Evaluation of the efficacy of neoadjuvant chemotherapy for intermediate and advanced breast cancer by 3.0T MR and ultrasound combined with tumour markers
作者机构：Thyroid and mammary departmentShandong Changle People’s HospitalWeifang 262400China. Gynecology DepartmentPingshan District Central HospitalShenzhen 518122China.
出 版 物：《Clinical Research Communications》 (临床研究通讯)
年 卷 期：2024年第7卷第3期
页 面：53-60页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Weifang Science and Technology Development Programme Project(Medicine)(2021YX144) Weifang Municipal Health Commission Chinese Medicine Research Project(WFZYY2024-1-014)
主 题：breast cancer neoadjuvant chemotherapy MR ultrasound tumour markers
摘 要：Objective:To evaluate the efficacy of neoadjuvant chemotherapy before and after neoadjuvant chemotherapy for intermediate and advanced breast cancer using 3.0T MR and ultrasound in combination with tumour markers(CEA,CA-153,CA125),and to provide therapeutic references for the clinicians,so as to better satisfy the needs of treatment for intermediate and advanced breast cancer ***:The team collected 30 patients who were diagnosed with intermediate and advanced breast cancer by biopsy and received neoadjuvant chemotherapy,and divided them into sensitive and insensitive groups according to the MP grading of postoperative pathological *** team retrospectively analysed the changes in the values of serum CEA,CA-153,and CA 125 before and after the neoadjuvant chemotherapy,the changes in the average ADC of the lesions before and after the observation by MRI,and the changes in the volume and size of lesions before and after the observation by ultrasonography to assess the effects of neoadjuvant chemotherapy individually,and the results of neoadjuvant chemotherapy were evaluated *** effect of neoadjuvant chemotherapy was assessed *** of the above was evaluated independently,and the accuracy of each item was calculated by comparing the evaluation results with the pathological examination results,and the accuracy of the single item was compared with the accuracy of the three combined tests to determine whether the combined evaluation was more ***:All three examination and testing methods can achieve high accuracy,and the combined evaluation of the three is more accurate than the evaluation of the single way,and the difference is statistically significant(P0.05).Conclusion:In neoadjuvant chemotherapy for breast cancer patients,the combined assessment of MR,CDFI and tumour markers can more comprehensively and accurately assess the effect of ADC,and more accurately guide the clinical treatment and determine the progn
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