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多发性骨髓瘤患者发生达雷妥尤单抗相关Ⅳ级不良反应1例

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解放军药学学报 2024年第3期37卷 294-296页

作者：刘丽英方海燕朱海燕钱李仁解放军总医院第五医学中心北京100071

多发性骨髓瘤(multiple myeloma,MM)是浆细胞克隆性增殖的血液系统恶性肿瘤,其主要临床表现为骨质受损、高钙血症、肾功能受损、贫血等。在最近10年,关于MM疗法的研究已取得明显成果,如来那度胺(Lenalidomide)、沙利度胺(Thalidomide)... 详细信息

多发性骨髓瘤(multiple myeloma,MM)是浆细胞克隆性增殖的血液系统恶性肿瘤,其主要临床表现为骨质受损、高钙血症、肾功能受损、贫血等。在最近10年,关于MM疗法的研究已取得明显成果,如来那度胺(Lenalidomide)、沙利度胺(Thalidomide)等免疫调节剂(immunomodulatory drugs,IMiDs);伊沙佐米(Ixazomib)、硼替佐米(Bortezomib)等蛋白酶体抑制剂(proteasome inhibitors,PIs)等.

关键词：多发性骨髓瘤达雷妥尤单抗药品不良反应

Micromagnetics and Signal Analysis of Shielded Spin-Valve Multilayer

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Chinese Physics Letters 1996年第6期13卷 469-472页

作者： ZHANG Huai-wu YANG Shi-qing liu ying-li WANG Hao-cai H.J.Kim Institute of Materials and Information Engineering University of Electronic Science and TechnologyChengdu 610054 Magnetic Alloy Laboratory Metals DivisionKorea Institute of Science and TechnologyP.O.Box 131ChenogryangSeoulKorea

In order to linearize a spin-valve giant magnetoresistance head,the exchanges layer sputtered at fringe area or a permanent magnet layer longitudinal biasing for domain stabilization based on a physical calculated model may be *** correlations between the head performance characteristic and head geometric parameters have been simulated by putting the head on a suitable front-end electric *** simulative results show that the optimal sensing current is from 10 to 40mA and the linear geometric parameteres for gap width are at the range of G_(1)+G_(2)≤0.5μm.

关键词： stabilization permanent Signal

Non-contact and full-field online monitoring of curing temperature during the in-situ heating process based on deep learning

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Advances in Manufacturing 2024年第1期12卷 167-176页

作者： Qiang-Qiang liu Shu-Ting liu ying-Guang li Xu liu Xiao-Zhong Hao College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016People’s Republic of China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing211816People’s Republic of China

Online monitoring of the curing temperature field is essential to improving the quality and efficiency of the manufacturing process of composite *** embedded sensor-based technologies have difficulty monitoring the full temperature field or have to introduce heterogeneous items that could have an undesired impact on the *** this paper,a non-contact,full-field monitoring method based on deep learning that predicts the internal temperature field of composite parts in real time using surface temperature measurements of auxiliary materials is *** the proposed method,an average temperature monitoring accuracy of 97%is achieved in various heating *** addition,this method also demonstrates satisfying feasibility when a stronger thermal barrier covers the *** method was experimentally validated during the self-resistance electric heating process,in which the monitoring accuracy reached 93.1%.This method can potentially be applied to automated manufacturing and process control in the composites industry.

关键词： Online monitoring Curing temperature field Deep learning(DL) In-situ heating

Synthesis and biological evaluation of novel steroid-linked nitrogen mustards

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Chinese Chemical Letters 2009年第6期20卷 680-683页

作者： Hua Bing Zhang Ji Jun Xue Xiao Long Zhao De Gang liu ying li State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 PR China

Two novel steroid-linked nitrogen mustard conjugates la and lb were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate la exhibited obvious increasing of activities.

关键词： Steroid Nitrogen mustards Synthesis Biological activity

Effect of partial liquid ventilation on oleic acid-induced inflammatory responses in piglets

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Chinese Medical Journal 2010年第15期123卷 2088-2093页

作者： ZHU Yao-bin WANG Qiang liu ying-long li Xiao-feng li Jian-an LU Xiao-dong liNG Feng liu Ai-jun FAN Xiang-ming Department of Pediatric Cardiac Surgery Center Fu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background Pediatric patients are susceptible to lung *** lung injury （Ali） in children often results in a high *** liquid ventilation （PLV） has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury *** study aimed to examine the hypothesis that PLV would attenuate the production of local and systemic cytokines in an immature piglet model of Ali induced by oleic acid （OA）.Methods Twelve Chinese immature piglets were induced to develop Ali by oleic *** animals were randomly assigned to two groups （n=6）：（1） conventional mechanical ventilation （MV） group and （2） PLV with FC-77 （10 ml/kg） *** Compared with MV group, PLV group got better cardiopulmonary variables （P 〈0.05）.These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen （PaO2）, PaO2/FiO2 and partial pressure of arterial carbon dioxide （PaCO2）.Partial liquid ventilation reduced IL-1β, IL-6, IL-10 and TN F-α both in plasma and tissue concentrations compared with MV group （P 〈0.05）.Conclusions Partial liquid ventilation provides protective effects against inflammatory responses in the lungs of oleic acid-induced immature piglets.

关键词： acute respiratory distress syndrome partial liquid ventilations inflammatory response cytokine piglets

Models to Simulate Effective Coverage of Fire Station Based on Real-Time Travel Times

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 483-513页

作者： Sicheng Zhu Dingli liu Weijun liu ying li Tian Zhou Department of Engineering Management Changsha University of Science and TechnologyChangsha410114China

In recent years,frequent fire disasters have led to enormous damage in *** firefighting rescues can minimize the losses caused by *** the rescue processes,the travel time of fire trucks can be severely affected by traffic conditions,changing the effective coverage of fire ***,it is still challenging to determine the effective coverage of fire stations considering dynamic traffic *** paper addresses this issue by combining the traveling time calculationmodelwith the effective coverage *** addition,it proposes a new index of total effective coverage area(TECA)based on the time-weighted average of the effective coverage area(ECA)to evaluate the urban fire *** also selects China as the case study to validate the feasibility of the models,a fire station(FS-JX)in ***-JX station and its surrounding 9,117 fire risk points are selected as the fire service supply and demand points,respectively.A total of 196 simulation scenarios throughout a consecutiveweek are ***,1,933,815 sets of valid sample data are *** results showed that the TECA of FS-JX is 3.27 km^(2),which is far below the standard requirement of 7.00 km^(2) due to the traffic *** visualization results showed that three rivers around FS-JX interrupt the continuity of its effective *** proposed method can provide data support to optimize the locations of fire stations by accurately and dynamically determining the effective coverage of fire stations.

关键词： Fire services fire station effective coverage real-time traffic simulation

Memory Trace for Fear Extinction:Fragile yet Reinforceable

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Neuroscience Bulletin 2024年第6期40卷 777-794页

作者： ying liu Shuai Ye Xin-Ni li Wei-Guang li Department of Rehabilitation Medicine State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai200032China

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing *** on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear *** brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain *** questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction *** this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

关键词： Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations

Micro-aluminum powder with bi-or tri-component alloy coating as a promising catalyst:Boosting pyrolysis and combustion of ammonium perchlorate

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Defence Technology（防务技术） 2024年第3期33卷 100-113页

作者： Chao Wang ying liu Mingze Wu Jia li ying Feng Xianjin Ning Hong li Ningfei Wang Baolu Shi School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

A novel design of micro-aluminum(μAl)powder coated with bi-/tri-component alloy layer,such as:Ni-P and Ni-P-Cu(namely,Al@Ni-P,Al@Ni-P-Cu,respectively),as combustion catalysts,were introduced to release its huge energy inside Al-core and promote rapid pyrolysis of ammonium perchlorate(AP)at a lower temperature in aluminized *** microstructure of Al@Ni-P-Cu demonstrates that a three-layer Ni-P-Cu shell,with the thickness of~100 nm,is uniformly supported byμAl carrier(fuel unit),which has an amorphous surface with a thickness of~2.3 nm(catalytic unit).The peak temperature of AP with the addition of Al@Ni-P-Cu(3.5%)could significantly drop to 316.2℃ at high-temperature thermal decomposition,reduced by 124.3℃,in comparison to that of pure AP with 440.5℃.It illustrated that the introduction of Al@Ni-P-Cu could weaken or even eliminate the obstacle of AP pyrolysis due to its reduction of activation energy with 118.28 kJ/*** laser ignition results showed that the ignition delay time of Al@Ni-P-Cu/AP mixture with 78 ms in air is shorter than that of Al@Ni-P/AP(118 ms),decreased by 33.90%.Those astonishing breakthroughs were attributed to the synergistic effects of adequate active sites on amorphous surface and oxidation exothermic reactions(7597.7 J/g)of Al@Ni-P-Cu,resulting in accelerated mass and/or heat transfer rate to catalyze AP pyrolysis and ***,it is believed to provide an alternative Al-based combustion catalyst for propellant designer,to promote the development the propellants toward a higher energy.

关键词： Micro-aluminum powder(μAl) Nano-sized alloy coating Combustion catalyst Ammonium perchlorate Pyrolysis behavior Ignition and combustion

TiO_(2)-Fe_(2)TiO_(5)heterostructure hollow spheres enable high-performance lithium-sulfur batteries via interfacial engineering

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Rare Metals 2024年第8期43卷 4006-4012页

作者： Kai-Tao liu Hong-Qiang Wang Zhuo Chen Shi-lin Zhang ying-ying Song Fang liu Qiao-ling li Jiao li School of Materials Science and Engineering Shandong University of TechnologyZibo 255049China College of Chemistry&Environmental Science Hebei UniversityBaoding 071002China School of Chemical Engineering Faculty of SciencesEngineering and TechnologyUniversity of AdelaideAdelaide 5005Australia School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

The shuttle effect of lithium polysulfides between sulfur cathode and lithium anode is a notorious problem in the commercial application of lithium-sulfur ***,heterostructured TiO_(2)-Fe_(2)TiO_(5)hollow spheres were ... 详细信息

关键词： lithium sulfide (5)

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