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Pyroptosis is a drug target for prevention of adverse cardiac remodeling: The crosstalk between pyroptosis, apoptosis, and autophagy

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The Journal of Biomedical Research 2022年第6期36卷 375-389页

作者： Natalia v.Naryzhnaya leonid N.Maslov Sergey v.Popov Alexandr v.Mukhomezyanov vyacheslav v.Ryabov Boris K.Kurbatov Alexandra E.Gombozhapova Nirmal Singh Feng Fu Jian-Ming Pei Sergey v.Logvinov Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Pharmaceutical Sciences and Drug Research Punjabi UniversityPatiala 147002India Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic MedicineFourth Military Medical UniversityXi'anShaanxi 710032China Department of Histology Embryology and CytologySiberian State Medical UniversityTomskTomsk Region 634055Russia

Acute myocardial infarction(AMI)is one of the main reasons of cardiovascular disease-related *** introduction of percutaneous coronary intervention to clinical practice dramatically decreased the mortality rate in *** cardiac remodeling is a serious problem in *** increase in the effectiveness of AMI treatment and prevention of adverse cardiac remodeling is difficult to achieve without understanding the mechanisms of reperfusion cardiac injury and cardiac *** of pyroptosis prevents the development of postinfarction and pressure overload-induced cardiac remodeling,and mitigates cardiomyopathy induced by diabetes and metabolic ***,it is reasonable to hypothesize that the pyroptosis inhibitors may find a role in clinical practice for treatment of AMI and prevention of cardiac remodeling,diabetes and metabolic syndrome-triggered *** was demonstrated that pyroptosis interacts closely with apoptosis and *** could be inhibited by nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 inhibitors,caspase-1 inhibitors,microRNA,angiotensin-converting enzyme inhibitors,angiotensinⅡreceptor blockers,and traditional Chinese herbal medicines.

关键词： pyroptosis apoptosis autophagy cardiac remodeling diabetes metabolic syndrome

Technogenic hydrogeochemical anomalies of tungsten deposits in Kykylbey ore region

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Journal of Geoscientific Research in Northeast Asia 2004年第1期7卷 52-57页

作者： leonid v.Zamana Larisa P.Chechel Institute of Natural Resources Ecology and Cryology SB RAS Chita 672014 RussiaInstitute of Natural Resources Ecology and Cryology SB RAS Chita 672014 Russia

Peculiarities of the tungsten deposits drainage flow chemical composition formation, the development of which was ceased almost 40 years ago, have been considered. Migration peculiarities of ore components have been covered, and forms of their migration have been calculated. Inertial characteristics of the surface flow contamination are shown.

关键词： tungsten deposits drainage flow ore components heavy metals fluorine Transbaikal

Study of the Electric Explosion of Titanium Foils in Uranium Salts

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Journal of Modern Physics 2010年第4期1卷 226-235页

作者： leonid I. Urutskoev Dmitry v. Filippov 不详

The results of experiments on electroexplosion titanic foil in water solutions of salts of uranium are presented in this paper. It is shown, that as a result of electroexplosion occurs appreciable (to 20%) distortion of an initial isotope parity of uranium. In the most solution parts, observable isotope distortion occurs in favour of enrichment by 235U. At the moment of electroexplosion it was not observed an appreciable stream of the neutrons. By means of Cs label and by methods by α, β, γ-spectrometry and mass-spectrometry it have been shown, that isotope distortion occurs at the expense of non-uniform “disappearance” of both isotopes from a solution. The isotope distortion leads to infringement of the 234Th secular equilibrium in the uranyl solution. The equilibrium infringement between the 234Th and 234mPa, i.e. within the proper thorium decay chain, was observed also. The assumption about that the effects are caused of low-energy nuclear reactions at the moment of electroexplosion is suggested.

关键词： Electric Explosion Nuclear Decay

Photoluminescence control by hyperbolic metamaterials and metasurfaces:a review

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Opto-Electronic Advances 2021年第8期4卷 30-56页

作者： leonid Yu.Beliaev Osamu Takayama Pavel N.Melentiev Andrei v.Lavrinenko DTU Fotonik-Department of Photonics Engineering Technical University of Denmark0rsteds Plads 343DK-2800 Kgs.LyngbyDenmark Institute of Spectroscopy RAS Moscow 108840Russia Higher School of Economics National Research UniversityMoscow 101000Russia

Photolu min esce nee in clud ing fluoresce nee plays a great role in a wide variety of applicati ons from biomedical sensing and imag ing to optoelectr on ***,the enhan ceme nt and con trol of photolu min esce nee has imme nse impact on both fun dame ntal scie ntific research and aforeme nti oned applicati *** various nano phot tonic schemes and nanostructures to enhance the photoluminescence,we focus on a certain type of nanostructures,hyperbolic metamaterials(HMMs).HMMs are highly ani sotropic metamaterials,which produce intense localized electric ***,HMMs n aturally boost photolu min esce nee from dye molecules,qua ntum dots,n itroge n-vaca ncy cen ters in diam on ds,perovskites and tra nsiti on metal dichalcoge *** provide an overview of various con figuratio ns of HMMs,i nclud ing metal-dielectric multilayers,trenches,metallic nanowires,and cavity structures fabricated with the use of noble metals,transparent conductive oxides,and refractory metals as plasmonic *** also discuss lasing action realized with HMMs.

关键词： fluorescence metamaterials metasurfaces Purcell effect nanophotonics hyperbolic metamaterials

A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

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The Journal of Biomedical Research 2023年第4期37卷 268-289页

作者： leonid N.Maslov Natalia v.Naryzhnaya Sergey v.Popov Alexandr v.Mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey v.Krylatov Feng Fu Jianming Pei vyacheslav v.Ryabov Evgenii v.vyshlov Svetlana v.Gusakova Alla A.Boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MvO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MvO in patients with acute myocardial ***,the major events preceding the appearance of MvO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MvO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MvO,with L-type Ca2+channel blockers appearing the most effective in treating MvO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage

High-voltage Nanosecond Pulse Generators of the ＂PROTEUS＂ Line for Discharge with Runaway Electrons Applications

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高电压技术 2013年第10期39卷 2506-2513页

作者： Anatoly N. Maltsev Maxim v. Martynov Alexey v. Mikov viktor G. Podkovyrov leonid L. Zhukov Alexander Yu. Ivanov Institute of Atmospheric Optics Russian Academy of Sciences Tomsk 634021 Russia Electrodynamic Systems & Technologies LLC Tomsk 634021 Russia Institute of High-current Electronics Russian Academy of Sciences Tomsk 634021 Russia

Many applications of gas discharge with runaway electrons (DRE) require high-voltage pulse generators (HvPG) with very high increasing rate of output voltage (up to 100 kv/ns), long operation life and low cost. Such HvPGs have to be controlled by external computer for working in combination with other modern equipment. In this paper, some HvPGs development for DRE application in industry and medicine are described. The functional structure and operation principles are discussed for the HvPG of "PROTEUS' line. It is shown that on different loads, the "PROTEUS" generators can produce high-voltage nanosecond pulse with energy up to 1 J, output voltage amplitude from zero to 150 kv, and pulse repetition frequency from zero to 2 000 Hz. Four models of the "PROTEUS" generators are described. The output voltage leading front duration is 150 ns for the "PROTEUS-I" model, 10-20 ns for the "PROTEUS-II", 2 ns for the "PROTEUS-IH" and 0.5 ns for the "PROTEUS-Iv". DRE parameters obtained by using "PROTEUS" HvPGs are demonstrated. Some results of DRE application in solid-state surface modification of natural textile and polymer films are shown as well.

关键词： PROTEUS 纳秒脉冲发生器电子应用气体放电高压失控输出电压脉冲重复频率

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基于显著感知与一致性约束的目标跟踪算法

北京航空航天大学学报 2023年第9期49卷 2244-2257页

作者：国强吴天昊徐伟 CHORNOGOR leonid 哈尔滨工程大学信息与通信工程学院哈尔滨150001 先进船舶通信与信息技术工业和信息化部重点实验室哈尔滨150001 哈尔科夫国立大学无线电物理学院哈尔科夫61166

针对空间正则相关滤波(SRDCF)算法正则权重固定和模型退化等问题,提出了一种基于显著感知与一致性约束的目标跟踪算法。提取方向梯度直方图特征、浅层特征及中层特征进行融合,提升物体外观模型的表达能力;通过显著性检测算法获得初始帧... 详细信息

针对空间正则相关滤波(SRDCF)算法正则权重固定和模型退化等问题,提出了一种基于显著感知与一致性约束的目标跟踪算法。提取方向梯度直方图特征、浅层特征及中层特征进行融合,提升物体外观模型的表达能力;通过显著性检测算法获得初始帧的显著感知参考权重,建立正则权重在相邻2帧之间的关联;最小化实际一致性响应与理想一致性响应之间的差异,约束一致性水平防止滤波器模板退化;提出一种动态约束策略,进一步提高跟踪器在复杂场景下的适应性。在OTB2015、TempleColor128和UAv20L公开数据集上对所提算法进行测试,实验结果表明:相比于SRDCF算法,所提算法在OTB2015数据集上距离精度提高了0.108,AUC提高了0.077,速度为22.41帧/s,实时性较好。

关键词：机器视觉目标跟踪相关滤波显著感知一致性约束

Determining the Drying Out of Coniferous Trees Using Airborne and Satellite Data

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Advances in Remote Sensing 2021年第2期10卷 25-46页

作者： Sviatlana I. Guliaeva Ilya I. Bruchkousky leonid v. Katkovsky Department of Aerospace Research A.N. Sevchenko Research Institute of Applied Physical Problems of the Belarusian State University Minsk Republic of Belarus

In recent decades, the problem of drying out of conifers has become a subject of significant importance due to the widespread mortality of trees caused by stem pest’s damage. Early detection of areas affected by insect outbreaks is of great relevance for preventing the further spread of pests. Forests of Belarus are largely affected by conifers dieback caused by the bark beetle. The aim of the study was to identify drying out conifers using a TripleSat satellite multispectral image of a woodland area in Belarus based on preliminary airborne measurements. Spectrometers operating in a spectral range of 400 - 900 nm were used in airborne measurements, resulting in distinguishing various drying out stages with an accuracy of 27%verdana;"> - 74% for aerial data. In this study, a supervised classification of the TripleSat image based on the method of linear discriminant analysis (LDA) was performed. The input data for LDA algorithm is a set of remote sensing vegetation indices. Results of the study demonstrate that about 90% of the test site is at the green-attack stage that is confirmed by ground surveys of this area.

关键词： Remote Sensing Forest Monitoring Stem Pest Spruce Dieback Spectral Clas-sification vegetation Indices Belarus

The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

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The Journal of Biomedical Research 2023年第4期37卷 230-254页

作者： Natalia v.Naryzhnaya leonid N.Maslov Ivan A.Derkachev Huijie Ma Yi Zhang NRajendra Prasad Nirmal Singh Feng Fu Jianming Pei Akpay Sarybaev Akylbek Sydykov Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical CenterRussian Academy of ScienceTomskTomsk Region 634012Russia Department of Physiology Hebei Medical UniversityShijiazhuangHebei 050017China Department of Biochemistry and Biotechnology Faculty of ScienceAnnamalai UniversityAnnamalainagarTamilnadu 608002India Department of Pharmaceutical Sciences and Drug Research Punjabi UniversityPatialaPunjabi 147002India Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Department of Mountain and Sleep Medicine and Pulmonary Hypertension National Center of Cardiology and Internal MedicineBishkek 720040Kyrgyzstan Kyrgyz-Indian Mountain Biomedical Research Center Bishkek 720033Kyrgyzstan Department of Internal Medicine Excellence Cluster Cardio-Pulmonary Institute(CPI)Member of the German Center for Lung Research(DZL)Justus Liebig University of GiessenGiessenHessen 35392Germany Department of Mountain and Sleep Medicine and Pulmonary Hypertension National Center of Cardiology and Internal MedicineBishkek 720040Kyrgyzstan.

The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed *** development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine.A study on the cardiovascular effects of chronic hypoxia(CH)may contribute to the development of these *** hypoxia exerts both positive and adverse *** positive effects are the infarct-reducing,vasoprotective,and antiarrhythmic effects,which can lead to the improvement of cardiac contractility in *** adverse effects are pulmonary hypertension and right ventricular *** review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/*** is an in-depth analysis of the published data on the underlying mechanisms,which can lead to future development of the cardioprotective effect of CH.A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.

关键词： heart vessels infarct size arrhythmias chronic hypoxia