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低氘水跨越皮肤屏障的应用潜力研究

上海医药 2024年第11期45卷 29-31,111页

作者：程建玮李永勇同济大学医学院生物医学工程与纳米科学研究院上海200092

近年来,随着科技的不断进步和人们对健康美容的需求增长,化妆品行业面临新的挑战和机遇,其中之一就是如何让化妆品中的有效成分更好地渗入皮肤,从而发挥其最大功效。低氘水(deuterium-depleted water)可能是一种有效的透皮试剂,现已引... 详细信息

近年来,随着科技的不断进步和人们对健康美容的需求增长,化妆品行业面临新的挑战和机遇,其中之一就是如何让化妆品中的有效成分更好地渗入皮肤,从而发挥其最大功效。低氘水(deuterium-depleted water)可能是一种有效的透皮试剂,现已引起广泛关注。本研究考察低氘水的溶解能力、透皮能力及其作为化妆品新透皮策略的应用潜力。

关键词：化妆品低氘水透皮吸收

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微针在化妆品透皮吸收中的研究进展

上海医药 2024年第11期45卷 32-36页

作者：余敏陈刚李永勇同济大学医学院生物医学工程与纳米科学研究院上海200092 西交利物浦大学智能工程学院苏州215123

化妆品中的功效成分如何透过皮肤屏障是化妆品行业的热点问题。微针技术通过微小的针头在皮肤表面形成微通道,可以促进化妆品中的功效成分渗透到皮肤深层,为传统的皮肤护理方法带来了革新。本文综述透皮吸收的途径和增加透皮吸收的方法... 详细信息

化妆品中的功效成分如何透过皮肤屏障是化妆品行业的热点问题。微针技术通过微小的针头在皮肤表面形成微通道,可以促进化妆品中的功效成分渗透到皮肤深层,为传统的皮肤护理方法带来了革新。本文综述透皮吸收的途径和增加透皮吸收的方法,以及微针技术在化妆品透皮吸收中的研究进展,讨论微针技术在化妆品行业中的发展前景以及面临的挑战,以期为未来的研究和开发提供参考。

关键词：微针透皮吸收化妆品

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高速公路天桥拆除力学分析与安全措施研究

山西交通科技 2024年第1期 68-71页

作者：李建军李永永翟启远山西晋阳高速改扩建项目管理有限公司山西晋城048000 山西省交通运输安全应急保障技术中心(有限公司) 山西太原030006 山西省交通建设工程质量检测中心(有限公司) 山西太原030032

晋阳高速公路改扩建工程是山西省第一条“四改八”高速公路,沿线地形地质条件复杂多变,原有路段技术标准较低且交通量较大,在边通车边施工的条件下项目建设期安全生产压力倍增。利用MIDAS Civil有限元软件对钢筋混凝土连续箱梁天桥拆除... 详细信息

晋阳高速公路改扩建工程是山西省第一条“四改八”高速公路,沿线地形地质条件复杂多变,原有路段技术标准较低且交通量较大,在边通车边施工的条件下项目建设期安全生产压力倍增。利用MIDAS Civil有限元软件对钢筋混凝土连续箱梁天桥拆除过程进行物理建模应力分析,根据计算结果复核拆除方案并补充完善安全控制措施,对同类桥梁工程安全快速拆除施工具有重要指导意义。

关键词：天桥拆除力学分析安全控制措施

Nanosystem-mediated lactate modulation in the tumor micro environment for enhanced cancer therapy

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Nano Research 2023年第1期16卷 654-671页

作者： Jingjing Gu Jiuyuan Sun Ying liu Gaowei Chong yongyong li Haiqing Dong Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration Ministry of EducationTongji HospitalSchool of MedicineTongji University389 Xincun RoadShanghai 200065China Shanghai Skin Disease Hospital School of MedicineTongji UniversityShanghai 200092China

Metabolic reprogramming allows tumor cells to prefer aerobic glycolysis as the main energy source,resulting in the massive accumulation of lactate in the tumor microenvironment(TME).It is found that lactate is no longer a waste product produced by glycolysis,but plays an important role in cancer *** modulation of lactate in the TME has become a promising target for cancer *** many small molecular inhibitors modulating the production or transport of lactate have appeared at present,their safety and efficacy have limited their further clinical application due to their non-specific targets and *** have shown that nanomedicine has unique advantages,improving drug delivery efficiency and treatment efficacy while reducing damage to normal tissues,which greatly promotes the development of the research of nanosystems based on lactate *** this review,we summarize the source and metabolism of lactate,the effect of lactate on the TME and recent advances in nanosystem-mediated strategies of lactate modulation for enhanced cancer therapy,hoping to provide ideas and directions for future research in related fields.

关键词： glycolysis lactate tumor microenvironment multifunctional nanosystems cancer therapy

Comprehensive Analysis and Artificial Intelligent Simulation of Land Subsidence of Beijing, China

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Chinese Geographical Science 2013年第2期23卷 237-248页

作者： ZHU lin GONG Huili li Xiaojuan li yongyong SU Xiaosi GUO Gaoxuan College of Resources Environment and Tourism Capital Normal University Laboratory Cultivation Base of Environment Process and Digital Simulation College of Environment and Resources Jilin University China Hydrogeology and Engineering Geology Team of Beijing

Mechanism and modeling of the land subsidence are complex because of the complicate geological background in Beijing, China. This paper analyzed the spatial relationship between land subsidence and three factors, including the change of groundwater level, the thickness of compressible sediments and the building area by using remote sensing and GIS tools in the upper-middle part of alluvial-proluvial plain fan of the Chaobai River in Beijing. Based on the spatial analysis of the land subsidence and three factors, there exist significant non-linear relationship between the vertical displacement and three factors. The Back Propagation Neural Network (BPN) model combined with Genetic Algorithm (GA) was used to simulate regional distribution of the land subsidence. Results showed that at field scale, the groundwater level and land subsidence showed a significant linear relationship. However, at regional scale, the spatial distribution of groundwater depletion funnel did not overlap with the land subsidence funnel. As to the factor of compressible strata, the places with the biggest compressible strata thickness did not have the largest vertical displacement. The distributions of building area and land subsidence have no obvious spatial relationships. The BPN-GA model simulation results illustrated that the accuracy of the trained model during fifty years is acceptable with an error of 51% of verification data less than 20 mm and the average of the absolute error about 32 mm. The BPN model could be utilized to simulate the general distribution of land subsidence in the study area. Overall, this work contributes to better understand the complex relationship between the land subsidence and three influencing factors. And the distribution of the land subsidence can be simulated by the trained BPN-GA model with the limited available dada and acceptable accuracy.

关键词： land subsidence groundwater level change compressible sediments thickness building area Back Propagation NeuralNetwork and Genetic Algorithm (BPN-GA) model

Bioengineering of nano metal-organic frameworks for cancer immunotherapy

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Nano Research 2021年第5期14卷 1244-1259页

作者： Gaowei Chong Jie Zang Yi Han Runping Su Nopphon Weeranoppanant Haiqing Dong yongyong li Shanghai Tenth People’s Hospital The Institute for Biomedical Engineering&Nano ScienceTongji University School of MedicineShanghai200092China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji HospitalTongji University School of Medicine389 Xincun RoadShanghai200065China Department of Chemical Engineering Burapha University169 Longhard BangsaenSaensookChonburi20131Thailand School of Biomolecular Science and Engineering(BSE) Vidyasirimedhi Institute of Science and Technology(VISTEC)555 Moo 1 PayupnaiWangchan21210Thailand

Immunotherapy techniques,such as immune checkpoint inhibitors,chimeric antigen receptor(CAR)T cell therapies and cancer vaccines,have been burgeoning with great success,particularly for specific cancer ***,side effects with fatal risks,dysfunction in tumor microenvironment and low immune response rates remain the bottlenecks in *** metal-organic frameworks(nMOFs),with an accurate structure and a narrow size distribution,are emerging as a solution to these *** addition to their function of temporospatial delivery,a large library of their compositions,together with flexibility in chemical interaction and inherent immune efficacy,offers opportunities for various designs of nMOFs for *** this review,we overview state-of-the-art research on nMOFs-based immunotherapies as well as their combination with other *** demonstrate that nMOFs are predominantly customized for vaccine delivery or tumor-microenvironment ***,a prospect of nMOFs in cancer immunotherapy will be discussed.

关键词： cancer immunotherapy nano metal-organic frameworks(nMOFs) bioengineering vaccine delivery tumor-microenvironment modulation

THE EXISTENCE AND CONCENTRATION OF GROUND STATE SOLUTIONS FOR CHERN-SIMONS-SCHR?DINGER SYSTEMS WITH A STEEP WELL POTENTIAL

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Acta Mathematica Scientia 2022年第3期42卷 1125-1140页

作者： Jinlan TAN yongyong li Chunlei TANG School of Mathematics and Statistics Southwest UniversityChongqing 400715China

In this paper,we investigate a class of nonlinear Chern-Simons-Schr?dinger systems with a steep well *** using variational methods,the mountain pass theorem and Nehari manifold methods,we prove the existence of a grou... 详细信息

关键词： Chern-Simons-Schrödinger system steep well potential ground state solution concentration

Native and engineered exosomes for inflammatory disease

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Nano Research 2023年第5期16卷 6991-7006页

作者： Xiaoyi Ma Bingbing liu limin Fan Yiqiong liu Yuge Zhao Tianbin Ren Yan li yongyong li Shanghai Skin Disease Hospital School of MedicineTongji UniversityShanghai 200092China

Exosomes are extracellular vesicles which carry specific molecular information from donor cells and act as an intercellular communication vehicle,which have emerged as a novel cell-free strategy for the treatment of many diseases including inflammatory ***,rising studies have developed exosome-based strategies for novel inflammation therapy due to their biocompatibility and *** not only use native exosomes as therapeutic agents for inflammation,but also strive to make up for the natural defects of exosomes through engineering methods to improve and update the property of exosomes for enhanced therapeutic *** engineered exosomes can improve cargo-loading efficiency,targeting ability,stability,etc.,to achieve combined and diverse treatment strategies in inflammation ***,a comprehensive overview of the recent advances in application studies of native and engineered exosomes as well as the engineered methods is ***,potential application prospects,possible challenges,the development of clinical researches of exosome treatment strategy are concluded from plentiful examples,which may be able to provide guidance and suggestions for the future research and application of exosomes.

关键词： inflammation exosome engineered exosome exosomes-based therapy

BOPPPS结合CBL教学法在老年医学科临床教学中的应用

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中国高等医学教育 2024年第5期 82-83,86页

作者：李勇湧李兴升蒲蝶项颖黄荣忠重庆医科大学附属第二医院重庆400010

目的:研究BOPPPS结合CBL教学法在老年医学科临床教学中的应用效果。方法:80名住院医师规范化培训的学生随机分为试验组(B0PPPS结合CBL教学法)和对照组(传统授课教学法)。对两组学生进行理论和技能考试,并采用调查问卷评价教学效果。结果... 详细信息

目的:研究BOPPPS结合CBL教学法在老年医学科临床教学中的应用效果。方法:80名住院医师规范化培训的学生随机分为试验组(B0PPPS结合CBL教学法)和对照组(传统授课教学法)。对两组学生进行理论和技能考试,并采用调查问卷评价教学效果。结果:试验组的理论、技能和总成绩均优于对照组(P<0.05)。试验组对教学效果指标的评价也优于对照组(P<0.05)。结论:BOPPPS结合CBL教学法有效提高了老年医学科规范化培训学生的综合临床能力,提升了教学效果。

关键词： BOPPPS 基于案例学习老年医学