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A hippocampal anti-hypertensive mechanism induced by twirling reinforcing-reducing manipulation in rats

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 106-117页

作者： Jiao Sun Liu Yan Yunhong Zhu jingrong liang Yingying Zang Tianxiao Zeng Xiaomin Hao Pui Yee Wong Qingguo Liu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102488China Department of Rehabilitation Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser Hospital)Qingdao 266033China Department of Acupuncture Mediseed Chinese Medicine Consulting CentrePetaling Jaya 46200Malaysia

Objective:To investigate a hippocampal anti-hypertensive mechanism induced by twirling reinforcingreducing manipulation(TRRM)using proteomics in ***:Forty-two male spontaneously hypertensive rats were randomly divided into 3 groups,and 14 Wistar-Kyoto rats were served as control *** the twirling reinforcing(TRF)group,needles were directly inserted into the Taichong(LR 3)point,then thumbs were moved heavily forward and lightly backward for 3 min,while needles remained inserted for 17 *** the twirling reduction(TRD)group,the same treatment was applied as in the TRF group except that the thumb moved lightly forward and heavily *** the model and control groups,only the corresponding grasping and fixation were *** interventions were conducted for 14 *** blood pressure(BP)of all rats was measured one day before intervention and every other day *** hematoxylin-eosin(H&E)staining,label-free and parallel reaction monitoring proteomic techniques were used to assess hippocampal samples from each ***:Systolic BPs showed a significant decrease in the TRF and TRD groups compared with the model group(P<.01).In the model group,H&E staining showed obvious pathological changes in the hippocampus,while in the TRF and TRD groups,the hippocampal morphology was only slightly *** proteomic analysis revealed 1163 differential protein expressions between *** Ontology enrichment analysis confirmed that the differentially expressed proteins were enriched in different biological processes,cellular components,and molecular *** Encyclopedia of Genes and Genomes enrichment analysis showed that TRRM proteins were expressed in the serotonergic synapse pathway,renin-angiotensin system,the mitogen-activated protein kinase signaling pathway,and the peroxisome pathway,which were all also related to BP ***:TRRM can significantly lower the BP of *** mode of action may be through the activation

关键词： Twirling reinforcing-reducing method Blood pressure Hypertension Hippocampus Proteomics Spontaneously hypertension rats Taichong Acupuncture

Effects of electroacupuncture at Taichong(LR 3) and Baihui(DU 20)on cardiac hypertrophy in rats with spontaneous hypertension

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Journal of Traditional Chinese Medicine 2019年第4期39卷 502-508页

作者： Ji Zhi Zhang Yue liang jingrong Wu Jiaojuan Jia Wenrui Wang Zhaoyang Liu Qingguo School of Acupuncture Moxibustion and TuinaBeijing University of Chinese MedicineBeijing 100029China Beijing University of Chinese Medicine Personnel DivisionBeijing 100029China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE: To investigate the effects of electroacupuncture(EA) at Taichong(LR 3) and Baihui(DU 20)on myocardial hypertrophy in spontaneously hypertensive rats(SHRs).METHODS: Thirty-six SHRs were randomly assigned to model, EA, and Losartan groups, with twelve rats per group. Twelve Wistar Kyoto rats were selected as the normal control group. Systolic blood pressure(SBP) and cardiac function were measured in all *** levels of factors associated with the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/Akt/mTOR) pathway were evaluated by Western blotting and real-time *** changes of the heart tissue were observed by hematoxylin-eosin ***: After treatment, enhanced SBP was significantly decreased in the EA and Losartan groups compared with the model group(P < 0.01). Echocardiographic and morphological analyses revealed that enhanced end-diastolic interventricular septal thickness and left ventricular posterior wall thickness, as well as ratio of left ventricular weight to body weight were markedly diminished in the EA and Losartan groups(P < 0.01 or P < 0.05), while reduced left ventricular end-diastolic dimension and left ventricular ejection fraction were significantly ameliorated(P < 0.01). Real-time PCR and western blotting analyses showed that the expression levels of PI3K,Akt, and mT OR in SHRs were significantly up-regulated by EA and Losartan(P < 0.01), while the expression levels of PTEN and ANP were down-regulated(P < 0.01).CONCLUSION: EA at Taichong(LR 3) and Baihui(DU20) inhibited the development of cardiac hypertrophy and improved the cardiac function in SHRs, possibly through regulation of the PI3K/Akt/mTOR signalling pathway.

关键词： Electroacupuncture Rats,inbred SHR Hypertrophy Phosphatidylinositol 3-kinases Proto-oncogene proteins c-akt Mammalian target of rapamycin

Effect of acupuncture at Renying(ST 9) on gene expression profile of hypothalamus in spontaneously hypertensive rats

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Journal of Traditional Chinese Medicine 2018年第2期38卷 227-241页

作者： Guo Yan Lu Juan liang jingrong Zhao Ruili Xu Jing Zhang Wei Park Kibeum Zhu Shipeng Chen Huan Ma liangxiao Department of Acupuncture and Moxibustion First Hospital Affiliated to Tianjin College of Traditional Chinese Medicine College of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine College of Acupuncture-Moxibustion and Tuina Second School of Clinical Medical of Nanjing University of Traditional Chinese Medicine Department of Acupuncture and Moxibustion Jiangsu Province Hospital

OBJECTIVE: To investigate changes in gene expression profiles in the hypothalamus related to the effects of acupuncture at the Renying(ST 9) acupoint in spontaneously hypertensive(SH) ***: We randomly divided 18 SH rats into Renying(ST 9) group and model control group, 9 body weight-matched Wistar-Kyoto rats were used as blank controls. Acupuncture was performed manually for 20-min daily over 28 d in the Renying(ST 9) group. Rat Gene 2.0 array technology was used for the determination of gene expression profiles and the screened key genes were verified by real-time quantitative polymerase chain reaction(RT-PCR) ***: The different groups exhibited differential gene expression: compared with the blank control group, 48 genes were up-regulated and 91 genes were down-regulated in the model group;compared with the model group, 79 genes were up-regulated and 80 genes were down-regulated in Renying(ST 9) group. The RT-PCR results of the key genes including Chi3 l1, Ephx2, Klk1, 5-HT1 A and Cbs were consistent with that of gene chip ***: Acupuncture at Renying(ST 9)could significantly lower the blood pressure of SH rats and affect their hypothalamic gene expression profile. Genes associated with the contraction of vascular smooth muscle and the regulation of inflammation, neurotransmitters may be involved in acupuncture's antihypertensive mechanism.

关键词：基因表达式高血压老鼠针灸侧面下丘 Wistar 聚合酶链反应

Effects of different acupuncture manipulations on protein expression in the parietal cortex of spontaneously hypertensive rats

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Journal of Traditional Chinese Medical Sciences 2021年第3期8卷 257-264页

作者： Jiaojuan Wu Tianxiao Zeng jingrong liang Xudong Zhang Qi Xie Taotao Lv Pui Yee Wong Zhi Ji Qingguo Liu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing102488China Department of Pain Management Huazhong University of Science and Technology Union Shenzhen HospitalShenzhen518052China Shu Guang TCM Healthcare Center KualaLumpur56000Malaysia Department of Acupuncture-Moxibustion China-Japan Friendship HospitalBeijing100029China

Objective: To analyze the effects of twirling reinforcing and reducing manipulations on protein expression in parietal cortex of spontaneously hypertensive rats(SHRs), and elucidate the main mechanisms and differences between two manipulations in hypertension ***: Rats were randomly divided into the control, model, twirling reinforcing manipulation(TRFM),and twirling reducing manipulation(TRDM) groups. The control and model groups received catch and fixation stimulations once a day for 14 days. The TRFM and TRDM groups were intervened once a day for 20 min for 14 days. On days 0, 2, 6, 10, and 14 after acupuncture, rat systolic blood pressures(SBPs) were measured. Differential protein(DP) expression in the rat parietal cortices was detected. Thereafter, GO functional significance and KEGG pathway enrichment analyses were ***: Compared with the model group, SBP of rats in the TRDM and TRFM groups decreased on days 6 and 10 of acupuncture, respectively(P=.009;P <.001). Moreover, SBP of the TRDM group was significantly lower than that of the TRFM group on days 10 and 14 of acupuncture(P=.015;P=.013).Compared with control group, 601 and 1040 DPs were up-and downregulated, respectively, in the model group. Compared with model group, 44 and 28 up-and downregulated DPs were expressed, respectively,in the TRFM group. Compared with model group, expression of 616 and 427 up-and downregulated DPs,respectively, was found in the TRDM group. After combining the results of GO and KEGG enrichment analyses, five and one pathways were found to be related to the central antihypertensive mechanism of the parietal cortex during twirling reducing and reinforcing manipulations, ***: TRDM showed a more effective antihypertensive effect on SHRs than TRFM;this antihypertensive effect was related to the regulation of different proteins and their biological functions.

关键词： Hypertension Proteomics Parietal cortex Acupuncture Manipulation

发射峰为875 nm的高热稳定性立方相Sc(PO_(3))_(3):Cr^(3+)荧光粉

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Science China Materials 2024年第3期67卷 931-938页

作者：刘乐聂文东吴会杰张景荣梁思思朱浩淼 CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Research Center of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021China

近红外(NIR)荧光粉转换型发光二极管(pc-LED)具有尺寸小、效率高以及光谱易于调节的特点,在特种照明、传感、微型近红外光谱仪等各领域有很好的应用前景.目前,已报道的发射波长超过850 nm的近红外荧光粉的荧光热稳定性较差.在本项研究中... 详细信息

近红外(NIR)荧光粉转换型发光二极管(pc-LED)具有尺寸小、效率高以及光谱易于调节的特点,在特种照明、传感、微型近红外光谱仪等各领域有很好的应用前景.目前,已报道的发射波长超过850 nm的近红外荧光粉的荧光热稳定性较差.在本项研究中,我们合成了一种立方相结构的Sc(PO_(3))_(3):xCr^(3+)(x=0,1,5,10,12,14,16,18 at%)荧光粉,其具有725–1150 nm的宽发射带,发射峰为875 nm,与之前报道的发射峰超过850 nm的荧光粉相比,其表现出优异的热稳定性,在423 K下,5 at%样品的积分发光强度保留了室温下的73.4%.通过对比研究立方相和单斜相Sc(PO_(3))_(3):Cr^(3+)荧光粉变温X射线衍射,发现立方相荧光粉优异的荧光热稳定性可能归因于高温下较小的键长和键角变化.利用该荧光粉制备的NIR pc-LED在150 mA电流驱动下,产生了26.62 mW的NIR辐射功率.驱动电流为10 mA时,最高电光转换效率为11.87%.这项工作为开发具有优异荧光热稳定性的Cr^(3+)离子掺杂近红外荧光粉提供了思路.

关键词： near infrared phosphor pc-LEDs broadband emission Sc(PO_(3))_(3) luminescent materials

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自噬在银屑病发病及治疗中的研究进展

皮肤科学通报 2022年第3期39卷 260-264,M0009页

作者：吴晓君梁靖蓉廖翔广东医科大学广东湛江524000 华中科技大学协和深圳医院广东深圳518052

自噬是一种进化高度保守的分解代谢途径,不仅在维持机体的细胞内稳态中具有重要意义,在免疫调节、细胞增殖分化方面也发挥着重要作用。在银屑病的发病中,以持续炎症反应、细胞过度增殖和分化不良为特征,自噬在这其中也起着重要的调节作... 详细信息

自噬是一种进化高度保守的分解代谢途径,不仅在维持机体的细胞内稳态中具有重要意义,在免疫调节、细胞增殖分化方面也发挥着重要作用。在银屑病的发病中,以持续炎症反应、细胞过度增殖和分化不良为特征,自噬在这其中也起着重要的调节作用。本文将综述自噬在银屑病发病机制和治疗中作用的研究,为银屑病的药物研发提供新思路。

关键词：自噬炎症反应增殖银屑病

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新能源车行业大屏控制系统的设计与实现

计算机应用文摘 2022年第19期38卷 59-61,65页

作者：伍凌云袁林海磨春妗钟小敏梁静荣上汽通用五菱汽车股份有限公司广西新能源汽车实验室广西汽车新四化重点实验室广西柳州545007

随着信息技术的发展和大数据时代的来临,大屏数据可视化技术已在电信、公安、交通、新能源汽车等各个行业得到广泛应用。然而,用户对大屏上显示的数据内容经常因需求不同而产生变化。因此,研究一种能够灵活配置的大屏控制系统是十分必... 详细信息

随着信息技术的发展和大数据时代的来临,大屏数据可视化技术已在电信、公安、交通、新能源汽车等各个行业得到广泛应用。然而,用户对大屏上显示的数据内容经常因需求不同而产生变化。因此,研究一种能够灵活配置的大屏控制系统是十分必要且有现实意义的。基于此,文章设计了一种新能源车行业大屏控制系统,通过屏幕设置、单屏设计、多屏拼接等功能实现了灵活的大屏数据可视化看板,从而满足新能源车行业不同角色多维度的数据监控分析需求,支持多场景的数据展示。

关键词：大屏控制数据可视化数据管理信息技术

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球形转向轮仿真设计

中国农机装备 2024年第3期 2-5页

作者：王佳伟余旌榕梁智翔史颖刚刘利西北农林科技大学机械与电子工程学院杨凌712100

设计一种应用于农田作业环境尤其是蔬菜大棚环境的球形转向轮,为农业机器人在农田环境下不能顺利球形移动的问题提供一种解决办法。球形转向轮采用双轮驱动方式,同轴直流减速电机驱动,产生转矩从而前后左右移动,并以陀螺仪检测补偿,实... 详细信息

设计一种应用于农田作业环境尤其是蔬菜大棚环境的球形转向轮,为农业机器人在农田环境下不能顺利球形移动的问题提供一种解决办法。球形转向轮采用双轮驱动方式,同轴直流减速电机驱动,产生转矩从而前后左右移动,并以陀螺仪检测补偿,实现轮系闭环控制,再通过上位机整体驱动轮系运转,并设置补偿环节,使得下位机整体闭环,实现该轮系整体驱动与控制,使得农业机器人在野外球形移动,尽可能少地受到环境的约束。

关键词：双轮驱动闭环控制球形移动

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电针对自发性高血压大鼠心肌肥厚的影响

中医杂志 2019年第5期60卷 427-432页

作者：纪智王紫娟袁静云张跃梁靖蓉张月刘清国北京中医药大学针灸推拿学院北京市100029

目的探讨电针治疗高血压病合并心肌肥厚的可能作用机制。方法将12周龄雄性WKY大鼠12只作为正常组,24只自发性高血压大鼠(SHR)随机分为模型组和电针组各12只。电针组大鼠采用毫针分别于"百会"和双侧"太冲"直刺1~2 mm,进针后不施任何补泻... 详细信息

目的探讨电针治疗高血压病合并心肌肥厚的可能作用机制。方法将12周龄雄性WKY大鼠12只作为正常组,24只自发性高血压大鼠(SHR)随机分为模型组和电针组各12只。电针组大鼠采用毫针分别于"百会"和双侧"太冲"直刺1~2 mm,进针后不施任何补泻手法。"百会"与右侧"太冲"分别连接韩氏电针仪的正负极,留针20 min。于每天上午针刺1次,连续针刺30天。正常组和模型组每天置于与电针组相同的固定装置中保持20 min。各组于开始针刺前1天及针刺第6、12、18、24、30天测量收缩压。以超声心动检测大鼠左心室肥厚程度和功能[包括舒张末左室后壁厚度(LVP-WT)、舒张末室间隔厚度(IVST)、左室舒张末内径(LVEDD)和左室射血分数(LVEF)],左心室质量指数(LVMI),HE染色观察心肌组织形态,并通过RT-PCR和Western blot技术检测各组大鼠心肌组织中磷脂酰肌醇激酶(PI3K)、蛋白激酶B (Akt)、哺乳动物雷帕霉素靶蛋白(m TOR)、同源性磷酸酶-张力蛋白(PTEN)、心房钠尿肽(ANP)蛋白与mRNA表达。结果与正常组比较,模型组大鼠LVMI、LVP-WT、IVST显著升高,LVEDD、LVEF显著降低(P <0. 01)。与模型组比较,电针组LVMI、LVP-WT、IVST明显降低,LVEDD、LVEF显著升高(P <0. 05或P <0. 01)。与正常组比较,模型组的心肌细胞排列相对紊乱,细胞横截面积明显变大,细胞间距变宽,细胞核增大深染。与模型组比较,电针组单位视野内细胞核的数量增多,心肌细胞横截面积相对较小,细胞间距相对更窄。与正常组比较,模型组心肌组织PI3K、Akt、m TOR蛋白和mRNA表达显著降低,PTEN蛋白和mRNA表达升高(P <0. 05或P <0. 01)。与模型组比较,电针组心肌组织PI3K、Akt、m TOR蛋白和mRNA表达显著升高,PTEN蛋白和mRNA表达降低(P <0. 05或P <0. 01)。结论电针"百会""太冲"可有效改善SHR心肌肥厚,电针激活PI3K/Akt通路可能是其机制之一。

关键词：自发性高血压心肌肥厚电针 PI3K/Akt信号转导通路