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Japanese encephalitis following liver transplantation: A rare case report

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World Journal of Clinical Cases 2020年第2期8卷 337-342页

作者： Zhi-li Qi li-Ying Sun Jing Bai Hai-Zhou Zhuang mei-li duan Department of Intensive Care Unit Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Japanese encephalitis(JE) is a serious public health concern with a high mortality rate in many Asian countries. For many years, JE virus(JEV) was considered the major cause of viral encephalitis in Asia. Although most JE cases are asymptomatic, the case fatality rate approaches 30%, and approximately 30%–50% of survivors have long-term neurological sequelae. To the best of our knowledge, JEV infection has never been reported following liver *** SUMMARY We report a case of a woman who underwent liver transplantation for autoimmune liver disease but presented with fever and neurological symptoms 13 d after transplantation. Magnetic resonance imaging revealed JEV infection,and positive immunoglobulin M antibody to JEV in blood and cerebrospinal fluid confirmed JE. The patient was treated with antiviral agents, immune regulation,and organ function support. No neurological sequelae were present after 1 year of *** Imaging and lumbar puncture examination should be performed as soon as possible in patients with fever and central nervous system symptoms after liver transplantation, and the possibility of atypical infection should be considered,which is helpful for early diagnosis and improved prognosis.

关键词： liver transplantation Japanese encephalitis virus Neurological complications Infection Case report

Changes in intestinal mucosal immune barrier in rats with endotoxemia

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World Journal of Gastroenterology 2009年第46期15卷 5843-5850页

作者： Chong liu Ang li Yi-Bing Weng mei-li duan Bao-En Wang Shu-Wen Zhang Departmentof Critical Care Medicine Beijing Friendship Hospital Affiliatedto Capital Medical University Beijing 100050 China liver Research Center Beijing FriendshipHospital Affiliated to Capital Medical University Beijing100050 China Department of Infectious Disease andCritical Care Medicine Beijing Friendship Hospital Affiliatedto Capital Medical University Beijing 100050 China

AIM： To investigate the dysfunction of the immunological barrier of the intestinal mucosa during endotoxemia and to elucidate the potential mechanism of this dysfunction. METHODS： Male Wistar rats were randomly distributed into two groups： control group and lipopolysaccharide （LPS） group. Endotoxemia was induced by a single caudal venous injection of LPS. Animals were sacrificed in batches 2, 6, 12 and 24 h after LPS infusion. The number of microfold （M）-cells, dendritic cells （DCs）, CD4＋ T cells, CD8＋ T cells, regulatory T （Tr） cells and IgA＋ B cells in the intestinal mucosa were counted after immunohistochemical staining. Apoptotic lymphocytes were counted after TUNEL staining. The levels of interleukin （IL）-4, interferon （IFN）-γ, and forkhead box P3 （Foxp3） in mucosal homogenates were measured by EliSA. The secretory IgA （sIgA） content in the total protein of one milligram of small intestinal mucus was detected using a radioimmunological ***： This research demonstrated that LPS-induced endotoxemia results in small intestinal mucosa injury. The number of M-cells, DCs, CD8~ T cells, and IgA~ B cells were decreased while Tr cell and apoptotic lymphocyte numbers were increased significantly. The number of CD4＋ T cells increased in the early stages and then slightly decreased by 24 h. The level of IL-4 significantly increased in the early stages and then reversed by the end of the study period. The level of IFN-T increased slightly in the early stages and then decreased markedly by the 24 h time point. Level of Foxp3 increased whereas sIgA level ***： Mucosal immune dysfunction forms part of the intestinal barrier injury during endotoxemia. The increased number and function of Tr cells as well as lymphocyte apoptosis result in mucosal immunode- ficiency.

关键词： Endotoxemia Rats Intestinal mucosa Immunity

Successful treatment of gastrointestinal infection-induced septic shock using the oXiris■ hemofilter: A case report

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World Journal of Clinical Cases 2021年第27期9卷 8157-8163页

作者： Yu li Xiao-Jun Ji Dan-Yang Jing Zheng-Hui Huang mei-li duan Department of Intensive Care Unit Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Septic shock leads to multiple organ failure,and bacterial endotoxins and endogenous cytokines play essential roles in the *** oXiris■hemofilter can efficiently adsorb endotoxins and *** SUMMARY We admitted a critically ill 59 year-old male patient with gastrointestinal septic shock due to infection by a Gram-negative bacterium and septic acute kidney injury(AKI).Prior to intensive care unit admission,the patient reported intermittent diarrhea and decreased urine *** blood pressure was 70/40 mmHg,necessitating fluid resuscitation and large doses of *** on the results of a blood culture and the presence of hypotension,oliguria,and hypoxemia,we diagnosed septic shock,AKI,and multiple organ *** administered continuous renal replacement therapy(CRRT)with an oXiris■hemofilter for 72 h with intermittent continuous veno-venous hemodiafiltration(CVVHDF),and changed the filter every 12 *** his hemodynamic parameters were stable,we used a traditional filter(AN69 hemofilter)with intermittent *** 72 h CRRT with the oXiris■hemofilter led to stabilization of his vital signs,marked reductions in disease severity scores,and decreased levels of procalcitonin,endotoxin,and inflammatory *** 8 d of CRRT,his kidney function had completely *** We conclude that the oXiris■hemofilter combined with appropriate antibacterial therapy was an effective treatment for this patient with gastrointestinal septic shock.

关键词： Sepsis Septic shock Acute kidney injury Continuous renal replacement therapy oXiris■ Case report

Over-expression of programmed death-ligand 1 and programmed death-1 on antigen-presenting cells as a predictor of organ dysfunction and mortality during early sepsis: a prospective cohort study

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World Journal of Emergency Medicine 2023年第3期14卷 179-185页

作者： Jia-bao li Miao-rong Xie mei-li duan Ya-nan Yu Chen-chen Hang Zi-ren Tang Chun-sheng li Department of Critical Care Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Emergency and Critical Care Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND:This study aimed to explore the changes of programmed death-ligand 1(PDL1)and programmed death-1(PD-1)expression on antigen-presenting cells(APCs)and evaluate their association with organ failure and mortality during early ***:In total,40 healthy controls and 198 patients with sepsis were included in this *** blood was collected within the first 24 h after the diagnosis of *** expression of PDL1 and PD-1 was determined on APCs,such as B cells,monocytes,and dendritic cells(DCs),by flow *** in plasma,such as interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),IL-6,IL-10,and IL-17A were determined by Luminex ***:PD-1 expression decreased significantly on B cells,monocytes,myeloid DCs(mDCs),and plasmacytoid DCs(pDCs)as the severity of sepsis ***-1 expression was also markedly decreased in non-survivors compared with *** contrast,PD-L1 expression was markedly higher on mDCs,pDCs,and monocytes in patients with sepsis than in healthy controls and in non-survivors than in *** PD-L1 expression on APCs(monocytes and DCs)was weakly related to organ dysfunction and infl *** area under the receiver operating characteristic curve(AUC)of the PD-1 percentage of monocytes(monocyte PD-1%)+APACHE II model(0.823)and monocyte PD-1%+SOFA model(0.816)had higher prognostic value than other parameters *** PD-1%was an independent risk factor for 28-day ***:The severity of sepsis was correlated with PD-L1 or PD-1 over-expression on ***-L1 in monocytes and DCs was weakly correlated with infl ammation and organ dysfunction during early *** combination of SOFA or APACHE II scores with monocyte PD-1%could improve the prediction ability for mortality.

关键词： Infl ammation Programmed death-ligand 1 Programmed death-1 Antigen-presenting cells

Metal-free phthalocyanine single crystal： Solvothermal synthesis and near-infrared electroluminescence

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Chinese Chemical Letters 2016年第5期27卷 764-768页

作者： Qing-Long Bai Chun-Hua Zhang Juan-Juan Song Jing-Hai liu Yan-Chun Feng li-mei duan Chuan-Hui Cheng Inner Mongolia Key Lab of Chemistry of Natural Products and Synthesis of Functional Molecules College of Chemistry and Chemical Engineering Inner Mongolia University for Nationalities Tongliao 028000 China School of Physics and Optoelectronics Technology Dalian University of Technology Dalian 116024 China

A metal-flee purple H2Pc single crystal was synthesized by a facile solvothermal method, and its solubility and near-infrared （NIR） optical properties were also investigated due to its potential applications as a light-emitting layer for OLEDs. The H2Pc single crystal is insoluble in 1-chlorine naphthalene and other organic solvents. It gives a wide absorption in the range from 620 nm to 679 nm and a wide emission in near 922 nm. As an active light-emitting layer, H2Pc was employed to fabricate electroluminescent （EL） devices with a structure of ITO/NPB （30 nm）/Alq3：H2Pc （30 nm）/BCP （20 nm）/ Alq3 （20 nm）/Al. The emission center is at 936 nm when the H2Pc doping concentration is 20 wt%. The doping concentration strongly governs the emission intensity. When doping concentration decreases from 10 wt% to 1 wt%, the emission intensity remarkably fades, and simultaneously the emission center undergoes a blue shift.

关键词： Solvothermal synthesis H2Pc single crystal Optical properties Near-infrared Electroluminescence

Paeonol Improves lipopolysaccharide-induced Microcirculatory Disturbance in Rat Mesentery

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World Journal of Traditional Chinese Medicine 2015年第1期1卷 37-44页

作者： Lei Dong Ang li mei-li duan Kai Sun Yu-Ying liu Ming-Xia Wang Chuan-She Wang Jing-Yu Fan Jing-Yan Han Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Tasly Microcirculation Research Center Peking University Health Science Center Department of Integration of Chinese and Western Medicine School of Basic Medical Sciences Peking University Key Laboratory of Microcirculation State Administration of Traditional Chinese Medicine of China Key Laboratory of Stasis and Phlegm of State Administration of Traditional Chinese Medicine

Objective: To investigate the effect of paeonol on lipopolysaccheride(LPS)-induced rat mesenteric microcirculatory ***: Male Wistar rats were randomly distributed into 5 groups(n=6 in each): Sham group, LPS group, paeonol group, paeonol+LPS group, and LPS+paeonol group. Endotoximia model was conducted by continuous LPS infusion. Changes in mesenteric microcirculatory variables, including diameter of venule, velocity of red blood cells in venule, leukocyte adhesion, free radicals produced in venule and albumin leakage from venule, were observed through an inverted intravital microscope. Meanwhile, the expression of myeloperoxidase(MPO), CD18,intercellular adhesion molecule-1(ICAM-1), toll-like receptor 4(TLR4), nuclear factor-kappa B p65 subunit(NF-κB p65), activator protein-1(AP-1), and Jun N-terminal kinase(JNK) was assessed by Western ***: After infusion of LPS, the number of leukocytes adherent to venular wall, the intensity of dihydrorhodamine 123(DHR)fluorescence in the venular walls, and albumin leakage from venules were significantly increased, whereas the red blood cell velocity in venule was decreased. All the manifestations were significantly reduced by pre-treatment and post-treatment with paeonol. Moreover, paeonol significantly attenuated the expression of MPO, CD18, ICAM-1, TLR4, NF-κB p65, AP-1 and JNK in rat mesentery after ***: The results demonstrated that paeonol could protect from and ameliorate the microcirculation disturbance induced by LPS.

关键词： Paeonol Microcirculation Leukocyte adhesion Albumin leakage

Distribution and mapping of temperate savanna in the sandy lands of eastern China

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Science China Earth Sciences 2025年第1期68卷 128-141页

作者： Xiaoya li Feng WANG Tao duan Kaijie YANG Bin YANG Chunmei WANG Xin TIAN Qi LU Institute of Ecological Conservation and Restoration Institute of Desertification Studies Chinese Academy of Forestry Institute of Desertification Institute of Desertification Studies Chinese Academy of Forestry Institute of Great Green Wall Satellite Application Centre for Ecology and Environment MEE Institute of Microelectronics Chinese Academy of Sciences Aerospace Information Research Institute Chinese Academy of Sciences Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Savannas are distributed globally across various *** perform a significant socioeconomic role in regulating net primary productivity and the terrestrial carbon *** to the high spatial heterogeneity induced by the mixed distribution of trees and grasses,current global land-cover classification maps often classify savannas as forests or grasslands Temperate savannas in China cover a vast area,yet their spatial patterns and extent remain poorly *** study developed a novel remote sensing temperate savannas mapping method by integrating very high-resolution （VHR） unmanned aerial vehicle （UAV） and GF-6 satellite imagery based on the vegetation structure characteristics of temperate savannas using the FAO definition of *** and validation datasets were collected from VHR UAV imagery covering the main temperate savannah types with a ground area of 1818 *** fractional woody vegetation cover （FWVC） and fractional herbaceous vegetation cover （FHVC） in temperate savannas were estimated by integrating Classification and Regression Tree and Random Forest *** current distribution of temperate savannas in the Horqin and Otindag Sandy Lands of Eastern China was mapped to a unit area of 0.5 *** root-mean-square error （RMSE） values for the FWVC and FHVC models were 10.69% and 11.67%,and the R2values were 0.66 and 0.63,*** assessment indicated that the new temperate savanna map had high identification accuracy,with a Kappa coefficient of 0.70,overall accuracy of 0.88,and average accuracy of *** savannas in the sandy lands of eastern China were primarily distributed in the northern Horqin Sandy Land the central and eastern regions of the Otindag Sandy Land,and the transition zone from the southern slopes of the Greater Khingan Mountains to the plains,covering a total area of 3.27×10～6 *** main savannah types were elm,oak/maple,and shrub *** savannas were widely distributed in the Otindag Sandy

关键词： Temperate savanna UAV imagery GF-6 Fractional woody vegetation cover Fractional herbaceous vegetation cover Machine learning

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空-谱协同流形重构的高光谱影像分类

光学精密工程 2018年第7期26卷 1827-1836页

作者：黄鸿陈美利段宇乐石光耀重庆大学光电技术与系统教育部重点实验室重庆400044

鉴于传统高光谱影像分类大都采用监督学习方法,且仅利用了光谱信息,未考虑影像空间特征和流形结构。提出一种基于空-谱协同流形重构误差的高光谱影像分类方法,该算法基于高光谱影像中地物分布的空间一致性,利用少量标记的样本和大量的... 详细信息

鉴于传统高光谱影像分类大都采用监督学习方法,且仅利用了光谱信息,未考虑影像空间特征和流形结构。提出一种基于空-谱协同流形重构误差的高光谱影像分类方法,该算法基于高光谱影像中地物分布的空间一致性,利用少量标记的样本和大量的无标记空间近邻样本来进行半监督学习,并利用测试样本在每一子流形上的重构误差来表征相似性,实现鉴别分类。在Indian Pines和University of Pavia数据集上的实验结果表明,本文方法的分类精度在各种条件下要优于其他分类算法,其最高总体精度分别达到了95.67%和91.92%。该算法将高光谱遥感影像中的空间-光谱信息融入不同地物的子流形结构表征,在训练样本数量较少时仍能得到好的分类效果,有效提升了分类性能。

关键词：高光谱遥感图像分类空-谱特征流形学习重构误差

Epidemiology of Sepsis-3 in a sub-district of Beijing: secondary analysis of a population-based database

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Chinese Medical Journal 2019年第17期132卷 2039-2045页

作者： Hong-Cheng Tian Jian-Fang Zhou li Weng Xiao-Yun Hu Jin-Min Peng Chun-Yao Wang Wei Jiang Xue-Ping Du Xiu-Ming Xi You-Zhong An mei-li duan Bin Du 无 Department of Critical Care Medicine China Rehabilitation Research Center Capital Medical University Beijing 100068 China Department of Critical Care Medicine Beijing Tian Tan Hospital Capital Medical University Beijing 100070 China Medical ICU Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100730 China Department of General Internal Medicine Fuxing Hospital Capital Medical University Beijing 100038 China Department of Critical Care Medicine Fuxing Hospital Capital Medical University Beijing 100038 China Department of Critical Care Medicine Peking University People’s Hospital Beijing 100044 China Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China for China Critical Care Clinical Trials Group (CCCCTG)

Background: With the publication of Sepsis-3 definition, epidemiological data based on Sepsis-3 definition from middle-income countries including China are scarce, which prohibits understanding of the disease burden of this newly defined syndrome in these settings. The purpose of this study was to describe incidence and outcome of Sepsis-3 in Yuetan sub-district of Beijing and to estimate the incidence rate of Sepsis-3 in China. Methods: The medical records of all adult residents hospitalized from July 1, 2012 to June 30, 2014 in Yuetan sub-district of Beijing were reviewed. Patients with sepsis-3 and severe sepsis/septic shock were identified. The incidence rates and mortality rate of sepsis-3 and sepsis/septic shock were calculated, incidence rates and in-hospital mortality rates were normalized to the population distribution in the 2010 National Census. Population incidence rate and case fatality rate between sexes were compared with the Z test, as the data conformed to Poisson distribution. Results: Of the 21,191 hospitalized patients, 935 patients were diagnosed with Sepsis-3, and 498 cases met severe sepsis/septic shock criteria. The crude annual incidence rate of Sepsis-3 in Yuetan sub-district was 363 cases per 100,000 population, corresponding to standardized incidence rates of 236 cases per 100,000 population per year, respectively. The overall case fatality rate of Sepsis-3 was 32.0%, the crude population mortality rates of Sepsis-3 was 116 cases per 100,000 population per year, the standardized mortality rate was 67 cases per 100,000 population per year, corresponding to a speculative extrapolation of 700,437 deaths in China. The incidence rate and mortality rate of Sepsis-3 were significantly higher in males, elderly people, and patients with more comorbidities. The 62.1% of patients with Sepsis-3 had community-acquired infections, compared with 75.3% of infected patients without Sepsis-3 (P < 0.001). The most common infection in patients with Sepsis-3

关键词： Sepsis-3 Severe sepsis Incidence Mortality