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文史哲 2014年第1期 165-168页

作者： Yang Yi li zhen chen Lai

Solubility measurement,correlation and thermodynamic properties of 2,3,4-trichloro-1,5-dinitrobenzene in fifteen mono-solvents at temperatures from 278.15 to 323.15 K

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Chinese Journal of Chemical Engineering 2023年第6期58卷 224-233页

作者： Yun-Zhang liu Lu-Yao Zhang Dan He li-zhen chen Zi-Shuai Xu Jian-Long Wang School of Chemical Engineering and Technology North University of ChinaTaiyuan 030051China Gansu Yinguang Chemical Industry Group Co.Ltd Baiyin 730900China

The solubility of 2,3,4-trichloro-1,5-dinitrobenzene(TCDNB) was measured by a laser dynamic method over the temperature range from 278.15 K to 323.15 K under 0.1 MPa in fifteen mono-solvents(methanol,ethanol,isopropanol,n-butanol,toluene,dichloromethane,chloroform,tetrachloromethane,1,2-dichloroethane,acetone,ethyl acetate,acetonitrile,N-methylpyrrolidone(NMP),N,Ndimethylformamide dimethyl sulfoxide(DMF),dimethyl sulfoxide(DMSO).The solubility of TCDNB could be increased with increasing temperature in fifteen *** solubility is in the following order at 298.15 K:NMP>DMF>DMSO>toluene>acetone>ethyl acetate>dichloromethane>1,2-dich loroethane>chloroform>acetonitrile>tetrachloromethane>methanol>ethanol>n-butanol>*** KAT-LSER model was used to investigate the solvent effect,which revealed that the hydrogen bond acidity of solvents has a greater effect on TCDNB *** van't Hoff model,the modified Apelblat model,theλh model,and the non-random two liquid(NRTL)model were used to correlate the solubility of *** calculated solubility data agreed well with the experimental data,and the modified Apelblat model fit ***,the van't Hoff and Gibbs equations were also used to calculate the dissolution thermodynamic properties of TCDNB in various *** dissolution could be an enthalpy-driven,non-spontaneous,and endothermic process in fifteen *** determination and fitting solubility of TCDNB,as well as the calculation of its thermodynamic properties,would be critical in the purification and crystallization of its preparation process research.

关键词： 2,3,4-Trichloro-1 5-dinitrobenzene(TCDNB) Solid-liquid equilibrium Laser dynamic method Solubility model Thermodynamics properties

Small RNA existed in commercial reverse transcriptase： primary evidence of functional small RNAs

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Protein & Cell 2015年第1期6卷 1-5页

作者： Jie Xu Xi chen Donghai li Qun chen zhen Zhou Dongxia Hou Jin Wang Qipeng Zhang Ke Zen chen-Yu Zhang Jiangsu Engineering Research Center for microRNA Biology and Biotechnology State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210093 China

SMALL RNA IN REVERSE TRANSCRIPTASE： TOO SMALL TO BE FOUND Significant background in no-template or no-primer RT-PCR is frequently noted. However, the underlying mechanism is still unclear. In this issue, Jie Xu and colleagues reveal that the com- mercial reverse transcriptases contain small RNAs. In AMV reverse transcriptase, they detected microRNAs derived from the virus host chick or other birds. This surprising finding at least partially explains the high background in some AMV reverse transcriptases based RT-PCR.

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Neuroimaging brain growth charts:A road to mental health

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Psychoradiology 2021年第4期1卷 272-286页

作者： li-zhen chen Avram JHolmes Xi-Nian Zuo Qi Dong State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Department of Psychology Yale UniversityNew HavenCT 06511USA Department of Psychiatry Yale UniversityNew HavenCT 06511USA National Basic Science Data Center Beijing 100190China Developmental Population Neuroscience Research Center International Data Group/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China Research Center for lifespan Development of Mind and Brain Institute of PsychologyChinese Academy of SciencesBeijing 100101China

Mental disorders are common health concerns and contribute to a heavy global burden on our modern *** is challenging to identify and treat them *** evidence suggests the incidence of various psychiatric and behavioral disorders is closely related to the atypical development of brain structure and *** identification and understanding of atypical brain development provide chances for clinicians to detect mental disorders earlier,perhaps even prior to onset,and treat them more *** invaluable and necessary method in identifying and monitoring atypical brain development are growth charts of typically developing individuals in the *** brain growth charts can offer a series of standard references on typical neurodevelopment,representing an important resource for the scientific and medical *** the present paper,we review the relationship between mental disorders and atypical brain development from a perspective of normative brain development by surveying the recent progress in the development of brain growth charts,including four aspects on growth chart utility:1)cohorts,2)measures,3)mechanisms,and 4)clinical *** doing so,we seek to clarify the challenges and opportunities in charting brain growth,and to promote the application of brain growth charts in clinical practice.

关键词： growth chart development neuroimaging reliability mental health

Effects of different brush border membrane vesicle isolation protocols on proteomic analysis of Cry1Ac binding proteins from the midgut of Helicoverpa armigera

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Insect Science 2008年第6期15卷 497-503页

作者： li-zhen chen Ge-Mei liang Brian G. Rector Jie Zhang Kong-Ming Wu Yu-Yuan Guo State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing China USDA-ARS European Biological Control Laboratory Montpellier France

Brush border membrane vesicles （BBMV） isolated from insect midguts have been widely used to study CrylA binding proteins. Sample preparation is important in two- dimensional electrophoresis （2-DE）, so to determine a suitable BBMV preparation method in Helicoverpa armigera for 2-DE, we compared three published BBMV preparation methods mostly used in sodium dodecyl sulfate-polyacrylamide gel electrophoresis （SDS- PAGE）. All methods yielded similar types and numbers of binding proteins, but in different quantities. The Abdul-Rauf and Ellar protocol was the best of the three, but had limitations. Sufficient protein quantity is important for research involving limited numbers of insects, such as studies of insect resistance to Bacillus thuringiensis in the field. Consequently, we integrated the three BBMV isolation methods into a single protocol that yielded high quantities of BBMV proteins from H. armigera larval midguts, which proved suitable for 2- DE analysis.

关键词： Bacillus thuringiensis binding protein brush border membrane vesicles Cry1Ac Helicoverpa armigera two-dimensional electrophoresis

PNPLA3 I148M variant in nonalcoholic fatty liver disease:Demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis

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World Journal of Gastroenterology 2015年第3期21卷 794-802页

作者： li-zhen chen Yong-Ning Xin Ning Geng Man Jiang Ding-Ding Zhang Shi-Ying Xuan Department of Gastroenterology Qingdao Municipal Hospital Medical College of Qingdao University

Patatin-like phospholipase domain-containing 3(PNPLA3 or adiponutrin) displays anabolic and catabolic activities in lipid metabolism,and has been reported to be significantly associated with liver fat *** have established a strong link between the 148 isoleucine to methionine protein variant(I148M) of PNPLA3 and liver diseases,including nonalcoholic fatty liver disease(NAFLD).However,detailed demographic and ethnic characteristics of the I148 M variant and its role in the development of nonalcoholic fatty liver fibrosis have not been fully *** present review summarizes the current knowledge on the association between the PNPLA3 I148 M variant and NAFLD,and especially its role in the development of nonalcoholic fatty liver ***,we analyze the impact of demographic and ethnic characteristics of the PNPLA3 I148 M variant and the presence of metabolic syndrome on the association between PNPLA3 I148 M and ***,we explore the role of the PNPLA3 I148 M in the development of nonalcoholic fatty liver fibrosis,and hypothesize the underlying mechanisms by speculating a pro-fibrogenic ***,we briefly highlight future research that may elucidate the specific mechanisms of the PNPLA3 I148 M variant in fibrogenesis,which,in turn,provides a theoretical foundation and valuable experimental data for the clinical management of nonalcoholic fatty liver fibrosis.

关键词： PNPLA3 I148M variant Polymorphism Nonalcoholic fat

TM6SF2 E167K Variant, a Novel Genetic Susceptibility Variant, Contributing to Nonalcoholic Fatty liver Disease

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Journal of Clinical and Translational Hepatology 2015年第4期3卷 265-270页

作者： li-zhen chen Harry Hua-Xiang Xia Yong-Ning Xin Zhong-Hua lin Shi-Ying Xuan Department of Gastroenterology Qingdao Municipal HospitalSchool of MedicineQingdao UniversityQingdaoShandongChina Qingdao Municipal Hospital School of MedicineQingdao UniversityQingdaoShandongChina

Nonalcoholic fatty liver disease(NAFLD)is one of the most common causes of liver dysfunction worldwide,and its prevalence is highly associated with genetic *** transmembrane 6 superfamily member 2(TM6SF2)E167K variant represents a general genetic determinant of hepatic triglyceride content and lobular inflammation,and its presence appears to be directly involved in the pathogenesis and development of *** this variant appears to be a novel powerful modifier in the development of NAFLD,whether it is associated with an increased risk of NAFLD-refated liver fibrosis and hepatocellular carcinoma(HCC)remains to be *** aim of this review is to describe the functions of the TM6SF2 E167K variant and its association with NAFLD,with particular emphasis on the underlying mechanisms of its role in the development and progression of ***,the links between the TM6SF2 E167K variant and NAFLD-related liver fibrosis and HCC will be discussed.

关键词： Nonalcoholic fatty liver disease TM6SF2 E167K variant Polymorphism

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广义逆高斯过程的步进应力加速退化试验设计

上海交通大学学报 2017年第2期51卷 186-192页

作者：李烁陈震潘尔顺上海交通大学机械与动力工程学院上海200240

对于高可靠性、长寿命产品的寿命估计问题,步进应力加速退化试验是一种经济快捷有效的方法.为了解决步进应力加速退化试验中样本量、测量时间间隔和各应力下测量次数的配置问题,建立描述产品性能退化轨迹的广义逆高斯过程,采用改进的蒙... 详细信息

对于高可靠性、长寿命产品的寿命估计问题,步进应力加速退化试验是一种经济快捷有效的方法.为了解决步进应力加速退化试验中样本量、测量时间间隔和各应力下测量次数的配置问题,建立描述产品性能退化轨迹的广义逆高斯过程,采用改进的蒙特卡洛模拟方法估计模型的参数.给出产品分位寿命渐近方差的表达式,并以其最小化为目标,在试验总费用、试验样本量和试验时间的限制下,探讨步进应力退化试验的优化配置.最后通过实例,验证了模型和方法的正确性和实用性.

关键词：广义逆高斯过程步进应力加速退化试验优化配置

Alcohol and tea consumption in relation to the risk ofnasopharyngeal carcinoma in Guangdong, China

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Frontiers of Medicine 2010年第4期4卷 448-456页

作者： Hong-lian RUAN Feng-Hua XU Wen-Sheng liU Qi-Sheng FENG li-zhen chen Yi-Xin ZENG Wei-Hua JIA State Key Laboratory of Oncology in Southern China Guangzhou 510060China School of Public Health Sun Yat-Sen UniversityGuangzhou 510080China Department of Experiment Research Sun Yat-sen UniversityCancer CenterGuangzhou 510060China

To investigate whether alcohol and tea con-sumption has an etiological association with nasophar-yngeal carcinoma(NPC)in a high-incident population,a large scale case-control study was *** study included 2846 individuals in Guangdong Province,China,with 1387 newly diagnosed cases of NPC and 1459 frequency-matched *** histories of alcohol and tea consumption were obtained via personal *** regarding socio-demographic charac-teristics(age,sex,education,dialect and household type),family history of NPC,Epstein-Barr virus(EBV)infection,dietary habits and other potential confounding factors was also *** analysis was performed using uncondi-tional logistic regression to calculate odds ratios(OR)and 95%conﬁdence intervals(CI).The risk of NPC was found to be associated with habitual alcohol consumption and tea *** consumption has been associated with a decreased occurrence of NPC(OR=0.62),while con-sumption of alcohol was associated with a complex ***ﬁcally,moderate consumption of alcohol was associated with decreased risk of NPC,while overuse,especially strong distillate spirits,appeared to be a risk factor.

关键词： nasopharyngeal carcinoma case-control study alcohol consumption tea consumption

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人脑同伦功能亲和度图谱

科学通报 2024年第24期69卷 3651-3665页

作者：陈丽珍左西年北京师范大学认知神经科学与学习国家重点实验室北京100875 北京师范大学麦戈文脑科学研究院发展人口神经科学研究中心北京100875 国家基础数据科学中心北京100190

人脑左右半球中空间对等的区域亦称同伦脑区,往往表现出功能相似性,即功能同伦.为理解人类心理行为的功能同伦规律和机制,本文基于脑连接组的双因子生成理论,提出一种人脑功能同伦研究方法:同伦功能亲和度.该方法通过计算同伦脑区的全... 详细信息

人脑左右半球中空间对等的区域亦称同伦脑区,往往表现出功能相似性,即功能同伦.为理解人类心理行为的功能同伦规律和机制,本文基于脑连接组的双因子生成理论,提出一种人脑功能同伦研究方法:同伦功能亲和度.该方法通过计算同伦脑区的全脑功能连接模式的余弦距离,量化同伦脑区的功能亲和度.使用美国和中国“人脑连接组计划”的全脑功能磁共振影像数据库,首先绘制了“700毫秒-2毫米”时空精度的同伦功能亲和度图谱,评估了其个体差异的重测信度.其次,对该图谱的系统分析定位出人类颞顶联合区的3个特定区域,并发现了其半球偏侧化的特征规律,揭示了与注意、语言和社会认知的功能关联.最后,通过多模态脑图谱关联分析进一步探索了人脑同伦功能亲和度与遗传、进化、结构与功能组织分布的相关规律.综上,本文所提出的同伦功能亲和度方法可为人口神经科学研究提供高信效度人脑功能测量图谱.

关键词：同伦脑区功能同伦亲和度连接组颞顶联合区文化多样性