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基于网络药理学与分子对接探索头花蓼抗肺炎的作用机制

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贵州科学 2024年第5期42卷 23-28页

作者：姜特张祥李来来柴艺汇蒲翔何兰兰卢礼平张丽艳贵州中医药大学贵州贵阳550025 贵州威门药业股份有限公司贵州贵阳550000

目的:运用网络药理学与分子对接探索头花蓼抗肺炎的作用机制。方法:通过查阅文献收集头花蓼的化学成分,在chemdraw软件绘制分子结构图,通过PharmMapper数据库选择(NF)≥0.9的靶点蛋白获取潜在化合物的靶点;运用GeneCards、OMIM、DRUGBAN... 详细信息

目的:运用网络药理学与分子对接探索头花蓼抗肺炎的作用机制。方法:通过查阅文献收集头花蓼的化学成分,在chemdraw软件绘制分子结构图,通过PharmMapper数据库选择(NF)≥0.9的靶点蛋白获取潜在化合物的靶点;运用GeneCards、OMIM、DRUGBANK数据库以获得肺炎核心靶点;使用Metascape平台将头花蓼活性成分靶点和肺炎核心靶点交集进行GO和KEGG富集分析;使用Cytoscape3.8.2软件构建成分-靶点-通路图,AutoDock Tools 1.5.7、Pymol软件进行分子对接。结果:头花蓼中筛选获得38个活性成分、116个成分靶点、6个核心靶点;KEGG富集分析结果主要集中在IL-17信号通路、MAPK信号通路、TNF信号通路等;分子对接结果显示ALB、EGFR、CASP3、MAPK1、MAPK14、SCR与头花蓼主要化学成分的结合活性较好。结论:头花蓼中的核心化合物槲皮素、木犀草素、儿茶素等,可能通过ALB、EGFR、CASP3、MAPK1、MAPK14、SCR等靶点作用于IL-17、MAPK、TNF信号通路,从而达到治疗肺炎的作用。

关键词：头花蓼网络药理肺炎分子对接作用机制

Physical and Mechanical Properties of Catalpa bungei Clones and Estimation of the Properties by Near-Infrared Spectroscopy

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Journal of Renewable Materials 2022年第12期10卷 3285-3302页

作者： Rui Wang lanlan Shi Yurong Wang Research Institute of Wood Industry Chinese Academy of ForestryBeijing100091China

Air-dry density,modulus of rupture(MOR),modulus of elasticity(MOE),compressive strength parallel to grain,and hardness of Catalpa bungei clones were investigated in this study with feasibility of predicting these properties by near infrared(NIR)*** best candidate Luoqiu 3'has been selected from three clones based on wood physical and mechanical property *** values of wood physical and mechanical properties have been found in the corewood compared to the *** were significant positive correlations between the air-dry density and mechanical *** from Cross section for air dry density,compressive strength parallel to grain,and hardness yielded prediction models with better effects,along with the best MOR and MOE modeling effects resulted from average sections'spectra *** scatter correction(MSC)+Savitzky-Golay(S-G)smoothing method has been proved to be the most applicable *** addition,the predictions from five point sampling method were slightly better than three point ***,results suggest NIR spectroscopy was viable to predict the physical and mechanical properties of C bungei dones with methods developed in this study proved effective in preliminary screening.

关键词： C.bungei wood density mechanical properties near-infrared spectroscopy

Highly stable aqueous rechargeable Zn-ion battery:The synergistic effect between NaV_(6)O_(15) and V_(2)O_(5) in skin-core heterostructured nanowires cathode

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Journal of Energy Chemistry 2021年第4期30卷 25-33页

作者： lanlan Fan Zhenhuan Li Weimin Kang Bowen Cheng State Key Laboratory of Separation Membranes and Membrane Processes National Center for International Joint Research on Separation MembranesTiangong UniversityTianjin 300387China School of Materials Science and EngineeringTiangong UniversityTianjin 300387China School of Textiles Tiangong UniversityTianjin 300387China

The aqueous rechargeable Zn-ion batteries based on the safe,low cost and environmental benignity aqueous electrolytes are one of the most compelling candidates for large scale energy storage ***,pursuing suitable insertion materials may be a great challenge due to the strong electrostatic interaction between Zn^(^(2+))and cathode ***,a novel NaV_(6)O_(15)/V_(2)O_(5) skin-core heterostructure nanowire is reported via a one-step hydrothermal method and subsequent calcination for high-stable aqueous Zn-ion batteries(ZIBs).The NaV_(6)O_(15)/V_(2)O_(5) cathode delivers high specific capacity of 390 m Ah/g at 0.3 A/g and outstanding cycling stability of 267 m Ah/g at 5 A/g with high capacity retention over 92.3%after 3000 *** superior electrochemical performances are attributed to the synergistic effect of skin-core heterostructured NaV_(6)O_(15)/V_(2)O_(5),in which the sheath of NaV_(6)O_(15) possesses high stability and conductivity,and the V_(2)O_(5) endows high specific ***,the heterojunction structure not only accelerates intercalation kinetics of Zn^(2+)transport but also further consolidates the stability of the layers of V_(2)O_(5) during the cyclic *** work provides a new perspective in developing feasible insertion materials for rechargeable aqueous ZIBs.

关键词： Aqueous zinc ion battery heterojunction structure High specific capacity Stable long cycle Synergistic effect

The prevalence,origin,and prevention of six human coronaviruses

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Virologica Sinica 2016年第1期31卷 94-99页

作者： lanlan Liu Tao Wang Jiahai Lu School of Public health Sun Yat-sen UniversityGuangzhou 510080China Key Laboratory for Tropical Disease Control Sun Yat-sen UniversityMinistry of EducationGuangzhou510080China Research Center for Prevention and Control of Infectious Diseases of Guangdong Province Guangzhou510080China One health Center Guangzhou 510080China Zhongshan Centers for Disease Control and Prevention Zhongshan 528400China Zhongshan Research Institute Zhongshan 528400China

CORONAVIRUSES Coronaviruses（CoVs）are a large group of viruses found in many species of animals around the world,particularly bats and wild *** result in various clinical manifestations ranging from asymptomatic resp... 详细信息

关键词： prevalence birds enteric origin prevention vaccines asymptomatic reservoir sequenced younger

Dissociation characteristics of methane hydrate using depressurization combined with thermal stimulation

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Chinese Journal of Chemical Engineering 2019年第9期27卷 2089-2098页

作者： Mingjun Yang Zhanquan Ma Yi Gao lanlan Jiang Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education Dalian University of Technology

Methane hydrate is considered as a potential energy source in the future due to its abundant reserves and high energy *** investigate the influence of initial hydrate saturation,production pressure,and the temperature of thermal stimulation on gas production rate and cumulative gas production percentage,we conducted the methane hydrate dissociation experiments using depressurization,thermal stimulation and a combination of two methods in this *** is found that when the gas production pressures are the same,the higher the hydrate initial saturation,the greater change in hydrate reservoir ***,it is easier to appear the phenomenon of icing and hydrate reformation when the hydrate saturation is *** example,the reservoir temperature dropped to below zero in depressurization process when the hydrate saturation was about 37%.However,the same phenomenon didn’t appear as the saturation was about 12%.This may be due to more free gas in the reservoir with hydrate saturated of 37%.We also find that the temperature variation of reservoir can be reduced effectively by combination of depressurization and thermal stimulation *** the average gas production rate is highest with combined method in the *** the pressure of gas production is 2 MPa,compared with depressurization,the average of gas production can increase 54%when the combined method is *** efficiency of gas production is very low when thermal stimulation was used *** the temperature of thermal stimulation is 11℃,the average rate of gas production in the experiment of thermal stimulation is less than 1/3 of that in the experiment of the combined method.

关键词： Methane hydrate Depressurization Thermal stimulation Dissociation characteristics

A Novel Synergy Selection Mechanism among Multi- Devices for Ubiquitous Services

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China Communications 2014年第A1期11卷 128-134页

作者： RUI lanlan MAO Xiyue QIU Xuesong StateKeyLaboratoryofNetworkingandSwitchingTechnology BeijingUniversityofPostsandTelecommunicationsBeijingChina

It is a challenge to select an optimal set of devices to accomplish a graph-based ubiquitous service and execute it continuously under the circumstances of dynamic environments and limited device capability. We elaborate a Synergy- aware Selection Mechanism （SSM） considering synergetic among devices. In the SSM, we design a distributed algorithm to integrate the devices and a dynamic updating weight method. The simulation results show that SSM can make devices composed together to ensure the continuity and smoothness of service

关键词： ubiquitous service synergy-aware quality of service sustainability

小牛血清去蛋白注射液对伽玛刀治疗NSCLC的药效研究

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西南国防医药 2013年第4期23卷 382-385页

作者：李迎春张小玉王卓敏何兰兰陈成宏任丽钟国成解放军452医院核医学科解放军452医院放疗科解放军452医院肿瘤科

目的研究小牛血清去蛋白注射液(DCBSI)联合伽玛刀治疗非小细胞肺癌(NSCLC)的临床疗效。方法选择诊断明确的NSCLC患者54例,随机分为:对照组27例,给予放疗及常规护理;联合组27例,除接受与对照组相同的治疗外,还给予DCBSI静脉滴注。比较两... 详细信息

目的研究小牛血清去蛋白注射液(DCBSI)联合伽玛刀治疗非小细胞肺癌(NSCLC)的临床疗效。方法选择诊断明确的NSCLC患者54例,随机分为:对照组27例,给予放疗及常规护理;联合组27例,除接受与对照组相同的治疗外,还给予DCBSI静脉滴注。比较两组患者的放射不良反应、免疫状态、疼痛评分、生活质量(QOL)及生存时间。结果治疗后联合组患者的不良反应发生率、免疫指标、疼痛、QOL、生存时间等均优于对照组(P<0.05)。结论 DCBSI能减轻NSCLC患者的放疗副反应,改善放疗患者的免疫状态和QOL,提高伽玛刀的临床疗效。

关键词：非小细胞肺癌小牛血清去蛋白注射液伽玛刀不良反应

Linkages between woody plant proliferation dynamics and plant physiological traits in southwestern North America

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Journal of Plant Ecology 2012年第4期5卷 407-416页

作者： Nan Liu lanlan Guan Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China South China Botanical Garden Chinese Academy of SciencesXingke Road 723Tianhe DistrictGuangzhou 510650China

Aims Woody plant encroachments in arid and semiarid ecosystems are widely reported but the physiological mechanisms still need to be further *** the current study,we aim to determine whether differences in leaf physiological traits help explain grassland susceptibility to woody plant encroachment and whether distinctive physiological adaptations allow some shrub species to invade *** We compared physiological traits(photosynthesis,leaf water status,pigment compositions and leaf antioxidant capacities)of six species representing three functional groups:woody encroachers(Prosopis velutina,Larrea tridentata),woody non-encroachers(Acacia greggii,Lycium fremontii)and C4 grasses(Bouteloua curtipendula,Bouteloua barbata)which are naturally growing in a botanical garden in University of Arizona,*** Findings We infer that ***(encroacher)but not *** or ***(non-encroachers)is encroaching in grasslands because the former species has higher water and light utilization efficiencies(instantaneous water use efficiency,instantaneous light use efficiency,and Fv/Fm).The extremely high carotenoid and total antioxidant capacity in its leaves appears to help the shrub ***(encroacher)survive high ambient oxidative damage caused by both drought and high light stresses in this *** two C4 grass species,*** and ***,grow well in the arid ecosystem but may be susceptible to disturbances.

关键词： shrub encroachment C4grass physiological characteristics leaf traits

小牛血清去蛋白注射液防治鼻咽癌放疗不良反应的疗效观察

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现代肿瘤医学 2013年第3期21卷 512-515页

作者：张小玉李迎春任丽王卓敏何兰兰陈成宏钟国成解放军第452医院核医学科四川成都610021 解放军第452医院放疗科四川成都610021 解放军第452医院肿瘤科四川成都610021

目的:研究小牛血清去蛋白注射液(DCBSI)对鼻咽癌放疗不良反应的临床疗效。方法:选择诊断明确的鼻咽癌患者72例,随机分为两组:对照组36例,给予放疗及常规护理;小牛组36例,除接受与对照相同的治疗外,还给予静脉滴注DCBSI,比较两组放疗不... 详细信息

目的:研究小牛血清去蛋白注射液(DCBSI)对鼻咽癌放疗不良反应的临床疗效。方法:选择诊断明确的鼻咽癌患者72例,随机分为两组:对照组36例,给予放疗及常规护理;小牛组36例,除接受与对照相同的治疗外,还给予静脉滴注DCBSI,比较两组放疗不良反应,免疫状态及生活质量(QOL)。结果:小牛组患者的放射性皮肤损伤情况明显好于对照组,治疗后小牛组患者的免疫状态、疼痛评分及QOL均优于对照组(P<0.05)。结论:DCBSI能减轻皮肤放射性损伤,促进创面愈合,提高放疗患者的免疫状态和QOL。

关键词：小牛血清去蛋白注射液鼻咽癌放射治疗不良反应