检索结果-南通市图书馆

Long term results of no- alcohol laser epithelial keratomileusis and photorefractive keratectomy for myopia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2015年第3期8卷 574-579页

作者： leopoldo spadea Francesca Verboschi Vittoria De Rosa Mariella Salomone Enzo Maria Vingolo Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome

AIM: To evaluate the long term clinical results of mechanical no-alcohol-assisted laser epithelial keratomileusis(LASEK) versus standard photorefractive keratectomy(PRK) for low-moderate ***: Twenty-five eyes treated with LASEK and twenty-five eyes treated with PRK were evaluated with a mean follow-up duration of 60 mo. Mechanical separation of the epithelium was performed with blunt spatula and without application of alcohol. Laser ablation was performed with the MEL-70 excimer laser. All patients were examined daily until epithelial closure; at 1, 3, 6,and 12 mo, and every year subsequently. Main outcome measures were uncorrected distance visual acuity(UDVA), corrected distance visual acuity(CDVA),manifest refraction, haze, efficacy and safety ***: Twenty-one eyes and 22 eyes completed follow-up of 60 mo in LASEK and PRK group respectively. Manifest refraction at 60 mo follow-up was-0.01 and 0.26 in LASEK and PRK group respectively. In the LASEK group mean UDVA and mean CDVA after60 mo were 20/22 and 20/20 respectively(P >0.01). In the PRK group mean UDVA and mean CDVA at 60 mo follow-up were 20/20 and 20/20 after 60mo(P >0.01). The efficacy indexes were 0.87 and 0.95, and the safety indexes were1.25 and 1.4 respectively for LASEK group and PRK ***: Both standard PRK and no-alcohol LASEK offer safe and effective correction of low-moderate myopia in the long term without any statistically significant difference between the two groups.

关键词： alcohol laser epithelial keratomileusis myopia photorefractive keratectomy

Photorefractive keratectomy after cataract surgery in uncommon cases: long-term results

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2018年第4期11卷 612-615页

作者： Anna Maria Roszkowska Mario Urso Giuseppe Alberto Signorino leopoldo spadea Pasquale Aragona Department of Surgery Ophthalmology Clinic University Hospital of Messina Department of Ophthalmology Andrzej Frycz Modrzewski Krakow University Department of Medical-Surgical Sciences and Biotechnologies La Sapienza University of Rome

AIM： To evaluate the efficacy and safety of the excimer laser correction of the residual refractive errors after cataract extraction with intraocular lens（IOL） implantation in uncommon ***： Totally 24 patients with high residual refractive error after cataract surgery with IOL implantation were examined. Twenty-two patients had a history of phacoemulsification and IOL implantation, and two had extra-capsular cataract extraction with IOL implantation. Detailed examination of preoperative medical records was done to explain the origin of the post-cataract refractive errors. All patients underwent photorefractire keratectomy（PRK） enhancement. The mean outcome measures were refraction, uncorretted visual acuity（UCVA）, best corrected visual acuity（BCVA） and corneal transparency and follow up ranged from 1 to 8 ***： The principal causes of residual ametropia was inexact IOL calculation in abnormal eyes with high myopia and congenital lens abnormalities, followed by corneal astigmatism both suture induced and preexisting. After cataract surgery and before the laser enhancement the mean spherical equivalent（SE） was-0.56±3 D ranging from-4.62 to ＋2.25 D in high myopic patients, instead it was-1±1.73 D ranging from-3.25 to ＋3.75 D in the astigmatic eyes, with a mean cylinder of-3.75±0 ranging from-3 to ＋5.50 D. After laser refractive surgery the mean SE was 0.1±0.73, ranging from-0.50 to ＋1.50 in the myopic group, and it was-0.50±0.57 ranging from-1.25 to ＋0.50 in astigmatic patients, with a mean cylinder of-0.25±0.75. In myopic patients the mean UCVA and BCVA were 0.038±0.072 logMAR and 0.018±0.04 respectively, both ranging from 0.10 to 0.0. In astigmatic patients, the mean UCVA and BCVA were 0.213±0.132 and 0.00±0.0 respectively, UCVA ranging from 0.50 to 0.22 and BCVA was 0.00. All patients presented normal corneal transparency. No ocular hypertension was detected and no corneal haze was observed. All registered values remained stable also at the end line e

关键词： photorefractive keratectomy cataract residual ametropia intraocular lens error high myopia

Focus on limbal stem cell deficiency and limbal cell transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2023年第6期13卷 321-330页

作者： Emanuele Tonti Gregorio Antonio Manco leopoldo spadea Marco Zeppieri Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

Limbal stem cell deficiency(LSCD)causes severe vision impairment and can lead to blindness,representing one of the most challenging ocular surface *** cell deficiency can be congenital or,more often,*** categorization of ocular surface transplantation techniques is crucial to achieving treatment homogeneity and quality of care,according to the anatomic source of the tissue being transplanted,genetic source,autologous or allogenic transplantation(to reflect histocompatibility in the latter group),and cell culture and tissue engineering *** aim of this minireview is to provide a summary of the management of LSCD,from clinical characteristics and therapeutic outcomes to the development of novel therapeutic *** manuscript also briefly summarizes recent findings in the current literature and outlines the future challenges to overcome in the management of the major types of ocular surface failure.

关键词： Limbal stem cell deficiency Conjunctival limbal autograft Conjunctival limbal allograft Keratolimbal allograft Cultivated limbal epithelial transplantation Simple limbal epithelial transplantation

Acute corneal graft rejection following photorefractive keratectomy for post-penetrating keratoplasty high astigmatism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2021年第3期14卷 476-477页

作者： leopoldo spadea Maria Ilaria Giannico Marta Armentano Ludovico Alisi Santino Pistella Department of Sense Organs Eye ClinicUniversity"LaSapienza"Rome 00185Italy

Dear Editor,We present an unusual case of acute graft rejection after photorefractive keratectomy(PRK),performed to correct high residual astigmatism after penetrating keratoplasty(PKP)for *** primary measures of succ... 详细信息

关键词： astigmatism acute keratoplasty

Unlocking the versatile potential:Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第2期16卷 89-101页

作者： Pier Luigi Surico Anna Scarabosio Giovanni Miotti Martina Grando Carlo Salati Pier Camillo Parodi leopoldo spadea Marco Zeppieri Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology Campus Bio-Medico UniversityRome 00128Italy Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy

This review comprehensively explores the versatile potential of mesenchymal stem cells(MSCs)with a specific focus on adipose-derived *** and oculoplastic surgery,encompassing diverse procedures for ocular and periocular enhancement,demands advanced solutions for tissue restoration,functional and aesthetic refinement,and *** immunomodulatory,regenerative,and healing capacities of MSCs,this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside,addressing common unmet needs in the field of reconstructive and regenerative surgery.

关键词： Stem cells Adipose stem cell Ocular therapy Oculoplastics Regenerative

Autologous blood in the management of ocular surface disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Experimental Medicine 2024年第4期14卷 39-52页

作者： Ayuba Suleman Gladness Aluyi-Osa Folorunsho Ashipa leopoldo spadea Caterina Gagliano Fabiana D’Esposito Marco Zeppieri Mutali Musa Department of Ophthalmology Africa Eye Laser CentreKm 7Benin 300105Nigeria Specsavers Optical LtdBristol BS13HBUnited Kingdom Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna“Kore”Enna 94100Italy Mediterranean Foundation“G.B.Morgagni” Catania 95125Italy Imperial College Ophthalmic Research Group Unit Imperial CollegeLondon NW15QHUnited Kingdom Department of Ophthalmology University Hospital of UdineUdine 33100Italy Department of Optometry University of BeninBenin 3000283Nigeria

Autologous blood therapy has emerged as a promising modality in managing ocular surface *** review provides a comprehensive overview of the current literature regarding the use of autologous blood in ocular surface disorders,encompassing its physiological basis,clinical applications,techniques,challenges,and future *** ocular surface,comprising the cornea,conjunctiva,and tear film,plays a critical role in maintaining visual function,and its disruption can lead to various pathological *** its rich composition of growth factors,cytokines,and other bioactive molecules,autologous blood offers therapeutic potential in promoting corneal wound healing,reducing inflammation,and improving tear film *** studies have demonstrated the efficacy and safety of autologous blood therapy in diverse ocular surface disorders,including persistent epithelial defects,neurotrophic keratopathy,and dry eye ***,challenges such as variability in treatment response,adverse effects,and optimal patient selection remain areas of *** research is needed to elucidate the underlying mechanisms of action,refine treatment protocols,and explore synergistic approaches with other therapeutic *** these challenges,autologous blood therapy holds promise as a valuable adjunctive treatment option for ocular surface disorders,offering new avenues for improving patient outcomes and quality of *** review examines the mechanisms underlying ocular surface disorders while discussing existing autologous blood-based therapies for managing these *** clinical trials are also summarized,and a comparison between autologous blood therapy and conventional eyedrops is ***,safe techniques and protocols for autologous blood medicine are elucidated,and adverse effects and future perspectives of this novel therapy are reviewed.

关键词： Autologous blood Ocular surface disorder Cytokines Tear film Dry eye

New frontiers in retinal transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2024年第4期14卷 67-77页

作者： Francesco Saverio Sorrentino Patrick Di Terlizzi Francesco De Rosa Carlo Salati leopoldo spadea Caterina Gagliano Mutali Musa Marco Zeppieri Department of Surgical Sciences Unit of OphthalmologyOspedale MaggioreBologna 40100Italy Department of Oncology IRCCS Istituto Romagnolo per lo Studio dei Tumori“Dino Amadori”Meldola 47014Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Centre for Sight AfricaNkporOnitsha 434112Nigeria

New frontiers about retinal cell transplantation for retinal degenerative diseases start from the idea that acting on stem cells can help regenerate retinal layers and establish new synapses among retinal *** or alterations of synaptic input and neurotrophic factors result in trans-neuronal degeneration of the inner retinal ***,the disruption of photoreceptors takes ***,even in advanced forms of retinal degeneration,a good percentage of the ganglion cells and the inner nuclear layer neurons remain *** phenomenon provides evidence for obtaining retinal circuitry through the transplantation of photoreceptors into the subretinal *** eye is regarded as an optimal organ for cell transplantation because of its immunological privilege and the relatively small number of cells collaborating to carry out visual *** eyeball's immunological privilege,characterized by the suppression of delayed-type hypersensitivity responses in ocular tissues,is responsible for the low rate of graft rejection in transplant *** main discoveries highlight the capacity of embryonic stem cells(ESCs)and induced pluripotent stem cells to regenerate damaged retinal *** progress has shown significant enhancements in transplant procedures and *** research also explores the ethical ramifications linked to the utilization of stem cells,emphasizing the ongoing issue surrounding *** analysis centers on recent breakthroughs,including the fabrication of three-dimensional retinal organoids and the innovation of scaffolding for cell ***,researchers are currently assessing the possibility of CRISPR and other advanced gene editing technologies to enhance the outcomes of retinal *** widespread use of universally recognized safe surgical and imaging methods enables retinal transplantation and monitoring of transplanted cell growth toward the correct ***,most therapy approaches

关键词： Retinal transplantation Retinal stem cell Human embryonic stem cells Pluripotent stem cells Retinal tissue transplant

Whole-eye transplantation: Current challenges and future perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2024年第2期14卷 28-39页

作者： Anna Scarabosio Pier Luigi Surico Vlad Tereshenko Rohan Bir Singh Carlo Salati leopoldo spadea Glenda Caputo Pier Camillo Parodi Caterina Gagliano Jonathan M Winograd Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Plastic Surgery Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco Hospital Viale Carlo Azeglio Ciampi 95121 CataniaItaly

Whole-eye transplantation emerges as a frontier in ophthalmology,promising a transformative approach to irreversible *** advancements,formidable challenges *** of donor eye viability post-enucleation necessitates meticulous surgical techniques to optimize retinal integrity and ganglion cell *** the inhibitory milieu of the central nervous system for successful optic nerve regeneration remains elusive,prompting the exploration of neurotrophic support and immunomodulatory *** tolerance,paramount for graft acceptance,confronts the distinc-tive immunogenicity of ocular tissues,driving research into targeted immunosup-pression *** and legal considerations underscore the necessity for stringent standards and ethical *** collaboration and ongoing research endeavors are imperative to navigate these ***,stem cell therapies,and precision immunomodulation represent promising avenues in this ***,the aim of this review is to critically assess the current landscape of whole-eye transplantation,elucidating the challenges and advancements while delineating future directions for research and clinical *** concerted efforts,whole-eye transplantation stands to revolu-tionize ophthalmic care,offering hope for restored vision and enhanced quality of life for those afflicted with blindness.

关键词： Eye Transplantation Optic nerve Nerve regeneration Immunological tolerance

Retinoscopes:Past and present

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Methodology 2024年第3期14卷 126-140页

作者： Mutali Musa Ehimare Enaholo Babatunde Ismail Bale Carlo Salati leopoldo spadea Marco Zeppieri Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser CentreBenin 300105Nigeria Department of Ophthalmology Centre for Sight AfricaNkpor 434101Nigeria Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy

BACKGROUND Retinoscopy is arguably the most important method in the eye clinic for diagnosing and managing refractive *** of retinoscopy include its noninvasive nature,ability to assess patients of all ages,and usefulness in patients with limited cooperation or communication *** To discuss the history of retinoscopes and examine current literature on the *** A search was conducted on the PubMed and with the reference citation analysis(https://***)database using the term"Retinoscopy,"with a range restricted to the last 10 years(2013-2023).The search string algorithm was:"Retinoscopy"(MeSH Terms)OR"Retinoscopy"(All Fields)OR"Retinoscopes"(All Fields)AND[(All Fields)AND 2013:2023(pdat)].RESULTS This systematic review included a total of 286 *** reviewed iterations of the retinoscope into autorefractors,infrared photo retinoscope,television retinoscopy,and the Wifi enabled digital *** The retinoscope has evolved significantly since its discovery,with a significant improvement in its diagnostic *** it has advantages such as non-invasiveness and broad applicability,limitations exist,and the need for skilled interpretation *** ongoing research,including the integration of artificial intelligence,retinoscopy is expected to continue advancing and playing a vital role in eye care.

关键词： Retinoscopy Autorefractor Refractive errors Ophthalmology Optics Artificial intelligence