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Indoleamine 2,3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines

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Cell Research 2005年第3期15卷 167-175页

作者： Shih ling HWANG,Nancy Pei-Yee CHUNG,Jacqueline Kwai-Yi CHAN,Chen-Lung steve lin Department of Surgery Kaohsiung Medical University Kaohsiung Taiwan China Department of Surgery The University of Hong Kong Medical Centre Queen Mary Hospital Pokfulam Road Hong KongSAR China Department of Surgery The University of Hong Kong Medical Centre Queen Mary Hospital Pokfulam Road Hong KongSAR China Department of Surgery The University of Hong Kong Medical Centre Queen Mary Hospital Pokfulam Road Hong KongSAR China

Indoleamine 2, 3-dioxygenase (IDO) is a rate-limiting enzyme for the tryptophan catabolism. In human and murine cells, IDO inhibits antigen-specific T cell proliferation in vitro and suppresses T cell responses to fetal alloantigens during murine pregnancy. In mice, IDO expression is an inducible feature of specific subsets of dendritic cells (DCs), and is important for T cell regulatory properties. However, the effect of IDO and tryptophan deprivation on DC func- tions remains unknown. We report here that when tryptophan utilization was prevented by a pharmacological inhibitor of IDO, 1-methyl tryptophan (1MT), DC activation induced by pathogenic stimulus lipopolysaccharide (LPS) or inflam- matory cytokine TNF-α was inhibited both phenotypically and functionally. Such an effect was less remarkable when DC was stimulated by a physiological stimulus, CD40 ligand. Tryptophan deprivation during DC activation also regu- lated the expression of CCR5 and CXCR4, as well as DC responsiveness to chemokines. These results suggest that tryptophan usage in the microenvironment is essential for DC maturation, and may also play a role in the regulation of DC migratory behaviors.

关键词： Indoleamine 2 3-dioxygenase (IDO) dendritic cells activation T cell tryptophan chemokine.

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用于去除单张图像高光的光照约束补色

软件学报 2004年第1期15卷 33-40页

作者：谭平杨杰雷蓓 steve lin 沈向洋上海交通大学图像处理与模式识别研究所上海200030 洛桑联邦科技大学(EPFL)计算机系微软亚洲研究院北京100080

在计算机视觉研究领域,如何检测和消除图像中的高光(specular)一直是个热点问题,有关的研究结果对于提高计算机视觉算法性能有着重要的影响.针对这一问题,提出了一种检测和消除高光的方法.首先,通过比较高光和漫反射光(diffuse)的色度... 详细信息

在计算机视觉研究领域,如何检测和消除图像中的高光(specular)一直是个热点问题,有关的研究结果对于提高计算机视觉算法性能有着重要的影响.针对这一问题,提出了一种检测和消除高光的方法.首先,通过比较高光和漫反射光(diffuse)的色度特性的不同,给出了一种交互检测单色物体表面高光区域的方法;然后,引入补色(inpainting)方法并结合光照约束条件,设计了一种去除单张图像中高光并还原出漫反射分量的新的补色算法.与一般补色方法不同,该算法充分利用了高光区域含有的信息来指导补色过程.通过综合利用观测到的像素值、光源的色度分析(illumination chromaticity analysis)、光源颜色的平滑性等来约束补色过程,保证了算法能够克服一般的补色方法无法保持物体表面细微明暗变化的缺点.实验结果表明,与以往的去除单张图像高光的方法相比,该算法能够提供更好的光源色度估计,从而得到更准确的结果.

关键词：高光补色光照约束

代谢综合征的发育程序化:利用第二代测序技术分析母胎高果糖摄取对子代大鼠转录组的影响（英文）

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生理学报 2016年第5期68卷 557-567页

作者：赵咏梅田佑霖吕史提吴芎历李伟嘉华瑜高雄长庚医院生物医学转化研究所高雄83301 高雄长庚医院儿童肾脏科高雄83301 高雄长庚医院泌尿科高雄83301

临床证据显示高果糖摄取与代谢综合征现象产生有高度相关性,然而关于母体在怀孕与哺乳期高果糖摄取对子代代谢综合征的发育程序化影响的研究却相对缺乏。本研究利用第二代测序(next-generation sequencing)技术分析母鼠高果糖摄取对新... 详细信息

临床证据显示高果糖摄取与代谢综合征现象产生有高度相关性,然而关于母体在怀孕与哺乳期高果糖摄取对子代代谢综合征的发育程序化影响的研究却相对缺乏。本研究利用第二代测序(next-generation sequencing)技术分析母鼠高果糖摄取对新生第一天、离乳后一天(出生后三周)、以及成年期(出生后三个月)子代大鼠脑部、心脏、肾脏与膀胱四个器官转录组的影响。结果显示:(1)母鼠在怀孕与哺乳期高果糖摄取,会程序化胎鼠使其于成年期产生代谢综合征;(2)同时,在仔鼠脑部、心脏、肾脏与膀胱四个器官引起不同程度的转录组变化;(3)在新生第一天子代大鼠,有两个基因,分别是Errfi1与Ctgf,同时在四个器官中表现受到影响,此现象在子代离乳与成年期则消失;(4)参与果糖代谢、糖酵解及糖异生、脂肪代谢、以及胰岛素信号传导通路的基因转录也受到不同程度影响,此现象在新生第一天尤为显著。该结果提示,可利用第二代测序技术寻找不同年龄层子代器官特异性受母体高果糖摄取影响的基因转录变化,进而研发代谢综合征发育程序化在不同器官引起病变的可能机制与治疗策略。

关键词：发育程序化代谢综合征第二代测序转录组

Formulation and procedure for in situ stress back-analysis from borehole strain changes measured during nearby underground excavation

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第8期15卷 1931-1943页

作者： Cui lin D.H.steve Zou Mineral Resource Engineering Dalhousie UniversityHalifaxCanada

Estimation of in situ stresses based on back-analysis of measured stress changes and displacements has become an alternative to the direct stress measurement *** order to help users conduct own measurement and analysis,this paper presents in detail a field stress back-analysis approach directly from borehole strain changes measured during nearby underground *** formulations in major steps and the procedure for the entire analysis process are provided to allow users to *** instrument for borehole strain change measurement can be the CSIR or CSIRO stress cells and other borehole strain cells that can measure strains on borehole *** changes corresponding to the stress changes at a borehole location are calculated in borehole *** stress changes due to nearby excavation can be calculated by an analytical model for a single circular opening and simulated by a numerical model for non-circular and multiple *** models are based on isotropic,homogeneous and linear elastic *** analysis of borehole strain changes is accomplished by multiple linear regression based on error minimization and an integrated process provides the best-fit solution directly to the in situ stresses.A statistical technique is adopted for screening outliers in the measurement data,checking measurement compatibility and evaluating the reliability of analysis *** application example is included to demonstrate the practical application and the analysis procedure.

关键词： In situ stress field Back-analysis Borehole strain change Multiple linear regression Underground excavation Data compatibility Result reliability

The synergistic effect of 3D-printed microscale roughness surface and nanoscale feature on enhancing osteogenic differentiation and rapid osseointegration

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Journal of Materials Science & Technology 2021年第4期63卷 18-26页

作者： Hui Wang Jiaqiang Liu Chengtao Wang steve Guofang Shen Xudong Wang Kaili lin Department of Oral and Cranio-maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011China School&Hospital of Stomatology Tongji UniversityShanghai Engineering Research Center of Tooth Restoration and RegenerationShanghai200072China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China Shanghai University of Medicine&Health Sciences Shanghai201318China

Personalized precision therapy and rapid osseointegration are the main development directions of dental implants.3 D printing is a vital advanced manufacturing technology for personalized precision ***,the osteogenesis of the 3 D printed Ti6 Al4 V implants is *** the bionic perspective,the hierarchical micro/nano-topography can mimic the microenvironment of the multilevel structure of natural bone tissue and may endow the implant surface with superior *** the present study,the hierarchical micro/nano-topography was successfully fabricated by construction the nanoscale feature on 3 D printed microscale roughness surface of 3 D-printed Ti6 Al4 V implants by alkali-heat treatment and hydrothermal *** the cell biological responses in vitro and osseointegration performance in vivo were systematically *** hierarchical micro/nano-topography evidently increased the roughness,improved the hydrophilicity and accelerated the hydroxyapatite deposition and mineralization,which significantly enhanced the adhesion,differentiation and extracellular matrix mineralization of bone marrow derived mesenchymal stromal cells(BMSCs).Most importantly,the hierarchical micro/nano-topography on 3 D-printed implants facilitated the new bone formation and rapid osseointegration in *** study suggested that 3 D-printed implant with micro/nano-topography may be a promising candidate to be applied in orthopedic field to meet the need of customized therapy and rapid osseointegration.

关键词： rapid roughness topography

Productivity Gap and Inward FDI Spillovers: Theory and Evidence from China

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China & World Economy 2021年第2期29卷 24-48页

作者： Jim Huangnan Shen Hao Wang steve Chu-Chia lin School of Management Fudan UniversityChina Center for International Development Harvard Kennedy SchoolUS School of Economics and Trade Guangdong University of Foreign StudiesChina School of Slavonic and East European Studies University College LondonUK Department of Economics National Chengchi UniversityTaiwanChina

This paper constructs a two-stage sequential game model to shed light on the spillover effect of inward FDI on the efficiency of domestic firms in host *** model shows that,given an optimal joint-venture policy made by foreign firms,the impact of the spillover effect of inward FDI is contingent upon the productivity gap between the domestic firms and foreign *** particular,we demonstrate that the spillover effect of inward FDI varies negatively with the productivity gap between domestic lowproductivity firms and foreign firms but works in the opposite way for high-productivity *** suggests that once the productivity gap widens,the entry of foreign firms will increase the efficiency of high-productivity firms but reduce the efficiency of lowproductivity *** support of our theoretical model,we provide robust empirical results by using the dataset of annual survey of Chinese industrial enterprises.

关键词： efficiency improvement inward FDI productivity gap spillover effect

Use of the DSI/Ponemah jacketed external telemetry system for ECG assessments in dog telemetry

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中国药理学与毒理学杂志 2013年第3期 601-602页

作者： WU Rui QU lin-hai Sue McPHERSON steve MASON Safety Pharmacology WuXi AppTec(Suzhou) Co.Ltd.

OBJECTIVE To demonstrate that the DSI /Ponemah Jet System(v5.00) can generate high quality ECG data with current methods,enabling cardiovascular function to be assessed in free moving dogs in their home *** Four male beagle dogs were used on this *** electrodes were placed on each animal and were connected to each JET *** JET device was then placed into a pocket of an externally worn animal jacket for each *** JET device transmits to a Bluetooth? *** Bluetooth? receiver can receive signals from up to 6 JET devices depending upon the device *** JET device can transmit data up to 10 meters with negligible interference and no cross-talk exists between *** animals underwent acclimatization to jackets prior to commencement of *** dog was placed into a pen and ECG measurements taken simultaneously using the DSI /Ponemah Jet *** were recorded for 1 hour pre-dose and continually for the following 23 hours under control conditions,then dosed with ascending doses of Moxifloxacin at intervals of 48 hours between each *** AND CONCLUSION Prolonged QT and QTcV(Van de Water's correction) interval was observed for animals dosed at 100 mg·kg-1 from 4-23 h *** QTcV effects(19% increase with 100 mg·kg-1 Moxifloxacin vs control).The DSI telemetry system performed well when testing the dog to the known pharmacological profile of *** sensitively and efficiently acquired ECG data from the beagle dogs and demonstrated the sensitivity of the system to detect test article induced QT *** allows a colony of dogs to be dedicated for toxicology and safety pharmacology *** DSI /ponemah JET system enables flexibility in study design and can be utilized on a range of study types to facilitate high quality ECGs and reduce the requirement for repeat dosing safety pharmacology *** data generated from this investigation demonstrate the DSI /ponemah JET system(v5.

关键词： ECG dog

Facile synthesis of insulin fusion derivatives through sortase A ligation

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2719-2725页

作者： Maria M.Disotuar Jake A.Smith Jinze Li steve Alam Nai-Pin lin Danny Hung-Chieh Chou Department of Biochemistry School of MedicineUniversity of UtahSalt Lake CityUT 84112USA Division of Endocrinology and Diabetes Department of PediatricsSchool of MedicineStanford UniversityPalo AltoCA 94305USA

Insulin derivatives such as insulin detemir and insulin degludec are *** and Drug Administration(FDA)-approved long-acting insulin currently used by millions of people with *** derivatives are modified in C-terminal B29 lysine to retain insulin *** and efficient methods for facile synthesis of insulin derivatives may lead to new discovery of therapeutic ***,we report a new method using sortase A(SrtA)-mediated ligation for the synthesis of insulin derivatives with high efficiency and functional group tolerance in the C-terminal B *** new insulin molecule(Ins-SA) with an SrtA-recognizing motif can be conjugated to diverse groups with N-terminal oligoglycines to generate new insulin *** further demonstrated that a new insulin derivative synthesized by this SrtA-mediated ligation shows strong cellular and in vivo *** enzymatic method can therefore be used for future insulin design and development.

关键词： Diabetes mellitus Insulin synthesis Sortase A(SrtA)ligation Albumin-binding peptide SA21 Long-acting insulin

High-performance polarization management devices based on thin-film lithium niobate

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Light(Science & Applications) 2022年第5期11卷 868-876页

作者： Zhongjin lin Yanmei lin Hao Li Mengyue Xu Mingbo He Wei Ke Heyun Tan Ya Han Zhaohui Li Dawei Wang X.steve Yao Songnian Fu Siyuan Yu Xinlun Cai State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen University510275 GuangzhouChina Department of Electrical and Computer Engineering The University of British ColumbiaVancouverBC V6T 1Z4Canada Photonics Information Innovation Center and Hebei Provincial Center for Optical Sensing Innovations College of Physics Science and TechnologyHebei University071002 BaodingChina Institute of Advanced Photonics Technology School of Information EngineeringGuangdong University of Technology510006 GuangzhouChina

High-speed polarization management is highly desirable for many applications,such as remote sensing,telecommunication,and medical ***,most of the approaches for polarization management rely on bulky optical components that are slow to respond,cumbersome to use,and sometimes with high drive ***,we overcome these limitations by harnessing photonic integrated circuits based on thin-film lithium niobate *** successfully realize a portfolio of thin-film lithium niobate devices for essential polarization management functionalities,including arbitrary polarization generation,fast polarization measurement,polarization scrambling,and automatic polarization *** present devices feature ultra-fast control speeds,low drive voltages,low optical losses and compact *** these devices,we achieve high fidelity polarization generation with a polarization extinction ratio up to 41.9 dB and fast polarization scrambling with a scrambling rate up to 65 Mrad s−1,both of which are best results in integrated *** also demonstrate the endless polarization state tracking operation in our *** demonstrated devices unlock a drastically new level of performance and scales in polarization management devices,leading to a paradigm shift in polarization management.

关键词： polarization lithium film