检索结果-南通市图书馆

Clinical and experimental studies on stomach carcinoma treated with yangwei Kangliu granules

World Journal of Gastroenterology 1997年第4期3卷 68-70页

作者： lu wenping, sun guizhi, piao bingkui, dong haitao, yang zongyan and lin hongsheng

IM To study the anticancer mechanism of yangwei Kangliu (YWKL) granules from the viewpoint of red blood cell (RBC) immunity and the relationship between the red blood cell immunity and T lymphocyte immunity.METHODS We treated advanced gastric carcinoma by combination of YWKL granules and chemotherapy (n=50). Before treatment and after one course treatment, blood samples from vein were obtained, the rosette rate of c3b receptor (RBCC3bRR), tumor and red cell (RRTR) and RBC immune complex (RBCICR) were measured by counting the rosette formed by sensitivated yeast or tumor cell or unsentivated yeast adhering blood cell under microscopy. The T lymphocyte subset was observed by the method of APAAP. Chemotherapy alone was used as controls (n=20). In addition, the dynamic changes of RBCC3bRR, RRTR and RBCICR of mice with tumor after treated by YWKL granules (n=30) were observed. The chemotherapy (n=30) and water (n=30) were used as controls.RESULT Clinical therapeutic effect of combination of YWKL granules and chemotherapy (the treatment group) was markedly superior to that of chemotherapy alone (the control group) (P<001). In the treatment group, the rosette rate of c3b receptor (RBCC3bRR) and the rosette rate of tumor and red cell (RRTR) were significantly increased (P<001) after treatment, the rate of RBC immune complex (RBCICR) was markedly decreased (P<001), and the ratio of CD4 to CD8 was obviously elevated (P<001). CD8 was much lower (P<001), and the ratio of CD4 to CD8 was much higher (P<001), than the control group. The RRTR rate was positively correlated with the ratio of CD4 to CD8. Experiment in mice showed on the ninth day of bearing cancer, the tumor weight in the YWKL granules alone group was much lighter than that of chemotherapy alone group or water alone group respectively, the RBC immune function of YWKL granules alone group was higher than the other two groups, and on the thirteenth day, there wer

关键词： Stomach neoplasms yangwei Kangliu granules RBC immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anodic dissolution of a crack tip at AA2024-T351 in 3.5wt% NaCl solution

引用

International Journal of Minerals,Metallurgy and Materials 2012年第10期19卷 939-944页

作者： hai sheng Chao-fang dong kui Xiao Xiao-gang Li lin lu School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

The anodic dissolution process of a crack tip at 2024-T351 aluminium alloy （AA2024-T351） was determined by means of scanning Kelvin probe （SKP）. Wedge-open loading （WOL） specimens were immersed in a 3.5wt% NaCl solution. After various durations of immersion, the Volta potential distributions around the crack were measured by SKP and the surface morphologies were observed by scanning electron microscopy （SEM）. It is found that there is a nonuniform distribution of Volta potential around the crack. Before immersion, the Volta potential at crack tip is more negative than that in other regions. However, after immersion, a converse result occurs with the most positive Volta potential measured at the crack tip. SEM observations demonstrate that the noticeable positive shift of Volta potential results fi：om the formation of corrosion products which deposit around the crack tip. Energy-dispersive spectrometry （EDS） analysis shows that the corrosion products are mainly A1 oxide and Cu-rich particles. These observations implicate that the applied stress contributes to the preferential anodic dissolution of the crack tip and the redistribution of Cu.

关键词： aluminium alloys crack tips dissolution brines stress corrosion cracking

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anefficient parallel and distributed solution to nonconvex penalized linear SVMs

引用

Frontiers of Information Technology & Electronic Engineering 2020年第4期21卷 587-603页

作者： Lei GUAN tao sun lin-bo QIAO zhi-hui yang dong-sheng LI Ke-shi GE Xi-cheng lu College of Computer National University of Defense TechnologyChangsha 410073China School of Computer Science Fudan UniversityShanghai 201203China Shanghai Key Laboratory of Data Science Shanghai 201203China

Support vector machines(SVMs)have been recognized as a powerful tool to perform linear *** combined with the sparsity-inducing nonconvex penalty,SVMs can perform classification and variable selection ***,the nonconvex penalized SVMs in general cannot be solved globally and efficiently due to their nondifferentiability,nonconvexity,and *** solutions to the nonconvex penalized SVMs typically solve this problem in a serial fashion,which are unable to fully use the parallel computing power of modern multi-core *** the other hand,the fact that many real-world data are stored in a distributed manner urgently calls for a parallel and distributed solution to the nonconvex penalized *** circumvent this challenge,we propose an efficient alternating direction method of multipliers(ADMM)based algorithm that solves the nonconvex penalized SVMs in a parallel and distributed *** design many useful techniques to decrease the computation and synchronization cost of the proposed parallel *** time complexity analysis demonstrates the low time complexity of the proposed parallel ***,the convergence of the parallel algorithm is *** evaluations on four LIBSVM benchmark datasets demonstrate the efficiency of the proposed parallel algorithm.

关键词： linear classification Support vector machine(SVM) Nonconvex penalty Alternating direction method of multipliers(ADMM) Parallel algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in cancer nanomedicine

引用

Cancer Biology & Medicine 2015年第3期12卷 141-142页

作者： lin-tao Cai zong-hai sheng Center for Nanomedicine and Nanobiotechnology Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

Cancer has become the leading cause of *** progress in diagnosis and treatment is still *** the past three decades,emergence and rapid development of nanotechnology have brought new hopes for cancer therapy.A repertoi... 详细信息

关键词：癌症治疗纳米医学纳米技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Internal circulating fluidized bed incineration system and design algorithm

引用

Journal of Environmental Sciences 2001年第2期13卷 185-188页

作者： TIAN wen dong WEI Xiao lin LI Jun sheng hong zhi ESTC Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

The internal circulating fluidized bed (ICFB) system is characterized with fast combustion, low emission, uniformity of bed temperature and controllability of combustion process. It is a kind of novel clean combustion system, especially for the low grade fuels, such as municipal solid waste(MSW). The experimental systems of ICFB with and without combustion were designed and set up in this paper. A series of experiments were carried out for further understanding combustion process and characteristics of several design parameters for MSW. Based on the results, a design routine for the ICFB system was suggested for the calculation of energy balance, airflow rate, heat transfer rate, and geometry arrangement. A test system with ICFB combustor has been set up and the test results show that the design of the ICFB system is successful.

关键词： fluidized bed ICFB MSW

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on the clogging mechanism of punching screen in sand control by the punching structure parameters

引用

Petroleum Science 2024年第1期21卷 609-620页

作者： Fu-Cheng Deng Fu-lin gui Bai-tao Fan Lei wen sheng-hong Chen Ning Gong Yun-Chen Xiao zhi-Hui Xu yangtze University Jingzhou434023HubeiChina CNOOC Research Institute Ltd. Beijing100028China CNOOC Ener Tech-Drilling&Production Co. Tianjin300457China Tianjin Branch of CNOOC Ltd. Tianjin300459China

As an independent sand control unit or a common protective shell of a high-quality screen,the punching screen is the outermost sand retaining unit of the sand control pipe which is used in geothermal well or oil and gas ***,most screens only consider the influence of the internal sand retaining medium parameters in the sand control performance design while ignoring the influence of the plugging of the punching screen on the overall sand retaining performance of the *** explore the clogging mechanism of the punching screen,this paper established the clogging mechanism calculation model of a single punching screen sand control unit by using the computational fluid mechanics-discrete element method(CFD-DEM)combined *** to the combined motion of particles and fluids,the influence of the internal flow state on particle motion and accumulation was *** results showed that(1)the clogging process of the punching sand control unit is divided into three stages:initial clogging,aggravation of clogging and stability of *** the initial stage of blockage,coarse particles form a loose bridge structure,and blockage often occurs preferentially at the streamline gathering place below chamfering inside the sand control *** the stage of blockage intensification,the particle mass develops into a relatively complete sand bridge,which develops from both ends of the opening to the center of the *** the stable plugging stage,the sand deposits show a“fan shape”and form a“V-shaped”gully inside the punching slot element.(2)Under a certain reservoir particle-size distribution,The slit length and opening height have a large influence on the permeability and blockage rate,while the slit width size has little influence on the permeability and blockage *** microscopic clogging mechanism and its law of the punching screen prevention unit are proposed in this study,which has some field guidance significance for the design of punching screen

关键词： Punching screen Plugging CFD-DEM Size parameter Sand control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integrated hybrid sensing and microenergy for compact active microsystems

引用

Microsystems & Nanoengineering 2022年第3期8卷 209-221页

作者： hai-tao Deng zhi-Yong Wang Y-lin Wang Dan-Liang wen Xiao-sheng Zhang School of Electronic Science and Engineering University of Electronic Science and Technology of China611731 ChengduChina

Wearable electronics,as essential components of the Internet of Things(IoT),have attracted widespread attention,and the trend is to configure attractive wearable smart microsystems by integrating sensing,powering,and other,***,we developed an elastic hybrid triboelectric-electromagnetic microenergy harvester(named EHTE)to realize hybrid sensing and microenergy *** EHTE is a highly integrated triboelectric nanogenerator(TENG)and electromagnetic nanogenerator(EMG).Based on the triboelectric-electromagnetic hybrid mechanism,an enhanced electrical output of the EHTE was achieved successfully,which demonstrates the feasibility of the EHTE for microelectronics ***,with the merits of the EMG,the developed hybrid microenergy harvester integrated both active frequency sensing and passive inductive sensing ***,the almost linear correlation of the electromagnetic outputs to the frequencies of the external stimulus endowed the proposed EHTE with an outstanding active frequency sensing *** addition,due to the unique structural configuration of the EMG(i.e,a conductive permanent magnet(PM),hybrid deformation layer,and flexible printed circuit board(FPCB)coil),an opportunity was provided for the developed EHTE to serve as a passive inductive sensor based on the eddy current effect(ie.,a form of electromagnetic induction).Therefore,the developed EHTE successfully achieved the integration of hybrid sensing(i.e,active frequency sensing and passive inductive sensing)and microenergy(ie,the combination of electromagnetic effect and triboelectric effect)within a single device,which demonstrates the potential of this newly developed EHTE for wearable electronic applications,especially in applications of compact active microsystems.

关键词： inductive energy generator

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of ingredient and heating value of municipal solid waste

引用

Journal of Environmental Sciences 2001年第1期13卷 87-91页

作者： TIAN wen-dong WEI Xiao-lin WU dong-yin LI Jun sheng hong-zhi Institute of Mechanics Chinese Academy of SciencesBeijing 100080China

Great differences between municipal solid wastes (MSW) produced at different places and different times in terms of such parameters as physical ingredient and heating value lead to difficulty in effective handling of MSW. In this paper, ingredient, heating value and their temporal varying trends of typical MSW in Beijing were continuously measured and analyzed. With consideration of the process in pyrolysis and incineration, correlation between physical ingredients and heating values was induced, favorable for evaluation of heating value needed in handling of MSW from simple analysis of physical ingredients of it.

关键词： MSW incineration pyrolysis ingredient heating value

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Possible Role of DNA Polymerase beta in Protecting Human Bronchial Epithelial Cells Against Cytotoxicity of Hydroquinone

引用

Biomedical and Environmental Sciences 2007年第2期20卷 171-177页

作者： DA-lin HU HUAN-wen TANG hai-RONG LIANG dong-sheng TANG YI-MING LIU WEI-dong JI JIAN-HUI YUAN YUN HE ZHENG-Yu ZHU JIAN-ping yang DAO-kui FANG yan SHA XIAO-zhi TU zhi-XIONG ZHUANG Department of Preventive Medicine School of Public Health Sun Yat-sen University Guangzhou 510080 Guangdong China Shenzhen Center for Disease Control and Prevention Shenzhen 518020 Guangdong China Medical College Foshan University Foshan 528000 Guangdong China School of Public Health Guangdong Medical College Dongguan 523808 Guangdong China Department of Biochemistry and Molecular Biology Sun Yat-sen University Guangzhou 510080 Guangdong China

Objective To explore the toxicological mechanism of hydroquinone in human bronchial epithelial cells and to investigate whether DNA polymerase beta is involved in protecting cells from damage caused by hydroquinone. Methods DNA polymerase beta knock-down cell line was established via RNA interference as an experimental group. Normal human bronchial epithelial cells and cells transfected with the empty vector of pEGFP-C1 were used as controls. Cells were treated with different concentrations of hydroquinone （ranged from 10 μmol/L to 120 μmol/L） for 4 hours. MTT assay and Comet assay [single-cell gel electrophoresis （SCGE）] were performed respectively to detect the toxicity of hydroquinone. Results assay showed that DNA polymerase beta knock-down cells treated with different concentrations of hydroquinone had a lower absorbance value at 490 nm than the control cells in a dose-dependant manner. Comet assay revealed that different concentrations of hydroquinone caused more severe DNA damage in DNA polymerase beta knock-down cell line than in control cells and there was no significant difference in the two control groups. Conclusions Hydroquinone has significant toxicity to human bronchial epithelial cells and causes DNA damage. DNA polymerase beta knock-down cell line appears more sensitive to hydroquinone than the control cells. The results suggest that DNA polymerase beta is involved in protecting cells from damage caused by hydroquinone.

关键词： Human bronchial epithelial cells RNA interference Hydroquinone Toxicology DNA polymerase beta

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Loss of heterozygosity analyzed by single nucleotide polymorphism array in cancer

引用

World Journal of Gastroenterology 2005年第43期11卷 6740-6744页

作者： hai-tao Zheng zhi-hai Peng sheng Li lin He Department of General Surgery Shanghai First People's Hospital Shanghai Jiaotong University Shanghai 200080 China Shanghai Institutes for Nutrition Science Chinese Academy of Sciences Shanghai 200031 China

Neoplastic progression is generally characterized by the accumulation of multiple genetic alterations including loss of tumor suppression gene function. Loss of heterozygosity （LOH） has been used to identify genomic regions that harbor tumor suppressor genes and to characterize different tumor types, pathological stages and progression. LOH pattern has been detected by allelotyping using restriction fragment length polymorphism, and later by simple sequence length polymorphisms （SSLPs or microsatellite） for 10 years. This paper reviews the detection of LOH by recently developed single nucleotide polymorphism （SNP） arrays （all analyzed by Affymetrix array）; furthermore, its advantage and disadvantage were analyzed in several kinds of cancer.

关键词： Loss of heterozygosity Single nucleotidepolymorphism Array Cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：