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LPCS Ni-Zn-Al_(2)O_(3) Intermediate Layer Enhanced SPS NiCr-Cr_(3)C_(2) Coating with Higher Corrosion and Wear Resistances

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 188-195页

作者：白杨 li Yan xinG Lukuo li Xiangbo WANG Zhenhua State Key Laboratory of Marine Coatings Marine Chemical Research Institute Co.Ltd.Qingdao 266071China College of Mechanical and Electrical Engineering University of China Petroleum(East China)Qingdao 266580China Science and Technology on Marine Corrosion and Protection Laboratory Luoyang Ship Materials Research InstituteQingdao 266101China

The double-layer NiCr-Cr_(3)C_(2)/Ni-Zn-Al_(2)O_(3) coatings with sufficient corrosion and wear resistance were prepared on low carbon steel *** intermediate layers Ni-Zn-Al_(2)O_(3) were fabricated by using low-pressure cold spray (LPCS) method to improve the salt fog corrosion resistance properties of the supersonic plasma spray (SPS) NiCr-Cr_(3)C_(2) *** friction and wear performance for the double-layer and single-layer NiCr-Cr_(3)C_(2) coatings were carried out by line-contact reciprocating sliding,*** with the coating surface analysis techniques,the effect of the salt fog corrosion on the tribological properties of the double-layer coatings was *** results showed that the double-layer coatings exhibited better wear resistance than that of the single-layer coatings,due to the better corrosion resistance of the intermediate layer;the wear mass losses of the double-layer coatings was reduced by 70%than that of the single layer coatings and the wear mechanism of coatings after salt fog corrosion conditions is mainly corrosion wear.

关键词： low-pressure cold spray NiCr-Cr_(3)C_(2)coating wear behavior salt fog corrosion

Automatic velocity picking based on optimal key points tracking algorithm

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Petroleum Science 2024年第2期21卷 903-917页

作者： Yong-Hao Wang Wen-Kai Lu Song-bai Jin Yang li Yu-Xuan li Xiao-Feng Gu The Institute for Artificial Intelligence(THUAI) Tsinghua UniversityBeijing100084China State Key Laboratory of Intelligent Technology and Systems Tsinghua UniversityBeijing100084China Beijing National Research Center for Information Science and Technology(BNRist) Beijing100084China The Department of Automation Tsinghua UniversityBeijing100084China

Picking velocities from semblances manually is laborious and necessitates experience. Although various methods for automatic velocity picking have been developed, there remains a challenge in efficiently incorporating information from nearby gathers to ensure picked velocity aligns with seismic horizons while also improving picking accuracy. The conventional method of velocity picking from a semblance volume is computationally demanding, highlighting a need for a more efficient strategy. In this study, we introduce a novel method for automatic velocity picking based on multi-object tracking. This dynamic tracking process across different semblance panels can integrate information from nearby gathers effectively while maintaining computational efficiency. First, we employ accelerated density clustering on the velocity spectrum to discern cluster centers without the requirement for prior knowledge regarding the number of clusters. These cluster centers embody the maximum likelihood velocities of the main subsurface structures. Second, our proposed method tracks key points within the semblance volume. Kalman filter is adopted to adjust the tracking process, followed by interpolation on these tracked points to construct the final velocity model. Our synthetic data example demonstrates that our proposed algorithm can effectively rectify the picking errors of the clustering algorithm. We further compare the performances of the clustering method(CM), the proposed tracking method(TM), and the variational method(VM) on a field dataset from the Gulf of Mexico. The results attest that our method offers superior accuracy than CM, achieves comparable accuracy with VM, and benefits from a reduced computational cost.

关键词： Velocity picking Multi-object tracking Density clustering Kalman filter

Enhancing Strength-Ductility Synergy of CoCrNi-Based Medium-Entropy Alloy Through Coherent L1_(2)Nanoprecipitates and Grain Boundary Precipitates

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 78-88页

作者： Leilei li Kaikai Song Qingwei Gao Changshan Zhou Xiaoming liu Yaocen Wang Xiaojun bai Chongde Cao School of Physical Science and Technology Northwestern Polytechnical UniversityXi’an710016China Weihai Research Institute of Industrial Technology Shandong UniversityWeihai264209China Research and Development Institute of Northwestern Polytechnical University in ShenzhenShenzhen518057China

The L1_(2)-strengthened Co_(34)Cr_(32)Ni_(27)Al_(4)Ti_(3)medium-entropy alloy(MEA)with precipitations of grain boundaries has been developed through selective laser melting(SLM)followed by cold rolling and annealing,exhibiting excellent strength-ductility *** as-printed alloy exhibits low yield strength(YS)of~384 MPa,ultimate tensile strength(UTS)of~453 MPa,and uniform elongation(UE)of 1.5%due to the existence of the SLM-induced *** cold rolling and annealing,the YS,UTS,and UE are significantly increased to~739 MPa,~1230 MPa,and~47%,*** enhancement primarily originates from the refined grain structure induced by cold rolling and *** presence of coherent sphericalγ'precipitates(L1_(2)phases)and Al/Ti-rich precipitates at the grain boundaries,coupled with increased lattice defects such as dislocations,stacking faults,and ultrafine deformation twins,further contribute to the property’s *** study highlights the potential of SLM in producing high-strength and ductile MEA with coherent L1_(2)nanoprecipitates,which can be further optimized through subsequent rolling and annealing *** findings offer valuable insights for the development of high-performance alloys for future engineering applications.

关键词： Medium-entropy alloy Selective laser melting Precipitation Strength Ductility

Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： JIANG Xiao-ying SHI li-ping ZHU Jun-long bai Ren-ren XIE Tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

Comprehensive evaluation of an ionic liquid based deep purification process for NH_(3)-containing industrial gas

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Journal of Environmental Sciences 2024年第2期136卷 698-708页

作者： Guoxiong Zhan Fei Cao Jianjun Chen Zhen Chen Yuanmeng Duan Fei Chang Shaojuan Zeng Yinge bai Zengxi li Xiangping Zhang Junhua li State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Sino-Danish College University of Chinese Academy of SciencesBeijing 100049China Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China College of Chemical and Engineering University of Chinese Academy of SciencesBeijing 100049China

Ammonia(NH_(3))emission has caused serious environment issues and aroused worldwide *** emerging ionic liquid(IL)provides a greener way to efficiently capture NH_(3).This paper provides rigorous process simulation,optimization and assessment for a novel NH_(3)deep purification process using *** process was designed and investigated by simulation and optimization using ionic liquid[C_(4)im][NTF_(2)]as *** objective functions,total purification cost(TPC),total process CO_(2)emission(TPCOE)and thermal efficiency(ηeff)were employed to optimize the absorption *** simulation and optimization results indicate that at same purification standard and recovery rate,the novel process can achieve lower cost and CO_(2)emission compared to benchmark *** process optimization,the optimal functions can achieve 0.02726$/Nm~3(TPC),311.27 kg CO_(2)/hr(TP-COE),and 52.21%(ηeff)for enhanced ***,compared with conventional process,novel process could decrease over$3 million of purification cost and 10000 tons of CO_(2)emission during the life *** results provide a novel strategy and guidance for deep purification of NH_(3)capture.

关键词： NH_(3) Capture Process Ionic liquid Process Simulation Process Optimization Deep purification

A Review on Engineering Transition Metal Compound Catalysts to Accelerate the Redox Kinetics of Sulfur Cathodes for lithium–Sulfur Batteries

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Nano-Micro Letters 2024年第5期16卷 300-332页

作者： liping Chen Guiqiang Cao Yong li Guannan Zu Ruixian Duan Yang bai Kaiyu Xue Yonghong Fu Yunhua Xu Juan Wang Xifei li Shaanxi Key Laboratory of Nanomaterials and Nanotechnology Xi’an University of Architecture and TechnologyXi’an 710055People’s Republic of China Institute of Advanced Electrochemical Energy and School of Materials Science and Engineering Xi’an University of TechnologyXi’an 710048People’s Republic of China Yulin University Yulin 719000People’s Republic of China School of Materials Science and Engineering Fuzhou UniversityFuzhou 350108People’s Republic of China

Engineering transition metal compounds(TMCs)catalysts with excellent adsorption-catalytic ability has been one of the most effec-tive strategies to accelerate the redox kinetics of sulfur ***,this review focuses on engineering TMCs catalysts by cation doping/anion doping/dual doping,bimetallic/bi-anionic TMCs,and TMCs-based heterostructure *** is obvious that introducing cations/anions to TMCs or constructing heterostructure can boost adsorption-catalytic capacity by regulating the electronic structure including energy band,d/p-band center,electron filling,and valence ***,the elec-tronic structure of doped/dual-ionic TMCs are adjusted by inducing ions with different electronegativity,electron filling,and ion radius,resulting in electron redistribution,bonds reconstruction,induced vacancies due to the electronic interaction and changed crystal structure such as lat-tice spacing and lattice *** from the aforementioned two strategies,heterostructures are constructed by two types of TMCs with different Fermi energy levels,which causes built-in electric field and electrons transfer through the interface,and induces electron redistribution and arranged local atoms to regulate the electronic ***,the lacking studies of the three strategies to comprehensively regulate electronic structure for improving catalytic performance are pointed *** is believed that this review can guide the design of advanced TMCs catalysts for boosting redox of lithium sulfur batteries.

关键词： lithium–sulfur battery Redox kinetic Transition metal compounds catalyst Multiple metals/anions

Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3

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Chinese Medical Journal 2024年第11期137卷 1351-1359页

作者： Jiacheng li Ruopu li Xue bai Wenlong Zhang Yu Nie Shengshou Hu State Key Laboratory of Cardiovascular Disease Fuwai Hospital and Cardiovascular InstituteNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Obstetrics and Gynecology Beijing Advanced Innovation Center for GenomicsThird HospitalSchool of Life SciencesPeking UniversityBeijing 100871China

Background:The ability to generate functional hepatocytes without relying on donor liver organs holds significant therapeutic promise in the fields of regenerative medicine and potential liver disease *** regularly interspaced short palindromic repeats(CRISPR)activator(CRISPRa)is a powerful tool that can conveniently and efficiently activate the expression of multiple endogenous genes simultaneously,providing a new strategy for cell fate *** main purpose of this study is to explore the feasibility of applying CRISPRa for hepatocyte reprogramming and its application in the treatment of mouse liver ***:The differentiation of mouse embryonic fibroblasts(MEFs)into functional induced hepatocyte-like cells(iHeps)was achieved by utilizing the CRISPRa synergistic activation mediator(SAM)system,which drove the combined expression of three endogenous transcription factors-Gata4,Foxa3,and Hnf1a-or alternatively,the expression of two transcription factors,Gata4 and *** vivo,we injected adeno-associated virus serotype 6(AAV6)carrying the CRISPRa SAM system into liver fibrotic Col1a1-Cre^(ER);Cas9^(fl/fl)mice,effectively activating the expression of endogenous Gata4 and Foxa3 in *** endogenous transcriptional activation of genes was confirmed using real-time quantitative polymerase chain reaction(RT-qPCR)and RNA-seq,and the morphology and characteristics of the induced hepatocytes were observed through *** level of hepatocyte reprogramming in vivo is detected by immunofluorescence staining,while the improvement of liver fibrosis is evaluated through Sirius red staining,alpha-smooth muscle actin(α-SMA)immunofluorescence staining,and blood alanine aminotransferase(ALT)***:Activation of only two factors,Gata4 and Foxa3,via CRISPRa was sufficient to successfully induce the transformation of MEFs into *** iHeps could be expanded in vitro and displayed functional characteristics similar to th

关键词： liver fibrosis CRISPRa Cell reprogramming Transcriptional activation Hepatocytes

Experimental and computational investigation on flow characteristics of rotating cavities with high inlet pre-swirl axial throughflow

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Chinese Journal of Aeronautics 2024年第4期37卷 276-293页

作者： Sipeng WANG Xiang LUO linji GUO Zeyu WU Yang bai Zongchao li lichun MA School of Energy and Power Engineering Beihang UniversityBeijing 100191China Research Institude of Aero-Enigine Beihang UniversityBeijing 100191China National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics Beihang UniversityBeijing 100191China Shenyang Aeroengine Research Institute Aero Engine Corporation of ChinaShenyang 110015China

As an integral part of the internal air system of aero-engines,the axial throughflow of the cooling air can interact with the cavity flow between the rotating compressor disks,forming a threedimensional,unsteady,and unstable flow *** flow characteristics in an engine-like rotating multi-stage cavity with throughflow were investigated using particle image velocimetry,flow visualization technology and three-dimensional unsteady Reynolds-Averaged Navier-Stokes (RANS)*** focus of current research was to understand the distribution of the mean swirl ratio and its variation with a wide range of non-dimensional parameters in the co-rotating cavity with high inlet pre-swirl axial *** maximum axial Reynolds number and rotational Reynolds numbers could reach 4.41×10^(4)and 1.24×10^(6),*** velocity measurement results indicate that the mean swirl ratio is greater than 1 and decreases with an increase in the radial *** flow structure is dominated by the Rossby number,and two different flow patterns (flow penetration and flow stratification) are identified and confirmed by flow visualization *** the absence of buoyancy,the flow penetration caused by the precession of the throughflow makes it easier for the throughflow to reach a high radius *** consistency of results between measurements and numerical calculations is *** study provides a theoretical basis and data support for toroidal vortex breakdown,which is of practical significance for the design of high-pressure compressor cavities.

关键词： Compressor Axial throughflow Rotating cavity flow Particle image velocimetry Unsteady RANS Flow pattern

Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis

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Journal of Traditional Chinese Medicine 2024年第2期44卷 408-416页

作者： li Zhenxuan WANG Xuerui Luis Ulloa Ayman Youssef bai Yunjing XU Xiaolong liU Qingquan Department of Infectious Diseases Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases Beijing 100010China Infection immunity laboratory Beijing Institute of Traditional Chinese MedicineBeijing 100010China Clinical College of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Center for Perioperative Organ Protection Department of AnesthesiologyDuke University Medical CenterDurhamNorth Carolina 27710USA

Sepsis-associated encephalopathy(SAE)is a common manifestation of sepsis,ranging from mild confusion and delirium to severe cognitive impairment and deep *** is associated with higher mortality and long-term outcomes,particularly substantial declines in cognitive *** mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain,a disrupted blood–brain barrier,oxidative stress,neurotransmitter dysfunction,and severe microglial *** evidence suggests that complementary and alternative medicine,especially Traditional Chinese Medicine(TCM),is favorable in alleviating cognitive decline after ***,we summarized the studies of traditional herbal remedies,TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms.

关键词： sepsis-associated encephalopathy cognitive dysfunction complementary therapies neuroinflammatory diseases medicine Chinese traditional review

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