Clinical and experimental studies on stomach carcinoma treated with Yangwei Kangliu granules

作     者：LU WenPing, SUN GuiZhi, PIAO BingKui, DONG HaiTao, YANG ZongYan and LIN HongSheng 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：1997年第3卷第4期

页      面：68-70页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Stomach neoplasms Yangwei Kangliu granules RBC immunity 

摘      要：IM To study the anticancer mechanism of Yangwei Kangliu (YWKL) granules from the viewpoint of red blood cell (RBC) immunity and the relationship between the red blood cell immunity and T lymphocyte immunity.METHODS We treated advanced gastric carcinoma by combination of YWKL granules and chemotherapy (n=50). Before treatment and after one course treatment, blood samples from vein were obtained, the rosette rate of c3b receptor (RBCC3bRR), tumor and red cell (RRTR) and RBC immune complex (RBCICR) were measured by counting the rosette formed by sensitivated yeast or tumor cell or unsentivated yeast adhering blood cell under microscopy. The T lymphocyte subset was observed by the method of APAAP. Chemotherapy alone was used as controls (n=20). In addition, the dynamic changes of RBCC3bRR, RRTR and RBCICR of mice with tumor after treated by YWKL granules (n=30) were observed. The chemotherapy (n=30) and water (n=30) were used as controls.RESULT Clinical therapeutic effect of combination of YWKL granules and chemotherapy (the treatment group) was markedly superior to that of chemotherapy alone (the control group) (P001). In the treatment group, the rosette rate of c3b receptor (RBCC3bRR) and the rosette rate of tumor and red cell (RRTR) were significantly increased (P001) after treatment, the rate of RBC immune complex (RBCICR) was markedly decreased (P001), and the ratio of CD4 to CD8 was obviously elevated (P001). CD8 was much lower (P001), and the ratio of CD4 to CD8 was much higher (P001), than the control group. The RRTR rate was positively correlated with the ratio of CD4 to CD8. Experiment in mice showed on the ninth day of bearing cancer, the tumor weight in the YWKL granules alone group was much lighter than that of chemotherapy alone group or water alone group respectively, the RBC immune function of YWKL granules alone group was higher than the other two groups, and on the thirteenth day, there wer