Metabolic determinants of stemness in medulloblastoma

作     者：Paula Martín-Rubio Pilar Espiau-Romera Alba Royo-García Laia Caja Patricia Sancho 

作者机构：Hospital Universitario Miguel ServetIIS AragónZaragoza 50009Spain Department of Medical Biochemistry and MicrobiologyBiomedical CenterUppsala UniversityUppsala SE-751Sweden 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第8期

页      面：587-598页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the Miguel Servet and pFIS fellowships,No.CP16/00121(P.S.) and No.FI21/00031(P.E-R.) from the Instituto de Salud Carlos Ⅲ and cofinanced by European funds(FSE:“el FSE invierte en tu futuro”) Magnus Bergvalls Stiftelse,No.2021-04284(L.C.) the Ⅳ Grant for Childhood Cancer Research from Asociación de Padres de Niños con Cáncer de Aragón(ASPANOA,P.S.) 

主　　题：Medulloblastoma Cancer stem cells Stemness Metabolism Glycolysis Lipids 

摘      要：Medulloblastomas(MBs)are the most prevalent brain tumours in *** are classified as grade IV,the highest in malignancy,with about 30%metastatic tumours at the time of *** stem cells(CSCs)are a small subset of tumour cells that can initiate and support tumour *** MB,CSCs contribute to tumour initiation,metastasis,and therapy *** differences among the different MB groups have started to *** hedgehog tumours show enriched lipid and nucleic acid metabolism pathways,whereas Group 3 MBs upregulate glycolysis,gluconeogenesis,glutamine anabolism,and glutathione-mediated anti-oxidant *** differences impact the clinical behaviour of MB tumours and can be exploited *** this review,we summarise the existing knowledge about metabolic rewiring in MB,with a particular focus on ***,we highlight some of the emerging metabolism-based therapeutic strategies for MB.