1,5-Anhydroglucitol Predicts Mortality in Patients with HBV-Related Acute-on-chronic Liver Failure
作者机构：State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangChina
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2022年第10卷第4期
页 面：651-659页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This study was supported by Key research and development project of Department of Science and Technology of Zhejiang Province(2017C03051) Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.81721091) the National Natural Science Foundation of China(81900572)
主 题：Acute-on-chronic liver failure 1,5-anhydroglucitol Prognosis
摘 要：Background and Aims:1,5-Anhydroglucitol(1,5AG)activ-ity has been reported in chronic liver *** B vi-rus(HBV)-related acute-on-chronic liver failure(HBV-ACLF)patients have a high *** aimed to discover the re-lationship between serum 1,5AG and the prognosis of ***:Serum 1,5AG levels were determined in 333 patients with HBV-ACLF,300 without diabetes were allo-cated to derivation(n=206)and validation cohorts(n=94),and 33 were recruited to evaluate 1,5AG in those with *** patients with chronic hepatitis B,40 with liver cir-rhosis,and 40 healthy people were controls in the validation ***:In the derivation and validation cohorts,serum 1,5AG levels were significantly lower in nonsurvivors than in *** AUC of 1,5AG for 28-day mortality was *** patients with diabetes,serum 1,5AG levels were also significantly lower in nonsurvivors than in *** multivariate Cox regression analysis,serum 1,5AG levels were independently associated with 28-day mortal-ity.A novel predictive model(ACTIG)based on 1,5AG,age,TB,cholesterol,and INR was derived to predict *** ACTIG,the AUC for 28-day mortality was 0.914,which was superior to some prognostic score *** was also comparable to those prognostic score models in pre-dicting 6-month *** mice with D-galactosamine/lipopolysaccharide-induced liver failure,1,5AG levels were significantly reduced in serum and significantly increased in urine and liver ***:Serum 1,5AG levels are a promising predictor of short-term mortality in HBV-ACLF *** 1,5AG distribution changed in mice with D-galactosamine/lipopolysaccharide-induced liver failure.
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