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Semi-Automated Synthesis of [F-18]FBAM, a Thiol Reactive Prosthetic Group, Using Continuous Flow Chemistry

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International Journal of Organic Chemistry 2016年第3期6卷 177-185页

作者： Murthy R. Akula Srinivasa R. Marepally lee T. collier W. George Kabalka Departments of Chemistry and Radiology University of Tennessee Knoxville Tennessee USA Advion Biosystems Ithaca NY USA

[F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was carried out microfluidically, a very small amount of precursor was used and over all radiochemical yield was 38% ± 4% (n = 8, decay corrected) and the radiochemical purity was ≥98% with specific activity of 430 mC/μmol. The total reaction time including HPLC purification was 55 min that is 14 min more than manual synthesis and 6 min less than fully automated synthesis.

关键词： Bifunctional Agent Micro-Reactor 6-Bromohexnol Radiofluorination Appel Reaction

Stem cells, growth factors and scaffolds in craniofacial regenerative medicine

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Genes & Diseases 2016年第1期3卷 56-71页

作者： Viktor Tollemar Zach J.collier Maryam K.Mohammed Michael J.lee Guillermo A.Ameer Russell R.Reid The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Department of Orthopedic Surgery and Rehabilitation Medicine The University of Chicago Medical CenterChicagoIL 60637USA Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago MedicineChicagoIL 60637USA Department of Surgery Feinberg School of MedicineChicagoIL 60611USA Biomedical Engineering Department Northwestern UniversityEvanstonIL 60208USA

Current reconstructive approaches to large craniofacial skeletal defects are often complicated and ***-sized defects are unable to heal via natural regenerative processes and require surgical intervention,traditionally involving autologous bone(mainly in the form of nonvascularized grafts)or *** bone grafts remain the gold standard of care in spite of the associated risk of donor site *** engineering approaches represent a promising alternative that would serve to facilitate bone regeneration even in large craniofacial skeletal *** strategy has been tested in a myriad of iterations by utilizing a variety of osteoconductive scaffold materials,osteoblastic stem cells,as well as osteoinductive growth factors and small *** of the major challenges facing tissue engineers is creating a scaffold fulfilling the properties necessary for controlled bone *** properties include osteoconduction,osteoinduction,biocompatibility,biodegradability,vascularization,and progenitor cell *** review will provide an overview of how optimization of the aforementioned scaffold parameters facilitates bone regenerative capabilities as well as a discussion of common osteoconductive scaffold materials.

关键词： Bone regeneration Craniofacial defects Osteogenesis Regenerative medicine Scaffolds Tissue engineering

Development of a highly-specific ^(18)F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1686-1695页

作者： Zhen Chen Wakana Mori Jian Rong Michael A.Schafroth Tuo Shao Richard S.Van Daisuke Ogasawara Tomoteru Yamasaki Atsuto Hiraishi Akiko Hatori Jiahui Chen Yiding Zhang Kuan Hu Masayuki Fujinaga Jiyun Sun Qingzhen Yu Thomas L.collier Yihan Shao Benjamin F.Cravatt lee Josephson Ming-Rong Zhang Steven H.Liang Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital&Department of RadiologyHarvard Medical SchoolBostonMA 02114USA Department of Advanced Nuclear Medicine Sciences National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan The Skaggs Institute for Chemical Biology and Department of Chemical Physiology The Scripps Research InstituteLa JollaCA 92037USA Department of Chemistry and Biochemistry University of OklahomaNormanOK 73019USA

As a serine hydrolase,monoacylglycerol lipase(MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol(2-AG) in the central nervous system(CNS),leading to the formation of arachidonic acid(AA).Dysfunction of MAGL has been associated with multiple CNS disorders and symptoms,including neuroinflammation,cognitive impairment,epileptogenesis,nociception and neurodegenerative *** of MAGL provides a promising therapeutic direction for the treatment of these conditions,and a MAGL positron emission tomography(PET) probe would greatly facilitate preclinical and clinical development of MAGL ***,we design and synthesize a small library of fluoropyridyl-containing MAGL inhibitor *** evaluation of these candidates by activity-based protein profiling identified 14 as a lead compound,which was then radiolabeled with fluorine-18 via a facile SNAr reaction to form 2-[^(18)F]fluoropyridine *** blood-brain barrier permeability and high in vivo specific binding was demonstrated for radioligand [^(18)F]14(also named as [^(18)F]MAGL-1902).This work may serve as a roadmap for clinical translation and further design of potent 18F-labeled MAGL PET tracers.

关键词： Monoacylglycerol lipase(MAGL) Central nervous system(CNS) 2-Arachidonylglycerol(2-AG) Arachidonic acid(AA) Positron emission tomography(PET) Fluorine-18

Multifaceted signaling regulators of chondrogenesis:Implications in cartilage regeneration and tissue engineering

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Genes & Diseases 2015年第4期2卷 307-327页

作者： Jordan D.Green Viktor Tollemar Mark Dougherty Zhengjian Yan Liangjun Yin Jixing Ye Zachary collier Maryam K.Mohammed Rex C.Haydon Hue H.Luu Richard Kang Michael J.lee Sherwin H.Ho Tong-Chuan He Lewis L.Shi Aravind Athiviraham The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Department of Orthopaedic Surgery and Rehabilitation Medicine The University of Chicago Medical CenterChicagoIL 60637USA Department of Orthopaedic Surgery The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China School of Bioengineering Chongqing UniversityChongqingChina

Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular *** surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous ***,we review the current understanding of the most important biological regulators of chondrogenesis and their interactions,to provide insight into potential applications for cartilage tissue *** include various signaling pathways,including fibroblast growth factors(FGFs),transforming growth factor b(TGF-b)/bone morphogenic proteins(BMPs),Wnt/b-catenin,Hedgehog,Notch,hypoxia,and angiogenic signaling *** and epigenetic regulation of chondrogenesis will also be *** in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering.

关键词： BMPs Cartilage Cell signaling Chondrogenesis FGF Regenerative medicine

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化纤及其产品的贸易格局正在改变

国际纺织导报 2009年第2期37卷 6-6,8,10页

作者： N. Bywater D. collier C. Nava R. lee 李刚泰可荣公司

虽说未来的化纤生产领域将逐渐被中国和亚洲其他国家所主导,但仍有部分产品亚洲化纤生产商是不具备能力涉足的,这部分产品依然由欧洲和北美的化纤生产商控制。针对这一由欧洲和北美生产商控制的市场,应利用化纤产品的核心创新技术,并联... 详细信息

虽说未来的化纤生产领域将逐渐被中国和亚洲其他国家所主导,但仍有部分产品亚洲化纤生产商是不具备能力涉足的,这部分产品依然由欧洲和北美的化纤生产商控制。针对这一由欧洲和北美生产商控制的市场,应利用化纤产品的核心创新技术,并联合当地相关方面的专家学者进行不断的研究和开发。

关键词：化纤产品贸易格局变化

Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance

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Genes & Diseases 2016年第1期3卷 11-40页

作者： Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.lee The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical UniversityChongqing 400016China Department of Surgery West China Hospital of Sichuan UniversityChengdu 610041China Departments of General Surgery and Neurosurgerythe Affiliated Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Orthopaedic Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430022China

Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell *** role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling *** past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue ***,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug ***,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current *** review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and *** begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug ***,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance.

关键词： Cancer drug resistance Cancer stem cells Canonical Wnt b-Catenin Wnt