Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis

作     者：LI Zhenxuan WANG Xuerui Luis Ulloa Ayman Youssef BAI Yunjing XU Xiaolong LIU Qingquan LI Zhenxuan;WANG Xuerui;Luis Ulloa;Ayman Youssef;BAI Yunjing;XU Xiaolong;LIU Qingquan

作者机构：Department of Infectious DiseasesBeijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious DiseasesBeijing 100010China Infection immunity laboratoryBeijing Institute of Traditional Chinese MedicineBeijing 100010China Clinical College of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China Center for Perioperative Organ ProtectionDepartment of AnesthesiologyDuke University Medical CenterDurhamNorth Carolina 27710USA 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2024年第44卷第2期

页      面：408-416页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Youth Project of National Natural Science Foundation of China:the Mechanism Study of Shenfuhuang Formula on Cognitive Impairment and Synaptic Plasticity in Sepsis via IL-33/ST2 Pathway-mediated Microglial Polarization(No.82004292) Special Project of National Natural Science Foundation of China:Study on the Mechanism and Material Basis of Jinhua Qinggan Granules in Regulating the Cytokine Storm of Viral Pneumonia(No.82141202) The National Interdisciplinary Innovation Team of TCM under the State Administration of TCM(ZYYCXTD-D-202201) The Financial project of Beijing Municipal Health Commission:Study on Pharmacodynamic Mechanism of Traditional Chinese Medicine in Treating Viral Pneumonia 

主　　题：sepsis-associated encephalopathy cognitive dysfunction complementary therapies neuroinflammatory diseases medicine Chinese traditional review 

摘      要：Sepsis-associated encephalopathy(SAE)is a common manifestation of sepsis,ranging from mild confusion and delirium to severe cognitive impairment and deep *** is associated with higher mortality and long-term outcomes,particularly substantial declines in cognitive *** mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain,a disrupted blood–brain barrier,oxidative stress,neurotransmitter dysfunction,and severe microglial *** evidence suggests that complementary and alternative medicine,especially Traditional Chinese Medicine(TCM),is favorable in alleviating cognitive decline after ***,we summarized the studies of traditional herbal remedies,TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms.