Promising Molecular Markers of Prostate Cancer Progression:ErbB3, Akt and NF-κB
作者单位：Institut du cancer de Montréal 1560 rue Sherbrooke EstMontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke EstMontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke EstMontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke EstMontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke EstMontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke EstMontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke EstMontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke EstMontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke EstMontréalQuébecH2L 4M1Canada
会议名称：《第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议》
会议日期：2006年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：正Background and Aims: The treatment of prostate cancer （PCa） depends on stage. To improve treatment strategies, it would be helpful to have reliable molecular markers able to predict PCa progression. However, to date, such markers have not yet been included in therapeutic decisions. Recently, several studies from our laboratory described the prognostic potential of molecular markers that include ErbB3, Akt and Nuclear Factor kappaB （NF- κB） . ErbB3 is a member of the growth factor receptor family ErbB. Akt is a signaling component of the ErbB receptor family. Phos-phoinositol 3 - kinase （PI3K） through Akt regulates downstream signaling proteins such as NF - κB. Most of these molecules are often overexpressed and/or activated in cancer cells. Furthermore, they can be detected in the cytoplasm and/or nucleus of PCa cells. They are known to be involved in cell survival, cell growth, cell cycle progression and apoptotic response. The aim of our study was to determine whether these molecules could be used as markers to predict PCa progression.