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Science China Chemistry 2009年第9期52卷 1314-1320页

作者： WANG Xin liu lingyan CHANG WeiXing LI Jing State Key Laboratory and Research Institute of Elemento-organic Chemistry Nankai UniversityTianjin 300071China

This paper presents Sonogashira coupling reaction of aryl bromides with protected homopropargyl alcohols such as tert-butyldimethyl(1-phenylbut-3-ynyloxy)silane and tert-butyldimethyl(1-(2,4-dichlorophenyl)but-3-ynyloxy)silane in piperidine catalyzed by PdCl2/PPh3 without copper(I). The coupling products, disubstituted acetylene, are obtained in good or excellent yields. These products can be further used for the synthesis of 2,5-disubstituted 3-bromofurans.

关键词： Sonogashira protected homopropargyl alcohol 2 5-disubstituted 3-bromofurans

Comparative experiment on layered Li(Ni_(1/3)Co_(1/3)Mn_(1/3))O_2 as the alternative material for LiCoO_2

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Journal of University of Science and Technology Beijing 2007年第2期14卷 173-177页

作者： Jingjing liu Weihua Qiu lingyan Yu Hailei Zhao Tao Li Materials Science and Engineering School University of Science and Technology Beijing Beijing 100083 China

This work was financially supported by the National Natural Science Foundation of China （No.50472093）.

关键词： Li(Ni1/3Co1/3Mn1/3)O2 cathode material lithium-ion batteries LiCoO2

A fluorescent probe operating under weak acidic conditions for the visualization of HOCl in solid tumors in vivo

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Science China Chemistry 2020年第8期63卷 1153-1158页

作者： Peng Wei lingyan liu Wei Yuan Jiajia Yang Ruohan Li Tao Yi State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua UniversityShanghai 201620China College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Department of Chemistry Fudan UniversityShanghai 200438China

Levels of reactive oxygen species(ROS)in cancer cells or in the tumor microenvironment differ noticeably from those in normal cells and cellular microenvironments because ROS play important roles in all aspects of tumor ***,due to the lack of adequate tools,it is difficult to study the relationship between ROS,especially certain types of ROS(e.g.,HOCl),and *** report herein an HOCl-specific fluorescent probe,FDOCl-20,containing a thiocarbamide group as a receptor,for the visualization of HOCl in solid tumors in *** probe displays high selectivity and sensitivity to HOCl,and is appropriate for use in acidic conditions,including the tumor *** FDOCl-20 as a tool,we can visualize HOCl in solid tumors in ***,the fluorescent intensity of FDOCl-20 is proportional to tumor ***,FDOCl-20 is a useful tool to investigate the relationship between HOCl and the physiological processes of tumors.

关键词： fluorescent probe hypochlorous acid imaging solid tumor

Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance

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Asian Journal of Pharmaceutical Sciences 2020年第5期15卷 646-660页

作者： Yinghuan Li Xi Tan Xuhan liu lingyan liu Yan Fang Rong Rao Yuanyuan Ren Xiangliang Yang Wei liu School of Pharmaceutical Sciences Beijing Area Major Laboratory of Peptide and Small Molecular DrugsEngineering Research Center of Endogenous Prophylactic of Ministry of Education of ChinaCapital Medical UniversityBeijing 100069China College of Life Science and Technology Huazhong University of Science and TechnologyWuhan 430074China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430074China

Multiple drug resistance(MDR)is a tough problem in developing hepatocellular carcinoma(HCC)***,we developed TPGS-coated cationic liposomes with Bcl-2 siRNA corona to load doxorubicin(Dox)i.e.,Bcl-2 siRNA/Dox-TPGS-LPs,to enhance anticancer effect of Dox in *** i.e.,d-α-tocopheryl polyethylene glycol 1000 succinate,inhibited Pglycoprotein(P-gp)efflux pump and Bcl-2 siRNA suppressed anti-apoptotic Bcl-2 *** Bcl-2 siRNA loaded in the liposomal corona was observed under transmission electron *** stability and hemolysis evaluation demonstrated Bcl-2 siRNA/Dox-TPGSLPs had good biocompatibility and siRNA-corona could protect the liposomal core to avoid the attachment of fetal bovine *** drug-resistant cells,TPGS effectively prolonged intracellular Dox retention time and siRNA-corona did improve the internalization of Dox from *** vitro and in vivo anticancer effect of this dual-functional nanostructure was examined in HCC-MDR Bel7402/5-FU tumor *** assay confirmed the IC50 value of Dox was 20–50 fold higher in Bel7402/5-FU MDR cells than that in sensitive Bel7402 ***-2 siRNA corona successfully entered the cytosol of Bel7402/5-FU MDR cells to downregulate Bcl-2 protein levels in vitro and in ***-2 siRNA/Dox-TPGS-LPs showed superior to TPGS-(or siRNA-)linked Dox liposomes in cell apoptosis and cytotoxicity assay in Bel7402/5-FU MDR cells,and 7-fold greater effect than free Dox in tumor growth inhibition of Bel7402/5-FU xenograft nude *** conclusion,TPGS-coated cationic liposomes with Bcl-2 siRNA corona had the capacity to inhibit MDR dual-pathways and subsequently improved the anti-tumor activity of the chemotherapeutic agent co-delivered to a level that cannot be achieved by inhibiting a MDR single way.

关键词： Multiple drug resistance(MDR) TPGS siRNA-corona Liposomes P-glycoprotein(P-gp) Bcl-2

Syntenic quantitative trait loci and genomic divergence for Sclerotinia resistance and ?owering time in Brassica napus

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Journal of Integrative Plant Biology 2019年第1期61卷 75-88页

作者： Fengqi Zhang Junyan Huang Minqiang Tang Xiaohui Cheng Yueying liu Chaobo Tong Jingyin Yu Tehrim Sadia Caihua Dong lingyan liu Baojun Tang Jianguo Chen Shengyi liu Key Laboratory of Biology and Genetic Improvement of Oil Crops the Ministry of AgricultureOil Crops Research Institute of CAAS Cereal Crops Research Institute Henan Academy of Agricultural Sciences Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources Faculty of Life ScienceHubei University

Oilseed rape(Brassica napus) is an allotetraploid with two subgenomes descended from a common ancestor. Accordingly, its genome contains syntenic regions with many duplicate genes, some of which may have retained their original functions, whereas others may have diverged. Here, we mapped quantitative trait loci(QTL) for stem rot resistance(SRR), a disease caused by the fungus Sclerotinia sclerotiorum, and flowering time(FT) in a recombinant inbred line population. The population was genotyped using *** 60 K single nucleotide polymorphism arrays and phenotyped in six(FT) and nine(SSR) experimental conditions or environments. In total, we detected 30 SRR QTL and 22 FT QTL and show that some of the major QTL associated with these two traits were co-localized,suggesting a genetic linkage between them. Two SRR QTL on chromosome A2 and two on chromosome C2 were shown to be syntenic, suggesting the functional conservation of these regions. We used the syntenic properties of the genomic regions to exclude genes for selection candidates responsible for QTL-associated traits. For example, 152 of the 185 genes could be excluded from a syntenic A2–C2 region. These findings will help to elucidate polyploid genomics in future studies, in addition to providing useful information for B. napus breeding programs.

关键词： napus Oilseed rape

Study on the Formation and Properties of Liquid Crystal Emulsion in Cosmetic

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第2期3卷 139-144页

作者： Wanping Zhang lingyan liu School of Perfume and Aroma technology Shanghai Institute of Technology Shanghai China

In this paper, the formation of liquid crystal structure in preparation of emulsion and the change of those liquid crystal structures during storage and usage were studied. Besides, the rheological and moisturizing property of the liquid crystal structure emulsion was investigated as well. The results show that the liquid crystal structure at oil-water interface in the emulsion forms gradually with cooling process after homogenization. The liquid crystal structure doesn’t change significantly during the storage within 12 months. And after emulsion being stored for 18 months, the crystal structure starts to decompose. Upon application on the skin, the liquid crystal structure of emulsion was found to transform into other form with rubbing, although the liquid crystal structure still remains. The rheological data shows that liquid crystal emulsion exhibits solid-like (elastic) property during storage, which is favorable for good stability. On the other hand, liquid crystal emulsion shows typical shear-thinning property upon usage, which leads to an excellent skin sensory feeling. And the improved moisturizing properties of such emulsion may be attributed to the liquid crystal structure.

关键词： Liquid Crystal Emulsion Rheology Stability Moisture

Allyltin tribromide: A versatile reagent involved in the ring-opening of epoxides

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Science China Chemistry 2010年第6期53卷 1294-1301页

作者： CHEN GuoHong,WANG Xin,JIN XiaoQian,liu lingyan,CHANG WeiXing & LI Jing State Key Laboratory and Research Institute of Elemento-organic Chemistry,Nankai University,Tianjin 300071,China 1. State Key Laboratory and Research Institute of Elemento-organic Chemistry Nankai University Tianjin 300071 China

This paper presents a versatile reagent for epoxide *** allyltin tribromide could act as a novel and easily prepared allylation reagent and halide atom donor to convert epoxides to the corresponding homoallyl alcohols and halohydrins in high yields with excellent regioselectivities under mild reaction conditions,*** could also act as a Lewis acid to catalyze the ring opening reactions of epoxides with alcohols.

关键词： versatile reagent allyltin tribromide ring opening of epoxides room temperature

Enhanced Expression of miR-425 Promotes Esophageal Squamous Cell Carcinoma Tumorigenesis by Targeting SMAD2

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Journal of Genetics and Genomics 2015年第11期42卷 601-611页

作者： lingyan liu Zitong Zhao Wei Zhou Xinyi Fan Qimin Zhan Yongmei Song State Key Laboratory of Molecular Oncology Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical College

Esophageal squamous cell carcinoma （ESCC） is one of the most common and deadly cancers in the world, Currently, clinical therapy of ESCC remains limited and the five-year survival rate is poor. The function of miR-425 has been reported in multiple human cancers. However. the tumorigenic role and clinical significance of miR-425 in ESCC remains unclear. We found that enhanced expression of miR- 425 in ESCC cell lines not only promoted cell proliferation and colony formation, but also increased cellular metastasis. Furthermore, we revealed the mechanism that miR-425 inhibited the expression of SMAD2 by targeting the second binding site in the 3＇-untranslated region （3＇-UTR） in ESCC. This mode of action influenced not only SMAD2 rnRNA expression but also protein expression. In addition, we detected the expression of miR-425 in ESCC tissues and plasma. Moreover, we analyzed the relationship between miR-425 expression and SMAD2 mRNA expression. We found that miR-425 was overexpressed in ESCC tissues and the plasma relative to adjacent normal tissues and plasma of healthy individuals. Furthermore, there was a negative correlation between miR-425 expression and SMAD2, Taken together, our results show that miR-425 functions as an oncogene by targeting the 3＇-UTR of SMAD2 and indicate the potential utility of plasma miR-425 as a novel biomarker for ESCC diagnosis.

关键词： Esophageal squamous cell carcinoma miR-425 Plasma miRNA SMAD2

Short-term exposure to ambient ozone associated with cardiac arrhythmias in healthy adults

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Global Health Journal 2022年第1期6卷 6-18页

作者： lingyan liu Yutong Zhu Hongbing Xu Yang Wang Tong Wang Qian Zhao Yi Zhang Jie Chen Shengcong liu Tieci Yi Rongshan Wu Shuo liu Xiaoming Song Jianping Li Wei Huang Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Peking University Institute of Environmental Medicine Peking UniversityBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Science CenterPeking UniversityBeijing 100191China Department of Prevention and Health Care Hospital of Health Science CenterPeking UniversityBeijing 100191 China Institute for Risk Assessment Sciences University Medical Centre UtrechtUniversity of UtrechtP.O.Box 801253508 TC Utrechtthe Netherlands Department of Cardiology Peking University First HospitalBeijing 100034China

Objective The exact biological mechanism whereby exposure to ambient ozone(O3)may contribute to clinical onset of cardiovascular events remains *** this study,we aim to examine the impacts of O3 exposure on cardiac arrhythmias and potential pathways involved through autonomic dysfunction and myocardial *** Seventy-three non-smoking healthy adults were followed with 4 repeated measurements of 24-hour ambulatory arrhythmias,heart rate variability,ST-segment deviation,and blood pressure(BP)in Beijing,China,2014‒*** additive mixed models coupled with distributed lag nonlinear models were constructed to evaluate the associations and potential interlinks between O3 exposure and outcome *** During the study period,24-hour average concentrations of ambient O3 were 47.4µg/m3(ranging from 1.0 to 165.9µg/m3).Increased risks of premature ventricular contraction and ventricular tachycardia were associated with interquartile range increases in O3 exposure during the last 5 days before each participant's clinic visit,with relative risks of 2.14(95%confidence interval[CI]:1.95 to 2.32)and 5.47(95%CI:3.51 to 7.43),*** analyses further showed that sympathetic activation,parasympathetic inhibition,and elevated BP levels,as well as heightened risks of ST-segment depression could mediate up to 47.74%of the risks of arrhythmias attributable to O3 *** Our results suggest that short-term exposure to ambient O3 could prompt the genesis of arrhythmias partially through worsening autonomic function and myocardial burden.

关键词： Ozone Cardiac arrhythmias Cardiac autonomic function Myocardial injury Panel study

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中国水资源效率的区域差异及影响因素分析

经济地理 2017年第7期37卷 12-19页

作者：俞雅乖刘玲燕宁波大学商学院/宁波港口经济圈协同创新中心中国浙江宁波315211

选取我国大陆30个省(市、自治区)的2004—2014年间相关统计数据,运用超效率DEA-Tobit两阶段模型对水资源效率进行评价,并对水资源效率的区域差异及其影响因素进行分析。水资源效率的区域差异分析结果表明:我国水资源效率相对较低,仅北... 详细信息

选取我国大陆30个省(市、自治区)的2004—2014年间相关统计数据,运用超效率DEA-Tobit两阶段模型对水资源效率进行评价,并对水资源效率的区域差异及其影响因素进行分析。水资源效率的区域差异分析结果表明:我国水资源效率相对较低,仅北京、天津、青海三省市的水资源效率高于1,其余大部分省市水资源效率处于0~0.2之间;同时,我国水资源效率还存在区域差异,东部地区高于中西部地区,华北、西北地区相较于其他区域处于较高水平。水资源效率区域差异的影响因素分析结果发现:水资源效率与治理废水项目完成投资额和产业用水结构呈负相关关系,与供水总量和科技水平呈正相关关系。因此,为了进一步提升水资源效率,必须在发展经济的同时,加大科技投入,提升科技水平,优化产业用水结构。

关键词：水资源效率区域差异影响因素超效率DEA—Tobit模型