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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé laia just-borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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An optimized high quality male DNA extraction from spermatophores in open thelycum shrimp species

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Integrative Zoology 2017年第5期12卷 421-427页

作者： laia PLANELLA sandra HERAs Manuel VERA José-Luis GARCÍA-MARÍN María Inés ROLDÁN Laboratory of Genetic Ichthyology University of GironaGironaSpain

The crucial step of most of the current genetic studies is the extraction of DNA of sufficient quantity and *** genomic DNA isolation methods have been described to successfully obtain male DNA from shrimp ***,all current protocols require invasive handling methods with males for DNA *** Aristeus antennatus as a model we tested a reliable non-invasive differential DNA extraction method to male DNA isolation from spermatophores attached to female *** present protocol provides high quality and quantity DNA for polymerase chain reaction amplification and male *** new approach could be useful to experimental shrimp culture to select sires with relevant genetic patterns for selective breeding *** importantly,it can be applied to identify the mating pairs and male structure in wild populations of species as ***,where males are often difficult to *** method could be also valuable for biological studies on other spermatophore-using species,such as myriapods,arachnids and insects.

关键词： differential spermatophore DNA extraction high quality DNA male genotyping non-invasive DNA extraction open thelycum shrimp

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Biology and pathology of the uterine micro environ merit and its natural killer cells

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Cellular & Molecular Immunology 2021年第9期18卷 2101-2113页

作者： Fuyan Wang Anita Ellen Qualls laia Marques-Fernandez Francesco Colucci Department of Obstetrics&Gynaecology University of CambridgeNational Institute for Health Research Cambridge Biomedical Research CentreCambridge CB20SWUK Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of PathophysiologySchool of MedicineNingbo UniversityNingbo 315211China Centre for Trophoblast Research University of CambridgeCambridge CB23EGUK

Tissues are the new frontier of discoveries in *** of the immune system are an integral part of tissue physiology and *** how immune cells inhabit,housekeep,and defend gut,lung,brain,liver,uterus,and other organs helps revealing the intimate details of tissue physiology and may offer new therapeutic targets to treat *** uterine microenvironment modulates the development and function of innate lymphoid cells[ILC,largely represented by natural killer(NK)cells],macrophages,T cells,and dendritic *** immune cells,in turn,contribute to tissue *** by ovarian hormones,the human uterine mucosa(endometrium)undergoes ~400 monthly cycles of breakdown and regeneration from menarche to menopause,with its fibroblasts,glands,blood vessels,and immune cells remodeling the tissue into the transient *** more transformative changes occur upon blastocyst *** the placenta is formed,the endometrial glands feed the embryo by histiotrophic nutrition while the uterine spiral arteries are stripped of their endothelial layer and smooth muscle *** arterial remodeling is carried out by invading fetal trophoblast and maternal immune cells,chiefly uterine NK(uNK)cells,which also assist fetal *** tran sformed arteries no Ion ger resp ond to mater nal stimuli and meet the increasi ng dema nds of the growing *** review focuses on how the everchanging uterine microenvironment affects uNK cells and how uNK cells regulate homeostasis of the decidua,placenta development,and fetal *** these pathways will help understand the causes of major pregnancy complications.

关键词： Natural killer cells Uterine microenvironment Pregnancy Decidua uNK

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Trihalomethane concentrations in tap water as determinant of bottled water use in the city of Barcelona

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Journal of Environmental sciences 2017年第8期29卷 77-92页

作者： laia Font-Ribera Jordi Colomer Cotta Anna Gómez-Gutiérrez Cristina M.Villanueva IsGlobal Centre for Research in Environmental Epidemiology (CREAL) 08003 Barcelona Spain IMIM (Hospital del Mar Medical Research Institute) 08003 Barcelona Spain Uniuersitat Pompeu Fabra (UPF) 08003 Barcelona Spain CIBER Epidemiologfa y salud Publica (CIBEREsP) 28029 Madrid Spain Public Health Agency of Barcelona (AsPB) 08023 Barcelona Spain

Bottled water consumption is increasing worldwide, despite its huge economic and environmental cost. We aim to describe personal and tap water quality determinants of bottled water use in the city of Barcelona. This cross-sectional study used data from the Health survey of Barcelona in 2006（N = 5417 adults）. The use of bottled water to drink and to cook was evaluated in relation to age, gender, educational level, district and levels of trihalomethanes（THMs）, free chlorine, conductivity, chloride, sodium, p H, nitrate and aluminium in municipal tap water using Robust Poisson Regression. The prevalence of bottled water use to drink and cook was 53.9% and 6.7%, respectively. Chemical parameters in water had a large variability（interquartile range of THMs concentrations： 83.2–200.8 μg/L）and were correlated between them, except aluminium. Drinking bottled water increased with educational level, while cooking with bottled water was higher among men than among women and decreased with age. After adjusting by these personal determinants, a dose–response relationship was found between concentrations of all chemicals except aluminium in tap water and bottled water use. The highest association was found for THMs,with a Prevalence Ratio of 2.00（95%CI = 1.86, 2.15） for drinking bottled water and 2.80（95%CI = 1.72, 4.58） for cooking with bottled water, among those with 〉 150 μg/L vs. 〈 100 μg/L THMs in tap water. Conclusion： More than half of Barcelona residents regularly drank bottled water, and the main determinant was the chemical composition of tap water,particularly THM level.

关键词： Tap water Drinking water Trihalomethanes Organoleptics Determinants Prevalence

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Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease

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Neural Regeneration Research 2022年第8期17卷 1666-1674页

作者： Alejandro R.Roda Gabriel serra-Mir laia Montoliu-Gaya Lidia Tiessler sandra Villegas Protein Design and Immunotherapy Group Departament de Bioquímica i Biologia MolecularFacultat de BiociènciesUniversitat Autònoma de BarcelonaBellaterraBarcelonaSpain Department of Psychiatry and Neurochemistry Institute of Neuroscience and PhysiologyThe Sahlgrenska AcademyUniversity of GothenburgSweden

Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018.A large amount of evidence supports the amyloid cascade hypothesis,which states that amyloid-beta accumulation triggers tau hyperphosphorylation and aggregation in form of neurofibrillary tangles,and these aggregates lead to inflammation,synaptic impairment,neuronal loss,and thus to cognitive decline and behavioral *** poor correlation found between cognitive decline and amyloid plaques,have led the scientific community to question whether amyloid-beta accumulation is actually triggering neurodegeneration in Alzheimer’s *** occurrence of tau neurofibrillary tangles better correlates to neuronal loss and clinical symptoms and,although amyloid-beta may initiate the cascade of events,tau impairment is likely the effector molecule of ***,it has been shown that amyloid-beta and tau cooperatively work to impair transcription of genes involved in synaptic function and,more importantly,that downregulation of tau partially reverses transcriptional *** mounting evidence points to an interplay between amyloid-beta and tau,some factors could independently affect both ***,the dual pathway hypothesis,which states that there are common upstream triggers causing both amyloid-beta and tau abnormalities has been *** others,the immune system seems to be strongly involved in amyloid-beta and tau *** factors,as the apolipoprotein Eε4 isoform has been suggested to act as a link between amyloid-beta and tau ***,amyloid-beta-immunotherapy reduces not only amyloid-beta but also tau levels in animal models and in clinical ***,it has been shown that tau-immunotherapy also reduces amyloid-beta ***,even though amyloid-beta immunotherapy is more advanced than tau-immunotherapy,combined amyloid-beta and tau-directed therapie

关键词： aggregation Alzheimer amyloid-beta dementia immunotherapy inflammation neurodegeneration tau

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