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Chinese Journal of Chemistry 2024年第7期42卷 705-710页

作者： juan Wang Qing-Xian Xie Xiang li Chang-Bin Yu Yong-Gui Zhou School of Chemistry Dalian University of Technology2 Linggong RoadDalianLiaoning 116024China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning 116023China

The planar-chiral ligands have been widely applied as a class of unique and significant ligands in asymmetric *** them,chiral[2.2]paracycyclophane has emerged as a privileged type of planar-chiral framework and has been utilized as an important toolbox due to their structural ***,we design and synthesize[2.2]paracyclophane-derived oxazole-pyrimidine ligands(abberviated as PYMCOX).These N,N-ligands with stable properties,rigid structure and large steric hindrance performed successfully in nickel-catalyzed asymmetric 1,2-reduction ofα,β-unsaturated ketones,affording the chiral allylic alcohols with up to 99%yield and 99%***,this reduction reaction could be conducted on gram-scale without loss of activity and enantioselectivity,and the chiral ligand could be conveniently recovered with high yield.

关键词： Oxazole-pyrimidine ligands Planar chirality Nickel Hydroboration Asymmetric synthesis

Predictive Ability of Hypertriglyceridemic Waist,Hypertriglyceridemic Waist-to-Height Ratio,and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 233-241页

作者： XIAO Tian li YUAN Shu Qian GAO Jing Yu Julien SBaker yang Yi De WANG Xi Jie ZHENG Chan juan DONG Yan Hui ZOU Zhi Yong Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina The Institute of Interdisciplinary Studies Hunan Normal UniversityChangsha 410013HunanChina Chenzhou First People's Hospital Chenzhou 423000HunanChina Centre for Health and Exercise Science Research Hong Kong Baptist UniversityKowloon TongHong Kong 999077China Department of Sport Physical Education and HealthHong Kong Baptist UniversityKowloon TongHong Kong 999077China Vanke School of Public Health Tsinghua UniversityBeijing 100084China Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk ***,it is not clear which indicator is more suitable for children and *** aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and *** This was a national cross-sectional *** and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in ***,physical activity,dietary intake,and family history of chronic diseases were obtained through ***,χ2 and logistic regression analysis was *** A significant sex difference was observed for HWHtR and WHR,but not for HW *** risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.

关键词： Hypertriglyceridemic waist Waist-to-hip ratio Children and adolescents China Hypertriglyceridemic waist-to-height ratio Cardiovascular risk factors

First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： Huizi Sha Fan Tong Jiayao Ni Yi Sun Yahui Zhu liang Qi Xiaoqin li Wei li Yan yang Qing Gu Xing Zhang Xiaoxuan Wang Chan Zhu Dongsheng Chen Baorui liu juan Du The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The Comprehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Oncology The Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National Institute of Healthcare Data Science at Nanjing University NanjingChina State Key Laboratory of Neurology and Oncology Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer ***,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable *** conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.

关键词： CA724 prospective centre

Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1449-1460页

作者： Fei Chen Wei-Wei li juan-Fen Mo Min-Jie Chen Su-Hang Wang Shu-Ying yang Zheng-Wei Song Department of Hepatobiliary Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina The Key Laboratory The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Intensive Medicine The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Neuroendocrine carcinoma(NEC)of the extrahepatic bile duct is very rare,and the treatment and prognosis are ***,we report the case of a middleaged female with primary large cell NEC(LCNEC)of the common hepatic duct combined with distal cholangiocarcinoma(dCCA).Additionally,after a review of the relevant literature,we summarize and compare mixed neuroendocrine-nonneuroendocrine neoplasm(MiNEN)and pure NEC to provide a reference for selecting the appropriate treatment and predicting the prognosis of this rare *** SUMMARY A 62-year-old female presented to the hospital due to recurrent abdominal pain for 2 *** examination showed mild tenderness in the upper abdomen and a positive Courvoisier *** tests showed elevated liver transaminase and carbohydrate antigen 199 *** examination revealed node dissection was performed,and hepatic duct tumours were unexpectedly found during *** suggested poorly differentiated LCNEC(approximately 0.5 cm×0.5 cm×0.4 cm),Ki-67(50%),synaptophysin+,and chromogranin A+.dCCA pathology suggested moderately differentiated *** patient eventually developed lymph node metastasis in the liver,bone,peritoneum,and abdominal cavity and died 24 months after *** sequencing methods were used to compare gene mutations in the two primary bile duct *** The prognosis of MiNEN and pure NEC alone is different,and the selection of treatment options needs to be differentiated.

关键词： Neuroendocrine carcinoma Mixed neuroendocrine-non-neuroendocrine neoplasm Cholangiocarcinoma Extrahepatic bile duct Case report

Application of Global Leadership Initiative on Malnutrition criteria in patients with liver cirrhosis

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Chinese Medical Journal 2024年第1期137卷 97-104页

作者： Minjie Jiang juan Chen Muchen Wu Jing Wu Xiaotong Xu juan li Can liu Yaping Zhao Xin Hua Qinghua Meng Department of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing 100069China Department of Medical Oncology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of Nutrition Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:The Global Leadership Initiative on Malnutrition(GliM)criteria were published to build a global consensus on nutritional *** muscle mass is a phenotypic criterion with strong evidence to support its inclusion in the GliM consensus ***,there is no consensus regarding how to accurately measure and define reduced muscle mass in clinical *** study aimed to investigate the optimal reference values of skeletal muscle mass index for diagnosing sarcopenia and GliM-defined malnutrition,as well as the prevalence of GliM-defined malnutrition in hospitalized cirrhotic ***:This retrospective study was conducted on 1002 adult patients with liver cirrhosis between January 1,2018,and February 28,2022,at Beijing You-An Hospital,Capital Medical *** patients with a clinical diagnosis of liver cirrhosis and who underwent an abdominal computed tomography(CT)examination during hospitalization were included in the *** patients were randomly divided into a modeling group(cohort 1,667 patients)and a validation group(cohort 2,335 patients).In cohort 1,optimal cut-off values of skeletal muscle index at the third lumbar skeletal muscle index(L3-SMI)were determined using receiver operating characteristic analyses against in-hospital mortality in different gender ***,patients in cohort 2 were screened for nutritional risk using the Nutritional Risk Screening 2002(NRS-2002),and malnutrition was diagnosed by GliM ***,the reference values of reduced muscle mass in GliM criteria were derived from the L3-SMI values from cohort *** logistic regression analysis was used to analyze the association between GliM-defined malnutrition and clinical ***:The optimal cut-off values of L3-SMI were 39.50 cm 2/m 2 for male patients and 33.06 cm 2/m 2 for female *** on the cut-off values,31.63%(68/215)of the male patients and 23.3%(28/120)of the female patients had CT-determ

关键词： Malnutrition liver cirrhosis Sarcopenia Clinical outcomes GliM criteria

Clinicopathological features,psychological status,and prognosis of 33 patients with occult breast cancer

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World Journal of Psychiatry 2024年第1期14卷 76-87页

作者： Hong-Mei Wang Ao-yang Yu lin-lin li Lu-Yao Ma Meng-Han Cao Yu-Le yang Xiao-Bing Qin juan-juanTang Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Graduate School Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Pathology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Occult breast cancer(OBC)has traditionally been considered to be a carcinoma of unknown primary origin with a favorable prognosis and can be treated as stage II-III breast *** to the small number of cases and limited clinical experience,treatments vary greatly around the world and no standardized treatment has yet been *** To investigate the clinicopathological features,psychological status and prognostic features of patients with *** The clinicopathological data of 33 OBC patients diagnosed and treated in the Affiliated Hospital of Xuzhou Medical University and Xuzhou Central Hospital from November 2015 to November 2022 were retrospectively *** psychological status of OBC patients was evaluated by the Self-rating Anxiety Scale and Self-rating Depression ***’emotions,stress perception and psychological resilience were evaluated by the Positive and Negative Affect Schedule,the Chinese Perceived Stress Scale,and the Connor-Davidson Resilience Scale(CD-RISC),*** survival was calculated using the Kaplan-Meier method,and survival curves were plotted for analysis with the log-rank *** and multivariate survival analyses were performed using the Cox regression *** The 33 OBC patients included 32 females and 1 *** the 33 patients,30(91%)had axillary tumors,3(9%)had a neck mass as the primary symptom;18(54.5%)had estrogen receptor-positive tumors,17(51.5%)had progesterone receptor-positive tumors,and 18(54.5%)had Her-2-positive tumors;24(72.7%)received surgical treatment,including 18 patients who underwent modified radical mastectomy,1 patient who underwent breast-conserving surgery plus axillary lymph node dissection(ALND),and 5 patients who underwent ALND alone;12 patients received preoperative neoadjuvant *** 30 patients developed anxiety and depression,with low positive affect scores and high negative affect scores,accompanied by a high stress level and poor psycho

关键词： Occult breast cancer Breast cancer Perceived Stress Scale Axillary lymph node dissection

Co-incorporation of Chinese milk vetch(Astragalus sinicus L.)and chemical fertilizers alters microbial functional genes supporting short-time scale positive nitrogen priming effects in paddy soils

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Pedosphere 2024年第3期34卷 567-576页

作者： limin WANG Chunmei HE Dongfeng HUANG Juhua YU Cailing liU Qinghua li Yibin HUANG juan li Fei WANG Institute of Resources Environment and Soil FertilizerSoil and Fertilizer InstituteFujian Academy of Agricultural SciencesFuzhou 350012(China) School of Resources and Environment Engineering Anhui UniversityHefei 230601(China)

Nitrogen(N)priming is a microbially mediated biochemical process as affected by different incorporation ***,little information is known about the microbial mechanisms driving the response of N priming to co-operation of Chinese milk vetch(CMV,Astragalus sinicus L.)and different rates of chemical fertilizers in paddy soils in South ***,an anaerobic incubation experiment was conducted to study N priming effects(PE)and their relationships with soil microbial functional genes after CMV incorporation alone(M),co-incorporation of CMV with 100%(normal dosage)chemical fertilizers(MC100),and co-incorporation of CMV with 80% chemical fertilizers(MC80).Co-incorporation of CMV and chemical fertilizers enhanced the short-time scale(the first 20 d of incubation)positive PE of N,while no significant differences existed among the three treatments on day 60 or 90 of incubation(P>0.05).Compared with the M treatment,gross priming effect(GPE)in the MC100 and MC80 treatments significantly increased by 34.0% and 31.3%,respectively,and net priming effect(NPE)increased by 47.7% and 47.8%,respectively,during the first 20 d of incubation(Plikely attributed to soil nutrient availability and added substrate *** MC100 and MC80 treatments increased the gdhA gene abundance by 5.0% and 9.8%,increased the gdh2 gene abundance by 12.7% and 45.7%,and increased the nasB gene abundance by 9.5% and 41.4%,respectively,in comparison with the M treatment on day 20 of *** analyses indicated that soil microbial functional genes involved in N mineralization(gdhA and gdh2),assimilatory nitrate reduction(nasB),and nitrification(amoB)were significantly correlated with N priming under different incorporation practices during the incubation period(Plizers can regulate soil microbial community functional gene structure,which may accelerate mineralization and assimilatory nitrate reduction and inhibit

关键词： green manure gross priming effect incorporation practice microbial mechanism net priming effect rice field soil

Effect of information-motivation-behavioral skills model based perioperative nursing on pain in patients with gallstones

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2232-2241页

作者： li Ma Ying Yu Bin-juan Zhao Yan-Nan Yu Yu li Department of Nursing Xi’an International Medical Center HospitalXi’an 710100Shaanxi ProvinceChina Department of Hepatobiliary Pancreatic and Spleen SurgeryXi’an International Medical Center HospitalXi’an 710100Shaanxi ProvinceChina

BACKGROUND The incidence of cholecystolithiasis is on the *** of information,motivation,and behavioral skills can play a positive role in promoting changes in individual health ***,reports on the effects of information-motivationbehavioral(IMB)skills model based high-quality nursing as a perioperative nursing intervention for patients with gallstones are *** To explore the application of IMB skills model based high-quality nursing in patients with *** Two hundred and sixteen patients with cholecystolithiasis treated at our hospital from January 2022 to January 2023 were enrolled and divided into a control,highquality,and combined nursing groups,with 72 patients in each *** control,high-quality,and combination groups received conventional,high-quality,and IMB skills model based perioperative nursing services,*** in clinical indicators,stress levels,degree of pain,emotional state,and quality of life were observed,and complications and nursing satisfaction among the three groups were *** After nursing,the time to recovery of gastrointestinal function in the high-quality and combined nursing groups was significantly shorter than that of the control group,with the recovery of gastrointestinal function being the fastest in the combined nursing group(Plity and combined nursing groups were closer to normal than those of the control group 24 h after surgery,with the combined nursing group having the closest to normal levels(Plity and combination ***,the pain score in the combination group was significantly lower than those of the control and high-quality nursing groups(P<0.05).After nursing intervention,the emotional states of all patients improved,and the scores of patients in

关键词： Biliary calculi Information-motivation-behavioral skills model High quality care Perioperative period Pain Application

New therapeutic target NCF1-directed multi-bioactive conjugate therapies prevent preterm birth and adverse pregnancy outcomes

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Science Bulletin 2024年第16期69卷 2604-2621页

作者： juan Cheng Xiaoyan Jia limei yang Siqi Zhang Zhiyu Chen Qian Gui Ting li Zedan Pu Hongbo Qi Jianxiang Zhang Chongqing Key Laboratory of Maternal and Fetal Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Women and Children’s Hospital of Chongqing Medical University Chongqing 401147China Department of Obstetrics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Pharmaceutics College of PharmacyThird Military Medical University(Army Medical University)Chongqing 400038China Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Yu-Yue Pathology Scientific Research Center Chongqing 400039China State Key Laboratory of Trauma and Chemical Poisoning Third Military Medical University(Army Medical University)Chongqing 400038China

Preterm birth(PTB)is a leading cause of neonatal morbidity and mortality worldwide,yet the cellular and molecular mechanisms driving this condition remain undeciphered,thus limiting discovery of new ***-depth analyses of human and mouse tissues associated with PTB,in combination with cellular studies,indicated that aberrantly high-expressed neutrophil cytoplasmic factor(NCF)1 leads to oxidative distress,recruitment,and pro-inflammatory activation of neutrophils and macrophages,while sequentially overexpressed pro-inflammatory mediators induce contractions of uterine smooth muscle cells(USMCs)as well as apoptosis of USMCs and amniotic epithelial cells,thereby causing *** to these new findings,we rationally engineered an amphiphilic macromolecular conjugate LPA by covalently integrating low-molecular-weight heparin,a reactive oxygen species-responsive/scavenging component,and an anti-inflammatory *** bioengineered macromolecular conjugate can selfassemble into multi-bioactive nanoparticles(LPA NP).In a mouse model of PTB,LPA NP effectively delayed PTB and inhibited adverse pregnancy outcomes,by regulating NCF1-mediated oxidativeinflammatory cascades,i.e.,attenuating oxidative stress,inhibiting inflammatory cell activation,reducing local inflammation,and decreasing contraction/apoptosis of myometrial *** LPA NP into temperature-responsive,self-healing,and bioadhesive hydrogel further potentiated its in vivo efficacies after intravaginal delivery,by prolonging retention time,sustaining nanotherapy release,and increasing bioavailability in the placenta/***,both the conjugate/nanotherapy and hydrogel formulations exhibited excellent safety profiles in pregnant mice,with negligible side effects on the mother and offspring.

关键词： Preterm birth Neutrophil cytoplasmic factor Bioactive conjugate Nanotherapy Hydrogel therapy

Fabrication of amorphous FeCoNiCuMnP x high-entropy phosphide/carbon composites with a heterostructured fusiform morphology for efficient oxygen evolution reaction

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Journal of Materials Science & Technology 2024年第1期168卷 62-70页

作者： Yifan Zhou Longqing Gao Haoyuan Chen Hao Wang juan Zhang Xiumin li Fangfang Duo Guoqing Guan School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Graduate School of Sustainable Community Studies Hirosaki University1-BunkyochoHirosaki 036-8560Japan Graduate School of Science and Technology Hirosaki University3-BunkyochoHirosaki 036-8561Japan Xinxiang University School of Chemistry&Materials EngineeringXinxiang 453003China Energy Conversion Engineering Laboratory Institute of Regional InnovationHirosaki University3-BunkyochoHirosaki 036-8561Japan

Amorphous high-entropy materials with abundant defects,coordinatively unsaturated sites,and loosely bonded atoms could exhibit excellent electrocatalytic ***,how to fabricate such ma-terials with nanostructure as well as amorphous structure is still full of *** this work,high-entropy metal organic framework(HE-MOF)is employed as the self-sacrificial template to fabricate FeCoNiCuMnP x high-entropy phosphide/carbon(HEP/C)*** obtained composite shows a het-erostructured fusiform morphology,in which the HEP is encapsulated by a carbon layer,revealing high electron conductivity as well as rich catalytic active sites for oxygen evolution reaction(OER).Beside,it is found that there is a short-range ordered crystal structure in the amorphous phase,which is bene-ficial for revealing high OER catalytic activity as well as good *** a result,the optimum HEP/C composite shows an overpotential 239 mV@10 mA cm^(−2)with a small Tafel slope of 72.5 mV dec^(−1) for catalyzing OER in alkaline solution.

关键词： Water electrolysis Oxygen evolution reaction High-entropy MOFs High-entropy phosphides Amorphous structure