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Presurgical structural imaging and clinical outcome in combined bed nucleus of the stria terminalis-nucleus accumbens deep brain stimulation for treatment-resistant depression

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General Psychiatry 2024年第3期37卷 412-421页

作者： Fengting Wang lulin Dai tao Wang Yingying Zhang Yuhan Wang Yijie Zhao Yixin Pan Liuguan Bian Dianyou Li Shikun Zhan Yijie Lai Valerie Voon Bomin Sun Department of Neurosurgery Shanghai Jiao Tong University Medical School Affiliated Ruijin HospitalShanghaiChina Department of Psychiatry Zhejiang University School of Medicine Sir Run Run Shaw HospitalHangzhouChina Fudan University Institute of Science and Technology for Brain-inspired Intelligence ShanghaiChina Clinical Research Center for Mental Disorders Shanghai Pudong New Area Mental Health CenterShanghaiChina Department of Psychiatry University of CambridgeCambridgeUK

Background Structural imaging holds great potential for precise targeting and stimulation for deep brain stimulation(DBS).The anatomical information it provides may serve as potential biomarkers for predicting the efficacy of DBS in treatment-resistant depression(TRD).Aims The primary aim is to identify preoperative imaging biomarkers that correlate with the efficacy of DBS in patients with *** Preoperative imaging parameters were estimated and correlated with the 6-month clinical outcome of patients with TRD receiving combined bed nucleus of the stria terminalis(BNST)-nucleus accumbens(NAc)*** matter(WM)properties were extracted and compared between the response/non-response and remission/non-remission *** connectome was constructed and analysed using graph *** of the volume of activated tissue(VAT)to the main modulating tracts were also estimated to evaluate the *** Differences in fibre bundle properties of tracts,including superior thalamic radiation and reticulospinal tract,were observed between the remission and nonremission *** of the centre of the VAT to tracts connecting the ventral tegmental area and the anterior limb of internal capsule on the left side varied between the remission and non-remission groups(p=0.010,t=3.07).The normalised clustering coefficient(γ)and the small-world property(σ)in graph analysis correlated with the symptom improvement after the correction of *** Presurgical structural alterations in WM tracts connecting the frontal area with subcortical regions,as well as the distance of the VAT to the modulating tracts,may influence the clinical outcome of BNST-NAc *** findings provide potential imaging biomarkers for the DBS treatment for patients with TRD.

关键词： stimulation alterations treatment

低温氦气引射液氮时液滴群在引射器扩散腔中的流动与传热特性

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低温工程 2024年第4期 25-31,85页

作者：杨璐琳王奇栋贺天彪金滔浙江大学制冷与低温研究所杭州310027 浙江省制冷与低温技术重点实验室杭州310027

为了优化低温氦气引射液氮过程中固体颗粒的生成效果,对氮液滴群与氦气在引射器扩散腔内的传热与流动过程建立数学模型,分析了液氮凝固的阶段性变化特征及传热机制,重点研究了液滴初始直径、气体初始状态和液气流量比对氮浆生成效果的... 详细信息

为了优化低温氦气引射液氮过程中固体颗粒的生成效果,对氮液滴群与氦气在引射器扩散腔内的传热与流动过程建立数学模型,分析了液氮凝固的阶段性变化特征及传热机制,重点研究了液滴初始直径、气体初始状态和液气流量比对氮浆生成效果的影响。结果表明:不同粒径液滴的凝固过程存在显著差异,粒径小的液滴更容易凝固,但在固体调温阶段会反向传热;随着液滴直径的增大,完全凝固位移呈现指数增长;传质的贡献随气体温度的升高而增大,在大液滴的冻结阶段起主导作用。降低气体初始速度和温度有利于提高出口凝固率,在30 K的气体初始温度下改变液气流量比时凝固率均高于99%;但固体生成速率和换热效率主要随液气流量比的增大而增大。

关键词：氮浆引射器液滴凝固传热传质

基于GPU加速的三维堆芯物理程序STORK的开发与验证

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原子能科学技术 2024年第3期58卷 662-671页

作者：俞陆林杨高升陈国华卑华蒋校丰高明敏王涛上海核星核电科技有限公司上海201103 核电运行研究(上海)有限公司上海200126

基于小型多GPU计算平台,采用二维全堆逐层特征线方法(MOC)和三维逐棒(pin-by-pin)三阶简化球谐函数方法(SP3方法)相耦合的方式开发了堆芯三维输运中子学计算程序STORK。在方法论方面,首先通过对堆芯各轴向层的二维MOC输运计算在线产生... 详细信息

基于小型多GPU计算平台,采用二维全堆逐层特征线方法(MOC)和三维逐棒(pin-by-pin)三阶简化球谐函数方法(SP3方法)相耦合的方式开发了堆芯三维输运中子学计算程序STORK。在方法论方面,首先通过对堆芯各轴向层的二维MOC输运计算在线产生栅元均匀化截面以及超级均匀化修正因子(SPH因子),然后采用SP3方法进行pin-by-pin三维堆芯计算。在程序开发方面,采用了CUDA、C++和Python的混合编程,且所有计算模块都基于CUDA/C++开发,并进行了大量的性能优化。通过对C5G7三维插棒基准题和VERA基准题的验证表明,与国际上同类中子学计算软件相比,基于CPU/GPU异构系统开发的STORK程序在计算效率和计算成本方面都具有明显优势。

关键词：中子输运图形处理器特征线方法在线均匀化逐棒 SP3 超级均匀化方法

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基于OCO-2卫星数据的中国CO_(2)浓度时空变化特征

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遥感信息 2024年第2期39卷 52-60页

作者：杨梅焕邓彦昊王涛姚明昊赵滢滢西安科技大学测绘科学与技术学院西安710054 西安科技大学国土空间研究所西安710054

大气CO_(2)浓度增加引起的全球变暖问题是国内外学者关注的热点议题,但对CO_(2)的监测一直存在较多的不确定性。利用2015—2022年OCO-2卫星观测的CO_(2)柱浓度混合比数据(XCO_(2)),基于克里金插值和标准差椭圆等方法,分析了中国CO_(2)... 详细信息

大气CO_(2)浓度增加引起的全球变暖问题是国内外学者关注的热点议题,但对CO_(2)的监测一直存在较多的不确定性。利用2015—2022年OCO-2卫星观测的CO_(2)柱浓度混合比数据(XCO_(2)),基于克里金插值和标准差椭圆等方法,分析了中国CO_(2)浓度时空分布与变化特征,有以下3个结论。1)基于OCO-2卫星数据的XCO_(2)数据集精度较高,与地面监测站(瓦里关站、鹿林站)观测结果的均方根误差仅为1.75 ppm和1.58 ppm,相关系数分别为0.91和0.96。2)年际上,2015—2022年中国年均XCO_(2)由399.52 ppm增至417.64 ppm,年均增速为2.56 ppm/a,高于过去10年全球CO_(2)浓度平均增速(2.06 ppm/a),但在2019年之后XCO_(2)增速呈下降趋势。季节上,XCO_(2)具有明显的季节变化特征,春季XCO_(2)最高,夏季最低。3)空间分布上,XCO_(2)表现出东部高,西部、东北地区低的空间分布特征。XCO_(2)浓度高值区域集中在京津冀和长三角等城市群。中国东北、西南地区XCO_(2)增速较快,高于华东、华南等经济发达地区。

关键词：遥感数据反演 OCO-2 XCO_(2) 时空分析

自主研发的柔性套阴茎保护装置对包皮环切术后阴茎具有保护作用:一项前瞻性随机对照试验

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现代泌尿外科杂志 2024年第4期29卷 363-367页

作者：拓鹏飞陈克伟刘鑫辰朱国栋贺会兴蔡涛李宇轩赵勋葛力源张树栋马潞林郭巍刘茁北京大学第三医院泌尿外科北京100191 北京大学第三医院延安分院泌尿外科陕西延安716099

目的探讨一种柔性套阴茎保护装置对包皮环切患者术后疼痛和伤口水肿的缓解作用。方法纳入2023年2月1日—2023年5月31日北京大学第三医院延安分院行包皮环切术的54例患者作为研究对象。采用随机数表法将患者分为试验组27例、对照组27例,... 详细信息

目的探讨一种柔性套阴茎保护装置对包皮环切患者术后疼痛和伤口水肿的缓解作用。方法纳入2023年2月1日—2023年5月31日北京大学第三医院延安分院行包皮环切术的54例患者作为研究对象。采用随机数表法将患者分为试验组27例、对照组27例,试验组患者术后使用柔性套阴茎保护装置,对照组患者术后使用传统纱布包扎的方法,比较两组患者术后疼痛、伤口水肿和并发症发生情况。结果在疼痛方面,试验组术后6 h[(1.7±0.9)分vs.(3.3±1.9)分,P0.05)。在水肿方面,试验组在术后第2天[(2.0±1.0)分vs.(4.0±0.8)分,P0.05)。结论在接受包皮环切术的患者中使用柔性套阴茎保护装置有减少术后早期疼痛和减轻水肿的显著效果,在临床上有一定的应用价值,值得推广。

关键词：包皮过长包茎包皮环切术随机对照试验阴茎保护装置

Dynamic blood single-cell immune responses in patients with COVID-19

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1280-1291页

作者： lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi Liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuanChina Natural Products Research Center Institute of Chengdu BiologySichuan Translational Medicine HospitalChinese Academy of SciencesChengduSichuanChina Institute of Health Management Health Management CenterSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Department of Infection Disease Zigong First Peopled HospitalZigongSichuanChina Department of Infection Disease Mianyang No.404 HospitalMianyangSichuanChina Infectious diseases laboratory Public Health and Clinical Center of ChengduChengduSichuanChina Sichuan Dazhou Central Hosptical DazhouSichuanChina Department of Infection Disease Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina

The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health ***,the virus'pathogenesis remains unclear,and there is no cure for the *** investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell *** obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic *** addition,we used three control *** found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical *** type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions *** with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 *** concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of *** and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 *** study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic poten

关键词： patients interferon lymphocytes

海上风电机组预应力钢管混凝土格构式塔架动力特性分析

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船舶工程 2022年第S2期44卷 112-115页

作者：周扬骆光进李晓艳李强宁潞林任涛中国船舶重工集团海装风电股份有限公司重庆400045

为避免风电结构发生共振,影响发电效率和结构安全,了解掌握风电机组支撑结构动力特性至关重要。预应力钢管混凝土格构式塔架是一种新型的风电机组支撑结构,在海上风电机组大型化过程中将扮演重要角色,本文采用有限元建模的方式对该塔架... 详细信息

为避免风电结构发生共振,影响发电效率和结构安全,了解掌握风电机组支撑结构动力特性至关重要。预应力钢管混凝土格构式塔架是一种新型的风电机组支撑结构,在海上风电机组大型化过程中将扮演重要角色,本文采用有限元建模的方式对该塔架固有频率进行分析,分析在不同底部跟开、不同角柱直径和壁厚、不同斜杆壁厚下的固有频率的变化特征,并提出设计建议,以期对设计人员提供思路。

关键词：海上风电机组动力特性预应力钢管混凝土格构式塔架固有频率

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Rac1促进异质型细胞叠套结构的形成

生物工程学报 2023年第10期39卷 4123-4134页

作者：胡涛冯鹏飞李浩源周鲁林牛祖彪黄一诺王小宁王晨曦刘惠吴成君大连理工大学生物医学工程学院辽宁大连116024 军事医学研究院生物工程研究所北京100071 解放军医学院北京100853 解放军总医院第二医学中心老年医学研究所、国家老年疾病临床医学研究中心、衰老与相关疾病研究北京市重点实验室北京100853 山东第一医科大学附属省立医院老年血液肿瘤科山东济南250021 首都医科大学附属北京世纪坛医院肿瘤内科肿瘤治疗性疫苗北京市重点实验室北京100038

异质型细胞叠套结构(heterotypic cell-in-cell structure,heCICs)与肿瘤发生和发展密切相关,在生命科学研究中的重要性逐渐显露。Ras相关C3肉毒毒素底物1(Ras-related C3 botulinum toxin substrate 1,Rac1)属于经典的Rho GTP酶,在细胞骨架以及细胞运动中起到关键调控作用。为研究Rac1在he CICs形成中的作用和机制,利用活细胞示踪剂cell-tracker分别标记肿瘤细胞和免疫杀伤细胞,建立heCICs模型。利用Rac1抑制剂NSC23766抑制Rac1活性后发现,肿瘤细胞与免疫杀伤细胞之间的heCICs形成率显著降低。通过分子克隆技术获得重组质粒pQCXIP-Rac1-EGFP,进行病毒包装感染肿瘤细胞获得Rac1过表达细胞系。进一步检测Rac1过表达对heCICs形成能力的影响,结果表明,Rac1表达水平升高后,heCICs形成率显著升高。本研究显示Rac1具有促进he CICs形成的作用,这为Rac1作为细胞叠套相关疾病的药物治疗靶点奠定了研究基础。

关键词：异质型细胞叠套结构肿瘤发生 Ras相关C3肉毒毒素底物1 免疫治疗

Detection of serum IgM and IgG for COVID-19 diagnosis

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Science China(Life Sciences) 2020年第5期63卷 777-780页

作者： Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang The Key Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengdu 610072China Natural Products Research Center Institute of Chengdu BiologySichuan Translational Medicine HospitalChinese Academy of SciencesChengdu 610072China Health Management Center Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Infectious Disease Department Zigong first people’s HospitalZigong 643000China Sichuan Mianyang 404 Hospital Mianyang 621000China Infectious Diseases Laboratory Public Health and Clinical Center of ChengduChengdu 610041China Sichuan Dazhou Central Hosptical Dazhou 635000China ABLINK Biotech Chengdu 610041China Maccura Biotechnology Co. Ltd.Chengdu 610041China Infectious Disease Department Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610041China

Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,*** outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020).

关键词： diagnosis al. infected