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Systematic review and meta-analysis on phosphodiesterase 5 inhibitors and α-adrenoceptor antagonists used alone or combined for treatment of LUTS due to BPH

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Asian Journal of Andrology 2015年第6期17卷 1022-1032,I0012页

作者： xing-Huan Wang Xiao Wang Ming-Jun Shi Sheng li tao liu xin-Hua Zhang Department of Urology Zhongnan Hospital of Wuhan University Wuhan 430071 China.

The aim of this systematic review is to determine the comparative effectiveness and safety of phosphodiesterase 5 inhibitors （PDE5-1s） and （x-blockers used alone or combined for the treatment of lower urinary tract symptoms （LUTS） due to benign prostatic hyperplasia （BPH）. An electronic search of PubMed, Cochrane library and Embase up to January 2014 was performed to identify randomized controlled trials comparing the efficacy and safety of PDE5-Is and （x-blockers for treatment of lower urinary tract symptoms due to benign prostatic hyperplasia, which assessed IPSS score, maximum flow rate, postvoided residual urine, quality of life and Erectile Function （IIEF） score as outcomes. Data were analyzed by fixed or random effect models using Cochrane Collaboration review manager software. A total of 12 studies were included, Our novel data demonstrated that there was a trend that （x-blockers were more efficacious than PDE5-Is on decreasing IPSS score and increasing maximum flow rate. （x-blockers were significantly more effective than PDE5-Is on reduction of postvoided residual urine with a mean difference of 3.67 （95% CI 1.56 to 5.77, P = 0.0006） and PDE5-Is showed greater effect than （x-blockers on increasing IIEF score with a mean difference of 9.82 （95% CI 3.80 to 15.85, P = 0.001）. In conclusion, our novel data demonstrated that PDE5-Is plus ABs ranked the highest on the improvement of LUTS/BPH. PDE5-Is monotherapy was also effective in this kind of disorder except less reduction of PVR than ABs, In addition, both combined- or mono-therapy were safe.

关键词： benign prostatic hyperplasia lower urinary tract symptoms meta-analysis phosphodiesterase 5 inhibitors -adrenoceptorantagonists

Gradient maturation experiment on hairs implies taphonomic changes in fossil hairs

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Science China Earth Sciences 2025年第1期68卷 62-73页

作者： xin li Yibo ZHOU tao ZHAO xingjian HE Yanhong PAN State Key Laboratory for Mineral Deposits Research Center for Critical Earth Material Cycling Centre for Research and Education on Biological Evolution and Environment and Frontiers Science School of Earth Sciences and Engineering Nanjing University Institute of Palaeontology Yunnan Key Laboratory of Earth System Science Yunnan Key Laboratory for PalaeobiologyYunnan University

Mammalian hair, as a key feature related to endothermy, physical protection, and camouflage, has a long geohistorical record that dates back even to the Mesozoic. However, the limited information on the taphonomy of hair hinders the understanding of its evolutionary significance in deep time. To address this, we conducted taphonomic experiments to simulate the transformation process of black hair. The changes in the morphological structure, microscopic characteristics, and chemical composition of hair during the simulated fossilization process were documented by scanning electron microscopy, Fourier transform infrared(FTIR) spectroscopy, and Raman spectroscopy. Our results revealed that damage to the morphology of hair began at a mild temperature(150–175°C), and hair transformed into a fluid-like mass at a relatively high temperature(200°C). In addition, the morphological structure of melanosomes had relatively greater preservation potential than keratins did, and the microscopic features of melanosomes were persistently stable. The Raman and FTIR spectra indicated that the characteristic melanin and keratin peaks changed as the temperature increased. Although the chemical signals were not lost completely, the variations in the characteristic amide bands in the FTIR spectra indicate that the keratins severely degraded at high temperatures(>200°C), whereas the characteristic melanin bands in the Raman spectra suggested that melanin signals were still recognizable, even at high temperatures(>200°C). These results were confirmed by principal component analysis(PCA) and principal component analysis linear discriminant analysis(PCA–LDA). In addition, the Raman signals of all the samples in the simulated experiments were distinguished from the signals of common geological carbonaceous materials(humic acid), which suggested that Raman spectroscopy can be used to detect melanin in fossils.

关键词： Mammalian hair Melanin Keratin Fossilization Experimental taphonomy

Small laser spot versus standard laser spot photodynamic therapy for idiopathic choroidal neovascularization： a randomized controlled study

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Chinese Medical Journal 2012年第24期125卷 4424-4428页

作者： li Xiao-xin tao Yong Department of Ophthalmology People's Hospital Peking University Key Laboratory of Vision Loss and Restoration Beijing China

Background Idiopathic choroidal neovascularization （ICNV） affects young patients and thus may have a significant impact on vision and life quality over a patient＇s lifespan. This study was designed to compare the visual outcome and retinal pigment epithelium （RPE） damage after photodynamic therapy （PDT） with small laser spot and PDT with standard laser spot for idiopathic choroidal neovascularization （ICNV）. Methods This was a randomized controlled study. Fifty-two patients with ICNV were enrolled and randomly divided into a study group （small laser spot PDT, n=27） and a control group （standard laser spot PDT, n=25）. Best corrected visual acuity （BCVA）, optic coherence tomography （OCT） and fluorescein angiography （FA） findings were the main measurements. The patients were followed up 1 week, 1, 3, 6, 9 months and 1 year after PDT. Results BCVA improvement was statistically significantly higher in the study group than the control group at 6-month （（25.53±15.01） letters vs. （14.71±11.66） letters, P=-0.025） and 9-month follow-ups （（27.53±17.78） letters vs. （15.59±12.21） letters, P=0.039）. At 3- and 6-month follow-ups, the quadrants of RPE damage between the two groups varied significantly （P 〈0.001 and P=0.023, respectively）. In each follow-up, the number of cases with decreased or unchanged leakage of choroidal neovascularization by FA and reduced subretinal fluid by OCT did not vary significantly between the two groups. Ten cases （37.0%） in the study group and eight cases （32.0%） in the control group suffered from recurrent CNV （P=-0.703）. Conclusions Better visual improvements, less RPE damage, a similar recurrent rate of CNV and change of subretinal fluid were observed in the small laser spot PDT group than in the standard laser spot PDT group for ICNV.

关键词： idiopathic choroidal neovascularization subfoveal photodynamic therapy small laser spot

BMI and BMI Changes to All-cause Mortality among the Elderly in Beijing： a 20-year Cohort Study

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Biomedical and Environmental Sciences 2017年第2期30卷 79-87页

作者： WANG Yun Feng TANG Zhe GUO Jin tao li xin liU Long li Hai Bin li Di Tian GUO Xiu Hua YANG xing Hua School of Public Health Capital Medical University Beijing 100069 China Beijing Municipal Key Laboratory of Clinical Epidemiology Beijing 100069 China School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China School of Basic Medical Sciences Peking University Health Science Center Beijing100191 China

Objective To explore the association between body mass index （BMI） and all-cause mortality among the elderly in Beijing. Methods This analysis was based on the Beijing multidimensional longitudinal study of aging （BLSA）, which included 2,090 subjects over 55 years old and was followed-up from 1992 to 2012. BMI-mortality curves were drawn to find the optimal BMI range with the lowest mortality. Cox proportional hazard models were used to obtain the hazard ratios （HRs） for BMI and BMI changes in the overall population and in specific stratified populations. Results During follow-up, 2,264 deaths were recorded; BMI-mortality curve was U-shaped, with the lowest mortality at a BMI of approximately 25 kg/m2. After adjusting for gender, age, smoking, drinking and some pre-existing diseases, HRs for underweight, overweight and obesity compared with normal weight were 2.372 （95% C/： 2.254-2.632）, 0.767 （95% CI： 0.666-0.884） and 0.872 （95% CI： 0.830-1.246）, respectively. HR for BMI drop was 3.245 （95% CI： 0.824-22.772） in the underweight group and 1.892 （95% C/： 0.830-1.246） in the normal weight group, HR for BMI rise was 1.795 （95% CI： 1.243-2.591） in normal weight group and 2.962 （95% CI： 2.202-3.203） in the overweight group. Conclusion Keeping BMI in an overweight status and stable is related to a reduced mortality

关键词： Body mass index All-cause mortality The elderly Beijing

Analysis of the generation mechanism of the S-shaped J–V curves of MoS_(2)/Si-based solar cells

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Chinese Physics B 2022年第3期31卷 608-612页

作者： He-Ju Xu li-tao xin Dong-Qiang Chen Ri-Dong Cong Wei Yu College of Science North China University of Science and TechnologyTangshan 063009China College of Physics Science and Technology Hebei UniversityBaoding 071002China

Amorphous–microcrystalline MoS_(2)thin films are fabricated using the sol-gel method to produce MoS_(2)/Si-based solar cells. The generation mechanisms of the S-shaped current density–voltage(J–V) curves of the solar cells are analyzed. To improve the performance of the solar cells and address the problem of the S-shaped J–V curve, a MoS_(2)film and a p^(+) layer are introduced into the front and back interfaces of the solar cell, respectively, which leads to the formation of a p–n junction between the p-Si and the MoS_(2)film as well as ohmic contacts between the MoS_(2)film and the ITO, improving the S-shaped J–V curve. As a result of the high doping characteristics and the high work function of the p^(+) layer, a high–low junction is formed between the p;and p layers along with ohmic contacts between the p;layer and the Ag electrode. Consequently,the S-shaped J–V curve is eliminated, and a significantly higher current density is achieved at a high voltage. The device exhibits ideal p–n junction rectification characteristics and achieves a high power-conversion efficiency(CE) of 7.55%. The findings of this study may improve the application of MoS_(2)thin films in silicon-based solar cells, which are expected to be widely used in various silicon-based electronic and optical devices.

关键词： MoS_(2)/Si-based solar cell S-shaped J–V curve power conversion efficiency p^(+)layer

Distribution and mapping of temperate savanna in the sandy lands of eastern China

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Science China Earth Sciences 2025年第1期68卷 128-141页

作者： Xiaoya li Feng WANG tao DUAN Kaijie YANG Bin YANG Chunmei WANG xin TIAN Qi LU Institute of Ecological Conservation and Restoration Institute of Desertification Studies Chinese Academy of Forestry Institute of Desertification Institute of Desertification Studies Chinese Academy of Forestry Institute of Great Green Wall Satellite Application Centre for Ecology and Environment MEE Institute of Microelectronics Chinese Academy of Sciences Aerospace Information Research Institute Chinese Academy of Sciences Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Savannas are distributed globally across various *** perform a significant socioeconomic role in regulating net primary productivity and the terrestrial carbon *** to the high spatial heterogeneity induced by the mixed distribution of trees and grasses,current global land-cover classification maps often classify savannas as forests or grasslands Temperate savannas in China cover a vast area,yet their spatial patterns and extent remain poorly *** study developed a novel remote sensing temperate savannas mapping method by integrating very high-resolution （VHR） unmanned aerial vehicle （UAV） and GF-6 satellite imagery based on the vegetation structure characteristics of temperate savannas using the FAO definition of *** and validation datasets were collected from VHR UAV imagery covering the main temperate savannah types with a ground area of 1818 *** fractional woody vegetation cover （FWVC） and fractional herbaceous vegetation cover （FHVC） in temperate savannas were estimated by integrating Classification and Regression Tree and Random Forest *** current distribution of temperate savannas in the Horqin and Otindag Sandy Lands of Eastern China was mapped to a unit area of 0.5 *** root-mean-square error （RMSE） values for the FWVC and FHVC models were 10.69% and 11.67%,and the R2values were 0.66 and 0.63,*** assessment indicated that the new temperate savanna map had high identification accuracy,with a Kappa coefficient of 0.70,overall accuracy of 0.88,and average accuracy of *** savannas in the sandy lands of eastern China were primarily distributed in the northern Horqin Sandy Land the central and eastern regions of the Otindag Sandy Land,and the transition zone from the southern slopes of the Greater Khingan Mountains to the plains,covering a total area of 3.27×10～6 *** main savannah types were elm,oak/maple,and shrub *** savannas were widely distributed in the Otindag Sandy

关键词： Temperate savanna UAV imagery GF-6 Fractional woody vegetation cover Fractional herbaceous vegetation cover Machine learning

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Estimation of Chloride Diffusivity in Hydrated Tricalcium Silicate Using a Hydration-Diffusion Integrated Method

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 49-64页

作者： WANG xin SHEN Dejian tao Sijie liU Ruixin WU Shengxing College of Civil and Transportation Engineering Hohai UniversityNanjing 210098China

This study aims to develop a chloride diffusion simulation method that considers the hydration microstructure and pore solution properties during the hydration of tricalcium silicate(C3S).The method combines the hydration simulation,thermodynamic calculation,and finite element analysis to examine the effects of pore solution,including effect of electrochemical potential,effect of chemical activity,and effect of mechanical interactions between ions,on the chloride effective diffusion coefficient of hydrated C3S *** results indicate that the effect of electrochemical potential on chloride diffusion becomes stronger with increasing hydration age due to the increase in the content of hydrated calcium silicate;as the hydration age increases,the effect of chemical activity on chloride diffusion weakens when the number of diffusible elements decreases;the effect of mechanical interactions between ions on chloride diffusion decreases with the increase of hydration age.

关键词： tricalcium silicate simulation method chloride diffusion coefficient pore solution

Fine-tuning the spatial allocation of phytohormones for smart canopy, smart breeding, and smart agriculture

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Science China life Sciences 2025年第1期68卷 309-310页

作者： tao Zhou lin li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University HuBei HongShan Laboratory

The dual challenges of global climate change and population growth have increased demand for higher crop yields per unit area. The innovative technology of smart agriculture aims to synergize breeding, cultivation, and production through the application of biological and informatics technologies. Historically, the “Green Revolution” introduced semidwarf varieties of certain key crops by utilizing mutations affecting gibberellin pathways, which significantly increased planting densities and yields.

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局部激光辐照下薄板结构的屈曲承载力分析

高压物理学报 2016年第2期30卷 142-148页

作者：李欣涛龙连春北京工业大学机械工程与应用电子技术学院北京100124

薄壁结构广泛应用于实际工程中,局部材料性能的变化、局部热应力等因素均影响结构的屈曲承载力。为考察局部升温对薄壁结构屈曲承载力的影响,通过激光辐照实现薄壁结构的局部快速升温。采用温度-位移耦合法进行非线性热屈曲分析,获得了... 详细信息

薄壁结构广泛应用于实际工程中,局部材料性能的变化、局部热应力等因素均影响结构的屈曲承载力。为考察局部升温对薄壁结构屈曲承载力的影响,通过激光辐照实现薄壁结构的局部快速升温。采用温度-位移耦合法进行非线性热屈曲分析,获得了激光功率密度、辐照光斑半径和薄板厚度对薄板热屈曲的影响;在此基础上采用弧长法分析轴向受压薄板结构在局部激光辐照下的整体屈曲承载力。数值结果表明:薄板结构的整体屈曲承载力随激光辐照时间的增加及辐照光斑半径的增大呈线性下降趋势,随薄板厚度的增加近似呈指数增大。

关键词：薄壁结构热屈曲激光辐照屈曲承载能力