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Mind-reading Machine Knows What You See

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当代外语研究 2005年第6期 33-34页

作者： Michael le page 邱楠

有时候你是否很想知道别人的心思呢?或许你会说,那是不可能的事情!但是最近研究者发现,通过遥测一个人的大脑活动而了解他的心思是很有可能的,而且这种技术还可以获得人们自己都可能没有意识到的信息!

关键词： Mind-reading Machine Knows What You See

Development of NK cell-based cancer immunotherapies through receptor engineering

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Cellular & Molecular Immunology 2024年第4期21卷 315-331页

作者： Audrey page Nicolas Chuvin Jenny Valladeau-Guilemond Stéphane Depil Centre de Recherche en Cancérologie de Lyon UMR INSERM U1052 CNRS 5286Centre Léon BérardLyonFrance ErVimmune LyonFrance Centre Léon Bérard LyonFrance UniversitéClaude Bernard Lyon 1 LyonFrance

Natural killer(NK)cell-based immunotherapies are attracting increasing interest in the field of cancer *** clinical trials have shown promising outcomes,alongside satisfactory product efficacy and *** developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic *** review focuses on surface receptor engineering in NK cell therapy and discusses its impact,challenges,and future *** approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen *** approach has increased the precision and potency of NK-mediated recognition and elimination of cancer *** addition,engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes,which broadens the range of target *** tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and ***,engineered NK cells have an improved ability to recognize and destroy target cells coated with specific antibodies,thereby increasing their antibodydependent cellular *** ability of NK cell receptor engineering to promote the expansion,persistence,and infiltration of transferred cells in the tumor microenvironment has also been ***-based strategies for sustained NK cell functionality within the tumor environment have also been discussed,and these strategies providing perspectives to counteract tumor-induced ***,receptor engineering has led to significant advances in NK cell-based cancer *** technical challenges are addressed,these innovative treatments will likely reshape cancer immunotherapy.

关键词： NK cells Cell therapy Receptor engineering CAR

Silicon-photonics-enabled chip-based 3D printer

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Light(Science & Applications) 2024年第7期13卷 1320-1330页

作者： Sabrina Corsetti Milica Notaros Tal Sneh Alex Stafford Zachariah A.page Jelena Notaros Research Laboratory of Electronics Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Chemistry The University of Texas at AustinAustinTX 78712USA

Imagine if it were possible to create 3D objects in the palm of your hand within seconds using only a single photonic *** 3D printing has revolutionized the way we create in nearly every aspect of modern society,current 3D printers rely on large and complex mechanical systems to enable layer-by-layer addition of *** limits print speed,resolution,portability,form factor,and material *** there have been recent efforts in developing novel photocuring-based 3D printers that utilize light to transform matter from liquid resins to solid objects using advanced methods,they remain reliant on bulky and complex mechanical *** address these limitations,we combine the fields of silicon photonics and photochemistry to propose the first chip-based 3D *** proposed system consists of only a single millimeter-scale photonic chip without any moving parts that emits reconfigurable visible-light holograms up into a simple stationary resin well to enable non-mechanical 3D ***,we experimentally demonstrate a stereolithography-inspired proof-of-concept version of the chip-based 3D printer using a visible-light beam-steering integrated optical phased array and visible-light-curable resin,showing 3D printing using a chip-based system for the first *** work demonstrates the first steps towards a highlycompact,portable,and low-cost solution for the next generation of 3D printers.

关键词： printer printing visible

多发性硬化症的治疗时机窗:单克隆抗体治疗的依据

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世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 39-40页

作者： Coles A.J Cox A le page 张慧 Department of Clinical Neurosciences Box 165 Addenbrooke's Hospital Cambridge CB2 2QQ United Kingdom

From 1991- 2002, we treated 58 patients with multiple sclerosis (MS) using the humanised monoclonal antibody, Campath-1H, which causes prolonged T lymphocyte depletion. Clinical and surrogate markers of inflammation were suppressed. In both the relapsing-remitting (RR) and secondary progressive (SP) stages of the illness, Campath-1H reduced the annual relapse rate (from 2.2 to 0.19 and from 0.7 to 0.001 respectively; both p lesion formation. However, despite these effects on inflammation, disability was differently affected depending on the phase of the disease. Patients with SPMS showed sustained accumulation of disability due to uncontrolled progression marked by unrelenting cerebral atrophy, attributable to ongoing axonal loss. The rate of cerebral atrophy was greatest in patients with established cerebral atrophy and highest inflammatory lesion burden before treatment (2.3 versus 0.7 ml/year; p = 0.04). In contrast, patients with RR disease showed an impressive reduction in disability at 6 months after Campath-1H (by a mean of 1.2 EDSS points) perhaps owing to a suppression of on-going inflammation in these patients with unusually active disease. In addition, there was a further significant, albeit smaller, mean improvement in disability up to 36 months after treatment. We speculate that this represents the beneficial effects of early rescue of neurons and axons from a toxic inflammatory environment, and that prevention of demyelination will prevent long-term axonal degeneration. These concepts are currently being tested in a controlled trial comparing Campath-1H and IFN-beta in the treatment of drug-na ve patients with early, active RR MS.

关键词：多发性硬化症人单克隆抗体抗体治疗治疗时机依据脑萎缩率 RRMS 轴突变性年复发率早期恢复

Promising Molecular Markers of Prostate Cancer Progression:ErbB3, Akt and NF-κB

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Promising Molecular Markers of Prostate Cancer Progression:E...

非凡与平凡现代科技可救人一命,也可料理餐食

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Isma■l Hervé Koumakpayi Cécile le page Laurent lessard Jean-Simon Diallo Philippe O. Gannon Benjamin Péant Nathalie Delvoye Anne-Marie Mes-Masson Fred Saad CHUM-Höpital Notre-Dame Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada

＜正＞Background and Aims: The treatment of prostate cancer （PCa） depends on stage. To improve treatment strategies, it would be helpful to have reliable molecular markers able to predict PCa progression. However, to date, such markers have not yet been included in therapeutic decisions. Recently, several studies from our laboratory described the prognostic potential of molecular markers that include ErbB3, Akt and Nuclear Factor kappaB （NF- κB） . ErbB3 is a member of the growth factor receptor family ErbB. Akt is a signaling component of the ErbB receptor family. Phos-phoinositol 3 - kinase （PI3K） through Akt regulates downstream signaling proteins such as NF - κB. Most of these molecules are often overexpressed and/or activated in cancer cells. Furthermore, they can be detected in the cytoplasm and/or nucleus of PCa cells. They are known to be involved in cell survival, cell growth, cell cycle progression and apoptotic response. The aim of our study was to determine whether these molecules could be used as markers to predict PCa progression.

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空中英语教室（高级版．彭蒙惠英语） 2024年第7期 14-16,40-42页

作者： page DESIGN BY VICKY TSUNG 不详

开创性的新生儿部分心脏移植手术2022年,杜克健康的外科医生们成功地为一名新生儿实施了全世界首例部分心脏移植手术,创造了历史。医生认为,这台历时8小时的开创性手术——将捐赠者心脏的活体动脉与瓣膜缝合于一名新生儿的心脏中——可... 详细信息

开创性的新生儿部分心脏移植手术2022年,杜克健康的外科医生们成功地为一名新生儿实施了全世界首例部分心脏移植手术,创造了历史。医生认为,这台历时8小时的开创性手术——将捐赠者心脏的活体动脉与瓣膜缝合于一名新生儿的心脏中——可以开创心脏外科手术的新领域,使年轻患者在日后的人生当中免于接受多次高风险的手术。

关键词：心脏移植手术心脏外科手术捐赠者年轻患者新生儿外科医生现代科技

人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化

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中华高血压杂志 2017年第6期25卷 527-527页

作者：刘莉叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE le page a Fulop T Remaley AT Rouis M

硫氧化还原蛋白（thioredoxin,TRX）1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法：使用特异性... 详细信息

硫氧化还原蛋白（thioredoxin,TRX）1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法：使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。

关键词：载脂蛋白E基因敲除小鼠硫氧化还原蛋白动脉粥样硬化人血浆血管生成酶联免疫吸附试验人巨噬细胞年龄

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乐高如何培养客户忠诚度

空中英语教室（高级版．彭蒙惠英语） 2024年第4期 32-33,48页

作者： Jason Aten VICKY TSUNG(page DESIGN) 不详

乐高出现在我们身边已经91年了,而其中的大部分时间,它都是全世界最热门的玩具之一。它也是目前营收额最高的玩具制造商,并且建立了堪称全世界忠诚度最高的粉丝群。顺带一提,那些粉丝可不只有儿童,数以百万计充满热情的成年人仍旧喜爱... 详细信息

乐高出现在我们身边已经91年了,而其中的大部分时间,它都是全世界最热门的玩具之一。它也是目前营收额最高的玩具制造商,并且建立了堪称全世界忠诚度最高的粉丝群。顺带一提,那些粉丝可不只有儿童,数以百万计充满热情的成年人仍旧喜爱用乐高积木建造作品。在你可能接触到的所有品牌当中,乐高也许拥有最忠诚的粉丝。

关键词：客户忠诚度粉丝玩具制造商成年人

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从空中发现疾病

空中英语教室（高级版．彭蒙惠英语） 2024年第4期 14-15,41,42页

作者： Grace Toohey OLIVE CHU(page DESIGN) 不详

美国宇航局的植物早期疾病检测技术具有重大潜在效益,新研究发现,美国宇航局的尖端影像技术能够检测-种植物病毒的早期迹象。这种病毒如果没有及时处理,往往会为酿酒厂与葡萄种植者带来严重损失。这项突破对于葡萄酒与葡萄产业而言是好... 详细信息

美国宇航局的植物早期疾病检测技术具有重大潜在效益,新研究发现,美国宇航局的尖端影像技术能够检测-种植物病毒的早期迹象。这种病毒如果没有及时处理,往往会为酿酒厂与葡萄种植者带来严重损失。这项突破对于葡萄酒与葡萄产业而言是好消息一此产业每年因为这种摧毁作物的疾病而损失数十亿美元一一同时,它也有助于全球农业的整体发展。

关键词：植物病毒葡萄种植疾病检测美国宇航局葡萄产业影像技术潜在效益葡萄酒