Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells(ESPCs)-mediated articular cartilage repair
作者机构：Musculoskeletal Research Laboratory of Department of Orthopaedics and Traumatology&Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory of Li Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong Kong999077Hong Kong SARChina Department of Biomedical EngineeringFaculty of EngineeringThe Hong Kong Polytechnic University999077Hong Kong SARChina Department of Orthopaedics and Sports MedicineErasmus MCUniversity Medical Center Rotterdam3015 GDRotterdamthe Netherlands Department of Oral and Maxillofacial SurgeryErasmus MCUniversity Medical Center Rotterdam3015 GDRotterdamthe Netherlands Centre for Regenerative Medicine and HealthHong Kong Institute of Science&InnovationChinese Academy of Sciences-CRMH999077Hong Kong SARChina Department of Biomedical EngineeringFaculty of EngineeringThe Chinese University of Hong Kong999077Hong Kong SARChina Department of OtorhinolaryngologyErasmus MCUniversity Medical Center Rotterdam3015 GDRotterdamthe Netherlands Department of Biomechanical EngineeringFaculty of MechanicalMaritime and Materials EngineeringDelft University of Technology(TU Delft)2600 AADelftthe Netherlands Centre for Translational Medicine Research and DevelopmentShenzhen Institute of Advanced TechnologyThe Chinese Academy of Sciences518000ShenzhenChina
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2023年第26卷第8期
页 面：490-512页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0836[工学-生物工程]
基 金：supported by the Areas of Excellence Scheme from University Grant Council of Hong Kong(AoE/M-402/20) the AO Foundation,Switzerland(AO-OCD Consortium TA1711481) the Theme-based Research Scheme from University Grant Council of Hong Kong(T13-402/17-N) the Mainland-Hong Kong Joint Funding Scheme of Innovation and Technology Fund:ITF MHKJFS(MHP/011/20)
主 题：Regenerative biomaterials Endogenous stem/progenitor cells(ESPCs) Articular cartilage(AC)repair Biochemical cues
摘 要：As a highly specialized shock-absorbing connective tissue,articular cartilage(AC)has very limited self-repair capacity after traumatic injuries,posing a heavy socioeconomic *** clinical therapies for small-to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies,including microfracture,mosaicplasty,autologous chondrocyte implantation(ACI),and matrix-induced ACI(MACI).However,these treatments frequently result in mechanically inferior fibrocartilage,low cost-effectiveness,donor site morbidity,and short-term *** prompts an urgent need for innovative approaches to pattern a pro-regenerative microenvironment and yield hyaline-like cartilage with similar biomechanical and biochemical properties as healthy native *** regenerative biomaterials can create a favorable local environment for AC repair without causing relevant regulatory and scientific concerns from cell-based treatments.A deeper understanding of the mechanism of endogenous cartilage healing is furthering the(bio)design and application of these ***,the utilization of regenerative biomaterials to magnify the repairing effect of joint-resident endogenous stem/progenitor cells(ESPCs)presents an evolving improvement for cartilage *** review starts by briefly summarizing the current understanding of endogenous AC repair and the vital roles of ESPCs and chemoattractants for cartilage *** several intrinsic hurdles for regenerative biomaterials-based AC repair are *** recent advances in novel(bio)design and application regarding regenerative biomaterials with favorable biochemical cues to provide an instructive extracellular microenvironment and to guide the ESPCs(***,migration,proliferation,differentiation,matrix production,and remodeling)for cartilage repair are ***,this review outlines the future directions of engineering the next-generation regenerative biomaterials toward ultim
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