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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-lopez Eduardo Andres-Leon laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

Polycaprolactone/mesoporous silica MCM-41 composites prepared by in situ polymerization

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Particuology 2017年第1期15卷 135-143页

作者： laura lopez-Figueras Nuria Navascues Silvia Irusta Department of Chemical Engineering Nanoscience Institute of Aragon (INA) University of Zaragoza 50018 Zaragoza Spain Networking Research Center on Bioengineering Biomaterials and Nanomedicine CIBER-BBN 50018 Zaragoza Spain

Composites of polycaprolactone （PCL） with mesoporous silica MCM-41 and N-[3- （trimethoxysilyl）propyl]-ethylenediamine （EPTES）-functionalized MCM-41 （EPTES/MCM-41） were prepared by in situ polymerization. The thermal properties of the composites were characterized by thermogravimetric analysis. There was an increase in the thermal decomposition temperature of PCL by more than 55 ℃, when the EPTES/MCM-41 loading was higher than 2 wt%. Tensile test results indicated that adding MCM-41 increased the brittleness of the PCL matrix, while adding 8 wt% of EPTES/MCM-41 increased the Young＇s modulus by 26%. Incorporating MCM-41 increased the crystallinity of the resulting PCL composite, compared with that of PCL. Incorporating up to 5 wt% EPTES/MCM-41 slightly reduced the crystallinity of PCL. The different effects of MCM-41 and EPTES/MCM-41 on the composite reflected the degree of interaction and dispersion of the silica filler in the polymer matrix, as evidenced by results from transmission electron microscopy and atomic force microscopy.

关键词： Nanocomposite Mesoporous silica Polycaprolactone

A micromirror array with annular partitioning for high-speed random-access axial focusing

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Light(Science & Applications) 2020年第1期9卷 241-255页

作者： Nathan Tessema Ersumo Cem Yalcin Nick Antipa Nicolas Pegard laura Waller Daniel lopez Rikky Muller The University of California Berkeley and University of CaliforniaSan Francisco Graduate Program in BioengineeringBerkeleyCA 94720USA Department of Electrical Engineering&Computer Sciences University of CaliforniaBerkeleyCA 94720USA Department of Applied Physical Sciences University of North Carolina at Chapel HillChapel HillNC 27514USA Chan Zuckerberg Biohub San FranciscoCA 94158USA Physical Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA

Dynamic axial focusing functionality has recently experienced widespread incorporation in microscopy,augmented/virtual reality(AR/VR),adaptive optics and material ***,the limitations of existing varifocal tools continue to beset the performance capabilities and operating overhead of the optical systems that mobilize such *** varifocal tools that are the least burdensome to operate(*** crystal,elastomeric or optofluidic lenses)suffer from low(≈100 Hz)refresh ***,the fastest devices sacrifice either critical capabilities such as their dwelling capacity(*** gradient lenses or monolithic micromechanical mirrors)or low operating overhead(*** mirrors).Here,we present a general-purpose random-access axial focusing device that bridges these previously conflicting features of high speed,dwelling capacity and lightweight drive by employing lowrigidity micromirrors that exploit the robustness of defocusing phase ***,the device consists of an 8.2mm diameter array of piston-motion and 48-μm-pitch micromirror pixels that provide 2πphase shifting for wavelengths shorter than 1100 nm with 10-90% settling in 64.8μs(i.e.,15.44 kHz refresh rate).The pixels are electrically partitioned into 32 rings for a driving scheme that enables phase-wrapped operation with circular symmetry and requires<30 V per *** experiments demonstrated the array’s wide focusing range with a measured ability to target 29 distinct resolvable depth ***,the features of the proposed array offer the potential for compact,straightforward methods of tackling bottlenecked applications,including high-throughput single-cell targeting in neurobiology and the delivery of dense 3D visual information in AR/VR.

关键词： mirror axial random

A complicated peribiliary cyst:An unusual hilar cholangiocarcinoma mimic

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 193-195页

作者： Oriana Barrios Kristel Mils laura Lladó Josefina lopez-Dominguez Emilio Ramos Division of Hepatobiliary Surgery Bellvitge University HospitalBarcelona 08907Spain

To the Editor:Peribiliary cysts are cystic dilatations of the extramural peribiliary glands that appears in the connective tissue around the hepatic *** can affect up to the fourth order intrahepatic bile ducts and do not communicate with the bile *** is a rare entity first described in 1984 by Nakanuma et al.[1].Its diagnosis is usually an incidental discovery in patients with advanced liver disease,portal thrombosis,and portal hypertension [2].

关键词： biliary diagnosis

Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro-oxidant activity

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Nano Research 2023年第5期16卷 7784-7791页

作者： laura Perez-Garrido Mariano Ortega-Muñoz Fernando Hernandez-Mateo F.Javier lopez-Jaramillo Francisco Santoyo-Gonzalez Department of Organic Chemistry Biotechnology InstituteSchool of SciencesCampus Fuentenueva snUniversity of Granada18071-GranadaSpain

Selenium(Se)has been defined as the“Janus element”,with one face showing antioxidant activity and the other pro-oxidant *** biological effect of Se depends on both dose and *** nanoparticles are attracting major interest,although their large-scale preparation for biomedical applications is not *** hypothesize that acid anhydride-coated carbon dots(AACD)are an attractive platform for preparing nanoparticles containing chemically defined *** reaction of AA-CD with 3-selenocyanatopropan-1-amine yields carbon dots bearing selenocyanate and carboxylate groups(CD-SeCN)that allow for tuning the ***-SeCN has a Se content of 0.36μmol per mg of nanoparticles,they show the typical photoluminescence of carbon *** selenocyanate groups(SeCN)exhibited glutathione peroxidase-like activity and *** show that antioxidant behavior differs between normal and tumor cells,the evaluation on HEK293 and A549 cells reveals that the toxicity of CD-SeCN depends on dose,time,intracellular glutathione(GSH)*** toxicity of CD-SeCN decreases with the time of incubation and the cell death mechanism switches from necrosis to apoptosis,indicating that CD-SeCN is ***,high levels of intracellular GSH exert a protective *** results support a pharmacological potential in cancers with low levels of intracellular *** use of AA-CD as nanoplatforms is a general strategy that paves the way for the engineering of advanced nanosystems.

关键词： selenium nanoparticles carbon dots glutathione peroxidase-like activity Janus element nanomedicine

Hepatocellular carcinoma risk after viral response in hepatitis C virus-advanced fibrosis: Who to screen and for how long?

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World Journal of Gastroenterology 2021年第40期27卷 6737-6749页

作者： Adriana Ahumada laura Rayón Clara Usón Rafael Bañares Sonia Alonso lopez Liver Unit Hospital General Universitario Gregorio MarañónMadrid 28007Spain Liver Unit Instituto de Investigación Sanitaria Gregorio Marañón(IiSGM)Madrid 28007Spain Medicine Universidad Complutense de MadridMadrid 28006Spain Centro de Investigación Biomédica En Red de Enfermedades Hepáticas y Digestivas(CIBERehd) Instituto de Salud Carlos IIIMadrid 28029Spain

Hepatitis C virus(HCV)chronic infection is associated with fibrosis progression,end-stage liver complications and *** surprisingly,HCV infection is a leading cause of liver-related morbidity and mortality *** sustained virological response(SVR),the risk of developing hepatocellular carcinoma is not completely eliminated in patients with established cirrhosis or with advanced ***,lifelong surveillance is currently *** strategy is likely not universally cost-effective and harmless,considering that not all patients with advanced fibrosis have the same risk of developing *** related to the severity of liver disease and its potential to improve after SVR,the molecular and epigenetic changes that occur during infection and other associated comorbidities might account for different risk levels and are likely essential for identifying patients who would benefit from screening programs after *** to develop predictive models and risk calculators,biomarkers and genetic panels and even deep learning models to estimate the individual risk of HCC have been made in the direct-acting antiviral agents era,when thousands of patients with advanced fibrosis and cirrhosis have reached *** tools could help to identify patients with very low HCC risk in whom surveillance might not be *** this review,factors affecting the probability of HCC development after SVR,the benefits and risks of surveillance,suggested strategies to estimate individualized HCC risk and the current evidence to recommend lifelong surveillance are discussed.

关键词： Hepatitis C virus Hepatocellular carcinoma Liver fibrosis Surveillance Sustained virologic response Epigenetic changes Predictive models Cost-effectiveness

Transanal endoscopic surgery in rectal cancer

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World Journal of Gastroenterology 2014年第33期20卷 11538-11545页

作者： Xavier Serra-Aracil laura Mora-lopez Manel Alcantara-Moral Aleidis Caro-Tarrago Carlos Javier Gomez-Diaz Salvador Navarro-Soto Coloproctology Unit General and Digestive Surgery Service Parc Tauli University Hospital Universitat Autònoma de Barcelona 08208 Sabadell (Barcelona) Spain

Total mesorectal excision(TME) is the standard treatment for rectal cancer, but complications are frequent and rates of morbidity, mortality and genitourinary alterations are high. Transanal endoscopic microsurgery(TEM) allows preservation of the anal sphincters and, via its vision system through a rectoscope, allows access to rectal tumors located as far as 20 cm from the anal verge. The capacity of local surgery to cure rectal cancer depends on the risk of lymph node invasion. This means that correct preoperative staging of the rectal tumor is necessary. Currently, local surgery is indicated for rectal adenomas and adenocarcinomas invading the submucosa, but not beyond(T1). Here we describe the standard technique for TEM, the different types of equipment used, and the technical limitations of this approach. TEM to remove rectal adenoma should be performed in the same way as if the lesion were an adenocarcinoma, due to the high percentageof infiltrating adenocarcinomas in these lesions. In spite of the generally good results with T1, some authors have published surprisingly high recurrence rates; this is due to the existence of two types of lesions, tumors with good and poor prognosis, divided according to histological and surgical factors. The standard treatment for rectal adenocarcinoma T2N0M0 is TME without adjuvant therapy. In this type of adenocarcinoma, local surgery obtains the best results when complete pathological response has been achieved with previous chemoradiotherapy. The results with chemoradiotherapy and TEM are encouraging, but the scientific evidence remains limited at present.

关键词： Rectal cancer Rectal adenocarcinoma Transanal endoscopic microsurgery Transanal endo-scopic surgery Colorectal cancer

Land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas Maria A.Garcia-lopez Jose M.Olano Gabriel Sanguesa-Barreda Miguel Garcia-Hidalgo Susana Gomez-Gonzalez Roberto lopez-Rubio Jose M.Fernandez-Palacios Ignacio Garcia-Gonzalez laura Lozano-lopez Paula Garcia-Gonzalez Ana I.Garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain Grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPLIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

Laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human *** the past,Canary laurel forests have been greatly altered by logging,livestock and *** remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic *** dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife *** cores were collected from over 80 trees per stand at three stands per *** used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed *** tree species were found in all stands,with Laurus novocanariensis,Ilex canariensis and Morella faya being the most common *** some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism *** trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past *** growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).Given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure Macaronesia Management cessation Tree rings

不同固定床位置生物质热解挥发物蒸汽催化重整反应中焦炭的形成和演化

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Chinese Journal of Catalysis 2023年第5期48卷 101-116页

作者： Enara Fernandez laura Santamaria Irati García Maider Amutio Maite Artetxe Gartzen lopez Javier Bilbao Martin Olazar 巴斯克大学化工系西班牙巴斯克科学基金会西班牙

对生物质热解挥发物蒸汽重整反应过程中催化剂的失活过程和主要机理进行了研究.在圆锥形喷动床反应器中于500℃进行生物质热解,随后在固定床反应器中于600℃进行重整反应;同时在不同轴向位置分析了催化剂位置对重整反应器的影响.采用N_... 详细信息

对生物质热解挥发物蒸汽重整反应过程中催化剂的失活过程和主要机理进行了研究.在圆锥形喷动床反应器中于500℃进行生物质热解,随后在固定床反应器中于600℃进行重整反应;同时在不同轴向位置分析了催化剂位置对重整反应器的影响.采用N_(2)吸附-脱附、X射线衍射、扫描电镜、透射电镜、程序升温氧化、拉曼光谱和傅里叶变换红外光谱对失活样品进行表征.结果表明,焦炭沉积是初始催化剂活性衰减的主要原因,且没有观察到镍位点的烧结或氧化.随着反应的进行,沿着重整催化床观察到失活情况,焦炭沉积于催化剂内,其性质和组成取决于到达床中每个轴向位置的挥发物组成.在催化床的入口部分,焦炭沉积在Ni位点上,并且具有一定的含氧量.在更深的轴向床位置,催化剂与挥发性物质接触,该挥发性物质的组成已经明显改变,从而形成具有石墨化程度更高的焦炭,并且形成更多的缩合聚芳烃化合物.此外,沉积在所有失活样品上的焦炭没有呈现任何特定的形态,这也表明,无论所处的催化床位置和反应时间,焦炭均呈现无定形结构.

关键词：生物质热解蒸汽重整失活积碳氢气生物油