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3D bioprinting of collagen-based materials for oral medicine

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Collagen and Leather 2024年第1期5卷 28-46页

作者： Bosen Yang Hai Liu linli Jiang Yiwei Zeng Yiyuan Han Chuanlu Sha Xin Xie hui Li Jiajing Zhou Wei lin College of Biomass Science and Engineering Key Laboratory of Leather Chemistry and Engineering of Ministry of EducationNational Engineering Laboratory for Clean Technology of Leather ManufactureSichuan UniversityChengdu 610065China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan UniversityChengdu 610065China Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA

Oral diseases have emerged as one of the leading public health challenges *** the existing clinical modalities for restoration of dental tissue loss and craniomaxillofacial injuries can achieve satisfactory therapeutic results,they cannot fully restore the original complex anatomical structure and physiological function of the tissue.3D printing of biological tissues has gained growing interest in the field of oral medicine with the ability to control the bioink component and printing structure for spatially heterogeneous repairing constructs,holding enormous promise for the precise treatment of oral ***,collagen-based materials have been recognized as promising biogenic bioinks for the regeneration of several tissues with high cell-activating and biocompatible *** this review,we summarize 3D printing methods for collagen-based biomaterials and their ***,we highlight the animal sources of collagen and their characteristics,as well as the methods of collagen ***,this review provides an overview of the 3D bioprinting technology for the regeneration of the pulpal nerve and blood vessels,cartilage,and periodontal *** envision that this technique opens up immense opportunities over the conventional ones,with high replicability and customized function,which can ultimately promote effective oral tissue regeneration.

关键词： 3D bioprinting Oral medicine Tissue engineering Collagen Scaffold materials Bioink Hydrogel

The Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating link Complements

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chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： Wei lin School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the *** on this result,he was able to argue the hyperbolicity of non-split prime alternating links in *** et *** that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of *** author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

taBOX: A water-soluble tetraanionic rectangular molecular container for conjugated molecules and taste masking for berberine and palmatine

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chinese Chemical Letters 2024年第5期35卷 175-178页

作者： Qihan lin Jiabin Xing Yue-Yang Liu Gang Wu Shi-Jia Liu hui Wang Wei Zhou Zhan-Ting Li Dan-Wei Zhang Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438China

A water-soluble macrocycle that bears four carboxylate anions has been designed and prepared,which forms a rectangular cavity that can efficiently encapsulate discrete electron-deficient aromatic compounds,including berberine and *** macrocycle is revealed to be highly biocompatible and able to inhibit the bitter taste of the two drugs.

关键词： Macrocycle Multianion Molecular container Molecular recognition Bitter taste masking

Correlation Study of Operational Data and System Performance of District Cooling System with Ice Storage

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Journal of Power and Energy Engineering 2024年第3期12卷 75-98页

作者： hui Cao Nan Li Jiajing lin School of Civil Engineering Chongqing University Chongqing China National Centre for International Research of Low-Carbon and Green Buildings Ministry of Science & Technology Chongqing University Chongqing China

The district cooling system (DCS) with ice storage can reduce the peak electricity demand of the business district buildings it serves, improve system efficiency, and lower operational costs. This study utilizes a monitoring and control platform for DCS with ice storage to analyze historical parameter values related to system operation and executed operations. We assess the distribution of cooling loads among various devices within the DCS, identify operational characteristics of the system through correlation analysis and principal component analysis (PCA), and subsequently determine key parameters affecting changes in cooling loads. Accurate forecasting of cooling loads is crucial for determining optimal control strategies. The research process can be summarized briefly as follows: data preprocessing, parameter analysis, parameter selection, and validation of load forecasting performance. The study reveals that while individual devices in the system perform well, there is considerable room for improving overall system efficiency. Six principal components have been identified as input parameters for the cold load forecasting model, with each of these components having eigenvalues greater than 1 and contributing to an accumulated variance of 87.26%, and during the dimensionality reduction process, we obtained a confidence ellipse with a 95% confidence interval. Regarding cooling load forecasting, the Relative Absolute Error (RAE) value of the light gradient boosting machine (lightGBM) algorithm is 3.62%, Relative Root Mean Square Error (RRMSE) is 42.75%, and R-squared value (R2) is 92.96%, indicating superior forecasting performance compared to other commonly used cooling load forecasting algorithms. This research provides valuable insights and auxiliary guidance for data analysis and optimizing operations in practical engineering applications. .

关键词： DCS Correlation Coefficient PCA Hourly Cooling Load System Performance

Imiquimod:A potential option for inhibition of repigmentation of congenital melanocytic nevus after laser ablation

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chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 76-78页

作者： Yifei Zhao Yun Zou Xiangyu Chen Hanlin Zeng Hanru Ying Xiaoxi lin hui Chen Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Shanghai Institute of Precision Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Department of Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai201900China

Congenital melanocytic nevi(CMN) are common skin tumors. Large and specially located nevi cannot be completely removed by surgery, posing the risks of both cosmetic deformities and potential *** treatments, such as laser therapy and physical dermabrasion, can overcome the limitations of surgery;however, the high rate of repigmentation remains an unresolved global challenge. We conducted a self-controlled observational study of a patient with a nevus on the chest. Two areas of the lesion were treated with an Er:YAG laser and 5% imiquimod cream was applied to one of these areas. After nearly 7-months of follow-up, we observed a significant difference in color between the two areas, suggesting that topical imiquimod may inhibit repigmentation and significantly enhance the effectiveness of laser treatment.

关键词： Imiquimod Congenital melanocytic nevus Recurrence Laser

Understanding the mechanism underlying the anti-inflammatory effect of dietary flavonoids on IBD: a focus on gut microbiota and its metabolites involved in SCFA， bile acid， tryptophan and lipopolysaccharides

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Food Science and Human Wellness 2024年

作者： huihui Xiong hui Chen lingli Chen Kehui Ouyang Suyun lin Wenjun Wang College of Food Science and Engineering， Jiangxi Agricultural University College of Animal Science and Technology， Jiangxi Agricultural University

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease with a high incidence. Treatment for IBD includes medications and diet， and common anti-inflammatory medications have limitations like drug resistance and serious adverse effects. Accumulating evidence has demonstrated that dietary flavonoids exhibit an alleviative effect on IBD by influencing gut microbiota. The microbiota-derived metabolites also regulate IBD and maintain intestinal homeostasis. In this review， we investigate the therapeutic effect of gut microbiota and metabolites on IBD by intestinal immune and intestinal barrier function. We demonstrate the underlying mechanism of dietary flavonoids as an anti-inflammatory molecule alleviating IBD by regulating gut microbiota， short chain fatty acid (SCFA)， bile acid (BA)， tryptophan (Trp) metabolism and lipopolysaccharides (LPS)-toll-like receptor 4 (TLR4) signaling pathway. Based on structural differences of flavonoids， we summarize the recent research progress on the role of different dietary flavonoids in alleviating IBD by gut microbiota and metabolites in animal and clinical trials. This review indicates that dietary flavonoids targeting gut microbiota and metabolites provide a promising strategy for the treatment of inflammation and novel insights into the management of IBD.

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Percutaneous transhepatic stenting for acute superior mesenteric vein stenosis after pancreaticoduodenectomy with portal vein reconstruction:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1195-1202页

作者： Chen lin Zi-Yan Wang Liang-Bo Dong Zhi-Wei Wang Ze-hui Li Wei-Bin Wang Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of General Surgery Peking Union Medical College HospitalBeijing 100730China Interventional Section Department of RadiologyPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Percutaneous transhepatic stent placement has become a common strategy for the postoperative treatment of portal vein(PV)/superior mesenteric veins(SMV)stenosis/*** has been widely used after liver transplantation surgery;however,reports on stent placement for acute PV/SMV stenosis after pancreatic surgery within postoperative 3 d are *** SUMMARY Herein,we reported a case of intestinal edema and SMV stenosis 2 d after pancreatic *** patient was successfully treated using stent *** the stenosis resolved after stent placement,complications,including bleeding,pancreatic fistula,bile leakage,and infection,made the treatment highly *** use of anticoagulants was adjusted multiple times to prevent venous thromboembolism and the risk of *** careful treatment,the patient stabilized,and stent placement effectively managed postoperative PV/SMV *** Stent placement is effective and feasible for treating acute PV/SMV stenosis after pancreatic surgery even within postoperative 3 d.

关键词： Pancreaticoduodenectomy Portal vein reconstruction Portal vein stenosis Portal vein stent Case report

Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19

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World Journal of Stem Cells 2024年第4期16卷 353-374页

作者： Xiang-Yi Hou La-Mu Danzeng Yi-lin Wu Qian-hui Ma Zheng Yu Mei-Ying Li Li-Sha Li The Key Laboratory of Pathobiology Ministry of EducationCollege of Basic Medical SciencesJilin UniversityChangchun 130021Jilin ProvinceChina Department of Pharmacy Jilin UniversityChangchun 130021Jilin ProvinceChina The First Hospital of Jilin University Jilin UniversityChangchun 130021Jilin ProvinceChina

Coronavirus disease 2019(COVID-19)is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).SARS-CoV-2 infection typically presents with fever and respiratory symptoms,which can progress to severe respiratory distress syndrome and multiple organ *** severe cases,these complications may even lead to *** of the causes of COVID-19 deaths is the cytokine storm caused by an overactive immune ***,suppressing the overactive immune response may be an effective strategy for treating *** stem cells(MSCs)and their derived exosomes(MSCs-Exo)have potent homing abilities,immunomodulatory functions,regenerative repair,and antifibrotic effects,promising an effective tool in treating *** this paper,we review the main mechanisms and potential roles of MSCs and MSCs-Exo in treating *** also summarize relevant recent clinical trials,including the source of cells,the dosage and the efficacy,and the clinical value and problems in this field,providing more theoretical references for the clinical use of MSCs and MSCs-Exo in the treatment of COVID-19.

关键词： COVID-19 Cytokine storm Immunomodulation Mesenchymal stem cell Mesenchymal stem cell-derived exosomes

Modeling urban redevelopment:A novel approach using time-series remote sensing data and machine learning

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Geography and Sustainability 2024年第2期5卷 211-219页

作者： Li lin Liping Di Chen Zhang Liying Guo Haoteng Zhao Didarul Islam hui Li Ziao Liu Gavin Middleton Center for Spatial Information Science and Systems George Mason UniversityFairfaxVA22030USA Department of Geography and Geoinformation Science George Mason UniversityFairfaxVA22030USA

Accurate mapping and timely monitoring of urban redevelopment are pivotal for urban studies and decisionmakers to foster sustainable urban *** mapping methods heavily depend on field surveys and subjective questionnaires,yielding less objective,reliable,and timely *** advancements in Geographic Information Systems(GIS)and remote-sensing technologies have improved the identification and mapping of urban redevelopment through quantitative analysis using satellite-based ***,challenges persist,particularly concerning accuracy and significant temporal *** study introduces a novel approach to modeling urban redevelopment,leveraging machine learning algorithms and remote-sensing *** methodology can facilitate the accurate and timely identification of urban redevelopment *** study’s machine learning model can analyze time-series remote-sensing data to identify spatio-temporal and spectral patterns related to urban *** model is thoroughly evaluated,and the results indicate that it can accurately capture the time-series patterns of urban *** research’s findings are useful for evaluating urban demographic and economic changes,informing policymaking and urban planning,and contributing to sustainable urban *** model can also serve as a foundation for future research on early-stage urban redevelopment detection and evaluation of the causes and impacts of urban redevelopment.

关键词： Urban redevelopment Urban sustainability Remote sensing Time-series analysis Machine learning