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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： lan zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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Digital Filter Algorithm Based on Morphological Lifting Scheme and Median Filter

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IEEE/CAA Journal of Automatica Sinica 2018年第5期5卷 1007-1011页

作者： lan zhang the institute of computer information management inner mongolia university of finance and economicsHohhot 010010 China

Abstract--When the circuits in which electronic products are fitted are disturbed by various interrupting signals, wave distortions occur to the normal voltage signals of these circuits. These wave distortions influence the normal operation and life cycle of electronic products. To eliminate the harmful effects of interrupting signals on electronic products, in this paper, a digital filter algorithm based on morphological lifting scheme and median filter （MLS-MF）, which will be used to filter various interrupting signals existing in the circuits in which electronic products are fitted, is proposed. A variety of interrupting sig- nals have been included in simulation studies, and simulation results have demonstrated the effectiveness and feasibility of the proposed digital filter algorithm in high frequency continuous interference, random background noise and damped oscillatory transient interference filter. Index Terms--Digital filter, lifting scheme, median filter, mor- phology.

关键词： Digital filter lifting scheme median filter morphology

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SUNet++: A Deep Network with Channel Attention for Small-Scale Object Segmentation on 3D Medical Images

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Tsinghua Science and Technology 2023年第4期28卷 628-638页

作者： lan zhang Kejia zhang Haiwei Pan College of Computer Science and Technology Harbin Engineering UniversityHarbin 150001China

As a deep learning network with an encoder-decoder architecture,UNet and its series of improved versions have been widely used in medical image segmentation with great ***,when used to segment targets in 3D medical images such as magnetic resonance imaging(MRI),computed tomography(CT),these models do not model the relevance of images in vertical space,resulting in poor accurate analysis of consecutive slices of the same *** the other hand,the large amount of detail lost during the encoding process makes these models incapable of segmenting small-scale tumor *** at the scene of small-scale target segmentation in 3D medical images,a fully new neural network model SUNet++is proposed on the basis of UNet and UNet++.SUNet++improves the existing models mainly in three aspects:1)the modeling strategy of slice superposition is used to thoroughly excavate the three dimensional information of the data;2)by adding an attention mechanism during the decoding process,small scale targets in the picture are retained and amplified;3)in the up-sampling process,the transposed convolution operation is used to further enhance the effect of the *** order to verify the effect of the model,we collected and produced a dataset of hyperintensity MRI liver-stage images containing over 400 cases of liver *** results on both public and proprietary datasets demonstrate the superiority of SUNet++in small-scale target segmentation of three-dimensional medical images.

关键词： 3D medical images small-scale target segmentation attention mechanism

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Formation and Bioactivity of SrTiO_3 Nanotubes on Titanium by Modified Anodization and Hydrothermal Treatment

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Journal of Materials Science & Technology 2016年第9期32卷 930-936页

作者： Yanni zhang Yong Han lan zhang State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University

SrTiO3 nanotube films with good adhesion strengths to Ti substrates were fabricated by using a hybrid approach with a modified anodization and a hydrothermal treatment （HT）. The effect of Sr^2＋ concentration in HT solutions on the morphologies and phase components of the nanotubes were investigated, the SrTiO3 nanotubes formation mechanism was explored, and the adhesion strengths, hydrophilicity and apatite-forming ability of the SrTiO3 nanotubes were also evaluated. The results demonstrated that with increasing the incorporation of Sr^2＋ into the nanotubes, no obvious changes of the lengths and outer diameters of the nanotubes were observed, but the wall thickness and the crystallinity of SrTiO3 in the nanotubes increased. The accumulation of Sr at the inner tube wall indicated that the reaction of Sr^2＋ with TiO2 mainly occurred in the vicinity of internal surfaces of the closely arranged nanotubes. The formation of the SrTiO3 nanotubes could be attributed to an in situ dissolution-recrystallization process. The SrTiO3 nanotubes exhibited good hydrophilicity and bioactivity, and the induced apatite preferred to nucleate on the nanotubes with higher crystallinity and Sr content, indicating a good hio-adaptability of the SrTiO3 nanotubes for orthopedic application.

关键词： SrTiO3 nanotubes Modified anodization Hydrothermal treatment Bio-adaptability

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The identification of comets in Chinese historical records

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Science China(Physics,Mechanics & Astronomy) 2011年第1期54卷 150-155页

作者： zhang lan ZHAO Gang National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

The historical records of astronomical phenomena may play a significant role in comet *** an accurate result is based on many factors,of which the calculation of orbital elements is the most *** paper presents a "Cross Reference" method in which the perturbation of Jupiter is the only considered factor used to attempt an efficient way of comet identification with ancient Chinese historical *** this method,the records before and after the calculated result from orbital determination within the error range are compared with the historical records to find the correlated perihelion time,and then,with five other orbital elements at the perihelion time,the ephemeris is *** the calculated ephemeris matches the historical records,it is concluded that the comet determined by orbital calculation is the same as the one recorded in *** this method,three comets with four historical records have already been found.

关键词： celestial mechanics methods:numerical comets:general

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Crystalline Size Effects on Texture Coefficient,Electrical and Optical Properties of Sputter-deposited Ga-doped ZnO Thin Films

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Journal of Materials Science & Technology 2015年第2期31卷 175-181页

作者： Yaqin Wang Wu Tang lan zhang State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University

C-axis oriented Ga-doped ZnO(GZO) films with various thicknesses were deposited on glass substrate by radio frequency(RF) magnetron sputtering. The dependence of crystal structure,electrical,and optical properties of the GZO films on crystalline size were systematically studied. The results showed that the texture coefficient of (002) peak (TC(002)) decreases with increasing crystalline size. The Hall mobility m was reciprocal to electron effective mass and the fitted relaxation time s was 0.11±0.01 ms. With the increase of average crystalline size,the resistivity increased slightly,which is caused by the competition of (002) and(101) plane,introducing in some defects and leading to carrier density reduction. The optical band gap was in the range from 3.454 to 3.319 eV with increasing crystalline size from 26.96 to 30.88 nm,showing a negative relationship. The dependence of optical band gap (Eopg) on the crystalline size(R) can be qualitatively explained by a quantum confinement effect. The relationship between Eopg and R of GZO films suggests that tuning up optical properties for desired applications can be achieved by controlling the crystalline size.

关键词： Ga-doped ZnO film Crystalline size Texture coeffic

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Zn and Ag Co-doped Anti-microbial TiO_2 Coatings on Ti by Micro-arc Oxidation

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Journal of Materials Science & Technology 2016年第9期32卷 919-924页

作者： lan zhang Qin Gao Yong Han State-key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University

Micro-porous TiO2 coatings co-doped with Zn^2＋ and Ag nanoparticles were fabricated on Ti by microarc oxidation （MAO） for 0.5, 1.5, 2 and 4 min, respectively. The evolutions of morphology and phase component of the coating as a function of processing time were investigated. The microstructure of the 2 min treated coating was further observed by transmission electron microscopy to explore the coating formation mechanism. The amounts of Ag and Zn released from the 2 min treated coating were measured and the antibacterial properties of the coatings against Staphylococcus aureus （S. aureus） were also investigated. The obtained results showed that with prolonged MAO time, the contents of Ag and Zn on the coating surfaces increased. All the coatings were micro-porous with pore diameters of 1 -4μm; however, some pores were blocked by deposits on the 4 min treated coating. The 2 rain treated coating was composed of amorphous TiO2, anatase, futile, ZnO, Zn2TiO4 and homogenously distributed Ag nanoparticles. After immersion, Zn^2＋, Ag^＋, Ti^2＋ and Ca^2＋ were released from the coating and with the immersion time prolonged, the accumulated concentrations of these ions increased. After immersion for 36 weeks, the accumulated Zn2. and Ag^＋ concentrations were 6.88 and 0.684 ppm, respectively, which are higher than the minimal inhibitory concentration but much lower than the cytotoxic concentration. Compared with polished Ti control, the coatings co-doped with Zn^2＋ and Ag nanoparticles significantly inhibited the ad- hesions of S. uureus and reduced the amounts of planktonic bacteria in culture medium, indicating that the Zn and Ag co-doped TiO2 could be a bio-adaptable coating for long-lasting anti-microbial performance.

关键词： Zn Ag nanoparticle Co-doped TiO2 Micro-arc oxidation Bio-adaptable

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Tunable wide-angle multi-band mid-infrared linear-to-linear polarization converter based on a graphene metasurface

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Chinese Physics B 2021年第12期30卷 607-612页

作者： lan-lan zhang Ping Li Xiao-Wei Song School of Medical Technology and Engineering Henan University of Science and TechnologyLuoyang 471000China

We present a high-efficiency tunable wide-angle multi-band reflective linear-to-linear(LTL)polarization converter,which is composed of an array of two L-shaped graphene patches with different *** the mid-infrared region,the proposed converter can transform x-polarized wave into y-polarized wave at four resonant *** polarization conversion ratios of the four bands reach 94.4%,92.7%,99.3%,and 93.1%,*** carefully choosing the geometric parameter,triple-band LTL polarization conversion can also be *** three polarization conversion ratios reach 91.50%,99.20%,and 97.22%,*** influence of incident angle on the performances of the LTL polarization converter is investigated,and it is found that our polarization converter shows the angle ***,the dynamically tunable properties of the proposed polarization converter are numerically studied by changing Fermi *** the simulation results are conducted by finite element method.

关键词： metasurface graphene polarization converter multi-band

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Novel ionic liquid based electrolyte for double layer capacitors with enhanced high potential stability

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Science China Chemistry 2016年第5期59卷 547-550页

作者： lan zhang Kun Dong Shimou Chen Suojiang zhang Beijing Key Laboratory of Ionic Liquids Clean Chemical Process State Key Laboratory of Multiphase Complex SystemsInstitute of Process and EngineeringChinese Academy of SciencesBeijing 100190China

Developing electrolyte with high electrochemical stability is the most effective way to improve the energy density of double layer capacitors(DLCs), and ionic liquid is a promising choice. Herein, a novel ionic liquid based high potential electrolyte with a stabilizer, succinonitrile, was proposed to improve the high potential stability of the DLC. The electrolyte with 7.5 wt% succinonitrile added has a high ionic conductivity of 41.1 m S cm^(-1) under ambient temperature, and the DLC adopting this electrolyte could be charged to 3.0 V with stable cycle ability even under a discharge current density of 6 A g^(-1). Moreover, the energy density could be increased by 23.4% when the DLC was charged to 3.0 V compared to that charged to 2.7 V.

关键词： double layer capacitor ionic liquid electrolyte high potential succinonitrile

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Application of quality by design in the current drug development

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Asian Journal of Pharmaceutical Sciences 2017年第1期12卷 1-8页

作者： lan zhang Shirui Mao Shenyang Pharmaceutical University

Quality by Test was the only way to guarantee quality of drug products before FDA launched current Good Manufacturing Practice. To clearly understand the manufacture processes, FDA generalized Quality by Design(QbD) in the field of pharmacy, which is based on the thorough understanding of how materials and process parameters affect the quality profile of final products. The application of QbD in drug formulation and process design is based on a good understanding of the sources of variability and the manufacture process. In this paper,the basic knowledge of QbD, the elements of QbD, steps and tools for QbD implementation in pharmaceutics field, including risk assessment, design of experiment, and process analytical technology(PAT), are introduced briefly. Moreover, the concrete applications of QbD in various pharmaceutical related unit operations are summarized and presented.

关键词： Quality by design(QbD) Process analytical technology(PAT) Critical quality attributes(CQA) Design of experiment(DoE) Risk assessment Near infrared(NIR)spectroscopy

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