Japanese encephalitis following liver transplantation: A rare case report

作     者：Zhi-Li Qi Li-Ying Sun Jing Bai Hai-Zhou Zhuang Mei-Li Duan 

作者机构：Department of Intensive Care UnitBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China Beijing Key Laboratory of Tolerance Induction and Organ Protection in TransplantationBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2020年第8卷第2期

页      面：337-342页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Liver transplantation Japanese encephalitis virus Neurological complications Infection Case report 

摘      要：BACKGROUND Japanese encephalitis(JE) is a serious public health concern with a high mortality rate in many Asian countries. For many years, JE virus(JEV) was considered the major cause of viral encephalitis in Asia. Although most JE cases are asymptomatic, the case fatality rate approaches 30%, and approximately 30%–50% of survivors have long-term neurological sequelae. To the best of our knowledge, JEV infection has never been reported following liver *** SUMMARY We report a case of a woman who underwent liver transplantation for autoimmune liver disease but presented with fever and neurological symptoms 13 d after transplantation. Magnetic resonance imaging revealed JEV infection,and positive immunoglobulin M antibody to JEV in blood and cerebrospinal fluid confirmed JE. The patient was treated with antiviral agents, immune regulation,and organ function support. No neurological sequelae were present after 1 year of *** Imaging and lumbar puncture examination should be performed as soon as possible in patients with fever and central nervous system symptoms after liver transplantation, and the possibility of atypical infection should be considered,which is helpful for early diagnosis and improved prognosis.