Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma:A case report and review of literature

作     者：Fei Chen Wei-Wei Li Juan-Fen Mo Min-Jie Chen Su-Hang Wang Shu-Ying Yang Zheng-Wei Song 

作者机构：Department of Hepatobiliary SurgeryThe Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Graduate SchoolBengbu Medical CollegeBengbu 233000Anhui ProvinceChina The Key LaboratoryThe Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of PathologyThe Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Intensive MedicineThe Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2024年第16卷第5期

页      面：1449-1460页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2022KY1246 Science and Technology Bureau of Jiaxing City,No.2023AZ31002 and No.2022AZ10009 

主　　题：Neuroendocrine carcinoma Mixed neuroendocrine-non-neuroendocrine neoplasm Cholangiocarcinoma Extrahepatic bile duct Case report 

摘      要：BACKGROUND Neuroendocrine carcinoma(NEC)of the extrahepatic bile duct is very rare,and the treatment and prognosis are ***,we report the case of a middleaged female with primary large cell NEC(LCNEC)of the common hepatic duct combined with distal cholangiocarcinoma(dCCA).Additionally,after a review of the relevant literature,we summarize and compare mixed neuroendocrine-nonneuroendocrine neoplasm(MiNEN)and pure NEC to provide a reference for selecting the appropriate treatment and predicting the prognosis of this rare *** SUMMARY A 62-year-old female presented to the hospital due to recurrent abdominal pain for 2 *** examination showed mild tenderness in the upper abdomen and a positive Courvoisier *** tests showed elevated liver transaminase and carbohydrate antigen 199 *** examination revealed node dissection was performed,and hepatic duct tumours were unexpectedly found during *** suggested poorly differentiated LCNEC(approximately 0.5 cm×0.5 cm×0.4 cm),Ki-67(50%),synaptophysin+,and chromogranin A+.dCCA pathology suggested moderately differentiated *** patient eventually developed lymph node metastasis in the liver,bone,peritoneum,and abdominal cavity and died 24 months after *** sequencing methods were used to compare gene mutations in the two primary bile duct *** The prognosis of MiNEN and pure NEC alone is different,and the selection of treatment options needs to be differentiated.