检索结果-南通市图书馆

不同剂量rt-PA静脉溶栓联合丁苯酞治疗对老年急性脑梗死治疗效果的对比研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川生理科学杂志 2024年第8期46卷 1855-1857页

作者：李世立洛阳市回族医院全科医学门诊河南洛阳471003

目的:探讨不同剂量阿替普酶(Alteplase,rt-PA)联合丁苯酞治疗老年急性脑梗死(Acute cerebral ischemic,ACI)的临床疗效。方法:收集2021年1月至2023年10月本院90例老年ACI患者的临床资料,根据治疗方案不同分为低剂量组和高剂量组(n=45),... 详细信息

目的:探讨不同剂量阿替普酶(Alteplase,rt-PA)联合丁苯酞治疗老年急性脑梗死(Acute cerebral ischemic,ACI)的临床疗效。方法:收集2021年1月至2023年10月本院90例老年ACI患者的临床资料,根据治疗方案不同分为低剂量组和高剂量组(n=45),分别采用0.6mg·kg^(-1)、0.9 mg·kg^(-1) rt-PA静脉溶栓联合丁苯酞100 mL静脉滴注进行治疗。治疗7 d后比较两组临床疗效、并发症发生情况,采用美国国立卫生院卒中量表(The National Institutes of Health Stroke Scale,NIHSS)评估患者神经功能,采用全自动凝血分析仪检测纤维蛋白原(Fibrinogen,FIB)、凝血酶原时间(Prothrombin time,PT)、活化部分凝血酶时间(Activated partial thromboplastin time,APTT),采用散射免疫比浊法检测[C反应蛋白(C-reactive protein,CRP)、基质金属蛋白酶-9(Matrix metalloprotein-9,MMP-9)、可溶性CD40配体(Soluble CD40 ligand,sCD40L)]水平。结果:两组临床疗效、并发症发生率比较无显著差异(P>0.05)。治疗3 d后与治疗前相比,两组PT、APTT均显著升高,FIB显著降低,其中高剂量组改善更为显著(P0.05)。结论:不同剂量rt-PA联合丁苯酞治疗老年ACI疗效一致,但低剂量能在一定程度上保护凝血功能。

关键词：急性脑梗死老年不同剂量阿替普酶丁苯酞

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于IMU数据的应变解析技术及其应用

科学技术与工程 2024年第7期24卷 2683-2689页

作者：何仁洋刘艳贺王海涛罗艳龙李仕力崔忠浩国家市场监管技术创新中心(油气管道与储存设备安全) 北京100029 中国特种设备检测研究院北京100029 中国石油大学机械与储运工程学院北京102249

长输埋地油气管线在严重的地灾作用下会引发管道变形,如果变形的管段存在缺陷,将极易导致管道失效,造成严重的环境污染和经济损失。准确地获取管道的变形情况并进行安全评价能够为保障管道安全稳定运行发挥重要的作用。基于IMU检测数据... 详细信息

长输埋地油气管线在严重的地灾作用下会引发管道变形,如果变形的管段存在缺陷,将极易导致管道失效,造成严重的环境污染和经济损失。准确地获取管道的变形情况并进行安全评价能够为保障管道安全稳定运行发挥重要的作用。基于IMU检测数据,通过小波变换降噪和油气管道设计规范进行特征识别的应变解析算法,能够有效地识别管线上的热偎弯管、冷弯管、弹性敷设段和重点关注段。该算法计算的管段弯曲拉伸应变值将结合ExxonMobil提出的拉伸应变容量预测模型对环焊缝进行基于应变的安全评价。在基于应变设计的高钢级油气管道已在国内油气运输行业得到广泛应用的背景下,可以参考该评价方法开展高钢级管道环焊缝的安全评价。

关键词：长输埋地油气管线高钢级惯性测量单元小波变换环焊缝拉伸应变容量

Matrix orthogonal polynomials, non-abelian Toda lattices, and B?cklund transformations

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第9期67卷 2071-2090页

作者： shi-Hao li Department of Mathematics Sichuan University

A connection between matrix orthogonal polynomials and non-abelian integrable lattices is investigated in this paper. The normalization factors of matrix orthogonal polynomials expressed using quasideterminants are shown to be the solutions to the non-abelian Toda lattice in semi-discrete and full-discrete cases. Moreover, with a moment modification method, we demonstrate that the B¨acklund transformation of the non-abelian Toda lattice given by Popowicz(1983) is equivalent to the non-abelian Volterra lattice, whose solutions can be expressed using quasi-determinants as well.

关键词： matrix orthogonal polynomial non-abelian Toda lattice Bäcklund transformation quasi-determinant technique

同方期刊数据库

Calcium-dependent activation of CPK12 facilitates its cytoplasm-to-nucleus translocation to potentiate plant hypoxia sensing by phosphorylating ERF-Ⅶ transcription factors

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2023年第6期16卷 979-998页

作者： Biao Fan Ke liao lin-Na Wang li-li shi Yi Zhang ling-Jing Xu Ying Zhou Jian-Feng li Yue-Qin Chen Qin-Fang Chen shi Xiao State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant Resourceschool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

Calcium-dependent protein kinases(CDPKs/CPKs)are key regulators of plant stress signaling that translate calcium signals into cellular responses by phosphorylating diverse substrate ***,the molecular mechanism by which plant cells relay calcium signals in response to hypoxia remains ***,we show that one member of the CDPK family in Arabidopsis thaliana,CPK12,is rapidly activated during hypoxia through calcium-dependent phosphorylation of its Ser-186 *** CPK12 shuttles from the cytoplasm to the nucleus,where it interacts with and phosphorylates the group Ⅶ ethylene-responsive transcription factors(ERF-Ⅶ)that are core regulators of plant hypoxia sensing,to enhance their ***,CPK12 knockdown lines show attenuated tolerance of hypoxia,whereas transgenic plants overexpressing CPK12 display improved hypoxia ***,loss of function of five ERF-Ⅶ proteins in an erf-vii pentuple mutant could partially suppress the enhanced hypoxia-tolerance phenotype of CPK12-overexpressing ***,we also discovered that phosphatidic acid and 14-3-3κ protein serve as positive and negative modulators of the CPK12 cytoplasm-to-nucleus translocation,*** together,these findings uncover a CPK12-ERF-Ⅶ regulatory module that is key to transducing calcium signals from the cytoplasm into the nucleus to potentiate hypoxia sensing in plants.

关键词： CPK12 hypoxia sensing cytoplasm-to-nucleus translocation ERF-Ⅶtranscription factors phospha-tidic acid 14-3-3 proteins

Constructing the Impossible Differential of Type-II GFN with Boolean Function and Its Application to WARP

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第1期33卷 80-89页

作者： Jiali shi Guoqiang liU Chao li College of liberal Arts and Sciences National University of Defense Technology Hunan Engineering Research Center of Commercial Cryptography Theory and Technology Innovation State Key Laboratory of Information Security Institute of Information Engineering

Type-Ⅱ generalized Feist el network(GFN) has attracted a lot of attention for its simplicity and high *** differential attack is one of the powerful cryptanalytic approaches for word-oriented block ciphers such as Feistel-like *** deduce the impossible differential of Type-Ⅱ GFN by analyzing the Boolean function in the middle *** main idea is to investigate the expression with the variable representing the plaintext(ciphertext) difference words for the internal state *** adopting the miss-in-the-middle approach,we can construct the impossible differential of Type-Ⅱ *** an illustration,we apply this approach to WARP,a lightweight 128-bit block cipher with a 128-bit key which was presented by Banik et *** SAC *** structure of WARP is a 32-branch Type-Ⅱ ***,we find two 21-round truncated impossible differentials and implement a 32-round key recovery attack on *** the 32-round key recovery attack on WARP,some observations are used to mount an effective *** the advantage of the early abort technique,the data,time,and memory complexities are 2125.69chosen plaintexts,2126.6832-round encryptions,and 2100-bit,*** the best of our knowledge,this is the best attack on WARP in the single-key scenario.

关键词： Ciphers Boolean functions Parallel processing Complexity theory

Rhodium-catalyzed addition reactions of benzylic C–H bonds to cyclic N-sulfonyl ketimines viaπ-coordination

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第3期35卷 287-291页

作者： Yuntong li Hang shi Department of Chemistry Zhejiang UniversityHangzhou 310027China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Department of ChemistrySchool of Science and Research Center for Industries of the FutureWestlake UniversityHangzhou 310030China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Mannich-type reactions are a widely used method for the synthesis of amines due to the readily availability of nucleophiles and ***,the inclusion of alkylarenes instead of active carbon pronucleophiles such as aldehydes and ketones in these addition reactions has been a challenge due to the inherent difficulty of benzylic *** this study,we present a novel approach for the construction of N-sulfonyl amines via rhodium-catalyzed addition of unbiased benzylic C–H bonds to cyclic N-sulfonyl ketamines throughπ-*** strategy enables the synthesis of a diverse range of N-sulfonyl amines,and subsequent diversification of the addition products showcases the synthetic potential of this protocol.

关键词： Benzylic deprotonation Cyclic N–sulfonyl ketimines π-Coordination Mannich-type addition Rhodium catalysis

Effect of droplet characteristics on liquid-phase distribution in spray zone of internal mixing air-mist nozzle

在线全文

学校读者我要写书评

暂无评论

China Foundry 2024年第2期21卷 185-196页

作者： Wei-li Wu Chang-gui Cheng Yang li shi-fa Wei De-li Chen The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081China Technology Center Fushun Special Steel Co.Ltd.Fushun 113001LiaoningChina

In continuous casting production,droplet characteristics are important parameters for evaluating the nozzle atomization quality,and have a significant impact on the secondary cooling effect and the slab *** order to study the behavior of atomized droplets after reaching the slab surface and to optimize the spray cooling effect,the influence of droplet diameter and droplet velocity on the migration behavior of droplets in the secondary cooling zone was analyzed by FLUENT *** show that the droplets in the spray zone and on the slab surface are mainly concentrated in the center,thus,the liquid volume fraction in the center is higher than that of either *** the droplet diameter increases,the region of high liquid volume fraction on the slab surface becomes wider,and the liquid phase distribution in the slab width direction becomes *** increasing the droplet velocity at the nozzle exit has little effect on droplet diffusion in the spray zone,the distribution becomes more uneven due to more liquid reaches the slab surface per unit time.A prediction formula of the maximum water flow rate on the slab surface for specific droplet characteristics was proposed based on dimensionless analysis and validated by simulated data.A nozzle spacing of 210 mm was recommended under the working conditions in this study,which ensures effective coverage of the spray water over the slab surface and enhances the distribution uniformity of water flow rate in the transverse direction.

关键词： continuous casting secondary cooling zone internal mixing air-mist nozzle droplet characteristics liquid phase distribution water flow rate

Physiological and pathological functions of circular RNAs in the nervous system

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第2期19卷 342-349页

作者： Min Zhou shi li Chuan Huang School of life Sciences Chongqing UniversityChongqingChina

Circular RNAs(circRNAs)are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and *** play crucial roles in physiological and pathological processes by sponging microRNAs,modulating gene transcription,controlling the activity of certain RNA-binding proteins,and producing functional peptides.A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 ***,the precise role of circRNAs in the nervous system has yet to be comprehensively *** this review,we first summarize the recently described roles of circRNAs in brain development,maturity,and ***,we focus on the involvement of circRNAs in various diseases of the central nervous system,such as brain cancer,chronic neurodegenerative diseases,acute injuries of the nervous system,and neuropathic pain.A better understanding of the functionality of circRNAs will help us to develop potential diagnostic,prognostic,and therapeutic strategies to treat diseases of the nervous system.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis brain development circRNAs neuropathic pain Parkinson’s disease

Supercritical CO_(2) Cycles for Nuclear-Powered Marine Propulsion:Preliminary Conceptual Design and Off-Design Performance Assessment

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第1期33卷 328-347页

作者： li Zhaozhi shi Mingzhu SHAO Yingjuan ZHONG Wenqi Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Using the efficient,space-saving,and flexible supercritical carbon dioxide(sCO_(2)) Brayton cycle is a promising approach for improving the performance of nuclear-powered *** purpose of this paper is to design and compare sCO_(2) cycle power systems suitable for nuclear-powered *** the characteristics of nuclear-powered ships,this paper uses different indicators to comprehensively evaluate the efficiency,cost,volume,and partial load performance of several nuclear-powered sCO_(2) *** load-following strategies are also designed and *** results show that the partial cooling cycle is most suitable for nuclear-powered ships because it offers both high thermal efficiency and low volume and cost,and can maintain relatively high thermal efficiency at partial ***,the new load-following strategy that adjusts the turbine speed can keep the compressor away from the surge line,making the cycle more flexible and efficient compared to traditional inventory and turbine bypass strategies.

关键词： supercritical CO_(2)cycle nuclear marine propulsion off-design performance