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Many-body dissipative particle dynamics with energy conservation:temperature-dependent long-term attractive interaction

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Applied Mathematics and Mechanics(English Edition) 2022年第4期43卷 497-506页

作者： Jie LI Kaixuan ZHANG Chensen LIN lanlan xiao Yang LIU Shuo CHEN School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China Institute of Biomechanics and Medical Engineering AMLDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084China School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Heat and mass transfer during the process of liquid droplet dynamic behaviors has attracted much attention in *** mesoscopic scale,numerical simulations of liquid droplets motion,such as impacting,sliding,and coalescence,have been widely studied by using the particle-based method named many-body dissipative particle dynamics(MDPD).However,the detailed information on heat transfer needs further *** paper develops a modified MDPD with energy conservation(MDPDE)by introducing a temperature-dependent long-term attractive *** fitting or deriving the expressions of the strength of the attractive force,the exponent of the weight function in the dissipative force,and the mesoscopic heat friction coefficient about temperature,we calculate the viscosity,self-diffusivity,thermal conductivity,and surface tension,and obtain the Schmidt number Sc,the Prandtl number P r,and the Ohnesorge number Oh for 273 K to 373 *** simulation data of MDPDE coincide well with the experimental data of water,indicating that our model can be used to simulate the dynamic behaviors of liquid ***,we compare the equilibrium contact angle of droplets wetting on solid surfaces with that calculated from three interfacial tensions by MDPDE *** coincident results not only stand for the validation of Young’s equation at mesoscale,but manifest the reliability of our MDPDE model and applicability to the cases with free *** model can be extended to study the multiphase flow withcomplex heat and mass transfer.

关键词： surface tension Young’s equation equilibrium contact angle many-body dissipative particle dynamics with energy conservation(MDPDE)

Characteristics of Elderly-Onset Rheumatoid Arthritis Patients With COVID-19

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Infectious Microbes & Diseases 2024年第1期6卷 36-42页

作者： lanlan xiao Xinlei Ma Jinzhi Wu Junyu Liang Weiqian Chen Jin Lin Department of Rheumatology the First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

This study aimed to investigate the clinical characteristics of elderly-onset rheumatoid arthritis(EORA)patients with *** ret-rospectively enrolled EORA patients diagnosed with COVID-19 from December 2022 through February 2023 and followed them *** characteristics of the patients and clinical data on COVID-19 were collected,and EORA-related data at the onset of rheu-matoid arthritis and during COVID-19 episodes were evaluated.A total of 102 EORA outpatients were enrolled and stratified into the COVID-19 group(n=60)and the non–COVID-19 group(n=42).In the COVID-19 group,56(93.3%)had symptoms,8(13.3%)had viral pneumonia,and 4(6.7%)developed severe *** logistic regression analysis showed that lack of COVID-19 vac-cination(P=0.016 and P=0.030,respectively)and having interstitial lung disease(P=0.013 and P=0.001,respectively)were inde-pendent risk factors for viral pneumonia and severe *** with the general population,EORA patients did not show significantly higher susceptibility to COVID-19 or a higher risk of severe ***,EORA patients with interstitial lung disease require special consideration during COVID-19 episodes.

关键词： COVID-19 elderly-onset rheumatoid arthritis COVID-19 vaccine interstitial lung disease

Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway in vivo and in vitro

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Frontiers of Medicine 2023年第3期17卷 534-548页

作者： Fen Zhang lanlan xiao Ya Yang Menghao Zhou Yalei Zhao Zhongyang Xie xiaoxi Ouyang Feiyang Ji Shima Tang Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Infectious Diseases First Affiliated Teaching HospitalSchool of MedicineXi'an Jiaotong UniversityXi'an 710049China Department of Surgical Oncology Sir Run Run Shaw HospitalZhejiang UniversityZhejiangHangzhou 310016China

Autoimmune hepatitis(AIH)is a severe globally distributed liver disease that could occur at any *** menstrual blood-derived stem cells(MenSCs)have shown therapeutic effect in acute lung injury and liver ***,their role in the curative effect of AIH remains ***,a classic AIH mouse model was constructed through intravenous injection with concanavalin A(Con A).MenSCs were intravenously injected while Con A injection in the treatment *** results showed that the mortality by Con A injection was significantly decreased by MenSCs treatment and liver function tests and histological analysis were also *** results of phosphoproteomic analysis and RNA-seq revealed that MenSCs improved AIH,mainly by apoptosis and c-Jun N-terminal kinase/mitogen-activated protein signaling *** analysis demonstrated that the protein expression of cleaved caspase 3 was increased by Con A injection and reduced by MenSCs transplantation,consistent with the TUNEL staining *** AML12 co-culture system and JNK inhibitor(SP600125)were used to verify the JNK/MAPK and apoptosis signaling *** findings suggested that MenSCs could be a promising strategy for AIH.

关键词： autoimmune hepatitis(AIH) concanavalin A(Con A) human menstrual blood-derived stem cells(MenSCs) apoptosis mitogen-activated protein kinase(MAPK)

1,5-Anhydroglucitol Predicts Mortality in Patients with HBV-Related Acute-on-chronic Liver Failure

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 651-659页

作者： Lingjian Zhang Yalei Zhao Zhongyang Xie lanlan xiao Qingqing Hu Qian Li Shima Tang Jie Wang Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangChina

Background and Aims:1,5-Anhydroglucitol(1,5AG)activ-ity has been reported in chronic liver *** B vi-rus(HBV)-related acute-on-chronic liver failure(HBV-ACLF)patients have a high *** aimed to discover the re-lationship between serum 1,5AG and the prognosis of ***:Serum 1,5AG levels were determined in 333 patients with HBV-ACLF,300 without diabetes were allo-cated to derivation(n=206)and validation cohorts(n=94),and 33 were recruited to evaluate 1,5AG in those with *** patients with chronic hepatitis B,40 with liver cir-rhosis,and 40 healthy people were controls in the validation ***:In the derivation and validation cohorts,serum 1,5AG levels were significantly lower in nonsurvivors than in *** AUC of 1,5AG for 28-day mortality was *** patients with diabetes,serum 1,5AG levels were also significantly lower in nonsurvivors than in *** multivariate Cox regression analysis,serum 1,5AG levels were independently associated with 28-day mortal-ity.A novel predictive model(ACTIG)based on 1,5AG,age,TB,cholesterol,and INR was derived to predict *** ACTIG,the AUC for 28-day mortality was 0.914,which was superior to some prognostic score *** was also comparable to those prognostic score models in pre-dicting 6-month *** mice with D-galactosamine/lipopolysaccharide-induced liver failure,1,5AG levels were significantly reduced in serum and significantly increased in urine and liver ***:Serum 1,5AG levels are a promising predictor of short-term mortality in HBV-ACLF *** 1,5AG distribution changed in mice with D-galactosamine/lipopolysaccharide-induced liver failure.

关键词： Acute-on-chronic liver failure 1,5-anhydroglucitol Prognosis

Value of Metagenomic Next-Generation Sequencing in Clinical Diagnosis and Targeted Therapy of Nontuberculous Mycobacteria Infection

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Infectious Microbes & Diseases 2024年第2期6卷 100-102页

作者： lanlan xiao Shuai Zhao Hongjuan Wang Liang Yu Jing Guo Xinyi Wu xiaowei Xu State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Affiliated Hospital of Nantong University NantongChina Zhejiang University City College HangzhouChina

The purpose of this study was to assess the value of metagenomic next-generation sequencing(mNGS)for rapid diagnosis of diseases caused by nontuberculous mycobacteria(NTM).We retrospectively reviewed four NTM-infected cases diagnosed by smear microscopy,mycobacterial culture and mNGS *** found that the mNGS method not only had a shorter detection turnaround time(3–4 days)than Mycobacterium culture(15–20 days)but also had higher sensitivity and specificity to identify NTM compared with conventional detection *** addition,mNGS was able to identify coinfections by NTM and other bacteria,fungi or ***,diagnosis of NTM by mNGS can provide timely and precise guidance for subsequent clinical treatment of NTM infections.

关键词： nontuberculous mycobacteria metagenomic next-generation sequencing mycobacterial culture turnaround time

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拜登气候新政初探

现代国际关系 2021年第5期 41-50,61页

作者：肖兰兰南京理工大学马克思主义学院

气候政策一直是美国总统拜登竞选时期和入主白宫以后的核心议题。拜登气候新政是影响最为深远的美国气候政策议程,它将气候变化问题置于美国国家安全与对外政策的核心,将长期战略目标与具体政策建议相结合,采取"全政府"合力应对的方式,... 详细信息

气候政策一直是美国总统拜登竞选时期和入主白宫以后的核心议题。拜登气候新政是影响最为深远的美国气候政策议程,它将气候变化问题置于美国国家安全与对外政策的核心,将长期战略目标与具体政策建议相结合,采取"全政府"合力应对的方式,气候实用主义色彩浓厚,重视多边主义并强调发挥美国的领导作用。拜登气候新政有助于促进全球气候治理《巴黎协定》及其实施细则的执行与落实,完善以《联合国气候变化框架公约》和《巴黎协定》为核心的全球气候治理机制,推动全球气候治理新的领导格局的形成,并提升全球气候科学和技术的研发力度。拜登气候新政的实施及效果无疑受到很多因素的制约,其中包括国会的掣肘,行政命令实施的易中断性和美国司法系统的相对保守性,拜登气候政策自身的减排力度和可信度以及拜登气候多边主义能否真正贯彻执行等。对中国来说,如何动态把握好竞争与合作是未来推进中美气候合作应予优先考虑的关键问题。

关键词：拜登气候新政全球气候治理 “全政府” 气候峰会

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对欧盟后哥本哈根国际气候政策的战略认知

社会科学 2010年第10期 35-42页

作者：肖兰兰武汉大学国际问题研究院

欧盟后哥本哈根国际气候政策是对其京都时期气候政策的延续和拓展,其应对理念、目标设定及措施实施都具有较强的可操作性。但作为主权国家林立的无政府状态下的一种战略博弈,它不可避免地带有深刻的利益内涵。对欧盟后哥本哈根国际气候... 详细信息

欧盟后哥本哈根国际气候政策是对其京都时期气候政策的延续和拓展,其应对理念、目标设定及措施实施都具有较强的可操作性。但作为主权国家林立的无政府状态下的一种战略博弈,它不可避免地带有深刻的利益内涵。对欧盟后哥本哈根国际气候政策的正确认知和客观评价不仅对我们真切把握欧盟的气候战略至关重要,而且对国际社会探寻后哥本哈根气候合作之路亦是不可或缺。

关键词：欧盟后哥本哈根国际气候政策

习近平关于共谋全球生态文明建设重要论述的科学体系

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思想教育研究 2023年第10期 3-9页

作者：肖兰兰南京理工大学马克思主义学院江苏南京210094

习近平关于共谋全球生态文明建设重要论述是习近平生态文明思想体系的重要组成部分。这一重要论述根植于全球生态环境治理对理论的现实需求,针对人类社会面临的严峻生态环境挑战,系统分析和探讨了共谋全球生态文明建设的理念基础、目标... 详细信息

习近平关于共谋全球生态文明建设重要论述是习近平生态文明思想体系的重要组成部分。这一重要论述根植于全球生态环境治理对理论的现实需求,针对人类社会面临的严峻生态环境挑战,系统分析和探讨了共谋全球生态文明建设的理念基础、目标指向、依赖力量、行动原则和行动方式等一系列重大问题,形成了具有严谨逻辑结构、系统理论框架和丰富思想内涵的科学体系。该重要论述是针对当前全球生态环境领域“世界怎么了,我们怎么办”给出的中国方案,是中国式现代化探索在全球生态环境治理领域达到一定高度的重要标志,为有效应对和化解日趋严峻的全球生态环境危机提供了方向指引。

关键词：共谋全球生态文明建设人与自然和谐共生共商共建共享多边主义科学体系

碳中和背景下的全球气候治理:中国推动构建人类命运共同体的生态路径

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福建师范大学学报（哲学社会科学版） 2022年第2期 33-42,169,170页

作者：肖兰兰南京理工大学马克思主义学院江苏南京210094

当前大多学术研究着重聚焦于把人类命运共同体作为背景因素或自变量,探讨其对全球气候治理的影响,而对两者关系的“反向”研究,即全球气候治理如何影响人类命运共同体的构建却鲜有涉及。鉴于全球气候治理对整个人类社会发展方式的规塑... 详细信息

当前大多学术研究着重聚焦于把人类命运共同体作为背景因素或自变量,探讨其对全球气候治理的影响,而对两者关系的“反向”研究,即全球气候治理如何影响人类命运共同体的构建却鲜有涉及。鉴于全球气候治理对整个人类社会发展方式的规塑和约束,它对人类命运共同体的构建背景与基础、价值共识以及方向与路径无疑会产生重要而深远的影响。全球气候变化影响的日益加剧使得世界各国客观上共同命运情势更加强烈,全球气候治理已经成为构建人类命运共同体的重要基础与背景,不仅巩固和增强了人类社会共同命运的价值共识,而且从政治、经济、安全、文化和生态五个层面对人类命运共同体“五个世界”的构建提供了具体而现实的方向与路径。当前,碳中和已经成为全球性潮流。在此背景下,中国要通过积极推进碳中和目标、不断贡献中国智慧、积极参与全球气候制度建设、加强绿色丝绸之路建设以及加强与发达国家的气候外交等方式,不断推动人类命运共同体“五个世界”的构建。

关键词：碳中和全球气候治理人类命运共同体价值共同体 “五个世界”