Effect of partial liquid ventilation on oleic acid-induced inflammatory responses in piglets

作     者：ZHU Yao-bin WANG Qiang LIU Ying-long LI Xiao-feng LI Jian-an LU Xiao-dong LING Feng LIU Ai-jun FAN Xiang-ming 

作者机构：Department of Pediatric Cardiac Surgery Center Fu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2010年第123卷第15期

页      面：2088-2093页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This study was supported by National Natural Science Foundation of China (No. 30670928) 

主　　题：acute respiratory distress syndrome partial liquid ventilations inflammatory response cytokine piglets 

摘      要：Background Pediatric patients are susceptible to lung *** lung injury （ALI） in children often results in a high *** liquid ventilation （PLV） has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury *** study aimed to examine the hypothesis that PLV would attenuate the production of local and systemic cytokines in an immature piglet model of ALI induced by oleic acid （OA）.Methods Twelve Chinese immature piglets were induced to develop ALI by oleic *** animals were randomly assigned to two groups （n=6）： （1） conventional mechanical ventilation （MV） group and （2） PLV with FC-77 （10 ml/kg） *** Compared with MV group, PLV group got better cardiopulmonary variables （P 〈0.05）.These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen （PaO2）, PaO2/FiO2 and partial pressure of arterial carbon dioxide （PaCO2）.Partial liquid ventilation reduced IL-1β, IL-6, IL-10 and TN F-α both in plasma and tissue concentrations compared with MV group （P 〈0.05）.Conclusions Partial liquid ventilation provides protective effects against inflammatory responses in the lungs of oleic acid-induced immature piglets.