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Yinlai Decoction Protects Microstructure of Colon and Regulates Serum Level of D-Lactic Acid in Pneumonia Mice Fed with High-Calorie and High-Protein Diet

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Chinese Journal of Integrative Medicine 2023年第8期29卷 714-720页

作者： WANG Yun-hui YU He liu tie-gang Teck Chuan Kong ZHENG Zi-an WAN Yu-xiang BAI Chen HAO Yu MAO Ying-qiu WU Jun XU Jing-nan CUI Li-jun WANG Yu-han SHAN Yan-ran SHAO Ying-jun GU Xiao-hong College of Chinese Medicine Beijing University of Chinese MedicineBeijing(100029)China Nanyang Technological University Singapore

Objective To investigate the effect of Yinlai Decoction(YD)on the microstructure of colon,and activity of D-lactic acid(DLA)and diamine oxidase(DAO)in serum of pneumonia mice model fed with high-calorie and high-protein diet(HCD).Methods Sixty male Kunming mice were randomly divided into 6 groups by the random number table method:normal control,pneumonia,HCD,HCD with pneumonia(HCD-P),YD(229.2 mg/mL),and dexamethasone(15.63 mg/mL)groups,with 10 in each group.HCD mice were fed with 52%milk solution by gavage.Pneumonia mice was modeled with lipopolysaccharide inhalation and was fed by gavage with either the corresponding therapeutic drugs or saline water,twice daily,for 3 days.After hematoxylin-eosin staining,the changes in the colon structure were observed under light microscopy and transmission electron microscope,respectively.Enzyme-linked immunosorbent assay was used to detect the protein levels of DLA and DAO in the serum of mice.Results The colonic mucosal structure and ultrastructure of mice in the normal control group were clear and intact.The colonic mucosal goblet cells in the pneumonia group tended to increase,and the size of the microvilli varied.In the HCD-P group,the mucosal goblet cells showed a marked increase in size with increased secretory activity.Loose mucosal epithelial connections were also observed,as shown by widened intercellular gaps with short sparse microvilli.These pathological changes of intestinal mucosa were significantly reduced in mouse models with YD treatment,while there was no significant improvement after dexamethasone treatment.The serum DLA level was significantly higher in the pneumonia,HCD,and HCD-P groups as compared with the normal control group(P0.05).Conclusions YD can protect function of intestinal

关键词： Yinlai Decoction Chinese medicine pneumonia microstructure D-lactic acid diamine oxidase

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Characteristics of Particulate Matter Emissions for Low-Sulfur Heavy Oil Used in Low-Speed Two-Stroke Diesel Engines of Ocean-Going Ships

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Journal of Thermal Science 2024年第2期33卷 739-750页

作者： WU gang MA Qianli WEI Lijiang JIANG Guohe WANG Tengfei LI tie Merchant Marine College Shanghai Maritime UniversityShanghai201306China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai200240China

In this work,particulate matter(PM) emissions from a large two-stroke,low-speed marine diesel engine were investigated when the engine was operated with low-sulfur heavy fuel oil(HFO) at various loads.Particle samples were collected in situ from the engine exhaust to determine the detailed physical and chemical properties.The nanostructure and morphology of the nanoparticles were analyzed using transmission electron microscopy images(TEM).The results show that volatile organic carbon(OC) accounts for more than 80% in the HFO particles and leads to an increase in particle size.The thermodynamic conditions of a low-speed engine favor the behavior of capturing the soluble organic components.A large number of spherical char HFO particles with aerodynamic diameters of 0.2 μm-0.5 μm and a suspected inner metal core were detected.The two peak aerodynamic diameters of the HFO nanoparticles are 15 nm and 86 nm.The morphological differences among the HFO nanoparticles in varied engine conditions represent the formation process from primary nascent particles to mature graphitized particles caused by thermodynamics.The above study will be valuable for understanding the characteristics of PM emissions from low-sulfur HFO to achieve the ship PM emissions reduction target.

关键词： low-speed diesel engine maritime regulations heavy fuel oil TEM particles size and distribution

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Organic thin-film transistors and related devices in life and health monitoring

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Nano Research 2024年第2期17卷 426-444页

作者： Chenfang Sun tie Wang Tianjin Key Laboratory of Drug Targeting and Bioimaging Life and Health Intelligent Research InstituteTianjin University of TechnologyTianjin 300384China

The early determination of disease-related biomarkers can significantly improve the survival rate of patients.Thus,a series of explorations for new diagnosis technologies,such as optical and electrochemical methods,have been devoted to life and health monitoring.Organic thin-film transistor(OTFT),as a state-of-the-art nano-sensing technology,has attracted significant attention from construction to application owing to the merits of being label-free,low-cost,facial,and rapid detection with multi-parameter responses.Nevertheless,interference from non-specific adsorption is inevitable in complex biological samples such as body liquid and exhaled gas,so the reliability and accuracy of the biosensor need to be further improved while ensuring sensitivity,selectivity,and stability.Herein,we overviewed the composition,mechanism,and construction strategies of OTFTs for the practical determination of disease-related biomarkers in both body fluids and exhaled gas.The results show that the realization of bio-inspired applications will come true with the rapid development of high-effective OTFTs and related devices.

关键词： organic thin-film transistors biosensors biomarkers organic bioelectronics organic semiconductors healthcare

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Stable,intense supercontinuum light generation at 1 kHz by electric field assisted femtosecond laser filamentation in air

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Light(Science & Applications) 2024年第2期13卷 354-365页

作者： Yaoxiang liu Fukang Yin tie-Jun Wang Yuxin Leng Ruxin Li Zhizhan Xu See Leang Chin State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics and CAS Center for Excellence in Ultra-intense Laser ScienceChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina Centre d’Optique Photonique et Laser(COPL)and Département de physiquede génie physique et d’optiqueUniversitéLavalQuébecQuébecCanada

Supercontinuum(SC)light source has advanced ultrafast laser spectroscopy in condensed matter science,biology,physics,and chemistry.Compared to the frequently used photonic crystal fibers and bulk materials,femtosecond laser filamentation in gases is damage-immune for supercontinuum generation.A bottleneck problem is the strong jitters from filament induced self-heating at kHz repetition rate level.We demonstrated stable kHz supercontinuum generation directly in air with multiple mJ level pulse energy.This was achieved by applying an external DC electric field to the air plasma filament.Beam pointing jitters of the 1 kHz air filament induced SC light were reduced by more than 2 fold.The stabilized high repetition rate laser filament offers the opportunity for stable intense SC generation and its applications in air.

关键词： intense repetition light

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Pushing the frontiers: Chip-based detection based on micro-and nano-structures

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Chinese Chemical Letters 2024年第4期35卷 86-98页

作者： Meihui liu Xinyuan Zhou Xiao Li Zhenjie Xue tie Wang Tianjin Key Laboratory of Life and Health Detection Life and Health Intelligent Research InstituteTianjin University of TechnologyTianjin 300384China

Changes in trace substances in human metabolites, which are related to disease processes and health status, can serve as chemical markers for disease diagnosis and symptom monitoring. Real-time online detection is an inevitable trend for the future of health monitoring, and the construction of chips for detection faces major challenges. The response of sensors often fails to meet the requirements for chipbased detection of trace substances due to the low efficiency of interfacial heterogeneous reactions, necessitating a rational design approach for micro-and nano-structures to improve sensor performance with respect to sensitivity and detection limits. This review focuses on the influence of micro-and nanostructures that used in chip on sensing. Firstly, this review categorizes sensors into chemiresistors, electrochemical sensors, fluorescence sensors, and surface enhanced Raman scattering(SERS) sensors based on their sensing principle, which have significant applications in disease diagnosis. Subsequently, commencing from the application requirements in the field of sensing, this review focuses on the different structures of nanoparticle(NP) assemblies, including wire, layered, core-shell, hollow, concave and deformable structures. These structures change in the size, shape, and morphology of conventional structures to achieve characteristics such as ordered alignment, high specific surface area, space limitation,vertical diffusion, and swaying behavior with fluid, thereby addressing issues such as poor signal transmission efficiency, inadequate adsorption and capture capacity, and slow mass transfer speed during sensing. Finally, the design direction of micro-and nano-structures, and possible obstacles and solutions to promote chip-based detection have been discussed. It is hope that this article will inspire the exploration of interface micro-and nano-structures modulated sensing methods.

关键词： Chip-based detection Micro-and nano-structures Real-time online detection Sensing Health monitoring

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Recent advances in halide perovskite memristors:From materials to applications

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Frontiers of physics 2024年第2期19卷 73-104页

作者： Sixian liu Jianmin Zeng Qilai Chen gang liu Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Aerospace Science&Industry Shenzhen(Group)Co.Ltd. Shenzhen 518000China

With the emergence of the Internet of Things(IoT)and the rapid growth of big data generated by edge devices,there has been a growing need for electronic devices that are capable of processing and transmitting data at low power and high speeds.Traditional Complementary Metal-Oxide-Semiconductor(CMOS)devices are nonvolatile and often limited by their ability for certain IoT applications due to their unnecessary power consumption for data movement in von Neuman architecture-based systems.This has led to a surge in research and development efforts aimed at creating innovative electronic components and systems that can overcome these shortcomings and meet the evolving needs of the information era,which share features such as improved energy efficiency,higher processing speeds,and increased functionality.Memristors are a novel type of electronic device that has the potential to break down the barrier between storage and computing.By storing data and processing information within the same device,memristors can minimize the need for data movement,which allows for faster processing speeds and reduced energy consumption.To further improve the energy efficiency and reliability of memristors,there has been a growing trend toward diversifying the selection of dielectric materials used in memristors.Halide perovskites(HPs)have unique electrical and optical properties,including ion migration,charge trapping effect caused by intrinsic defects,excellent optical absorption efficiency,and high charge mobility,which makes them highly promising in applications of memristors.In this paper,we provide a comprehensive overview of the recent development in resistive switching behaviors of HPs and the underlying mechanisms.Furthermore,we summarize the diverse range of HPs,their respective performance metrics,as well as their applications in various fields.Finally,we critically evaluate the current bottlenecks and possible opportunities in the future research of HP memristors.

关键词： halide perovskite memristor mechanism neuromorphic computing non-volatile memory

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A Correlation-Based Stochastic Model for Massive MIMO Channel

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China Communications 2024年第1期21卷 175-187页

作者： Yang liu gang Li Chengxiang Wang National Mobile Communications Research Laboratory School of Information Science and EngineeringSoutheast UniversityNanjing 211189China School of Internet of Things Engineering Jiangnan UniversityWuxi 214122China Pervasive Communication Research Center Purple Mountain LaboratoriesNanjing 211111China

In this paper,the channel impulse response matrix(CIRM)can be expressed as a sum of couplings between the steering vectors at the base station(BS)and the eigenbases at the mobile station(MS).Nakagami distribution was used to describe the fading of the coupling between the steering vectors and the eigenbases.Extensive measurements were carried out to evaluate the performance of this proposed model.Furthermore,the physical implications of this model were illustrated and the capacities are analyzed.In addition,the azimuthal power spectrum(APS)of several models was analyzed.Finally,the channel hardening effect was simulated and discussed.Results showed that the proposed model provides a better fit to the measured results than the other CBSM,i.e.,Weichselberger model.Moreover,the proposed model can provide better tradeoff between accuracy and complexity in channel synthesis.This CIRM model can be used for massive MIMO design in the future communication system design.

关键词： CBSM channel capacity channel hardening channel modeling massive MIMO

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Phylotranscriptomic discordance is best explained by incomplete lineage sorting within Allium subgenus Cyathophora and thus hemiplasy accounts for interspecific trait transition

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Plant Diversity 2024年第1期46卷 28-38页

作者： Zengzhu Zhang gang liu Minjie Li State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems College of EcologyLanzhou UniversityLanzhou 730000GansuPR China

The transition of traits between genetically related lineages is a fascinating topic that provides clues to understanding the drivers of speciation and diversification.Much can be learned about this process from phylogeny-based trait evolution.However,such inference is often plagued by genome-wide gene-tree discordance(GTD),mostly due to incomplete lineage sorting(ILS)and/or introgressive hybridization,especially when the genes underlying the traits appear discordant.Here,by collecting transcriptomes,whole chloroplast genomes(cpDNA),and population genetic datasets,we used the coalescent model to turn GTD into a source of information for ILS and employed hemiplasy to explain specific cases of apparent“phylogenetic discordance”between different morphological traits and probable species phylogeny in the Allium subg.Cyathophora.Both concatenation and coalescence methods consistently showed the same phylogenetic topology for species tree inference based on single-copy genes(SCGs),as supported by the KS distribution.However,GTD was high across the genomes of subg.Cyathophora:~27%e38.9%of the SCG trees were in conflict with the species tree.Plasmid and nuclear incongruence was also present.Our coalescent simulations indicated that such GTD was mainly a product of ILS.Our hemiplasy risk factor calculations supported that random fixation of ancient polymorphisms in different populations during successive speciation events along the subg.Cyathophora phylogeny may have caused the character transition,as well as the anomalous cpDNA tree.Our study exemplifies how phylogenetic noise can be transformed into evolutionary information for understanding character state transitions along species phylogenies.

关键词： Hemiplasy Multispecies coalescence Lineage sorting Gene tree discordance Phylotranscriptomics Allium subg.Cyathophora

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Method for triangular fuzzy multiple attribute decision making based on two-dimensional density operator method

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Journal of Systems Engineering and Electronics 2024年第1期35卷 178-185页

作者： LIN Youliang LI Wu liu gang HUANG Dong School of Economics and Management Hunan Institute of Science and TechnologyYueyang 414000China Hunan Vocational College for Nationalities Yueyang 414000China School of Information Science and Engineering Hunan Institute of Science and TechnologyYueyang 414000China

Aiming at the triangular fuzzy(TF)multi-attribute decision making(MADM)problem with a preference for the distribution density of attribute(DDA),a decision making method with TF number two-dimensional density(TFTD)operator is proposed based on the density operator theory for the decision maker(DM).Firstly,a simple TF vector clustering method is proposed,which considers the feature of TF number and the geometric distance of vectors.Secondly,the least deviation sum of squares method is used in the program model to obtain the density weight vector.Then,two TFTD operators are defined,and the MADM method based on the TFTD operator is proposed.Finally,a numerical example is given to illustrate the superiority of this method,which can not only solve the TF MADM problem with a preference for the DDA but also help the DM make an overall comparison.

关键词： fuzzy decision making clustering density operator multi-attribute decision making(MADM)

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Vibration attenuation performance of wind turbine tower using a prestressed tuned mass damper under seismic excitation

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 511-524页

作者： Lei Zhenbo liu gang Wang Hui Hui Yi School of Civil Engineering Chongqing UniversityChongqing 400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityMinistry of EducationChongqing 400045China

With the rapid development of large megawatt wind turbines,the operation environment of wind turbine towers(WTTs)has become increasingly complex.In particular,seismic excitation can create a resonance response and cause excessive vibration of the WTT.To investigate the vibration attenuation performance of the WTT under seismic excitations,a novel passive vibration control device,called a prestressed tuned mass damper(PS-TMD),is presented in this study.First,a mathematical model is established based on structural dynamics under seismic excitation.Then,the mathematical analytical expression of the dynamic coefficient is deduced,and the parameter design method is obtained by system tuning optimization.Next,based on a theoretical analysis and parameter design,the numerical results showed that the PS-TMD was able to effectively mitigate the resonance under the harmonic basal acceleration.Finally,the time-history analysis method is used to verify the effectiveness of the traditional pendulum tuned mass damper(PTMD)and the novel PS-TMD device,and the results indicate that the vibration attenuation performance of the PS-TMD is better than the PTMD.In addition,the PS-TMD avoids the nonlinear effect due to the large oscillation angle,and has the potential to dissipate hysteretic energy under seismic excitation.

关键词： wind turbine tower prestressed tuned mass damper vibration control seismic excitation numerical simulation

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