Semi-Automated Synthesis of [F-18]FBAM, a Thiol Reactive Prosthetic Group, Using Continuous Flow Chemistry

作     者：Murthy R. Akula Srinivasa R. Marepally Lee T. Collier W. George Kabalka Murthy R. Akula;Srinivasa R. Marepally;Lee T. Collier;W. George Kabalka

作者机构：Departments of Chemistry and Radiology University of Tennessee Knoxville Tennessee USA Advion Biosystems Ithaca NY USA 

出 版 物：《International Journal of Organic Chemistry》 (有机化学国际期刊（英文）)

年 卷 期：2016年第6卷第3期

页      面：177-185页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Bifunctional Agent Micro-Reactor 6-Bromohexnol Radiofluorination Appel Reaction 

摘      要：[F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was carried out microfluidically, a very small amount of precursor was used and over all radiochemical yield was 38% ± 4% (n = 8, decay corrected) and the radiochemical purity was ≥98% with specific activity of 430 mC/μmol. The total reaction time including HPLC purification was 55 min that is 14 min more than manual synthesis and 6 min less than fully automated synthesis.