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Pyroptosis is a drug target for prevention of adverse cardiac remodeling: The crosstalk between pyroptosis, apoptosis, and autophagy

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The Journal of Biomedical Research 2022年第6期36卷 375-389页

作者： Natalia v.Naryzhnaya leonid N.Maslov Sergey v.Popov Alexandr v.Mukhomezyanov vyacheslav v.Ryabov Boris K.Kurbatov Alexandra E.Gombozhapova Nirmal Singh Feng Fu Jian-Ming Pei Sergey v.Logvinov Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Pharmaceutical Sciences and Drug Research Punjabi UniversityPatiala 147002India Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic MedicineFourth Military Medical UniversityXi'anShaanxi 710032China Department of Histology Embryology and CytologySiberian State Medical UniversityTomskTomsk Region 634055Russia

Acute myocardial infarction(AMI)is one of the main reasons of cardiovascular disease-related *** introduction of percutaneous coronary intervention to clinical practice dramatically decreased the mortality rate in *** cardiac remodeling is a serious problem in *** increase in the effectiveness of AMI treatment and prevention of adverse cardiac remodeling is difficult to achieve without understanding the mechanisms of reperfusion cardiac injury and cardiac *** of pyroptosis prevents the development of postinfarction and pressure overload-induced cardiac remodeling,and mitigates cardiomyopathy induced by diabetes and metabolic ***,it is reasonable to hypothesize that the pyroptosis inhibitors may find a role in clinical practice for treatment of AMI and prevention of cardiac remodeling,diabetes and metabolic syndrome-triggered *** was demonstrated that pyroptosis interacts closely with apoptosis and *** could be inhibited by nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 inhibitors,caspase-1 inhibitors,microRNA,angiotensin-converting enzyme inhibitors,angiotensinⅡreceptor blockers,and traditional Chinese herbal medicines.

关键词： pyroptosis apoptosis autophagy cardiac remodeling diabetes metabolic syndrome

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Basic formation mechanisms of Lake Doroninskoye soda water, East Siberia, Russia

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Acta Geochimica 2018年第4期37卷 546-558页

作者： Svetlana v. Borzenko leonid v. Zamana Larisa I. Usmanova Institute of Natural Resources Ecology and Cryology of Siberian Branch of Russian Academy of Sciences ChitaRussia 672049 Tomsk Department of the Trofimuk Institute of Petroleum-Gas Geology and Geophysics of Siberian Branch of the Russian Academy of Sciences Tomsk Russia 634050

The primary scientific goal of studying salt lakes is to better understand the formation of small continentaltype hydrogeochemical systems. Many scientists have attributed the metamorphism of the chemical composition of salt lakes to the evaporative concentration of water. However, the formation of soda water is inconsistent with this hypothesis. Thus, analyzing intrabasinal biochemical processes and water—rocks interactions during the evaporative concentration of water allows us to understand the major mechanisms of the formation and evolution of water compositions. Therefore, the aim of this paper is to identify the key processes involved in the formation of the chemical composition of the water in Lake Doroninskoye. An analysis of the distribution of major components shows that Na^+,HCO^-_3, CO^(2-)_3, and Cl-are dominant in this water. High concentrations of these elements are the result of evaporative water concentration. Calcium, magnesium, and potassium are not accumulated because the water is saturated in minerals containing these elements. The main barrier to the growth of the sulfate content of water is sulfate *** process also contributes to the additional reproduction of carbon dioxide, which reacts with the products of the hydrolysis of aluminosilicates OH-to form HCO^-_3 and CO^(2-)_3, thus further contributing to the natural processes of soda formation.

关键词：苏打水流水西伯利亚机制东方俄国生物化学硫酸盐

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A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

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The Journal of Biomedical Research 2023年第4期37卷 268-289页

作者： leonid N.Maslov Natalia v.Naryzhnaya Sergey v.Popov Alexandr v.Mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey v.Krylatov Feng Fu Jianming Pei vyacheslav v.Ryabov Evgenii v.vyshlov Svetlana v.Gusakova Alla A.Boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MvO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MvO in patients with acute myocardial ***,the major events preceding the appearance of MvO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MvO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MvO,with L-type Ca2+channel blockers appearing the most effective in treating MvO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage

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Argo floats revealing bimodality of large-scale mid-depth circulation in the North Atlantic

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Acta Oceanologica Sinica 2008年第2期27卷 1-10页

作者： CHU Peter C IvANOv leonid M MELNICHENKO Oleg v LI Rongfeng Department of Oceanography Naval Postgraduate School Monterey California USA International Pacific Research Center University of Hawaii at Manoa Hawaii USA Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

Analysis of Argo float trajectories at 1 000 m and temperature at 950 m in the North Atlantic between November 2003 and January 2005 demonstrates the existence of two different circulation modes with fast transition between them. Each mode has a pair of cyclonic - anticyclonic gyres. The difference is the location of the cyclonic gyre. The cyclonic gyre stretches from southeast to northwest in the first mode and from the southwest to the northeast in the second mode. The observed modes strongly affect the heat and salt transport in the North Atlantic. In particular, the second mode slows down the westward transport of the warm and saline water from the Mediterranean Sea.

关键词： Argo trajectory data Atlantic Ocean biomodality mid-depth circulation optimal spectral decomposition

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基于显著感知与一致性约束的目标跟踪算法

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北京航空航天大学学报 2023年第9期49卷 2244-2257页

作者：国强吴天昊徐伟 CHORNOGOR leonid 哈尔滨工程大学信息与通信工程学院哈尔滨150001 先进船舶通信与信息技术工业和信息化部重点实验室哈尔滨150001 哈尔科夫国立大学无线电物理学院哈尔科夫61166

针对空间正则相关滤波(SRDCF)算法正则权重固定和模型退化等问题,提出了一种基于显著感知与一致性约束的目标跟踪算法。提取方向梯度直方图特征、浅层特征及中层特征进行融合,提升物体外观模型的表达能力;通过显著性检测算法获得初始帧... 详细信息

针对空间正则相关滤波(SRDCF)算法正则权重固定和模型退化等问题,提出了一种基于显著感知与一致性约束的目标跟踪算法。提取方向梯度直方图特征、浅层特征及中层特征进行融合,提升物体外观模型的表达能力;通过显著性检测算法获得初始帧的显著感知参考权重,建立正则权重在相邻2帧之间的关联;最小化实际一致性响应与理想一致性响应之间的差异,约束一致性水平防止滤波器模板退化;提出一种动态约束策略,进一步提高跟踪器在复杂场景下的适应性。在OTB2015、TempleColor128和UAv20L公开数据集上对所提算法进行测试,实验结果表明:相比于SRDCF算法,所提算法在OTB2015数据集上距离精度提高了0.108,AUC提高了0.077,速度为22.41帧/s,实时性较好。

关键词：机器视觉目标跟踪相关滤波显著感知一致性约束

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The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

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The Journal of Biomedical Research 2023年第4期37卷 230-254页

作者： Natalia v.Naryzhnaya leonid N.Maslov Ivan A.Derkachev Huijie Ma Yi Zhang NRajendra Prasad Nirmal Singh Feng Fu Jianming Pei Akpay Sarybaev Akylbek Sydykov Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical CenterRussian Academy of ScienceTomskTomsk Region 634012Russia Department of Physiology Hebei Medical UniversityShijiazhuangHebei 050017China Department of Biochemistry and Biotechnology Faculty of ScienceAnnamalai UniversityAnnamalainagarTamilnadu 608002India Department of Pharmaceutical Sciences and Drug Research Punjabi UniversityPatialaPunjabi 147002India Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Department of Mountain and Sleep Medicine and Pulmonary Hypertension National Center of Cardiology and Internal MedicineBishkek 720040Kyrgyzstan Kyrgyz-Indian Mountain Biomedical Research Center Bishkek 720033Kyrgyzstan Department of Internal Medicine Excellence Cluster Cardio-Pulmonary Institute(CPI)Member of the German Center for Lung Research(DZL)Justus Liebig University of GiessenGiessenHessen 35392Germany Department of Mountain and Sleep Medicine and Pulmonary Hypertension National Center of Cardiology and Internal MedicineBishkek 720040Kyrgyzstan.

The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed *** development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine.A study on the cardiovascular effects of chronic hypoxia(CH)may contribute to the development of these *** hypoxia exerts both positive and adverse *** positive effects are the infarct-reducing,vasoprotective,and antiarrhythmic effects,which can lead to the improvement of cardiac contractility in *** adverse effects are pulmonary hypertension and right ventricular *** review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/*** is an in-depth analysis of the published data on the underlying mechanisms,which can lead to future development of the cardioprotective effect of CH.A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.

关键词： heart vessels infarct size arrhythmias chronic hypoxia

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Do reactive oxygen species damage or protect the heart in ischemia and reperfusion?Analysis on experimental and clinical data

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The Journal of Biomedical Research 2023年第4期37卷 255-267页

作者： leonid N.Maslov Natalia v.Naryzhnaya Maria Sirotina Alexandr v.Mukhomedzyanov Boris K.Kurbatov Alla A.Boshchenko Huijie Ma Yi Zhang Feng Fu Jianming Pei viacheslav N.Azev vladimir A.Pereverzev Cardiology Research Institute Tomsk National Research Medical Centerthe Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology Hebei Medical UniversityShijiazhuangHebei 050017China Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China The Branch of the Institute of Bioorganic Chemistry Russian Academy of SciencesPushchinoMoscow Oblast 142290Russia Department of Normal Physiology Belarusian State Medical UniversityMinsk 220083Belarus

The role of reactive oxygen species(ROS)in ischemic and reperfusion(I/R)injury of the heart has been discussed for more than 40 *** has been demonstrated that reperfusion triggers a multiple increase in free radical generation in the isolated *** were found to have the ability to mitigate I/R injury of the ***,it is unclear whether their cardioprotective effect truly depends on the decrease of ROS levels in myocardial *** high doses and high concentrations of antioxidants were experimentally used,it is highly likely that the cardioprotective effect of antioxidants depends on their interaction not only with free radicals but also with other *** has been demonstrated that the antioxidant N-2-mercaptopropionyl glycine or NDPH oxidase knockout abolished the cardioprotective effect of ischemic ***,there is evidence that ROS protect the heart against the I/R injury.

关键词： reactive oxygen species free radicals antioxidants heart reperfusion patients

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Photoluminescence control by hyperbolic metamaterials and metasurfaces:a review

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Opto-Electronic Advances 2021年第8期4卷 30-56页

作者： leonid Yu.Beliaev Osamu Takayama Pavel N.Melentiev Andrei v.Lavrinenko DTU Fotonik-Department of Photonics Engineering Technical University of Denmark0rsteds Plads 343DK-2800 Kgs.LyngbyDenmark Institute of Spectroscopy RAS Moscow 108840Russia Higher School of Economics National Research UniversityMoscow 101000Russia

Photolu min esce nee in clud ing fluoresce nee plays a great role in a wide variety of applicati ons from biomedical sensing and imag ing to optoelectr on ***,the enhan ceme nt and con trol of photolu min esce nee has imme nse impact on both fun dame ntal scie ntific research and aforeme nti oned applicati *** various nano phot tonic schemes and nanostructures to enhance the photoluminescence,we focus on a certain type of nanostructures,hyperbolic metamaterials(HMMs).HMMs are highly ani sotropic metamaterials,which produce intense localized electric ***,HMMs n aturally boost photolu min esce nee from dye molecules,qua ntum dots,n itroge n-vaca ncy cen ters in diam on ds,perovskites and tra nsiti on metal dichalcoge *** provide an overview of various con figuratio ns of HMMs,i nclud ing metal-dielectric multilayers,trenches,metallic nanowires,and cavity structures fabricated with the use of noble metals,transparent conductive oxides,and refractory metals as plasmonic *** also discuss lasing action realized with HMMs.

关键词： fluorescence metamaterials metasurfaces Purcell effect nanophotonics hyperbolic metamaterials

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改进算术优化算法用于稀布平面阵列综合

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西安电子科技大学学报 2023年第3期50卷 202-212页

作者：国强刘从业王亚妮王勇 CHERNOGOR leonid 哈尔滨工程大学信息与通信工程学院黑龙江哈尔滨150001 先进船舶通信与信息技术工业和信息化部重点实验室黑龙江哈尔滨150001 乌克兰哈尔科夫国立大学空间无线电物理系乌克兰哈尔科夫61022

针对稀布平面阵列方向图旁瓣电平抑制和零陷综合问题,提出了一种基于改进算术优化算法的阵列天线综合算法。首先,为平衡开发和勘探过程比重,对算术优化算法中的算术优化加速器采用非线性函数重构;其次,采用前三优的个体代替当前最优个... 详细信息

针对稀布平面阵列方向图旁瓣电平抑制和零陷综合问题,提出了一种基于改进算术优化算法的阵列天线综合算法。首先,为平衡开发和勘探过程比重,对算术优化算法中的算术优化加速器采用非线性函数重构;其次,采用前三优的个体代替当前最优个体进行勘探开发,并引入精英变异策略,以增强算法跳出局部最优的能力,提高算法的收敛精度;最后,提出了一种自适应矩阵映射法则,对当前阵元分布进行判断,若其不满足最小阵元间距约束,则通过调整策略对其进行调整,在避免不可行解的同时保证了阵元的自由度。与现有文献中的算法相比,改进的算术优化算法对单峰和多峰标准测试函数的优化精度和稳定性均有一定的提高;在稀布平面阵列旁瓣电平抑制实验和零陷综合实验中,所提算法可以综合出更优的峰值旁瓣电平和零陷深度,证明了所提算法的有效性。

关键词：阵列综合稀布阵列矩阵映射法则算术优化算法

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High-voltage Nanosecond Pulse Generators of the ＂PROTEUS＂ Line for Discharge with Runaway Electrons Applications

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高电压技术 2013年第10期39卷 2506-2513页

作者： Anatoly N. Maltsev Maxim v. Martynov Alexey v. Mikov viktor G. Podkovyrov leonid L. Zhukov Alexander Yu. Ivanov Institute of Atmospheric Optics Russian Academy of Sciences Tomsk 634021 Russia Electrodynamic Systems & Technologies LLC Tomsk 634021 Russia Institute of High-current Electronics Russian Academy of Sciences Tomsk 634021 Russia

Many applications of gas discharge with runaway electrons (DRE) require high-voltage pulse generators (HvPG) with very high increasing rate of output voltage (up to 100 kv/ns), long operation life and low cost. Such HvPGs have to be controlled by external computer for working in combination with other modern equipment. In this paper, some HvPGs development for DRE application in industry and medicine are described. The functional structure and operation principles are discussed for the HvPG of "PROTEUS' line. It is shown that on different loads, the "PROTEUS" generators can produce high-voltage nanosecond pulse with energy up to 1 J, output voltage amplitude from zero to 150 kv, and pulse repetition frequency from zero to 2 000 Hz. Four models of the "PROTEUS" generators are described. The output voltage leading front duration is 150 ns for the "PROTEUS-I" model, 10-20 ns for the "PROTEUS-II", 2 ns for the "PROTEUS-IH" and 0.5 ns for the "PROTEUS-Iv". DRE parameters obtained by using "PROTEUS" HvPGs are demonstrated. Some results of DRE application in solid-state surface modification of natural textile and polymer films are shown as well.

关键词： PROTEUS 纳秒脉冲发生器电子应用气体放电高压失控输出电压脉冲重复频率

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