysaccharide Voriconazole Metabolism RUCAM Bifidobacterium bifidum Anti-inflammatory responses Gut Microbiota Hepatotoxicity

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Palladium-catalyzed vinylation of indoles with vinyl ethers via deoxygenative coupling

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Science China Chemistry 2024年第11期67卷 3785-3790页

作者： Bowen Wang Jianxiao Li Wanqing Wu liangbin Huang Huanfeng Jiang Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of Technology

Indole is a promising heteroarene in many natural products and pharmaceuticals; therefore, various synthetic methods for indole functionalizations have arisen in recent years. Herein, we report a Pd-catalyzed deoxygenative coupling for the N-vinylation of indoles by employing vinyl ethers. The vinylated indoles could be readily prepared in good to excellent yields with N1-regioselectivity regardless of the electronic characteristics and substitution patterns of indole substrates. Some indole-based pharmaceutical molecules, such as gramine, evodiamine, rutaecarpine, and melatonine, are also successfully vinylated. Moreover, carbazoles and indazoles are shown to participate. Additionally, vinylated indole can readily transform into structurally interesting indole derivatives.

关键词： indole vinylation regioselectivity N-vinyl indole palladium catalyst

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Functionalized Hydrogels for Articular Cartilage Tissue Engineering

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Engineering 2022年第6期8卷 71-90页

作者： liangbin zhou Peng Guo Matteo D’Este Wenxue Tong Jiankun Xu Hao Yao Martin J.Stoddart Gerjo J.V.M.van Osch Kevin Ki-Wai Ho Zhen Li Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China AO Research Institute Davos DavosCH 7270Switzerland Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518000China Department of Orthopaedics and Sports Medicine&Department of Otorhinolaryngology Erasmus MCUniversity Medical CenterRotterdam 3000 CAthe Netherlands f Department of Biomechanical EngineeringDelft University of TechnologyDelft 2600 AAthe Netherlands Centre for Translational Medicine Research and Development Shenzhen Institute of Advanced TechnologyThe Chinese Academy of SciencesShenzhen 518000China

Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial *** defects are common in the knees of young and physically active *** of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage *** rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating *** can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of *** article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC ***,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation.

关键词： Articular cartilage Functionalized hydrogels Cartilage repair Cartilage tissue engineering Clinical translation

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Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells(ESPCs)-mediated articular cartilage repair

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Bioactive Materials 2023年第8期26卷 490-512页

作者： liangbin zhou Jietao Xu Andrea Schwa Wenxue Tong Jiankun Xu Lizhen Zheng Ye Li Zhuo Li Shunxiang Xu Ziyi Chen Li Zou Xin Zhao Gerjo J.V.Mvan Osch Chunyi Wen Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics and Traumatology&Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences Faculty of MedicineThe Chinese University of Hong Kong999077Hong Kong SARChina Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic University999077Hong Kong SARChina Department of Orthopaedics and Sports Medicine Erasmus MCUniversity Medical Center Rotterdam3015 GDRotterdamthe Netherlands Department of Oral and Maxillofacial Surgery Erasmus MCUniversity Medical Center Rotterdam3015 GDRotterdamthe Netherlands Centre for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of Sciences-CRMH999077Hong Kong SARChina Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong Kong999077Hong Kong SARChina Department of Otorhinolaryngology Erasmus MCUniversity Medical Center Rotterdam3015 GDRotterdamthe Netherlands Department of Biomechanical Engineering Faculty of MechanicalMaritime and Materials EngineeringDelft University of Technology(TU Delft)2600 AADelftthe Netherlands Centre for Translational Medicine Research and Development Shenzhen Institute of Advanced TechnologyThe Chinese Academy of Sciences518000ShenzhenChina

As a highly specialized shock-absorbing connective tissue,articular cartilage(AC)has very limited self-repair capacity after traumatic injuries,posing a heavy socioeconomic *** clinical therapies for small-to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies,including microfracture,mosaicplasty,autologous chondrocyte implantation(ACI),and matrix-induced ACI(MACI).However,these treatments frequently result in mechanically inferior fibrocartilage,low cost-effectiveness,donor site morbidity,and short-term *** prompts an urgent need for innovative approaches to pattern a pro-regenerative microenvironment and yield hyaline-like cartilage with similar biomechanical and biochemical properties as healthy native *** regenerative biomaterials can create a favorable local environment for AC repair without causing relevant regulatory and scientific concerns from cell-based treatments.A deeper understanding of the mechanism of endogenous cartilage healing is furthering the(bio)design and application of these ***,the utilization of regenerative biomaterials to magnify the repairing effect of joint-resident endogenous stem/progenitor cells(ESPCs)presents an evolving improvement for cartilage *** review starts by briefly summarizing the current understanding of endogenous AC repair and the vital roles of ESPCs and chemoattractants for cartilage *** several intrinsic hurdles for regenerative biomaterials-based AC repair are *** recent advances in novel(bio)design and application regarding regenerative biomaterials with favorable biochemical cues to provide an instructive extracellular microenvironment and to guide the ESPCs(***,migration,proliferation,differentiation,matrix production,and remodeling)for cartilage repair are ***,this review outlines the future directions of engineering the next-generation regenerative biomaterials toward ultim

关键词： Regenerative biomaterials Endogenous stem/progenitor cells(ESPCs) Articular cartilage(AC)repair Biochemical cues

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Matrix metalloproteinase 2 contributes to adult eclosion and immune response in the small hive beetle,Aethina tumida

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Insect Science 2024年第3期31卷 733-747页

作者： Lixian Wu Yajing Xu liangbin Li Dainan Cao Fang Liu Hongxia Zhao Guangdong Key Laboratssory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouChina

During the pupal-adult eclosion process of holometabolous insects,the old cuticle is shed and replaced by a completely different new cuticle that requires tanning and expansion,along with extensive extracellular matrix(ECM)*** vertebrates,matrix metalloproteinases(MMPs),a class of zinc-dependent endopeptidases,play key roles in regulating the ECM that surrounds ***,little is known about these extracellular proteinases available in *** small hive beetle(SHB),Aethina tumida,is a widespread invasive parasite of honey *** this study,6 MMP homologs were identified in the SHB *** interference experiments showed that all 6 AtMmps are not required for the larval-pupal transition,only AtMmp2 was essential for pupal-adult eclosion in *** of AtMmp2 resulted in eclosion defects and wing expansion failure,as well as mortality within 3 d of adult *** analysis revealed that knockdown of AtMmp2 significantly increased expression of the Toll and Imd pathways,chitin metabolism,and cross-linking(such as the pro-phenoloxidase activating cascade pathway and the tyrosine-mediated cuticle sclerotization and pigmentation pathway).These data revealed evolutionarily conserved functions of Mmp2 in controlling adult eclosion and wing expansion,also provided a preliminary exploration of the novel function of regulating Toll and Imd pathways,as well as new insights into how MMPs regulate insect development and defense barriers.

关键词： Aethina tumida adult eclosion immune response matrix metalloproteinase RNAinterference

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Nickel-catalyzed arylcyanation of alkenes via cyano group translocation:access to 1,n-dinitriles or 4-amino nitriles

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Science China Chemistry 2024年第9期67卷 2975-2981页

作者： Xiaohong Li Shenfan Wang Xiangxiang Fu Donghui Xing Zeyuan Fu Yuanfu Deng Huanfeng Jiang liangbin Huang State Key Laboratory of Pulp and Paper Engineering School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China

Herein,a nickel-catalyzed arylcyanation of unactivated alkenes via cyano group translocation with aryl boronic acids has been *** transformations provided a robust approach to constructing structurally diverse 1,n-dinitriles or 4-amino nitriles from easily prepared and commercially available starting *** cyano group translocation was achieved,involving the addition into the intramolecular C–N triple bond followed by the retro-Thorpe *** studies revealed that high temperature and CsHCO_(3) as the base were crucial for the cyano group translocation.

关键词： arylcyanation nickel catalysis cyano group translocation 1 n-dinitriles 4-amino nitriles

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欧盟体外诊断医疗器械分类监管体系变化与思考

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中国医疗器械杂志 2021年第6期45卷 674-679页

作者：周良彬崔乐程娟黄颖广东省医疗器械质量监督检验所广州市510663 中国食品药品检定研究院北京市100050

分析对比欧盟新法规IVDR与旧指令IVDD及相关指南文件中IVD产品分类监管体系,探讨其中监管变革思路,为行业人员了解掌握新的欧盟IVD分类体系提供参考,以供我国进行中的分类管理改革工作作为借鉴。

关键词：体外诊断器械分类监管体系法规欧盟

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转基因何首乌毛状根生物转化瑞香素的研究

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中国中药杂志 2011年第3期36卷 351-355页

作者：邓文娟周良彬于荣敏暨南大学药学院广东广州510632

目的:利用转基因何首乌毛状根对瑞香素(I)进行生物转化研究,对其生物转化产物进行分离、鉴定,并建立其产物的时效曲线图。方法:将瑞香素投入何首乌毛状根悬浮培养体系中,共培养36 h后,利用TLC和HPLC进行产物检测,硅胶柱层析法分离纯化,... 详细信息

目的:利用转基因何首乌毛状根对瑞香素(I)进行生物转化研究,对其生物转化产物进行分离、鉴定,并建立其产物的时效曲线图。方法:将瑞香素投入何首乌毛状根悬浮培养体系中,共培养36 h后,利用TLC和HPLC进行产物检测,硅胶柱层析法分离纯化,核磁共振技术进行结构鉴定,利用HPLC考察共培养时间对转化产物(Ⅱ)、降解产物含量的影响及分析转化产物降解的原因。结果:瑞香素在何首乌毛状根悬浮培养体系中发生了生物转化反应。分离鉴定出一个产物:瑞香素-8-O-β-D-葡萄糖苷(Ⅱ)。何首乌毛状根悬浮培养体系转化生成Ⅱ的最佳共培养时间为36 h,总摩尔转化率为32.11%。蔗糖-水培养基(仅含有蔗糖和水)可以使何首乌毛状根悬浮培养体系转化产率大幅增加,总摩尔转化率达72.44%。初步推断产物(Ⅱ)的降解与MS培养基中金属离子有关。结论:使用何首乌毛状根悬浮培养体系可大量生物合成天然药材中含量极低的活性化合物——瑞香素-8-O-β-D-葡萄糖苷。

关键词：何首乌毛状根生物转化瑞香素瑞香素-8-O-β-D-葡萄糖苷

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Controlled Synthesis of Proton-Conductive Porous Organic Polymer Gels via Electrostatically Stabilized Colloidal Formation

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CCS Chemistry 2024年第7期6卷 1767-1775页

作者： Bin Chen Yifeng Kuang Lu Liu Linkun Cai Zaoming Wang Panchao Yin liangbin Huang Cheng Gu State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSouth China University of TechnologyGuangzhou 510640 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065 Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641 South China Advanced Institute for Soft Matter Science and Technology South China University of TechnologyGuangzhou 510640 Institute for Integrated Cell-Material Sciences Institute for Advanced StudyKyoto UniversityKyoto 606-8501

Porous organic polymers(POPs)have attracted extensive interest due to their structural diversity and predesigned ***,the majority of POPs are synthesized as insoluble and unprocessable powders,which greatly impede their advanced applications because of limited mass transport and inadaptation for device ***,we report a controlled synthetic strategy of macroscopic POP gels by a cation-stabilized colloidal formation mechanism,which is widely adaptable to a large variety of tetra-/tri-amino build blocks for the synthesis of Tröger’s base-linked POP gels,aerogels,and ionic *** POP gels combined the integrated advantages of hierarchically porous structures and tailorable mechanical stiffness,whereas they could load substantial amounts of phosphoric acids and construct unimpeded transport pathways for proton conduction,exhibiting unprecedented proton conductivity at subzero *** strategy offers a new solution to the intractable processing issues of POPs toward device applications with cutting-edge performances.

关键词： porous organic polymers Tröger’s base linkage gels superprotonic conduction subzero temperatures

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2,3-二氢环戊二烯香豆素类化合物对转基因何首乌毛状根生长及其二苯乙烯苷累积的影响

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中国中药杂志 2012年第9期37卷 1197-1201页

作者：刘玲周良彬张明华于荣敏暨南大学中药生物技术研究所广东广州510632 暨南大学药学院天然药物化学研究室广东广州510632

目的:考察2,3-二氢环戊二烯香豆素类化合物对何首乌毛状根生长的影响,并研究其对毛状根中有效成分二苯乙烯苷累积的刺激作用。方法:将2,3-二氢环戊二烯香豆素类化合物在不同的培养时间加入到毛状根中,共培养特定时间后测定其二苯乙烯苷... 详细信息

目的:考察2,3-二氢环戊二烯香豆素类化合物对何首乌毛状根生长的影响,并研究其对毛状根中有效成分二苯乙烯苷累积的刺激作用。方法:将2,3-二氢环戊二烯香豆素类化合物在不同的培养时间加入到毛状根中,共培养特定时间后测定其二苯乙烯苷的含量及生长量,并通过考察不同浓度和继代次数确定最佳实验条件。结果:加入香豆素类化合物的最佳时间为预培养第4天,最佳质量浓度为0.025 g.L-1,毛状根的生长量有较大提高,与对照组相比二苯乙烯苷的含量增加4倍左右。结论:2,3-二氢环戊二烯香豆素类化合物作为一类非生物诱导子能够促进何首乌毛状根的生长及有效成分二苯乙烯苷的累积。

关键词： 2,3-二氢环戊二烯香豆素诱导作用何首乌毛状根二苯乙烯苷

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