Presurgical structural imaging and clinical outcome in combined bed nucleus of the stria terminalis-nucleus accumbens deep brain stimulation for treatment-resistant depression

作     者：Fengting Wang Lulin Dai Tao Wang Yingying Zhang Yuhan Wang Yijie Zhao Yixin Pan Liuguan Bian Dianyou Li Shikun Zhan Yijie Lai Valerie Voon Bomin Sun 

作者机构：Department of NeurosurgeryShanghai Jiao Tong University Medical School Affiliated Ruijin HospitalShanghaiChina Department of PsychiatryZhejiang University School of Medicine Sir Run Run Shaw HospitalHangzhouChina Fudan University Institute of Science and Technology for Brain-inspired IntelligenceShanghaiChina Clinical Research Center for Mental DisordersShanghai Pudong New Area Mental Health CenterShanghaiChina Department of PsychiatryUniversity of CambridgeCambridgeUK 

出 版 物：《General Psychiatry》 (综合精神医学（英文）)

年 卷 期：2024年第37卷第3期

页      面：412-421页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by an unrestricted,investigator-initiated research grant by Scenery(BS),which provided the devices used.The project was sponsored by SJTU Trans-med Awards Research(2019015 to BS) Shanghai Clinical Research Centre for Mental Health(19MC191100 to BS) sponsored by the National Natural Science Foundation of China(81771482) supported by the Guangci Professorship Programme of Ruijin Hospital(N/A)and a Medical Research Council Senior Clinical Fellowship(MR/P008747/1) sponsored by the National Natural Science Foundation of China(82101546) the Shanghai Sailing Program(21YF1426700).The funding sources were not involved in the design and conduct of the study 

主　　题：stimulation alterations treatment 

摘      要：Background Structural imaging holds great potential for precise targeting and stimulation for deep brain stimulation(DBS).The anatomical information it provides may serve as potential biomarkers for predicting the efficacy of DBS in treatment-resistant depression(TRD).Aims The primary aim is to identify preoperative imaging biomarkers that correlate with the efficacy of DBS in patients with *** Preoperative imaging parameters were estimated and correlated with the 6-month clinical outcome of patients with TRD receiving combined bed nucleus of the stria terminalis(BNST)-nucleus accumbens(NAc)*** matter(WM)properties were extracted and compared between the response/non-response and remission/non-remission *** connectome was constructed and analysed using graph *** of the volume of activated tissue(VAT)to the main modulating tracts were also estimated to evaluate the *** Differences in fibre bundle properties of tracts,including superior thalamic radiation and reticulospinal tract,were observed between the remission and nonremission *** of the centre of the VAT to tracts connecting the ventral tegmental area and the anterior limb of internal capsule on the left side varied between the remission and non-remission groups(p=0.010,t=3.07).The normalised clustering coefficient(γ)and the small-world property(σ)in graph analysis correlated with the symptom improvement after the correction of *** Presurgical structural alterations in WM tracts connecting the frontal area with subcortical regions,as well as the distance of the VAT to the modulating tracts,may influence the clinical outcome of BNST-NAc *** findings provide potential imaging biomarkers for the DBS treatment for patients with TRD.