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Can we omit systematic biopsies in patients undergoing MRI fusion-targeted prostate biopsies?

Asian journal of Andrology 2023年第1期25卷 43-49页

作者： jeffrey j Leow Soon Hock Koh Marcus WL Chow Wayren Loke Rolando Salada Seok Kwan Hong Yuyi Yeow Chau Hung lee Cher Heng Tan Teck Wei Tan Department of Urology Tan Tock Seng HospitalSingapore 308433Singapore lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of Diagnostic Radiology Tan Tock Seng HospitalSingapore 308433Singapore

Magnetic resonance imaging(MRI)-targeted prostate biopsy is the recommended investigation in men with suspicious lesion(s)on *** role of concurrent systematic in addition to targeted biopsies is currently *** our prospectively maintained database,we identified men with at least one Prostate Imaging-Reporting and Data System(PI-RADS)≥3 lesion who underwent targeted and/or systematic biopsies from May 2016 to May *** significant prostate cancer(csPCa)was defined as any Gleason grade group≥2 *** 545 patients who underwent MRI fusion-targeted biopsy,222(40.7%)were biopsy naïve,247(45.3%)had previous prostate biopsy(s),and 76(13.9%)had known prostate cancer undergoing active *** cancer was more commonly found in biopsy-naïve men(63.5%)and those on active surveillance(68.4%)compared to those who had previous biopsies(35.2%;both P<0.001).Systematic biopsies provided an incremental 10.4%detection of csPCa among biopsy-naïve patients,versus an incremental 2.4%among those who had prior negative *** regression found age(odds ratio[OR]=1.03,P=0.03),prostate-specific antigen(PSA)density≥0.15 ng ml^(−2)(OR=3.24,P<0.001),prostate health index(PHI)≥35(OR=2.43,P=0.006),higher PI-RADS score(vs PI-RADS 3;OR=4.59 for PI-RADS 4,and OR=9.91 for PI-RADS 5;both P<0.001)and target lesion volume-to-prostate volume ratio≥0.10(OR=5.26,P=0.013)were significantly associated with csPCa detection on targeted *** conclusion,for men undergoing MRI fusion-targeted prostate biopsies,systematic biopsies should not be omitted given its incremental value to targeted biopsies *** factors such as PSA density≥0.15 ng ml^(−2),PHI≥35,higher PI-RADS score,and target lesion volume-to-prostate volume ratio≥0.10 can help identify men at higher risk of csPCa.

关键词： prostate biopsy prostate cancer prostate health index prostate-specific antigen software fusion Uronav

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SOPHIE: Generative Neural Networks Separate Common and Specific Transcriptional Responses

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Genomics, Proteomics & Bioinformatics 2022年第5期20卷 912-927页

作者： Alexandra j.lee Dallas L.Mould jake Crawford Dongbo Hu Rani K.Powers Georgia Doing james C.Costello Deborah A.Hogan Casey S.Greene Genomics and Computational Biology Graduate Program University of PennsylvaniaPhiladelphiaPA 19104USA Department of Microbiology and Immunology Geisel School of Medicine at DartmouthHanoverNH 03755USA Department of Systems Pharmacology and Translational Therapeutics University of PennsylvaniaPhiladelphiaPA 19104USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMA 02115USA Department of Pharmacology University of Colorado School of MedicineDenverCO 80045USA Center for Health AI University of Colorado School of MedicineDenverCO 80045USA Department of Biochemistry and Molecular Genetics University of Colorado School of MedicineDenverCO 80045USA

Genome-wide transcriptome profiling identifies genes that are prone to differential expression(DE)across contexts,as well as genes with changes specific to the experimental *** genes that are specifically changed in a context of interest from common differentially expressed genes(DEGs)allows more efficient prediction of which genes are specific to a given biological process under ***,common DEGs or pathways can only be identified through the laborious manual curation of experiments,an inordinately time-consuming *** we pioneer an approach,Specific cOntext Pattern Highlighting In Expression data(SOPHIE),for distinguishing between common and specific transcriptional patterns using a generative neural network to create a background set of experiments from which a null distribution of gene and pathway changes can be *** apply SOPHIE to diverse datasets including those from human,human cancer,and bacterial pathogen Pseudomonas *** identifies common DEGs in concordance with previously described,manually and systematically determined common *** molecular validation indicates that SOPHIE detects highly specific but low-magnitude biologically relevant transcriptional ***’s measure of specificity can complement log2 fold change values generated from traditional DE *** example,by filtering the set of DEGs,one can identify genes that are specifically relevant to the experimental condition of ***,these results can inform future research *** scripts used in these analyses are available at https://***/greenelab/*** can access https://***/greenelab/sophie to run SOPHIE on their own data.

关键词： Neural network Transcriptomics Software Differential expression analysis Machine learning

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Clinical utility of non-invasive tests to predict clinical outcomes in non-alcoholic fatty liver disease

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 916-918页

作者： Shi Yan lee Darren j.H.Tan Wen Hui Lim Cheng Han Ng Mark Muthiah Daniel Q.Huang Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore

Non-alcoholic fatty liver disease(NAFLD)is the leading cause of chronic liver disease,and the fastest-growing cause of hepatocellular carcinoma(HCC)worldwide(1,2).As the number of people with NAFLD is too great to perform surveillance in all,risk-stratification strategies are increasingly important to identify those at the highest risk of decompensation and HCC(3,4).

关键词： Non-alcoholic fatty liver disease(NAFLD) non-invasive tests fibrosis-4(FIB-4) vibration-controlled transient elastography(VCTE) clinical outcomes

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FTIR Studies on NO Adsorption on [Co+Mg(Sr)] /ZSM-5

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Chemical Research in Chinese Universities 2002年第4期18卷 389-392页

作者： lee C. W. CHONG P. j. KRICT Taejon 305-606 KoreaKRICT Taejon 305-606 Korea

The adsorption of NO on /ZSM-5 zeolites with different contents was studied by means of FTIR spectroscopy. The dominant NO species adsorbed on /ZSM-5 was found to be in a dinitrosyl form, as demonstrated by the IR bands at 1 813 and 1 896 cm -1. NO was adsorbed in a mononitrosyl form as shown in the region of 1 937-1 939 cm -1 as a minor species. Samples /ZSM-5 showed a new band near 1 858 cm -1(w) attributable to the species of Co_3O_4-NO. It was found that zeolite /ZSM-5 exhibits superior performance characteristics for SCR of NO molecules, and is promising as a useful catalyst. The typical catalyst /ZSM-5 for SCR resulted from the collaboration of the metal alkalinity and the ionic radius of the metal(such as Mg or Sr).

关键词： Infrared spectroscopy Nitric oxide Adsorption Mononitrosyl Dinitrosyl Cobalt oxide

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Effects of Processing Parameters on Microstructure and Properties of Ultra High Strength Linepipe Steel

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journal of Materials Science & Technology 2012年第10期28卷 889-894页

作者： Xiaodan Wu Hakcheol lee Young Min Kim Nack j.Kim University of Pittsburgh Pittsburghl PA 15213USA Pohang University of Science and Technology Pohang 790-784Korea

To examine the effect of processing parameters on microstructural evolution and to obtain the excellent combination of strength and toughness, simulation of thermo-mechanical processing was conducted using the Gleeble machine. Trial production was then conducted under the conditions obtained by Gleeble tests. Based on the results of microstructure analysis and mechanical property evaluation, the relationship between microstructural features and mechanical properties was elucidated. The result shows that the volume fraction of constituted phases can be controlled through adjusting the cooling rate and finish cooling temperature in order to get different strength levels. As cooling rate increases, the volume fraction of upper bainite increases, which leads to the increase of strength. The upper shelf energy （USE） increases with increasing volume fraction of acicular ferrite in bainite base because of the small effective acicular ferrite grain size. Ductile-brittle transition temperature （DBTT） decreases with increasing acicular ferrite volume fraction. High reduction in the rough stage has great influence on grain refinement.

关键词： Linepipe steel Microstructure Gleeble test TMCP (thermomechanicalcontrol process)

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Complications associated with energy-based devices during thyroidectomy from 2010–2020

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World journal of Otorhinolaryngology-Head and Neck Surgery 2023年第1期9卷 35-44页

作者： Esther lee jane Y.Tong Luke j.Pasick Daniel A.Benito Arjun joshi Punam G.Thakkar joseph F.Goodman Division of Otolaryngology-Head and Neck Surgery George Washington University School of Medicine&amp Health SciencesWashingtonDCUSA Western University of Health Sciences PomonaCAUSA Department of Otolaryngology-Head and Neck Surgery Drexel University College of MedicinePhiladelphiaPAUSA Department of Otolaryngology-Head and Neck Surgery University of Miami Miller School of MedicineMiamiFLUSA

Objective:Harmonic Focus(Ethicon,johnson and johnson,Cincinnati,OH,USA),LigaSure Small jaw(Medtronic,Covidien Products,Minneapolis,MN,USA),and Thunderbeat Open Fine jaw(Olympus,japan)are electrosurgical instruments used widely in head and neck *** study aims to compare device malfunctions,adverse events to patients,operative injuries,and interventions related to Harmonic,LigaSure,and Thunderbeat use during ***:The US Food and Drug Administration's Manufacture and User Facility Device Experience(MAUDE)database was queried for adverse events associated with Harmonic,LigaSure,and Thunderbeat from january 2005 to August *** were extracted from reports pertaining to ***:Of the 620 adverse events extracted,394(63.5%)involved Harmonic,134(21.6%)LigaSure,and 92(14.8%)*** reported device malfunctions most frequently associated with Harmonic was damage to the blade(110(27.9%)),LigaSure was inappropriate function(47(43.1%)),Thunderbeat was damage to the tissue or Teflon pad(27(30.7%)),*** injury and incomplete hemostasis were the most commonly reported adverse *** operative injury reported most frequently when using Harmonic and LigaSure was burn *** operator injuries were reported with Thunderbeat ***:The most frequently reported device malfunctions were damage to the blade,inappropriate function,and damage to the tissue or Teflon *** most frequently reported adverse events to patients was a burn injury and incomplete *** aimed at improving physician education may help reduce adverse events attributed to improper use.

关键词： Adverse events Harmonic LigaSure Manufacture and User Facility Device Experience Patient safety Quality Thunderbeat Thyroidectomy

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Adenosine-treated bioprinted muscle constructs prolong cell survival and improve tissue formation

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Bio-Design and Manufacturing 2021年第3期4卷 441-451页

作者： Dongxu Ke Adam M.jorgensen Sang j.lee james j.Yoo Sean V.Murphy Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNCUSA Novaprint Therapeutics Suzhou Co. LtdSuzhouJiangsuChina

It is crucial to maintaining the viability of biofabricated human-sized tissues to ensure their successful survival and function after *** is a purine nucleoside that has the function to suppress cellular metabolism and has been previously proposed as a method to prolong cell viability under *** this study,we optimized the dose concentration of adenosine for incorporation into bioprinted constructs to preserve long-term cell viability in *** results showed that muscle cells(C2C12)containing 6,7,or 8 mM adenosine maintained high cell viability for 20 days under hypoxic conditions(0.1%O2),whereas cells without adenosine treatment showed 100%cell death after 11 *** 20 days under hypoxic conditions,muscle cells treated with adenosine proliferated and differentiated when transferred to normoxic *** these adenosine concentrations,6 mM was picked as the optimized adenosine concentration for further investigations due to its most effective results on improving cell *** bioprinted muscle constructs containing adenosine(6 mM)maintained high cell viability for 11 days under hypoxic conditions,while the control constructs without adenosine had no live *** in vivo validation,the bioprinted constructs with adenosine implanted under the dorsal subcutaneous space in mice,showed the enhanced formation of muscle tissue with minimal central necrosis and apoptosis,when compared to the constructs without *** positive in vitro and in vivo results demonstrate that the use of adenosine is an effective approach to preventing the challenge of hypoxia-induced necrosis in bioprinted tissues for clinical translation.

关键词： Bioprinting Hypoxia Adenosine Cell viability In vivo

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Efficient dispersion modeling in optical multimode fiber

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Light(Science & Applications) 2023年第2期12卷 194-206页

作者： Szu-Yu lee Vicente j.Parot Brett E.Bouma Martin Villiger Harvard Medical School and Massachusetts General Hospital Wellman Center for PhotomedicineBostonMA 02114USA Harvard-MIT Health Sciences and Technology Massachusetts Institute of TechnologyCambridgeMA 02140USA Institute for Biological and Medical Engineering Pontificia Universidad Catolica de ChileSantiago 7820244Chile institute for Medical Engineering and Science Massachusetts Institute of TechnologyCambridgeMA 02140USA

Dispersion remains an enduring challenge for the characterization of wavelength-dependent transmission through optical multimode fiber(MMF).Beyond a small spectral correlation width,a change in wavelength elicits a seemingly independent distribution of the transmitted *** we report on a parametric dispersion model that describes mode mixing in MMF as an exponential map and extends the concept of principal modes to describe the fiber's spectrally resolved transmission matrix(TM).We present computational methods to fit the model to measurements at only a few,judiciously selected,discrete *** validate the model in various MMF and demonstrate an accurate estimation of the full TM across a broad spectral bandwidth,approaching the bandwidth of the best-performing principal modes,and exceeding the original spectral correlation width by more than two orders of *** model allows us to conveniently study the spectral behavior of principal modes,and obviates the need for dense spectral measurements,enabling highly effcient reconstruction of the multispectral TM of MMF.

关键词： fiber optical dispersion

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术前影像学结果预测胆道闭锁病人Kasai术后2年自体肝生存率

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国际医学放射学杂志 2024年第3期 373-373页

作者： H.Kim S.Y.Yoo j.H.Kim M.j.Kim S.lee T.Y.jeon 吴玉平

摘要目的探讨应用术前影像学指标预测胆道闭锁（BA）病人Kasai术后2年自体肝生存率的可行性。方法回顾性分析2000—2020年接受Kasai手术的190例BA病人，

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Alleviating Interfacial Recombination of Heterojunction Electron Transport Layer via Oxygen Vacancy Engineering for Efficient Perovskite Solar Cells Over 23%

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Energy & Environmental Materials 2023年第2期6卷 311-322页

作者： Yohan Ko Taemin Kim Chanyong lee Changhyun lee Yong ju Yun Yongseok jun Graduate School of Energy and Environment(KU-KIST Green School) Korea UniversitySeoul 02841Korea

Electron transport layer(ETL)is pivotal to charge carrier transport for PSCs to reach the Shockley-Queisser *** study provides a fundamental understanding of heterojunction electron transport layers(ETLs)at the atomic level for stable and efficient perovskite solar cells(PSCs).The bilayer structure of an ETL composed of SnO_(2) on TiO_(2) was examined,revealing a critical factor limiting its potential to obtain efficient *** of oxygen vacancies in the TiO_(2) underlayer via an annealing process is found to induce manipulated band offsets at the interface between the TiO_(2) and SnO_(2) ***-depth electronic investigations of the bilayer structure elucidate the importance of the electronic properties at the interface between the TiO_(2) and SnO_(2) *** apparent correlation in hysteresis phenomena,including current density-voltage(j-V)curves,appears as a function of the type of band *** functional theory calculations reveal the intimate relationship between oxygen vacancies,deep trap states,and charge transport efficiency at the interface between the TiO_(2) and SnO_(2) *** formation of cascade band alignment via control over the TiO_(2) underlayer enhances device performance and suppresses *** performance exhibits a power conversion efficiency(PCE)of 23.45%with an open-circuit voltage(V_(oc))of 1.184 V,showing better device stability under maximum power point tracking compared with a staggered bilayer under one-sun continuous illumination.

关键词： electron transport bilayer heterojunction bilayers interfacial defect oxygen vacancy engineering perovskite solar cells

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