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C2 domain of synaptotagmin I associates with lipid rafts of plasma membrane

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Chinese Science Bulletin 2008年第9期53卷 1373-1380页

作者： lu jihua HE Li SUI SenFang Department of Biological Sciences & Biotechnology State Key Laboratory of Biomembrane and Membrane Biotechnology TsinghuaUniversity Beijing 100084 China

In this paper we report that the C2 domain of synaptotagmin I (syt I) could associate with lipid rafts of plasma membrane. We demonstrate that phosphatidylinositol 4,5-bisphosphate (PIP2) in the target membrane and Ca2+ are the key factors to enhance the raft association of the C2 domain. We also found that the raft association of the C2 domain could be fulfilled by either C2A or C2B alone, suggesting that their raft association might be complementary. Finally, we indicate that destroying lipid rafts or blocking syt I-raft association could significantly reduce the Ca2+-driven release of glutamates. Our data indicate that the raft association of the C2 domain might play an important role in the regulated exocytosis.

关键词：碳晶体脂质等离子体膜薄

Effect of chemical vapor infiltration treatment on the wave-absorbing performance of carbon fiber/cement composites

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Journal of University of Science and Technology Beijing 2008年第6期15卷 808-815页

作者： Kezhi Li Chuang Wang Hejun Li Lingjun Guo jihua lu School of Materials Science Northwestern Polytechnical University Xi＇an 710072 China

Short carbon fibers were treated at high temperatures around 1100℃ through chemical vapor infiltration technology. A thinner layer ofpyrocarbon was deposited on the fiber surface. The dispersion of carbon fibers in a cement matrix and the mechanical properties of carbon fiber/cement composites were investigated by scanning electron microscopy （SEM） and other tests. The reflec- tivity of electromagnetic waves by the composites was measured in the frequency range of 8.0-18 GHz for different carbon fiber contents of 0.2wt%, 0.4wt%, 0.6wt%, and 1.0wt%. The results show that the reflectivity tends to increase with the increase of fiber content above 0.4wt%. The minimum reflectivity is -19.3 dB and the composites exhibit wave-absorbing performances. After pyrocarbon is deposited on the fiber, all the refiectivity data are far greater. They are all above -10 dB and display mainly wave-reflecting performances.

关键词： carbon fibers chemical vapor infiltration cement reflectivity wave-absorbing property

冬凌草甲素调节JAK2/STAT3/SOCS-1信号通路对糖耐量异常大鼠胰岛素抵抗的影响

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河北医药 2024年第6期46卷 830-834页

作者：甘志远陆济华刘岩陈汝斌曾志美广西壮族自治区南宁市妇幼保健院检验科 530011 广西壮族自治区南宁市第八人民医院检验科

目的探讨冬凌草甲素(Oridonin,Ori)对糖耐量异常(impaired glucose tolerance,IGT)大鼠胰岛素抵抗(insulin resistance,IR)的影响及作用机制。方法采用高脂饮食喂养联合链脲佐菌素注射法构建IGT大鼠IR模型,大鼠分为正常组(CT组)、IGT模... 详细信息

目的探讨冬凌草甲素(Oridonin,Ori)对糖耐量异常(impaired glucose tolerance,IGT)大鼠胰岛素抵抗(insulin resistance,IR)的影响及作用机制。方法采用高脂饮食喂养联合链脲佐菌素注射法构建IGT大鼠IR模型,大鼠分为正常组(CT组)、IGT模型组(IGT组)、Ori组(10 mg·kg^(-1)·d^(-1))、Ori+Colivelin(COL)组(10 mg·kg^(-1)·d^(-1)Ori+2 mg/kg COL),每组6只。血糖检测仪测定空腹血糖(FPG)、葡萄糖耐量试验(OGTT)2 h血糖(2 hPG),ELISA试剂盒测定空腹胰岛素(FINS)、单核细胞趋化蛋白1(MCP-1)、肿瘤坏死因子α(TNF-α)含量,计算胰岛素抵抗指数(HOMA-IR),血液自动分析仪测定血清胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平,HE染色观察肝脏病理形态,Western blot验证附睾脂肪磷酸化(p)-激活Janus激活激酶2(JAK2)、JAK2、p-信号转导和转录激活因子3(STAT3)、STAT3、p-细胞因子信号传导抑制蛋白1(SOCS-1)、SOCS-1蛋白表达。结果与CT组比较,IGT组大鼠肝脏细胞肿胀,胞浆内可见大量大小不一的脂肪空泡,细胞核被脂肪空泡挤压偏位,且发生炎性细胞浸润,FPG、2hPG、FINS、HOMA-IR、TC、TG、LDL-C、MCP-1、TNF-α以及p-JAK2/JAK2、p-STAT3/STAT3、p-SOCS-1/SOCS-1蛋白表达水平升高,血清HDL-C水平下降(P<0.05);与IGT组相比,Ori组大鼠肝脏细胞胞浆内脂肪滴及空泡数量明显减少,细胞肿胀有所缓解,未见炎性细胞浸润,FPG、2hPG、FINS、HOMA-IR、TC、TG、LDL-C、MCP-1、TNF-α以及p-JAK2/JAK2、p-STAT3/STAT3、p-SOCS-1/SOCS-1蛋白表达水平下降,血清HDL-C水平升高(P<0.05);与Ori组相比,Ori+COL组大鼠肝脏脂肪变状况加剧,细胞肿大,血清FPG、2hPG、FINS、HOMA-IR、TC、TG、LDL-C、MCP-1、TNF-α以及p-JAK2/JAK2、p-STAT3/STAT3、p-SOCS-1/SOCS-1蛋白表达水平升高,血清HDL-C水平下降(P<0.05)。结论Ori对IGT大鼠IR的缓解作用可能与抑制JAK2/STAT3/SOCS-1信号通路激活有关。

关键词：糖耐量异常胰岛素抵抗冬凌草甲素 Janus激活激酶2 信号转导和转录激活因子3 细胞因子信号传导抑制蛋白1

Performance of a Dual-Hop Multi-relay Cooperative Network in a Nakagami-m Fading Environment

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China Communications 2012年第4期9卷 55-62页

作者： lu jihua An Jianping Li Xiangming School of Information and Electronics Beijing Institute of TechnologyBeijing 100081P.R.China

An exact average symbol error rate analysis for the distributed dual-hop relay cooperative network with multiple relays in a Nakagami-m fading environment is *** the derivation of the moment generation function of receiver Signal-to-Noise Ratio(SNR),the sectional integral method is used,instead of the cumulative density function method which is ordinarily used by the deduction of the outage probability of S-R-D *** accurate symbol error rate of a dual-hop relay cooperative network is obtained with the closed-form Moment Genoration Function (MGF) *** correctness of the symbol error rate is verified through numerical simulations and is compared with other analytical *** deductions clearly show that the distributed cooperative diversity network presented has strong superiorities in overcoming severe fading and can achieve full diversity order.

关键词： dual-hop relay cooperative communication average symbol error rate closed-form MGF amplify-and-forward Nakagami-m fading

Optimization of fermentation medium for xylanase-producing strain Xw2

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Frontiers in Biology 2013年第6期8卷 611-617页

作者： Bingying YE Ting XUE Shichao YE Shengyan XU Weiyan LI jihua lu Fang WEI Wenjin HE Youqiang CHEN College of Life Sciences Fujian Normal University Fuzhou 350108 China Key Laboratory of Developmental and Neural Fuzhou 350108 China Key Laboratory of Sugarcane Biology and Genetic Breeding of Ministry of Agriculture Fuzhou 350108 China Environmental Protection Agency Fuzhou Sanming 350400 China

To improve the fermentation yield of xylanase by optimizing the fermentation conditions for strain Xw2, a Plackett-Burman design was used to evaluate the effects of eight variables on xylanase production by strain Xw2. The steepest ascent （descent） method was used to approach the optimal response surface experimental area. The optimal fermentation conditions were obtained by central composite design and response surface analysis. The results showed that the composition of the optimal fermentation medium was corn cob ＋ 1.5% wheat bran （1：1）, 0.04% MnSO4, 0.04% K2HPO4. 3H2O, and an inoculum size of 6% in 50 mL liquid volume （pH = 6.0）. The optimal culture conditions were 28oc at 150 r/min for 54.23 h. The results of this study can serve as the basis for the industrial production and application of xylanase.

关键词： enzyme activity fermentation Plackett-Burman test xylan

Medical Diagnosis System Based on Fast-weights Scheme

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Instrumentation 2020年第1期7卷 51-57页

作者： TIAN Shining lu jihua GU Boyu WANG Huan School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

Clinical examination data often have the features of carrying vague information,missing data and incomplete examination records,which lead to higher probabilities of misdiagnosis.A variational recursive-discriminant joint model with fast weights(FWs)scheme is ***-III data sets are trained and tested,and the results are used to *** recurrent neural network(VRNN)with FWs can better obtain the temporal features with partly missing data,and discriminant neural network(DNN)is for ***,layer regularization(LN)avoids the overflow of loss function and stabilize the dynamic parameters of each *** the simulations,10 laboratory tests were selected to predict 10 diseases,1600 samples and 400 samples were used for training and testing,*** test accuracy of disease diagnosis without FWs is 72.55%,and that with FWs is 85.80%.Simulations reveal that the FWs mechanism can effectively optimize the system model,abstracting the features for diagnose,and significantly improve the accuracy of decision-making.

关键词： Fast Weights Scheme Discriminant Neural Network Variational Recurrent Neural Network Diagnosis Accuracy

Audit Mechanisms to Select Alliance Member of Industrial Clusters in Scenic Spot

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Audit Mechanisms to Select Alliance Member of Industrial Clu...

Recent Advances in C-F Bond Formation from Carbon-Centered Radicals

战略与管理工程：企业、环境与危机——2009战略管理国际会议

作者： lu jihua ZHAO Xi'nan DAi Xunfeng School of Business Administration Northeastern University

Based on the Principal-Agent theory and the assumption of fixed cost and audit cost and utility retention,the alliance leader of the industrial clusters in the scenic spot has to design excellent audit mechanisms to select the alliance member,and to enable every alliance member to participate actively in the alliance and work harder for it for implementing the efficient resource allocation,according to the correlativity of private information actually offered by each and every alliance *** study is done with the intention of solving the profit sharing problem in a industrial cluster of the scenic spot based on asymmetric information in accordance to how a member worked and what and how much information a member *** also provides a theoretical base to a certain degree to solve the problem of alliance member selection of such industrial cluster of the scenic spot.

关键词： Industrial Cluster Scenic Spot Audit Mechanism Profit Sharing

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Chinese Journal of Chemistry 2024年第9期42卷 1009-1031页

作者： jihua Zhang Juanjuan Wang Qiang Cheng College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072China

Construction of C-F bonds is a direct and efficient method for introducing fluorine into pharmaceuticals,agrochemicals,and *** such as nucleophilic,electrophilic,radical,and transition-metal catalyzed fluorination have been developed to meet the demand of diverse C-F bond *** them,radical fluorination has been witnessed with substantial advancement in a recent ***,we reviewed methods for formation of C-F bonds with carbon-centered radicals as key intermediates,especially in recent five *** introduce in the paper with different fluorinating reagents,strategies for radical generation,and application in late-stage functionalization and synthesis of PET *** also indicate the current limitations and propose the direction of the field for the future development.

关键词： Fluorine Fluorinating reagents Late-stage fluorination [^(18)F]jfluorination Radical reactions Synthetic methods

Topographic Information Based Three-Dimensional Localization Algorithm for Wireless Sensor Networks

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Topographic Information Based Three-Dimensional Localization...