A fluorescent probe operating under weak acidic conditions for the visualization of HOCl in solid tumors in vivo

作     者：Peng Wei Lingyan Liu Wei Yuan Jiajia Yang Ruohan Li Tao Yi Peng Wei;Lingyan Liu;Wei Yuan;Jiajia Yang;Ruohan Li;Tao Yi

作者机构：State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsDonghua UniversityShanghai 201620China College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Department of ChemistryFudan UniversityShanghai 200438China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2020年第63卷第8期

页      面：1153-1158页

核心收录：

学科分类：081704[工学-应用化学] 1002[医学-临床医学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(21877013,21671043) the Initial Research Funds for Young Teachers of Donghua University 

主　　题：fluorescent probe hypochlorous acid imaging solid tumor 

摘      要：Levels of reactive oxygen species(ROS)in cancer cells or in the tumor microenvironment differ noticeably from those in normal cells and cellular microenvironments because ROS play important roles in all aspects of tumor ***,due to the lack of adequate tools,it is difficult to study the relationship between ROS,especially certain types of ROS(e.g.,HOCl),and *** report herein an HOCl-specific fluorescent probe,FDOCl-20,containing a thiocarbamide group as a receptor,for the visualization of HOCl in solid tumors in *** probe displays high selectivity and sensitivity to HOCl,and is appropriate for use in acidic conditions,including the tumor *** FDOCl-20 as a tool,we can visualize HOCl in solid tumors in ***,the fluorescent intensity of FDOCl-20 is proportional to tumor ***,FDOCl-20 is a useful tool to investigate the relationship between HOCl and the physiological processes of tumors.