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Evaluation of the efficacy of neoadjuvant chemotherapy for intermediate and advanced breast cancer by 3.0T MR and ultrasound combined with tumour markers

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Clinical Research Communications 2024年第3期7卷 53-60页

作者： Bao-Jun Pan Chun-Lei Sun Yu-Hua liu guo-Zheng Tan Chun-Yun liu hai-Jie Xu Qing-Yu Meng Ji-Xuan liu Xiang-Dong Wei Wen-ming Cao Thyroid and mammary department Shandong Changle People’s HospitalWeifang 262400China. Gynecology Department Pingshan District Central HospitalShenzhen 518122China.

Objective:To evaluate the efficacy of neoadjuvant chemotherapy before and after neoadjuvant chemotherapy for intermediate and advanced breast cancer using 3.0T MR and ultrasound in combination with tumour markers(CEA,CA-153,CA125),and to provide therapeutic references for the clinicians,so as to better satisfy the needs of treatment for intermediate and advanced breast cancer ***:The team collected 30 patients who were diagnosed with intermediate and advanced breast cancer by biopsy and received neoadjuvant chemotherapy,and divided them into sensitive and insensitive groups according to the MP grading of postoperative pathological *** team retrospectively analysed the changes in the values of serum CEA,CA-153,and CA 125 before and after the neoadjuvant chemotherapy,the changes in the average ADC of the lesions before and after the observation by MRI,and the changes in the volume and size of lesions before and after the observation by ultrasonography to assess the effects of neoadjuvant chemotherapy individually,and the results of neoadjuvant chemotherapy were evaluated *** effect of neoadjuvant chemotherapy was assessed *** of the above was evaluated independently,and the accuracy of each item was calculated by comparing the evaluation results with the pathological examination results,and the accuracy of the single item was compared with the accuracy of the three combined tests to determine whether the combined evaluation was more ***:All three examination and testing methods can achieve high accuracy,and the combined evaluation of the three is more accurate than the evaluation of the single way,and the difference is statistically significant(P<0.05).Conclusion:In neoadjuvant chemotherapy for breast cancer patients,the combined assessment of MR,CDFI and tumour markers can more comprehensively and accurately assess the effect of ADC,and more accurately guide the clinical treatment and determine the progn

关键词： breast cancer neoadjuvant chemotherapy MR ultrasound tumour markers

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Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation

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Acta Pharmacologica Sinica 2007年第12期28卷 1991-1995页

作者： Jun-ming guo~(2,3),Bing-xiu XIAO~2,Qiong liu~2,Shun ZHANG~(2,4),Dong-hai liu~(2,4),Zhao-hui GONG~2~2 Ningbo University School of Medicine,Ningbo 315211,China ~4 Affiliated Hospital(Ningbo № 2 Hospital),Ningbo University School ofMedicine,Ningbo 315010,China Ningbo University School of Medicine Ningbo China Affiliated Hospital (Ningbo No 2 Hospital) Ningbo University School of Medicine Ningbo China

Aim:The aim of this study was to investigate the effects of aloe-emodin,a naturalcompound from the root and rhizome of Rheum palmatum,on the growth of hu-man cervical cancer cells,***:HeLa ceils were treated with variousconcentrations of aloe-emodin for 1-5 d,and cell growth was measured by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide *** long-termgrowth effect was investigated by crystal violet *** distributions of thecell cycle and apoptosis were analyzed by flow *** alkaline phos-phatase （ALP） activity was analyzed by a chemical ***,Westernblotting was used to indicate the abundant changes of protein kinase C （PKC）,c-myc,cyclins,cyclin-dependent kinases （CDK）,and proliferating cell nuclear anti-gen （PCNA）.Results:Aloe-emodin inhibited the growth of HeLa cells in a dose-dependent manner at concentrations ranging between 2.5 and 40 μmol/*** cytometric analysis showed that HeLa cells were arrested at the G2/M *** effect was associated with the decrease in cyclin A and CDK2,and theincrease in cyclin B1 and *** importantly,the ALP activity was found tobe increased by aloe-emodin treatment,and accompanied by the inhibition ofPCNA *** addition,aloe-emodin suppressed the expression of PKCαand ***:These findings provide a possible mechanistic explana-tion for the growth inhibitory effect of aloe-emodin on HeLa,which includes cellcycle arrest and inducing differentiation.

关键词： HeLa cells cell cycle aloe-emodin alkaline phosphatase c-myc

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Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective noncomparative study

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1248-1254页

作者： hai-Shuang Lin Xiao-Ping Xu Xuan-Li Zheng Ji-Bing Wang Su-Jie Fan Zuo-HongWu Su-Mian Cheng Li-Jun Zhao Qin-Hua Cai Shao-Dan Zhang Shan-Shan liu Ai-guo Lyu Ying Zhang Hong Chen Dan-Ni Jiang Wu-Liang Li Nathan Congdon Clement C Tham ming-Guang He Yuan-Bo Liang the Malignant Glaucoma TreatmentTrial Study(MGTT)Group Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Ningbo Eye Hospital Ningbo 315100Zhejiang ProvinceChina Weifang Eye Hospital Weifang 261000Shandong ProvinceChina Handan Eye Hospital Handan 056000Hebei ProvinceChina Aier Eye Hospital(Wuhan) Wuhan 430061Hubei ProvinceChina Hebei Eye Hospital Xingtai 054001Hebei ProvinceChina The Third People’s Hospital of Dalian Dalian 116033Liaoning ProvinceChina First Affiliated Hospital of Suzhou University Suzhou 215031Jiangsu ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Centre for Public Health Queen’s University BelfastBelfast BT71NNUK Orbis International New YorkUSA Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong SAR 999077China Centre for Eye Research Australia University of MelbourneRoyal Victorian Eye and Ear HospitalEast Melbourne 3000VICAustralia 不详

AIM:To report a one-year clinical outcomes of low-dose laser cycloplasty(LCP)among malignant glaucoma ***:In this prospective,multicenter,noncomparative clinical study,participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in *** were followed up at 1wk,1,3,6,and *** pressure(IOP),number of glaucoma medications,anterior chamber depth(ACD),and complications were *** success was defined as the reformation of the anterior chamber based on slit-lamp *** was defined by the presence of a shallow orﬂat anterior chamber after initial recovery from ***:A total of 34 eyes received *** IOP and medications decreased from 36.1±11.5 mm Hg with 3.3±1.5 glaucoma medications pre-treatment to 20.9±9.8 mm Hg(P1)with 2.9±1.6 medications(P=0.046)at 1d,and 17.4±6.7 mm Hg(P1)with 1.3±1.7 medications(P1)at *** ACD increased from 1.1±0.8 mm at baseline to 1.7±1.0 mm and to 2.0±0.5 mm at 1d and 12mo,respectively.A total of 32(94.1%)eyes achieved initial anatomical *** follow-up,2(5.9%)eyes failed and 8(23.5%)eyes relapsed,yielding a 12-month anatomical success rate of 64.3%.Complications including anterior synechia(8.82%),choroidal/ciliary detachment(5.88%)and hypopyon(2.94%)were observed within ***:LCP is simple,safe,and effective in reforming the anterior chamber in malignant glaucoma.

关键词： anterior chamber reformation intraocular pressure low-dose laser cycloplasty malignant glaucoma anatomical success

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Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang Li-Tao yang Qian Yue Ke-Jun Kang Yuan-Jing Li hai-Peng An C.Greeshma Jian-Ping Chang Yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju guo Xu-Yuan guo Li He Sheng-ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang hai-Tao Jia Xi Jiang S.Karmakar Hao-Bin Li Jian-Min Li Jin Li Qian-Yun Li Ren-ming-Jie Li Xue-Qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan liu Shu-Kui liu Yan-Dong liu Yu liu Yuan-Yuan liu Zhong-Zhi liu Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang yang Tian Guang-Fu Wang Li Wang Qing Wang Yu-Feng Wang Yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu hai-Jun Yu Jian-Feng Yue ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang Kang-Kang Zhao ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

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Nondegenerate Four Wave Mixing in Rare-Earth Doped Fiber Under theInfluence of Coherent Population Trapping

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Chinese Physics Letters 2000年第4期17卷 275-276页

作者： guo yang ming hai liu Fang-xin XU Li-Xin Structure Research Laboratory University of Science and Technology of ChinaHefei 230026 Department of Physics University of Science and Technology of ChinaHefei 230026 Department of Astronomy and Applied Physics University of Science and Technology of ChinaHefei 230026

By applying a strong coupling field between a lower state and the upper state of an allowed transition to ground,an enhancement of nondegenerate four wave mixing(NDFWM)with a resonantly enhanced third-order nonlinear susceptibility in a rare-earth doped fiber can be *** have derived an expression for the third-order nonlinear susceptibility using quantum theory and discussed the conversion efficiency for *** theoretical result shows that the conversion efficiency has a maximum value while the third-order nonlinear susceptibility shows constructive interference at the Rabi frequencyΩ_(23)=±-√Г2Г*** account of phase-mismatch,the frequency conversion efficiency has a maximum value over a certain small range of frequency separation(such as 030 GHz at the wavelengthλ_(c)=1.55μm),and the frequency conversion range increases with increase of the third-order nonlinear susceptibility.

关键词： degenerate susceptibility nonlinear

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盾粉/橡胶增容复合材料性能与机理的光谱学分析

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光谱学与光谱分析 2024年第4期44卷 1177-1182页

作者：于先坤徐维成张浩吴玉喜李海丽龙红明程峥明刘自民容北国张贵文冶金减排与资源综合利用教育部重点实验室(安徽工业大学) 安徽马鞍山243002 安徽工业大学冶金工程学院安徽马鞍山243032 安徽工业大学建筑工程学院安徽马鞍山243032 中钢集团马鞍山矿山研究院股份有限公司安徽马鞍山243000 首钢京唐钢铁联合有限责任公司河北唐山063200 马鞍山钢铁股份有限公司安徽马鞍山243003 桂林鸿程矿山设备制造有限责任公司广西桂林541002 江苏华安橡胶科技有限公司江苏宿迁223600

碳酸钙是橡胶生产中重要的无机填充剂,具有增容、补强等功能。随着中国橡胶需求量的不断增长,碳酸钙用量不断扩大,其生产成本与能源消耗等问题日益突出。钢渣是炼钢过程中产生的副产品,存在着利用率低、堆积量大等问题。钢渣的主要成分... 详细信息

碳酸钙是橡胶生产中重要的无机填充剂,具有增容、补强等功能。随着中国橡胶需求量的不断增长,碳酸钙用量不断扩大,其生产成本与能源消耗等问题日益突出。钢渣是炼钢过程中产生的副产品,存在着利用率低、堆积量大等问题。钢渣的主要成分为CaO、SiO_(2)、Fe_(x)O_(y)、Al_(2)O_(3)等物质,物化性能与传统填料相近,且钢渣的耐磨性与多孔性优异,因此利用钢渣替代部分碳酸钙作为橡胶填充材料不仅具有重要研究意义而且可以缓解能源消耗、环境污染等问题。基于此,利用自制功能复合剂和超细立磨的方法对钢渣进行联合处理得到粒径800目的样品盾粉,制备活性碳酸钙与盾粉用量比不同的盾粉/橡胶增容复合材料。利用智能型硫化仪、电子拉力机、橡胶硬度计、微型量热仪(MCC)对制备的盾粉/橡胶增容复合材料进行性能测试,热重分析-傅里叶变换红外光谱仪(TG-FTIR)、拉曼光谱仪(Ram)对盾粉/橡胶增容复合材料进行表征分析。结果表明:盾粉替代部分活性碳酸钙对橡胶体系硫化性能有一定的促进作用,可以提高盾粉/橡胶增容复合材料的硫化速度;盾粉的加入可以提高复合橡胶体系的力学性能与阻燃性能;通过微型量热仪(MCC)和拉曼光谱仪(Ram)对盾粉/橡胶增容复合材料分析发现,盾粉替代部分活性碳酸钙后的橡胶体系热释放能力和总热释放量降低、炭渣石墨化程度提升,进一步说明了盾粉替代部分活性碳酸钙在保证盾粉/橡胶增容复合材料物理学性能的前提下也具有一定的阻燃性能。热重-红外分析表明盾粉/橡胶增容复合材料在裂解过程中产生的气体主要为碳氢化合物;自制功能复合剂的加入可以缓解钢渣界面与橡胶界面不相容的问题,优化橡胶复合材料。以上研究为制备性能更优的盾粉/橡胶增容复合材料提供数据理论支持。

关键词：钢渣橡胶表面改性固废利用

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Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： Xue-Mei Lu Xiao-Fen Yu guo-Qiang Li ming-Hao Qu Huan Wang Chuang liu Yu-Ping Man Xiao-Han Jiang Mu-Zi Li Jian Wang Qi-Qi Chen Rui Lei Cheng-Cheng Zhao Yun-Qiu Zhou Zheng-Wang Jiang Zuo-Zhou Li Shang Zheng Chang Dong Bai-Lin Wang Yan-Xiang Sun Hui-Qin Zhang Jie-Wei Li Quan-Hui Mo Ying Zhang Xin Lou hai-Xu Peng Ya-Ting Yi He-Xin Wang Xiu-Jun Zhang Yi-Bo Wang Dan Wang Li Li Qiong Zhang Wen-Xia Wang Yongbo liu Lei Gao Jin-Hu Wu Yan-Chang Wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina College of Life Sciences University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina College of Agricultural Sciences Xichang UniversityXichangSichuanChina Department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina College of Life Sciences Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina Xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of Modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina College of Agriculture Eastern Liaoning UniversityDandongLiaoningChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina Hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research Limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 116 *** and clustering of 101 geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 12.9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1,AaPME1,and AaDOF1)related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3)or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening

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Influence of Finishing Cooling Temperature and Holding Time on Nanometer-size Carbide of Nb-Ti Microalloyed Steel

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Journal of Iron and Steel Research International 2014年第4期21卷 433-438页

作者： hai-long YI yang XU ming-xue SUN Zhen-yu liu guo-dong WANG State Key Laboratory of Rolling and Automation Northeastern University

The nanometer-size carbides formed in ferrite matrix of Nb-Ti microalloyed steel at different finishing cooling temperatures and holding time have been investigated. The characteristics of nanometer-size carbides in ferrite were observed by transmission electron microscopy, and mechanical properties of ferrite were detected by a nano-hardness tester. The results showed that interphase precipitation and diffusion precipitation were observed at different finishing cooling temperatures, and the interphase precipitation was planar and curved. Sheet spacing of inter-phase precipitation increased with the increase of finishing cooling temperature and changed a little when holding for 50--1000 s. Interphase precipitation shows higher nano-hardness at 640℃ compared with diffusion precipitation at 600℃, and the contribution of interphase precipitation to the mechanical properties of ferrite was larger than that of diffusion precipitation.

关键词： nanometer-size arbide Nb-Ti microalloyed steel interphase precipitation diffusion precipitation

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基于光子晶体光纤的局部放电检测

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激光与红外 2024年第7期54卷 1164-1171页

作者：张海徐广陈明刘伟何国斌李建东云南电网有限责任公司大理供电局云南大理671000

局部放电检测对于保障高压电力系统的安全运行至关重要。本文提出了一种针对高压设备局部放电检测的表面等离子体共振D型光子晶体光纤传感器,该方案采用一种光致变色凝胶作为敏感单元,用于感知局部放电所产生的紫外线辐射。该凝胶的折... 详细信息

局部放电检测对于保障高压电力系统的安全运行至关重要。本文提出了一种针对高压设备局部放电检测的表面等离子体共振D型光子晶体光纤传感器,该方案采用一种光致变色凝胶作为敏感单元,用于感知局部放电所产生的紫外线辐射。该凝胶的折射率会随辐射强度的变化而变化,从而影响光纤纤芯和表面等离激元模式之间的耦合共振波长。通过全矢量有限元法对传感器的性能进行了理论和仿真分析,并对传感器的几何参数进行了研究,以优化传感器的灵敏度,最后进行了实验验证。结果表明所设计传感器的灵敏度值可达2.4 nm/mW·cm^(-2)。该传感器结构简单、成本低廉,为光纤局部放电传感的研究提供了参考。

关键词：光纤传感器光子晶体光纤局部放电检测等离子激元

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Microwave Absorption in Electron Cyclotron Resonance Plasma

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Chinese Physics Letters 2000年第1期17卷 31-33页

作者： liu ming-hai HU Xi-Wei WU Qin-Chong YU guo-yang Institute of Plasma Physics Chinese Academy of SciencesHefei 230031 Department of Modern Physics University of Science and Technology of ChinaHefei 230026

The microwave power absorption in electron cyclotron resonance plasma reactor was investigated with a two-dimensional *** results indicated that there are two typical power deposition profiles over the entire parameter region:(1)microwave power deposition peaks on the axis and decreases in radial direction,(2)microwave power deposition has its maximum at some radial position,i.e.,a hollow *** spatial distribution of electron temperature resembles always to the microwave power absorption *** dependence of plasma parameter on the gas pressure is discussed also.

关键词： microwave absorption Electron

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