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The Consistencies of Y‑Chromosomal and Autosomal Continental Ancestry Varying among Haplogroups

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Journal of Forensic Science and Medicine 2016年第4期2卷 229-232页

作者： Chuan-Chao Wang Lei Shang Hui‑Yuan Yeh lan‑hai wei Department of Genetics Harvard Medical SchoolBostonMAUSA Department of Archaeogenetics Max Planck Institute for the Science of Human HistoryJenaGermany Key Laboratory of Forensic Genetics Institute of Forensic ScienceMinistry of Public SecurityBeijingChina School of Humanities and Social Sciences Nanyang Technological UniversitySingapore State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology Collaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghaiChina

The Y‑chromosome has been widely used in ancestry inference based on its region‑specific haplogroup ***,there is always a debate on how informative such a single marker is for inferring an individual’s genetic ***,we compared genetic ancestry inferences at continental level made by Y‑chromosomal haplogroups to those made by autosomal single‑nucleotide polymorphisms in 1230 samples of Affymetrix Human Origins *** highest ancestry proportions of a majority of individuals match the highest average continental‑ancestry proportions in haplogroups A,B,D,H,I,K,L,T,O,and *** high consistencies have not been observed in haplogroups E,C,G,J,N,Q,and R,but in some of their sublineages,such as E1a,E1b1a1,E1b1b1b1a,E2b1a,J1a2b,Q1a1a1,Q1a2a1a1,R1b1a2a1a,and *** the consistencies of Y‑chromosomal and autosomal continental ancestry vary among haplogroups,Y‑chromosome could provide valuable clues for individual’s continental ancestry.

关键词： Ancestry inference autosomal single‑nucleotide polymorphism Y‑chromosome

Ancient Y-DNA with reconstructed phylogeny provides insights into the demographic history of paternal haplogroup N1a2-F1360

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Journal of Genetics and Genomics 2021年第12期48卷 1130-1133页

作者： Pengcheng Ma Xuan Yang Shi Yan Chunxiang Li Shizhu Gao Binghua Han Kan Hou Martine Robbeets lan-hai wei Yinqiu Cui School of Life Sciences Jilin UniversityChangchun 130012China School of Ethnology and Sociology Minzu University of ChinaBeijing 100081China College of Pharmacia Sciences Jilin UniversityChangchun 130021China Shanxi Provincial Institute of Archaeology Taiyuan 030001China School of History and Culture Shanxi UniversityTaiyuan 030006China Max Planck Institute for the Science of Human History Jena 07745Germany Department of Anthropology and Ethnology Institute of AnthropologyXiamen UniversityXiamen 361005China B&R International Joint Laboratory for Eurasian Anthropology Fudan UniversityShanghai 200438China Research Center for Chinese Frontier Archaeology of Jilin University Jilin UniversityChangchun 130012China

Northern Eurasia (nEA) has been considered crucial for the dispersal of the anatomically modern human (AMH) in recent *** the Last Glacial Maximum (LGM),ancient populations from different locations were redistributed throughout the region (Sikora et al.,2019;Yu et al.,2020;Kílínc et al.,2021;Mao et al.,2021).It is suggested that the emergence of many diverse ethnolinguistic groups.

关键词： insight phylogeny

High-performance Si/VO_(2)-nanorod heterojunction photodetector based on photothermoelectric effect for detecting human radiation

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Rare Metals 2024年第3期43卷 1177-1185页

作者： Fu-hai Guo lan-Zhong Hao wei-Zhuo Yu Si-Qi Li Guan-Chu Liu Jing-Yi Hao Yun-Jie Liu College of Science China University of PetroleumQingdao266580China School of Materials Science and Engineering China University of PetroleumQingdao266580China

As a typical candidate of optoelectronic materials,vanadium dioxide(VO_(2))has wide applications in photodetectors(PDs),but is still challenging in largely enhancing the photodetecting performance for low-power human ***,high-performance Si/VO_(2)nanorods(NRs)heterojunction PDs based on the photothermoelectric(PTE)effect are *** uniform VO_(2)-NRs array films were deposited on Si by using magnetron sputtering technique,and a Si/VO_(2)heterojunctions were *** device exhibits a four-stage photoresponse and broadband photoresponse from ultraviolet to long-wavelength *** from the unique nanorods structure and the strong PTE effect,the fabricated device exhibits a large enhancement of the photodetecting performance,showing an ultrahigh photodetectivity of 1.6×10^(13)Jones and ultrafast response rates with a risingedge time of~65.0μs,three orders of magnitude higher than other VO_(2)-based ***,the device exhibits unique abilities to detect human radiation even when the human fingers are far away from the device surface up to 10.0 ***,the fabricated Si/VO_(2)devices can also be applied as breath sensors to distinguish different breathing *** results supply an effective route to design high-performance photodetectors toward detecting human thermal radiation and respiration.

关键词： Vanadium dioxide Heterojunction Photodetector Photothermoelectric Human radiation and respiration sensing

Technical review of electric vehicle charging distribution models with considering driver behaviors impacts

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 643-666页

作者： wei Lin Heng wei lan Yang Xiangmo Zhao ART-EngineS Transportation Research Laboratory Department of Civil and Architectural Engineering and Construction ManagementUniversity of CincinnatiCincinnatiOH 45221USA School of Information Engineering Chang'an UniversityXi'an 710064China

Amassive market penetration of electric vehicles(EVs)associated with nonnegligible energy consumption and environmental issues has imposed a big challenge on evaluating electrical power distribution and related transportation facilities improvement in response to the largescale EV charging service *** deployment of EV charging stations including location and determination ofnumber of slowcharging stations and fast charging stationshas become an emerging concern and one of the most pressing needs in *** paper conducts a comprehensive survey of EV charging demand and distribution models with consideration of realistic driver behaviors *** is currently a shortage in academic literature,but indeed has drawn practical attention in the strategic planning *** address the need,this paper presents an in-depth literature review of relevant studies that have identified different types of EV charging facilities,needs or concerns that are considered into EV charging demand and distribution modeling,alongside critical impacting factor identification,mathematical relationshipsof the contributing factorsandEVchargingdemand and distribution *** findings from the current literature are summarized with strategies for optimized plan of charging station deployments(i.e.,location and related number of charging station),in an attempt to provide a valuable reference for interested readers.

关键词： Charging demand estimation Strategic charging station deployment Electric vehicle Driver behavior

Recent progress in photocatalytic NAD(P)H regeneration for photocatalytic-enzymatic-coupling system

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 1-24页

作者： wei lan Maodi Wang Huicong Dai Qihua Yang Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Zhejiang Key Laboratory for Reactive Chemistry on Solid SurfacesInstitute of Physical ChemistryZhejiang Normal UniversityJinhua 321004China

The enzymatic redox reactions in natural photosynthesis rely much on the participation of cofactors,with reduced nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate(NADH/NADPH)or their oxidized form(NAD+/NADP+)as an important redox *** photocatalytic regeneration of expensive and unstable NADH/NADPH in vitro is an important process in enzymatic reduction and has attracted much research *** different types of photocatalysts have been developed for photocatalytic NADH/NADPH regeneration,the efficiency is still relatively *** elucidate the key factors affecting the performance of photocatalytic NADH/NADPH regeneration is helpful to rationally design the photocatalyst and improve the photocatalytic *** this paper,we overview the recent progress in photocatalytic NADH/NADPH regeneration with the focus on the strategies to improve the visible light adsorption,the charge separation and migration efficiency,as well as the surface reaction,which jointly determine the overall photocatalytic regeneration *** potential development of photocatalytic NADH/NADPH regeneration and photocatalyticenzymatic-coupling system is prospected finally.

关键词： photocatalytic-enzymatic coupling NAD(P)H regeneration photocatalysis efficiency

Traditional Chinese medicines derived natural inhibitors of ferroptosis on ischemic stroke

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Chinese Journal of Natural Medicines 2024年第8期22卷 746-755页

作者： WANG Yongliang lan Xiaobing LIU Ning MA Lin DU Juan wei wei hai Dongmei WU Jing YU Jianqiang LIU Yue School of Pharmacy Ningxia Medical UniversityYinchuan 750000China Ningxia Key Laboratory of Drug Development and Generic Drug Research Ningxia Medical UniversityYinchuan 750000China Ningxia Characteristic Traditional Chinese Medicine Modern Engineering Research Center Ningxia Medical UniversityYinchuan 750000China College of Basic Medical Sciences Ningxia Medical UniversityYinchuan 750000China

Ischemic stroke(IS)is a globally prevalent cerebrovascular disorder resulting from cerebral vessel occlusion,leading to significant morbidity and *** intricate pathological mechanisms underlying IS complicate the development of effective therapeutic ***,a form of programmed cell death(PCD)characterized by iron overload and accumulation of lipid peroxidation products,has been increasingly recognized as a key contributor to IS *** Chinese medicines(TCMs)have long been utilized in the management of IS,prompting extensive research into their potential as sources of natural ferroptosis *** review investigates the critical role of ferroptosis in IS and provides a comprehensive analysis of current research on natural ferroptosis inhibitors identified in TCMs,aiming to lay a theoretical groundwork for the development of innovative anti-IS therapies.

关键词： Ischemic stroke Traditional Chinese medicines Natural inhibitors Ferroptosis

Exploring the therapeutic potential of Qi Teng Mai Ning recipe in ischemic stroke and vascular cognitive impairment

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Traditional Medicine Research 2024年第10期9卷 21-35页

作者： Jia-Yan Yao Yue-lan Yang wei-Jian Chen hai-Ying Fan Department of Neurosurgery Changxing People’s HospitalChangxing 313100China Department of Ultrasound Medicine Changxing People’s HospitalChangxing 313100China Department of Orthopedics The Fifth Clinical College of Guangzhou University of Chinese MedicineGuangzhou 510095China

Background:This study aims to explore the therapeutic effects of the Qi Teng Mai Ning recipe on ischemic stroke and vascular cognitive impairment through its potential to modulate cellular autophagy,with a focus on identifying its active ingredients and their target ***:The study began with the identification of active ingredients in the Qi Teng Mai Ning *** proceeded to screen the gene expression omnibus database for ischemic stroke and vascular cognitive impairment-associated differentially expressed mRNAs and to identify cellular autophagy-related proteins via the Human Autophagy *** proteins were annotated with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functions and subjected to molecular docking with the recipe’s core active *** vitro cell experiments were conducted on hypoxic HT22 cells,involving CCK8 assay,lentiviral transfection to silence autophagy related 9B(ATG9B),immunofluorescence staining,and qPCR validation to investigate the effects of the recipe on ***:The analysis identified 104 active ingredients targeting 408 proteins and forming a complex ingredient-target *** 55 ischemic stroke-related and 909 vascular cognitive impairment-related differentially expressed mRNAs revealed 14 co-expressed *** docking showed quercetin,kaempferol,myrcene,and conferone as key ingredients targeting autophagy-related *** experiments indicated that the recipe significantly enhanced cell viability under hypoxic conditions,reduced apoptosis,and modulated the expression of autophagy-related factors,thereby decreasing apoptosis rates in HT22 ***:The Qi Teng Mai Ning recipe offers protective effects against ischemic stroke and vascular cognitive impairment by modulating autophagy-related *** efficacy highlights the potential of traditional Chinese medicine in treating these conditions,though further research is needed to fully understand its

关键词： Qi Teng Mai Ning recipe autophagy ischemic stroke vascular cognitive impairment traditional Chinese medicine

Cognitive impairment in cerebral small vessel disease induced by hypertension

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Neural Regeneration Research 2024年第7期19卷 1454-1462页

作者： weipeng wei Denglei Ma Lin Li lan Zhang Department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center Beijing Engineering Research Center for Nervous System DrugsNational Center for Neurological DisordersNational Clinical Research Center for Geriatric DiseasesBeijingChina

Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular *** r,the causal relationship between hypertension and cerebral small vessel disease remains *** has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular *** hypertension and lifestyle factors are associated with risks for stro ke and dementia,and cerebral small vessel disease can cause dementia and *** is the main driver of cerebral small vessel disease,which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction,leukoaraiosis,white matter lesions,and intracerebral hemorrhage,ultimately res ulting in cognitive decline and demonstrating that the brain is the to rget organ of *** review updates our understanding of the pathogenesis of hypertensioninduced cerebral small vessel disease and the res ulting changes in brain structure and function and declines in cognitive *** also discuss drugs to treat cerebral small vessel disease and cognitive impairment.

关键词： blood-brain barrier cerebral small vessel disease cognitive impairment dementia endothelial dysfunction enlarged perivascular space hypertension lacunar infarction neuroinflammation treatment white matter high signal intensity

Editable semiconductor photo-electrodes for sustainable ammonia synthesis

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Nano Research 2024年第4期17卷 3107-3112页

作者： Ning lan Kun Du Erling Zhao wei Zhao Tao Ling Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education Institute of New-EnergySchool of Materials Science and EngineeringTianjin UniversityTianjin 300072China School of Materials Science and Engineering Tianjin Chengjian UniversityTianjin 300384China

Powered by an inexhaustible supply of solar energy,photoelectrochemical(PEC)nitrogen reduction reaction(NRR)provides an ideal solution for the synthesis of green ammonia(NH_(3)).Although great efforts have been made in the past decades,there are still significant challenges in increasing the NH_(3) yields of the PEC-NRR *** addition to the issues of low activity and selectivity similar to electrochemical NRR,the progress of PEC-NRR is also impeded by the limited increase in NH_(3) yields as the electrode is ***,we propose an editable electrode design strategy that parallels unit photo-electrodes to achieve a linear increase in NH_(3) yields with electrode active *** demonstrate that the editable electrode design strategy minimizes the electrode charge transfer resistance,allowing more photo-generated carriers to reach the electrode surface and promote the catalytic *** believe that this editable electrode design strategy provides an avenue to achieve sustainable PEC NH_(3) production.

关键词： editable electrode photoelectrochemical nitrogen reduction reaction parallel electrode ZnSe