Rhodium-catalyzed addition reactions of benzylic C–H bonds to cyclic N-sulfonyl ketimines viaπ-coordination

作     者：Yuntong Li Hang Shi Yuntong Li;Hang Shi

作者机构：Department of ChemistryZhejiang UniversityHangzhou 310027China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang ProvinceDepartment of ChemistrySchool of Science and Research Center for Industries of the FutureWestlake UniversityHangzhou 310030China Institute of Natural SciencesWestlake Institute for Advanced StudyHangzhou 310024China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第3期

页      面：287-291页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(Nos.22271235,22071198) the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(No.2022SDXHDX0006) the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2020R01004)for research support 

主　　题：Benzylic deprotonation Cyclic N–sulfonyl ketimines π-Coordination Mannich-type addition Rhodium catalysis 

摘      要：Mannich-type reactions are a widely used method for the synthesis of amines due to the readily availability of nucleophiles and ***,the inclusion of alkylarenes instead of active carbon pronucleophiles such as aldehydes and ketones in these addition reactions has been a challenge due to the inherent difficulty of benzylic *** this study,we present a novel approach for the construction of N-sulfonyl amines via rhodium-catalyzed addition of unbiased benzylic C–H bonds to cyclic N-sulfonyl ketamines throughπ-*** strategy enables the synthesis of a diverse range of N-sulfonyl amines,and subsequent diversification of the addition products showcases the synthetic potential of this protocol.