The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

作     者：Natalia V.Naryzhnaya Leonid N.Maslov Ivan A.Derkachev Huijie Ma Yi Zhang NRajendra Prasad Nirmal Singh Feng Fu Jianming Pei Akpay Sarybaev Akylbek Sydykov 

作者机构：Laboratory of Experimental CardiologyCardiology Research InstituteTomsk National Research Medical CenterRussian Academy of ScienceTomskTomsk Region 634012Russia Department of PhysiologyHebei Medical UniversityShijiazhuangHebei 050017China Department of Biochemistry and BiotechnologyFaculty of ScienceAnnamalai UniversityAnnamalainagarTamilnadu 608002India Department of Pharmaceutical Sciences and Drug ResearchPunjabi UniversityPatialaPunjabi 147002India Department of Physiology and PathophysiologyNational Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Department of Mountain and Sleep Medicine and Pulmonary HypertensionNational Center of Cardiology and Internal MedicineBishkek 720040Kyrgyzstan Kyrgyz-Indian Mountain Biomedical Research CenterBishkek 720033Kyrgyzstan Department of Internal MedicineExcellence Cluster Cardio-Pulmonary Institute(CPI)Member of the German Center for Lung Research(DZL)Justus Liebig University of GiessenGiessenHessen 35392Germany Department of Mountain and Sleep Medicine and Pulmonary HypertensionNational Center of Cardiology and Internal MedicineBishkek 720040Kyrgyzstan. 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2023年第37卷第4期

页      面：230-254页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Russian Science Foundation grant 22-15-00048 The section dedicated to the role of kinases in the cardioprotective effect of CH is framed within the framework of state assignments 122020300042-4 

主　　题：heart vessels infarct size arrhythmias chronic hypoxia 

摘      要：The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed *** development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine.A study on the cardiovascular effects of chronic hypoxia(CH)may contribute to the development of these *** hypoxia exerts both positive and adverse *** positive effects are the infarct-reducing,vasoprotective,and antiarrhythmic effects,which can lead to the improvement of cardiac contractility in *** adverse effects are pulmonary hypertension and right ventricular *** review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/*** is an in-depth analysis of the published data on the underlying mechanisms,which can lead to future development of the cardioprotective effect of CH.A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.