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The Hyers-Ulam Stability of a Functional Equation Deriving from Quadratic and Cubic Functions in Quasi-β-normed Spaces

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Acta Mathematica Sinica,English Series 2010年第12期26卷 2335-2348页

作者： li Guang wang bo liU School of Mathematical Sciences Qufu Normal University Qufu 273165 P. R. China

In this paper, we investigate the Hyers-Ulam stability of the following function equation 2f（2x ＋ y）＋ 2f（2x - y） = 4f（x ＋ y）＋ 4f（x - y）＋ 4f（2x）＋ f（2y） - Sf（x） - 8f（y） in quasi-β-normed spaces.

关键词： Hyers-Ulam stability quadratic mapping cubic mapping quasi-β-normed spaces (β,p)-Banach spaces

Risk factors for Clostridioides difficile infection in children and adolescents with inflammatory bowel disease: a systematic review and meta-analysis

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World Journal of Pediatrics 2022年第1期18卷 27-36页

作者： Sheng-bo Fang Yan-Qing Song Chun-Yan Zhang li-bo wang Department of Pharmacy First Hospital of Jilin UniversityChangchunChina Department of Pediatric Gastroenterology Unit First Hospital of Jilin University71 Xinmin StreetChangchun130021China

Background Risk factors and consequences associated with Clostridioides difficile infection(CDI)in children and adolescents with inflammatory bowel disease(IBD)are still *** conduct a systematic review and meta-analysis to assess risk factors and outcomes associated with CDI in children and adolescents with *** PubMed,EMBASE and Cochrane library databases were searched from inception to 24th February,*** investigating risk factors,bowel surgery rate in pediatric IBD patients with and without CDI were ***-effects model was used for calculating summary ***–Ottawa scale(NOS)was used for quality *** Fourteen studies,comprising 17,114 patients,were *** was a significant association between 5-aminosalicylic acid(5-ASA)use and CDI[odds ratio(OR)=1.95,95%confidence interval(CI)1.26–3.03],with minimal heterogeneity(I^(2)=0.00%).Increased risk of active disease(OR=4.66,95%CI 2.16–10.07)were associated with CDI in those studies performed in high quality score(NOS>6)and significantly higher CDI rates in studies conducted outside USA(OR=2.94,95%CI 1.57–5.58).The bowel surgery rate in IBD with CDI was 3.8–57.1%,compared to that in IBD without CDI(0–21.3%).All studies were of moderate to high *** 5-ASA use and active disease might be risk factors associated with CDI in children and adolescents with *** surgery rates associated with CDI in IBD patients varied ***-scale clinical studies on CDI in children and adolescents with IBD are still needed to verify risk factors and outcomes.

关键词： Adolescent Children Clostridioides difficile infection Inflammatory bowel disease

Comparison between open phase fault of arc suppression coil and single phase to earth fault in coal mine distribution network

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Journal of China University of Mining and Technology 2008年第3期18卷 368-372页

作者： li Xiao-bo wang Chong-lin School of Information ＆ Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

When, in a coal mine distribution network whose neutral point is grounded by an arc suppression coil (ASC), a fault occurs in the ASC, compensation cannot be properly realized. Furthermore, it can damage the safe and reliable run of the network. We first introduce a three-phase five-column arc suppression coil (TPFCASC) and discuss its autotracking compensation theory. Then we compare the single phase to ground fault of the coal mine distribution network with an open phase fault at the TPFCASC using the Thévenin theory, the symmetrical-component method and the complex sequence network respectively. The results show that, in both types of faults, zero-sequence voltage of the network will appear and the maximum magnitude of this zero-sequence voltage is different in both faults. Based on this situation, a protection for the open phase fault at the TPFCASC should be estab-lished.

关键词： open phase protection single phase to ground fault three-phase five-column arc suppression coil (TPFCASC)

A new compound with cytotoxic activities from the leaves of Panax ginseng C.A. Meyer

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Chinese Chemical Letters 2008年第7期19卷 837-840页

作者： li bo wang Zhao Hua Wu Hui Yuan Gao Jian Huang bo Hang Sun li Jun Wu School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Department of Pharmacology Mudanjiang Medical College Mudanjiang 157001 China

A new compound, 3,6,20（S）-trihydroxy- 12,23-epoxydammar-24-ene,6,20-di-O-β-D-glucopyranoside （1）, was isolated from the leaves of Panax ginseng C.A. Meyer, whose structural elucidation was carried out by means of spectral analysis （including IR, HR- FAB-MS and NMR）. This compound showed the moderate cytotoxic activities against U937 and HeLa cells by using the MTT method.

关键词： Panax ginseng 3,6,20(S)-Trihydroxy-12,23-epoxy-dammar-24-ene,6,20-Di-O-β-D-glucopyranoside Cytotoxic activity

The chemical constituents of the tissue culture cells of Daphne giraldii cullus

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Chinese Chemical Letters 2009年第11期20卷 1335-1338页

作者： Zhao Hua Wu li bo wang Hui Yuan Gao Jian Huang bo Hang Sun Shu Hui li li Jun Wu School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Department of Pharmacology Mudanjiang Medical College Mudanjiang 157001 China

Three compounds were isolated from the tissue culture cells of Daphne giraldii cullus, their structures were identified as daphneolone （1）, S-（＋）-1-（4-hydroxy-3-methoxyphenyl）-3-hydroxy-5-phenyl-l-pentanone （2）, S-（＋）-1-（4-methoxyphenyl）-3- hydroxy-5-phenyl-l-pentanone （3）, and among them, 2 was a new compound, 3 was a novel natural product.

关键词： Tissue culture cells Daphne giraldii cullus Chemical constituents Structural identification

Clinical characteristics and risk factors of severe respiratory syncytial virus-associated acute lower respiratory tract infections in hospitalized infants

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World Journal of Pediatrics 2014年第4期10卷 360-364页

作者： Xiao-bo Zhang li-Juan liu li-ling Qian Gao-li Jiang Chuan-Kai wang Pin Jia Peng Shi Jin Xu li-bo wang Department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China

Background:To investigate the clinical characteristics and analyze risk factors for severe respiratory syncytial virus(RSV)infection in hospitalized infants with acute lower respiratory tract infections(ALRIs).Methods:A retrospective review of the medical records of infants with RSV-associated ALRIs between March 1st,2011 and February 29th,2012 was *** were followed up over the phone or by outpatient visit six and twelve months after ***:Among 913 RSV-associated ALRIs infants,288(31.5%)had severe infections,which accounted for 4.2%of hospitalized *** hospital RSV mortality rate was 1.0%.The proportions of cases with tachypnea,apnea,cyanosis,and fine rales were significantly higher in the severe ALRIs group(all Plities[2.246(1.008-5.005)]were independent risk factors for severe *** incidence of bronchitis,pneumonia and readmission in the severe group was significantly higher than that of the non-severe group during the one-year follow-up(all Plization in the following year.

关键词： infant respiratory infectious diseases respiratory syncytial virus

Clinical features of postinfectious bronchiolitis obliterans in children undergoing long-term nebulization treatment

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World Journal of Pediatrics 2018年第5期14卷 498-503页

作者： Xiao-Mei Zhang Ai-Zhen Lu Hao-Wei Yang li-ling Qian li-bo wang Xiao-bo Zhang Respiratory Department Children's Hospital of Fudan University399 Wan Yuan RdShanghaiChina Radiology Department Children's Hospital of Fudan University399 Wan Yuan RdShanghaiChina

Background limited data are available in relation to the clinical features of PIbo undergoing prolonged nebulization treat-ment with budesonide, terbutaline and ipratropium bromide. This retrospective study aimed to outline the features of clini-cal, high-resolution computed tomography (HRCT) and pulmonary function test (PFT) of PIbo, undergoing maintenance therapy utilizing a triple nebulization treatment and to determine the factors associated with prognosis. Methods Children diagnosed with PIbo were followed up between April 2014 and March 2017. The clinical features after maintenance nebulization treatment for 12 months were thereafter summarized. Results Thirty patients, 21 boys and 9 girls, were enrolled in the study. The median age of patients was 17.4 months, with a range between 3.0 and 33 months. Persistent coughing and wheezing were detected whilst wheezing and crackles were the common manifestations presented. HRCT scans revealed patchy ground and glass opacity, while PFT showed fixed airway obstruction in all patients. Four patients were lost during follow-up. After treatment, the clinical symptoms were improved greatly in all patients (Plization treatment of budesonide, terbutaline, ipratropium bromide on PIbo, due to its efficacy as indicated in the improved clinical symptoms, pulmonary functions and CT manifesta-tions identified in the children. New prospective and controlled studies are required to confirm this proposition.

关键词： Clinical features Nebulization treatment Post-infectious bronchiolitis obliterans Prognosis

Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder

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Neural Regeneration Research 2023年第8期18卷 1795-1801页

作者： Xiao-Hui li Hong-Can Zhu Xue-Min Cui wang wang lin Yang li-bo wang Neng-Wei Hu Dong-Xiao Duan Department of Physiology and Neurobiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina

We previously showed that death-associated protein kinase 1(DAPK1)expression is increased in hippocampal tissue in a mouse model of major depressive disorde and is related to cognitive dysfunction in Alzheimer's *** addition,depression is a risk factor for developing Alzheimer's disease,as well as an early clinical manifestation of Alzheimer's ***,cognitive dysfunction is a distinctive feature of major depressive ***,DAPK1 may be related to cognitive dysfunction in major depressive *** this study,we established a mouse model of major depressive disorder by housing mice individually and exposing them to chronic,mild,unpredictable *** found that DAPK1 and tau protein levels were increased in the hippocampal CA3 area,and tau was hyperphosphorylated at Thr231,Ser262,and Ser396 in these ***,DAPK1 shifted from axonal expression to overexpression on the cell *** and treatment with the antidepressant drug citalopram decreased DAPK1 expression and tau protein phosphorylation in hippocampal tissue and improved both depressive symptoms and cognitive *** results indicate that DAPK1 may be a potential reason and therapeutic target of cognitive dysfunction in major depressive disorder.

关键词： Alzheimer's disease antidepressant drug behavioral tests cognitive dysfunction death-associated protein kinase 1 exercise hippocampus major depressive disorder phosphorylation tau protein

Comprehensive Analysis of the Molecular Mechanism for Gastric Cancer Based on Competitive Endogenous RNA Network

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World Journal of Traditional Chinese Medicine 2023年第1期9卷 29-42页

作者： Hong-Jin Wu Wei-Wei Dai li-bo wang Jie Zhang Cheng-Long wang Central Laboratory for Science and Technology Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghaiChina

Objective: To explore the regulatory mechanism of competitive endogenous RNAs(ce RNA) in gastric cancer(GC) and to predict the prognosis of GC. Materials and Methods: Expression profiles of long noncoding RNAs(lnc RNAs), micro RNAs(mi RNAs), and m RNAs were obtained from The Cancer Genome Atlas platform. Differentially expressed RNAs(DERNAs) were screened to construct a lnc RNA-mi RNA-m RNA ce RNA network. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed on the ce RNA network-related differentially expressed m RNAs(DEm RNAs). Next, the DERNAs were subjected to Cox regression and survival analyses to identify crucial prognostic factors for patients with GC. Results: We detected 1029 differentially expressed lnc RNAs, 104 differentially expressed mi RNAs, and 1659 DEm RNAs in patients with GC. Next, we performed bioinformatic analysis to construct the lnc RNA-mi RNA-m RNA ce RNA network, which included 10 mi RNAs, 65 lnc RNAs, and 10 m RNAs. Subsequently, Kaplan Meier(K-M) analysis showed that the survival rate of the high-risk group was significantly lower than that of the low-risk group, and the area under the curve value of the receiver operating characteristic curve revealed that the polygenic model had good predictive ability. The results indicated that ADAMTS9-AS1, ATAD2, and CADM2 might be potential therapeutic targets and prognostic biomarkers for GC. Conclusions: Our study has implications for predicting prognosis and monitoring surveillance of GC and provides a new theoretical and experimental basis for the clinical prognosis of GC.

关键词： Competitive endogenous RNAs network gastric cancer prognostic biomarkers The Cancer Genome Atlas