Bioengineering of nano metal-organic frameworks for cancer immunotherapy
作者机构：Shanghai Tenth People’s HospitalThe Institute for Biomedical Engineering&Nano ScienceTongji University School of MedicineShanghai200092China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of EducationOrthopaedic Department of Tongji HospitalTongji University School of Medicine389 Xincun RoadShanghai200065China Department of Chemical EngineeringBurapha University169 Longhard BangsaenSaensookChonburi20131Thailand School of Biomolecular Science and Engineering(BSE)Vidyasirimedhi Institute of Science and Technology(VISTEC)555 Moo 1 PayupnaiWangchan21210Thailand
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2021年第14卷第5期
页 面：1244-1259页
核心收录：
学科分类：0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(Nos.51773154,31771090,31971323 and 81871315) Shanghai Science and Technology Innovation(18JC1414500) N.W.would like to acknowledge supports from both Burapha and VISTEC
主 题：cancer immunotherapy nano metal-organic frameworks(nMOFs) bioengineering vaccine delivery tumor-microenvironment modulation
摘 要：Immunotherapy techniques,such as immune checkpoint inhibitors,chimeric antigen receptor(CAR)T cell therapies and cancer vaccines,have been burgeoning with great success,particularly for specific cancer ***,side effects with fatal risks,dysfunction in tumor microenvironment and low immune response rates remain the bottlenecks in *** metal-organic frameworks(nMOFs),with an accurate structure and a narrow size distribution,are emerging as a solution to these *** addition to their function of temporospatial delivery,a large library of their compositions,together with flexibility in chemical interaction and inherent immune efficacy,offers opportunities for various designs of nMOFs for *** this review,we overview state-of-the-art research on nMOFs-based immunotherapies as well as their combination with other *** demonstrate that nMOFs are predominantly customized for vaccine delivery or tumor-microenvironment ***,a prospect of nMOFs in cancer immunotherapy will be discussed.
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