Clinical characteristics and risk factors of severe respiratory syncytial virus-associated acute lower respiratory tract infections in hospitalized infants

作     者：Xiao-Bo Zhang Li-Juan Liu Li-Ling Qian Gao-Li Jiang Chuan-Kai Wang Pin Jia Peng Shi Jin Xu Li-Bo Wang 

作者机构：Department of Respiratory MedicineChildren's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2014年第10卷第4期

页      面：360-364页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Supported by Medical Guide Project of Shanghai Municipal Science and Technology Commission(No.134119a4200) Shanghai municipal commission of health and family planning(No.20134249) 

主　　题：infant respiratory infectious diseases respiratory syncytial virus 

摘      要：Background:To investigate the clinical characteristics and analyze risk factors for severe respiratory syncytial virus(RSV)infection in hospitalized infants with acute lower respiratory tract infections(ALRIs).Methods:A retrospective review of the medical records of infants with RSV-associated ALRIs between March 1st,2011 and February 29th,2012 was *** were followed up over the phone or by outpatient visit six and twelve months after ***:Among 913 RSV-associated ALRIs infants,288(31.5%)had severe infections,which accounted for 4.2%of hospitalized *** hospital RSV mortality rate was 1.0%.The proportions of cases with tachypnea,apnea,cyanosis,and fine rales were significantly higher in the severe ALRIs group(all P0.001).Multivariate logistic regression showed that low-birth-weight[1.698(1.028-2.805)],age less than 3 months old[3.385(2.174-5.271)],congenital heart disease[1.667(1.149-2.418)],bronchopulmonary dysplasia[8.505(1.731-41.780)],and airway abnormalities[2.246(1.008-5.005)]were independent risk factors for severe *** incidence of bronchitis,pneumonia and readmission in the severe group was significantly higher than that of the non-severe group during the one-year follow-up(all P0.001).Conclusions:Younger age,low birth weight and underlying disease are associated with severe RSVassociated ***,severe RSV infections may be associated with a higher frequency of subsequent bronchitis,pneumonia and re-hospitalization in the following year.