Synthesis of 4-[F-18]Fluoro-4-Deoxy-N-Acetyl-1,3,6-Tri-O-Acetylglucosamine, a Potential Brain Imaging PET Agent

作     者：Murthy Akula Derek Cressy Lee Collier George Kabalka Dustin Osborne Murthy Akula;Derek Cressy;Lee Collier;George Kabalka;Dustin Osborne

作者机构：Department of Radiology The University of Tennessee Medical Center Knoxville USA Advion Biosciences Ithaca USA 

出 版 物：《Natural Science》 (自然科学期刊（英文）)

年 卷 期：2024年第16卷第3期

页      面：19-23页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：N-Acetylglucosamine Amyloidogenesis Lipase-Candida rugosa 

摘      要：The synthesis of a promising brain imaging agent 4-[F-18]fluoro-4-deoxy-N-acetyl-1,3,6-tri-O-acetylglucosamine, 2, was successfully accomplished from commercially available N-acetyl glucosamine in 5 steps. The non-decay corrected radiochemical yield and purity were found to be 31% ± 4% (n = 3) and 98% respectively. The total reaction time for radio labelling step was 50 min.